5/30/2025
Last update
5/30/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.6
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Thiamin (as Thiamine Mononitrate)
25 mg
2,083%
Riboflavin
25 mg
1,923%
Niacin (as Nicotinic Acid)
25 mg NE§
156%
Vitamin B6 (as Pyridoxine HCl [25 mg] and Pyridoxal 5-Phosphate [10 mg])
35 mg
2,059%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
100 mcg
4,167%
Biotin (as d-Biotin)
300 mcg
1,000%
Pantothenic Acid (as Calcium D-Pantothenate)
100 mg
2,000%
Choline (as Choline Bitartrate)
50 mg
9%
Pantethine
25 mg
†
Inositol
50 mg
†
Top Medical Research Studies
9.5
Pediatric migraine treatment with riboflavin
Our examination focused on the effectiveness of riboflavin, a form of Vitamin B2, in treating migraines in children and adolescents aged six to 18. We conducted a retrospective observational study involving 42 patients, where we measured the frequency, intensity, and duration of their headaches.
Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.
Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.
Read More
8
Vitamin B-complex shows migraine relief
We explored how vitamin B-complex supplementation might help reduce migraines in children by lowering serum homocysteine levels. In a randomized double-blinded trial with 90 kids under 15, one group received vitamin B-complex while the other got a placebo for six months.
After the treatment, we observed that the children taking vitamin B experienced fewer headaches, lower headache severity, and less overall headache-related disability compared to the placebo group.
While the results are promising, indicating a potential benefit of vitamin B-complex, more research is necessary to validate these findings.
After the treatment, we observed that the children taking vitamin B experienced fewer headaches, lower headache severity, and less overall headache-related disability compared to the placebo group.
While the results are promising, indicating a potential benefit of vitamin B-complex, more research is necessary to validate these findings.
Read More
9
We explored the impact of B vitamin supplementation on women suffering from episodic migraines. In this double-blind, placebo-controlled trial involving 120 participants, we found that those taking B vitamins experienced a significant decrease in headache frequency and migraine-related disability compared to the placebo group.
Over 12 weeks, the vitamin groups also needed fewer abortive medications. While results are promising, further research with larger samples is necessary to confirm these findings and better understand the long-term benefits of B vitamins for migraine sufferers.
Over 12 weeks, the vitamin groups also needed fewer abortive medications. While results are promising, further research with larger samples is necessary to confirm these findings and better understand the long-term benefits of B vitamins for migraine sufferers.
Read More
Most Useful Reviews
9
Quick healing
1 people found this helpful
I purchased this complex for a relative suffering from neurological issues and severe headaches. The doctor recommended it, and she expressed gratitude for the improvement. I've also taken note of its effectiveness for myself.
Read More
9
Stress disappeared
1 people found this helpful
These vitamins work immediately; my skin, hair, and nails have improved remarkably. Notably, my stress and headaches have also vanished. I'm very pleased with the effects.
Read More
4
Initial headaches experience
Took this for the first time and it gave me a headache that lasted three days. However, when I tried it again months later, I managed to tolerate it better.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.6
- All Researches
9.5
Pediatric migraine treatment with riboflavin
Our examination focused on the effectiveness of riboflavin, a form of Vitamin B2, in treating migraines in children and adolescents aged six to 18. We conducted a retrospective observational study involving 42 patients, where we measured the frequency, intensity, and duration of their headaches.
Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.
Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.
Read More
9
We looked at a rare case involving a 14-year-old girl experiencing persistent headaches and high intracranial pressure. Testing revealed a significant plasma homocysteine level and a mutation related to the MTHFR gene, previously unreported in cerebral venous thrombosis (CVT) cases.
After administering anticoagulation therapy and B-vitamin supplements, her symptoms improved significantly within a month, with no headaches reported and reduced thrombosis. This case highlights the importance of checking for specific genetic factors when dealing with unusual CVT cases and underscores the potential for successful treatment.
