Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.4
USERS' SCORE
Medium or Average
Based on 9 Reviews
6.8
Supplement Facts
Serving Size: 1 Caplet
Amount Per Serving
%DV
Organic ashwagandha powder (root)(0.2% Withanolides, 0.76 mg)
380 mg
*
Organic ashwagandha extract (root)(0.5% Withanolides, 1.4 mg)
280 mg
*
Organic ashwagandha supercriticalCO2 extract (root) (Withania somnifera) (8% Withanolides, 0.8 mg)
10 mg
*

Top Medical Research Studies

We aimed to explore the link between dietary intake of long-chain omega-3 fatty acids, specifically docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), and their potential impact on headache prevalence in the U.S. Using data from the National Health and Nutrition Examination Surveys conducted between 1999 and 2004, we looked at a diverse group of over 12,000 adults aged 20 and older.

Through interviews, participants reported experiences of severe headaches or migraines in the past three months. We also measured dietary EPA and DHA from their food intake and assessed levels of C-reactive protein, which is an indicator of inflammation. Our analysis suggested that increased intake of omega-3 fatty acids correlated with a lower prevalence of severe headaches or migraines. Specifically, each log unit increase in EPA was linked to a 6% reduction in the prevalence—while DHA showed a similar reduction.

Interestingly, we found that this effect was more pronounced among non-Mexican Hispanic participants compared to others. Importantly, our results remained robust even after considering inflammation levels. Thus, this study supports the idea that omega-3 fatty acids may be beneficial in helping to prevent or alleviate headaches.
Read More
9
We explored how dietary changes, specifically increasing omega-3 fatty acids like docosahexaenoic acid (DHA) while lowering omega-6 fatty acids, can influence headache pain. In a trial involving 55 chronic headache patients, we observed significant benefits from this targeted dietary intervention.

Participants in the study experienced notable increases in beneficial compounds derived from DHA, including 2-docosahexaenoylglycerol and docosahexaenoylethanolamine, alongside a decrease in a compound derived from omega-6 fatty acids. Our findings indicate that these changes in endocannabinoids are linked to reductions in both physical pain and psychological distress related to headaches.

The results suggest that adopting a diet rich in omega-3 fatty acids could be a promising way to manage headaches and related psychological issues effectively. This highlights the potential relevance of diet in addressing chronic pain, opening the door for further exploration into personalized nutrition as a valuable strategy for headache relief.
Read More
In our exploration of how different fatty acids influence migraine frequency, we found intriguing results regarding docosahexaenoic acid (DHA). We assessed the dietary habits of 105 migraine patients aged between 15 and 50 years, using a food frequency questionnaire to track their intake of various fatty acids such as eicosapentaenoic acid (EPA) and saturated fatty acids (SFA).

The data told a compelling story: a higher intake of omega-3 fatty acids, specifically DHA and EPA, was linked to a lower frequency of migraine attacks. When we looked closer, we discovered that for individuals with lower levels of these omega-3 fats, the frequency of migraines was notably higher. This trend was consistent across both men and women, suggesting a robust relationship between increased DHA intake and reduced headache occurrences.

On the other hand, the study did not find any significant connection between saturated fatty acid intake and migraine frequency. This could indicate that not all fats are created equal when it comes to managing headaches. The findings point to the potential of DHA, alongside EPA, as a dietary intervention for migraine relief, although further studies are needed to deepen our understanding.
Read More

Most Useful Reviews

9
Completely prevents headaches
2 people found this helpful
Ashwagandha offers calmness and energy! I gave it to my mother and grandmother during stressful times. Surprisingly, my mother didn’t experience a headache, though she typically faced issues with them before. My grandmother, often unwell, became more lively and started to engage in activities again, gaining strength and an improved mood after taking Ashwagandha.
Read More
9
Effective relief
This is better than the large pink one. After consuming this, the tension dissipates and the headache is alleviated.
Read More
7.5
Headaches due to fatigue
Mamata Quality Organic High Ingredients Organic Ashwagandha has helped me considerably over three months. It improves my mood and activity levels, particularly with muscle pain and persistent headaches that I experienced.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.4
  • All Researches
We conducted a clinical trial to see how dietary changes targeting omega-3 and omega-6 fatty acids could help people dealing with chronic headaches. Over 12 weeks, we divided participants into two groups: one that increased their omega-3 intake while reducing omega-6 and another that just focused on lowering omega-6.

Our findings were quite promising! Those in the group increasing their omega-3 levels experienced a greater reduction in headache severity and frequency compared to those simply lowering omega-6. Specifically, the high omega-3 group had a significant drop in both daily headache hours and pain impact, while altering levels of important headache-relief mediators in the body.

