Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 7 Reviews
8.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Thiamin (as Thiamine Mononitrate)
25 mg
2,083%
Riboflavin
25 mg
1,923%
Niacin (as Nicotinic Acid)
25 mg NE§
156%
Vitamin B6 (as Pyridoxine HCl [25 mg] and Pyridoxal 5-Phosphate [10 mg])
35 mg
2,059%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFEâĄ
170%
Vitamin B12 (as Methylcobalamin)
100 mcg
4,167%
Biotin (as d-Biotin)
300 mcg
1,000%
Pantothenic Acid (as Calcium D-Pantothenate)
100 mg
2,000%
Choline (as Choline Bitartrate)
50 mg
9%
Pantethine
25 mg
â
Inositol
50 mg
â
Top Medical Research Studies
8
Pyridoxine promotes glioblastoma cell death
We explored the effect of vitamin B6 (pyridoxine) and B12 (cobalamin) on human glioblastoma cells, known for their aggressive nature. By treating cell cultures with varying doses of these vitamins over 24-72 hours, we aimed to see how they influenced cell survival and progression through their life cycle.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
Read More
7
We investigated how nicotinamide, a form of vitamin B3, impacts glioblastoma (GB) cells. Our findings reveal that it can induce a state of senescence, slowing down cell growth and altering their internal processes.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
Read More
Most Useful Reviews
9
Transformed my life
7 people found this helpful
Changed My Life! I have tried every type of B12 vitamin available; including injectable options and designer prescription varieties. This is the only B12 supplement that has been effective for me. I am not usually one to write reviews, but this has genuinely changed my life. I transitioned from being barely able to manage fatigue to actively participating in life again. The brain fog is gone, and I finally feel like I've regained control of my life.
Read More
9
Enhanced concentration
Great product! It helps with concentration and relieves my brain fogginess.
Read More
7.5
Prevented brain fog
Quite useful! B complex is essential for brain health and helps in avoiding brain fog.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
Pyridoxine promotes glioblastoma cell death
We explored the effect of vitamin B6 (pyridoxine) and B12 (cobalamin) on human glioblastoma cells, known for their aggressive nature. By treating cell cultures with varying doses of these vitamins over 24-72 hours, we aimed to see how they influenced cell survival and progression through their life cycle.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
Read More
7
We investigated how nicotinamide, a form of vitamin B3, impacts glioblastoma (GB) cells. Our findings reveal that it can induce a state of senescence, slowing down cell growth and altering their internal processes.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Transformed my life
7 people found this helpful
Changed My Life! I have tried every type of B12 vitamin available; including injectable options and designer prescription varieties. This is the only B12 supplement that has been effective for me. I am not usually one to write reviews, but this has genuinely changed my life. I transitioned from being barely able to manage fatigue to actively participating in life again. The brain fog is gone, and I finally feel like I've regained control of my life.
Read More
9
Enhanced concentration
Great product! It helps with concentration and relieves my brain fogginess.
Read More
7.5
Prevented brain fog
Quite useful! B complex is essential for brain health and helps in avoiding brain fog.
Read More
7.5
Enhanced brain function
10 people found this helpful
I love Jarrow Formulas for their quality and affordable vitamins. This complex provides essential B vitamins in their active forms, such as methylfolate and methylcobalamin. One can lasts a long time, as I take them every six months. My hair has improved noticeably, and I maintain optimal ferritin levels. These B vitamins also enhance brain function, which is crucial for me.
Read More
8
Effective nutrient
1 people found this helpful
It is the most effective nutrient for recovering from fatigue. It also aids in improving brain function and should be a basic addition for students.
Read More
Frequently Asked Questions
7.5
Improved energy
An excellent supplement for brain function; after taking it, my general tone improved significantly, and I had more energy.
9
Transformed my life
7 people found this helpful
Changed My Life! I have tried every type of B12 vitamin available; including injectable options and designer prescription varieties. This is the only B12 supplement that has been effective for me. I am not usually one to write reviews, but this has genuinely changed my life. I transitioned from being barely able to manage fatigue to actively participating in life again. The brain fog is gone, and I finally feel like I've regained control of my life.
9
Enhanced concentration
Great product! It helps with concentration and relieves my brain fogginess.
8
Effective nutrient
1 people found this helpful
It is the most effective nutrient for recovering from fatigue. It also aids in improving brain function and should be a basic addition for students.
7
We investigated how nicotinamide, a form of vitamin B3, impacts glioblastoma (GB) cells. Our findings reveal that it can induce a state of senescence, slowing down cell growth and altering their internal processes.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
8
Pyridoxine promotes glioblastoma cell death
We explored the effect of vitamin B6 (pyridoxine) and B12 (cobalamin) on human glioblastoma cells, known for their aggressive nature. By treating cell cultures with varying doses of these vitamins over 24-72 hours, we aimed to see how they influenced cell survival and progression through their life cycle.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
References
- Narayanan A, Saurty-Seerunghen MS, Michieletto J, Delaunay V, Bruneel A, et al. Nicotinamide metabolism reprogramming drives reversible senescence of glioblastoma cells. Cell Mol Life Sci. 2025;82:126. doi:10.1007/s00018-025-05641-9
- MartĂnez-Mendiola CA, Estrada JA, Zapi-ColĂn LĂ, Contreras-ChĂĄvez GG, Contreras I. Effect of pyridoxine or cobalamin supplementation on apoptosis and cell cycle progression in a human glioblastoma cell line. Int J Neurosci. 2024;134:1320. doi:10.1080/00207454.2023.2263815