After administering anticoagulation therapy and B-vitamin supplements, her symptoms improved significantly within a month, with no headaches reported and reduced thrombosis. This case highlights the importance of checking for specific genetic factors when dealing with unusual CVT cases and underscores the potential for successful treatment.
Read More
9
We explored the impact of B vitamin supplementation on women suffering from episodic migraines. In this double-blind, placebo-controlled trial involving 120 participants, we found that those taking B vitamins experienced a significant decrease in headache frequency and migraine-related disability compared to the placebo group.
Over 12 weeks, the vitamin groups also needed fewer abortive medications. While results are promising, further research with larger samples is necessary to confirm these findings and better understand the long-term benefits of B vitamins for migraine sufferers.
Over 12 weeks, the vitamin groups also needed fewer abortive medications. While results are promising, further research with larger samples is necessary to confirm these findings and better understand the long-term benefits of B vitamins for migraine sufferers.
Read More
9
We delved into how Vitamin B2 could aid in preventing migraines, traditionally tackled with medications. This systematic review and meta-analysis involved rigorous searching across several databases, analyzing data from nine studies with over 670 participants.
We discovered that a daily dose of 400 mg of Vitamin B2 for three months notably reduced the number of migraine days, their duration, frequency, and pain intensity. These findings support the potential of Vitamin B2 as an effective supplement for those suffering from migraines.
We discovered that a daily dose of 400 mg of Vitamin B2 for three months notably reduced the number of migraine days, their duration, frequency, and pain intensity. These findings support the potential of Vitamin B2 as an effective supplement for those suffering from migraines.
Read More
8
We explored the potential of riboflavin, or vitamin B2, as a treatment for migraine prevention in adults. The findings suggest that riboflavin can be recommended for adults dealing with migraines, albeit with no proven benefit for children.
While adverse events are minimal, caution is advised when considering other nutraceuticals like coenzyme Q10 and feverfew, as their effectiveness and safety require further research.
Overall, vitamin B2 shows promise for adults struggling with headaches, but more robust studies are needed to confirm its efficacy.
While adverse events are minimal, caution is advised when considering other nutraceuticals like coenzyme Q10 and feverfew, as their effectiveness and safety require further research.
Overall, vitamin B2 shows promise for adults struggling with headaches, but more robust studies are needed to confirm its efficacy.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Quick healing
1 people found this helpful
I purchased this complex for a relative suffering from neurological issues and severe headaches. The doctor recommended it, and she expressed gratitude for the improvement. I've also taken note of its effectiveness for myself.
Read More
9
Stress disappeared
1 people found this helpful
These vitamins work immediately; my skin, hair, and nails have improved remarkably. Notably, my stress and headaches have also vanished. I'm very pleased with the effects.
Read More
4
Initial headaches experience
Took this for the first time and it gave me a headache that lasted three days. However, when I tried it again months later, I managed to tolerate it better.
Read More
2
Severe headaches
I encountered severe headaches and a drop in blood pressure, likely due to the excessive dosage for my condition. I have circulation issues, and I couldn’t finish the medication or notice any positive effects. It was not suitable for me.
Read More
0
Severe headaches
I find the composition of this complex good, but my husband has experienced severe headaches while taking it, possibly due to the presence of niacin or another component.
Read More
Frequently Asked Questions
9
Stress disappeared
1 people found this helpful
These vitamins work immediately; my skin, hair, and nails have improved remarkably. Notably, my stress and headaches have also vanished. I'm very pleased with the effects.
4
Initial headaches experience
Took this for the first time and it gave me a headache that lasted three days. However, when I tried it again months later, I managed to tolerate it better.
7.5
Eases headaches
7 people found this helpful
This is an effective complex of B vitamins, containing excellent dosages for those frequently bothered by headaches. Although taking it on an empty stomach can cause temporary reddening and itchiness, I found the headaches considerably eased and my overall wellbeing improved. It’s a reasonable choice for anyone needing a little extra support.