This suggests that increasing omega-3, particularly docosahexaenoic acid, can be an effective strategy for reducing headache symptoms and improving overall quality of life among chronic headache sufferers. These dietary adjustments could provide a new avenue for managing headaches more effectively.
Read More
9
We explored how dietary changes, specifically increasing omega-3 fatty acids like docosahexaenoic acid (DHA) while lowering omega-6 fatty acids, can influence headache pain. In a trial involving 55 chronic headache patients, we observed significant benefits from this targeted dietary intervention.

Participants in the study experienced notable increases in beneficial compounds derived from DHA, including 2-docosahexaenoylglycerol and docosahexaenoylethanolamine, alongside a decrease in a compound derived from omega-6 fatty acids. Our findings indicate that these changes in endocannabinoids are linked to reductions in both physical pain and psychological distress related to headaches.

The results suggest that adopting a diet rich in omega-3 fatty acids could be a promising way to manage headaches and related psychological issues effectively. This highlights the potential relevance of diet in addressing chronic pain, opening the door for further exploration into personalized nutrition as a valuable strategy for headache relief.
Read More
We investigated the potential of docosahexaenoic acid (DHA) and its oxidized derivatives in predicting chronic posttraumatic headache (PTH) after traumatic brain injury (TBI). In a study involving patients within three days of a TBI, we focused on measuring circulating oxylipins—molecules derived from fatty acids like DHA and arachidonic acid. Our goal was to see if these could help indicate which patients might develop chronic headaches later on.

We found that some DHA-related oxylipins, specifically 4-hydroxy-DHA and 19,20-epoxy-docosapentaenoate, seemed to correlate with lower headache severity. Conversely, a linoleic acid derivative known as 11-hydroxy-9-epoxy-octadecenoate was positively linked to more severe headaches. This suggests that not all fatty acid derivatives act similarly concerning headache severity.

Our findings support the idea that DHA-derived oxylipins have the potential to serve as biomarkers for predicting the onset of chronic headaches after a brain injury, highlighting an exciting area for further research into treatment options.
Read More
We aimed to explore the link between dietary intake of long-chain omega-3 fatty acids, specifically docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), and their potential impact on headache prevalence in the U.S. Using data from the National Health and Nutrition Examination Surveys conducted between 1999 and 2004, we looked at a diverse group of over 12,000 adults aged 20 and older.

Through interviews, participants reported experiences of severe headaches or migraines in the past three months. We also measured dietary EPA and DHA from their food intake and assessed levels of C-reactive protein, which is an indicator of inflammation. Our analysis suggested that increased intake of omega-3 fatty acids correlated with a lower prevalence of severe headaches or migraines. Specifically, each log unit increase in EPA was linked to a 6% reduction in the prevalence—while DHA showed a similar reduction.

Interestingly, we found that this effect was more pronounced among non-Mexican Hispanic participants compared to others. Importantly, our results remained robust even after considering inflammation levels. Thus, this study supports the idea that omega-3 fatty acids may be beneficial in helping to prevent or alleviate headaches.
Read More
We examined how the balance of omega-6 and omega-3 polyunsaturated fatty acids (PUFAs) influences headache intensity. The study included 605 adults and focused on various chronic pain conditions, including orofacial pain, headache, low back pain, irritable bowel syndrome, and bodily pain.

The findings revealed that a higher ratio of omega-6 to omega-3 fatty acids was linked to increased pain intensity across several conditions, particularly in headaches. Interestingly, docosahexaenoic acid (DHA), a specific type of omega-3 fatty acid, was found to have a strong inverse relationship with pain intensity, indicating that higher levels of DHA may help reduce headache severity.

However, it’s important to note that while the study found a consistent association between the overall ratio of omega-6 to omega-3 and headache intensity, it did not isolate the effect of DHA alone on headaches. This suggests that while DHA may be beneficial, its exact impact on headache pain requires further investigation to fully understand its role.
Read More

User Reviews

USERS' SCORE
Medium or Average
Based on 9 Reviews
6.8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Completely prevents headaches
2 people found this helpful
Ashwagandha offers calmness and energy! I gave it to my mother and grandmother during stressful times. Surprisingly, my mother didn’t experience a headache, though she typically faced issues with them before. My grandmother, often unwell, became more lively and started to engage in activities again, gaining strength and an improved mood after taking Ashwagandha.
Read More
9
Effective relief
This is better than the large pink one. After consuming this, the tension dissipates and the headache is alleviated.
Read More
7.5
Headaches due to fatigue
Mamata Quality Organic High Ingredients Organic Ashwagandha has helped me considerably over three months. It improves my mood and activity levels, particularly with muscle pain and persistent headaches that I experienced.
Read More
6
Decreases headache frequency
8 people found this helpful
I’ve been drinking this with plain hot water every morning for around a month now. I feel more refreshed from physical fatigue and dullness, and my headache has also diminished. I’m keen to continue!
Read More
7.5
Cures headache
It is beneficial for headaches, as it is often resolved using this, ubiquinol, and magnesium.
Read More

Frequently Asked Questions

6
Decreases headache frequency
8 people found this helpful
I’ve been drinking this with plain hot water every morning for around a month now. I feel more refreshed from physical fatigue and dullness, and my headache has also diminished. I’m keen to continue!
7.5
Headaches due to fatigue
Mamata Quality Organic High Ingredients Organic Ashwagandha has helped me considerably over three months. It improves my mood and activity levels, particularly with muscle pain and persistent headaches that I experienced.
2
Headaches discontinued use
I got headaches the first three times I took this, so I discontinued use. I’m uncertain about the cause of these headaches.
9
Completely prevents headaches
2 people found this helpful
Ashwagandha offers calmness and energy! I gave it to my mother and grandmother during stressful times. Surprisingly, my mother didn’t experience a headache, though she typically faced issues with them before. My grandmother, often unwell, became more lively and started to engage in activities again, gaining strength and an improved mood after taking Ashwagandha.
9
Effective relief
This is better than the large pink one. After consuming this, the tension dissipates and the headache is alleviated.
2
Not suitable for headaches
This product has good quality, but unfortunately, it didn’t suit me as it caused headaches.
2
No headache relief
5 people found this helpful
I took these pills for two months, but the effect was non-existent; I still experienced drowsiness and a sense of apathy. My husband, who suffered from headaches, stopped taking them immediately due to this lack of efficacy—especially as the price has risen almost twofold.
0
Every dose triggers headaches
I’m unsure about this as every time I take it, I get a headache. Perhaps I am allergic.
7.5
Cures headache
It is beneficial for headaches, as it is often resolved using this, ubiquinol, and magnesium.
We examined how the balance of omega-6 and omega-3 polyunsaturated fatty acids (PUFAs) influences headache intensity. The study included 605 adults and focused on various chronic pain conditions, including orofacial pain, headache, low back pain, irritable bowel syndrome, and bodily pain.

The findings revealed that a higher ratio of omega-6 to omega-3 fatty acids was linked to increased pain intensity across several conditions, particularly in headaches. Interestingly, docosahexaenoic acid (DHA), a specific type of omega-3 fatty acid, was found to have a strong inverse relationship with pain intensity, indicating that higher levels of DHA may help reduce headache severity.

However, it’s important to note that while the study found a consistent association between the overall ratio of omega-6 to omega-3 and headache intensity, it did not isolate the effect of DHA alone on headaches. This suggests that while DHA may be beneficial, its exact impact on headache pain requires further investigation to fully understand its role.
We conducted a clinical trial to see how dietary changes targeting omega-3 and omega-6 fatty acids could help people dealing with chronic headaches. Over 12 weeks, we divided participants into two groups: one that increased their omega-3 intake while reducing omega-6 and another that just focused on lowering omega-6.

Our findings were quite promising! Those in the group increasing their omega-3 levels experienced a greater reduction in headache severity and frequency compared to those simply lowering omega-6. Specifically, the high omega-3 group had a significant drop in both daily headache hours and pain impact, while altering levels of important headache-relief mediators in the body.

This suggests that increasing omega-3, particularly docosahexaenoic acid, can be an effective strategy for reducing headache symptoms and improving overall quality of life among chronic headache sufferers. These dietary adjustments could provide a new avenue for managing headaches more effectively.
In our exploration of how different fatty acids influence migraine frequency, we found intriguing results regarding docosahexaenoic acid (DHA). We assessed the dietary habits of 105 migraine patients aged between 15 and 50 years, using a food frequency questionnaire to track their intake of various fatty acids such as eicosapentaenoic acid (EPA) and saturated fatty acids (SFA).

The data told a compelling story: a higher intake of omega-3 fatty acids, specifically DHA and EPA, was linked to a lower frequency of migraine attacks. When we looked closer, we discovered that for individuals with lower levels of these omega-3 fats, the frequency of migraines was notably higher. This trend was consistent across both men and women, suggesting a robust relationship between increased DHA intake and reduced headache occurrences.

On the other hand, the study did not find any significant connection between saturated fatty acid intake and migraine frequency. This could indicate that not all fats are created equal when it comes to managing headaches. The findings point to the potential of DHA, alongside EPA, as a dietary intervention for migraine relief, although further studies are needed to deepen our understanding.
4
Dietary study on headache relief
We conducted a study to explore the effects of dietary changes, specifically focusing on docosahexaenoic acid (DHA), on persistent post-traumatic headaches (PTH) among service members. Our trial involved 122 participants suffering from chronic headaches following traumatic brain injuries. Participants followed a controlled diet for 12 weeks, with one group increasing their intake of n-3 fatty acids like DHA while reducing n-6 fatty acids, while the control group maintained a typical diet.

Throughout the trial, we gathered data through daily headache diaries and measured various clinical outcomes, including the impact of headaches on daily living. While our goal was to determine whether increasing DHA could lead to significant improvements in headache symptoms, we need to note that the results did not show a clear benefit directly attributable to DHA alone.

It’s important to understand that while dietary modifications involving DHA were studied, the presence of other dietary components makes it challenging to isolate its specific impact on headaches. The overall findings suggest that while dietary interventions are being explored, more focused research is needed to fully understand the role of DHA in headache management.
7
Dietary omega-3 impacts migraines
We designed a study to investigate how dietary alterations, particularly in omega-3 fatty acids like docosahexaenoic acid (DHA), affect migraine headaches. Our randomized, controlled trial involved 153 adults with episodic migraines, allowing us to analyze the impact of increased intake of n-3 EPA and DHA, compared to standard dietary intakes of n-6 linoleic acid.

Over a span of 16 weeks, participants followed one of three dietary plans while being completely unaware of the specific guidelines. These plans included a regimen with high n-3 and low n-6 intake, a high n-3 with usual n-6 intake, and a standard diet. Throughout the study, we provided participants with specific oils and foods, ensuring they received the necessary nutritional support.

Our focus was not just on the dietary changes, but also on how these changes could modulate headache pain and improve quality of life. By measuring various biochemical and clinical outcomes, we were poised to gain insightful knowledge about the role of DHA and its potential benefits for managing migraine headaches.

However, we also found that combining these fatty acids made it challenging to isolate the specific effects of DHA alone on headache outcomes. Therefore, while this study offers valuable insights into dietary influences on migraine, we must exercise caution in attributing efficacy solely to DHA.

References

  1. Sanders AE, Weatherspoon ED, Ehrmann BM, Soma PS, Shaikh SR, et al. Circulating Polyunsaturated Fatty Acids and Pain Intensity in Five Chronic Pain Conditions. J Pain. 2023;24:478. doi:10.1016/j.jpain.2022.10.008
  2. Faurot KR, Cole WR, MacIntosh BA, Dunlap M, Moore CB, et al. Targeted dietary interventions to reduce pain in persistent post-traumatic headache among service members: Protocol for a randomized, controlled parallel-group trial. Contemp Clin Trials. 2022;119:106851. doi:10.1016/j.cct.2022.106851
  3. Ramsden CE, Zamora D, Faurot KR, MacIntosh B, Horowitz M, et al. Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial. BMJ. 2021;374:n1448. doi:10.1136/bmj.n1448
  4. Domenichiello AF, Jensen JR, Zamora D, Horowitz M, Yuan ZX, et al. Identifying oxidized lipid mediators as prognostic biomarkers of chronic posttraumatic headache. Pain. 2020;161:2775. doi:10.1097/j.pain.0000000000001983
  5. Sanders AE, Shaikh SR, Slade GD. Long-chain omega-3 fatty acids and headache in the U.S. population. Prostaglandins Leukot Essent Fatty Acids. 2018;135:47. doi:10.1016/j.plefa.2018.06.008
  6. Mann JD, Faurot KR, MacIntosh B, Palsson OS, Suchindran CM, et al. A sixteen-week three-armed, randomized, controlled trial investigating clinical and biochemical effects of targeted alterations in dietary linoleic acid and n-3 EPA+DHA in adults with episodic migraine: Study protocol. Prostaglandins Leukot Essent Fatty Acids. 2018;128:41. doi:10.1016/j.plefa.2017.11.002
  7. Sadeghi O, Maghsoudi Z, Khorvash F, Ghiasvand R, Askari G. The relationship between different fatty acids intake and frequency of migraine attacks. Iran J Nurs Midwifery Res. 2015;20:334.
  8. Ramsden CE, Zamora D, Makriyannis A, Wood JT, Mann JD, et al. Diet-induced changes in n-3- and n-6-derived endocannabinoids and reductions in headache pain and psychological distress. J Pain. 2015;16:707. doi:10.1016/j.jpain.2015.04.007
  9. Ramsden CE, Faurot KR, Zamora D, Suchindran CM, MacIntosh BA, et al. Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. Pain. 2013;154:2441. doi:10.1016/j.pain.2013.07.028
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