7.5
Headaches lessened
1 people found this helpful
An excellent complex of B vitamins prescribed by my doctor, I've been taking one capsule with lunch. I've noticed that my headaches have lessened and I feel a surge of energy. I highly recommend this product for those needing a boost.
9
Quick healing
1 people found this helpful
I purchased this complex for a relative suffering from neurological issues and severe headaches. The doctor recommended it, and she expressed gratitude for the improvement. I've also taken note of its effectiveness for myself.
0
Severe headaches
I find the composition of this complex good, but my husband has experienced severe headaches while taking it, possibly due to the presence of niacin or another component.
9
We delved into how Vitamin B2 could aid in preventing migraines, traditionally tackled with medications. This systematic review and meta-analysis involved rigorous searching across several databases, analyzing data from nine studies with over 670 participants.
We discovered that a daily dose of 400 mg of Vitamin B2 for three months notably reduced the number of migraine days, their duration, frequency, and pain intensity. These findings support the potential of Vitamin B2 as an effective supplement for those suffering from migraines.
We discovered that a daily dose of 400 mg of Vitamin B2 for three months notably reduced the number of migraine days, their duration, frequency, and pain intensity. These findings support the potential of Vitamin B2 as an effective supplement for those suffering from migraines.
8
Vitamin B-complex shows migraine relief
We explored how vitamin B-complex supplementation might help reduce migraines in children by lowering serum homocysteine levels. In a randomized double-blinded trial with 90 kids under 15, one group received vitamin B-complex while the other got a placebo for six months.
After the treatment, we observed that the children taking vitamin B experienced fewer headaches, lower headache severity, and less overall headache-related disability compared to the placebo group.
While the results are promising, indicating a potential benefit of vitamin B-complex, more research is necessary to validate these findings.
After the treatment, we observed that the children taking vitamin B experienced fewer headaches, lower headache severity, and less overall headache-related disability compared to the placebo group.
While the results are promising, indicating a potential benefit of vitamin B-complex, more research is necessary to validate these findings.
9
We explored the impact of B vitamin supplementation on women suffering from episodic migraines. In this double-blind, placebo-controlled trial involving 120 participants, we found that those taking B vitamins experienced a significant decrease in headache frequency and migraine-related disability compared to the placebo group.
Over 12 weeks, the vitamin groups also needed fewer abortive medications. While results are promising, further research with larger samples is necessary to confirm these findings and better understand the long-term benefits of B vitamins for migraine sufferers.
Over 12 weeks, the vitamin groups also needed fewer abortive medications. While results are promising, further research with larger samples is necessary to confirm these findings and better understand the long-term benefits of B vitamins for migraine sufferers.
8
We investigated the relationship between vitamin B and folate intake and the likelihood of experiencing severe headaches or migraines in adults. Analyzing data from the National Health and Nutrition Examination Survey, we found that higher intake of these nutrients is linked to a lower risk of migraines.
Specifically, individuals who consumed adequate amounts of vitamin B and folate had significantly reduced chances of migraines. These findings suggest that these vitamins might be valuable in managing headache symptoms, but they don’t guarantee relief for everyone.
Specifically, individuals who consumed adequate amounts of vitamin B and folate had significantly reduced chances of migraines. These findings suggest that these vitamins might be valuable in managing headache symptoms, but they don’t guarantee relief for everyone.
8
We investigated how dietary intake of folate, or vitamin B, relates to severe headaches among adults in the U.S. By analyzing data from the National Health and Nutrition Examination Survey involving nearly 10,000 participants, we found that higher folate intake was significantly linked to lower instances of severe headaches.
Specifically, those with higher folate levels reported fewer severe headache episodes, particularly women aged 20-50, who could benefit from increased folate awareness. These findings suggest that diet could play a role in headache management.
Specifically, those with higher folate levels reported fewer severe headache episodes, particularly women aged 20-50, who could benefit from increased folate awareness. These findings suggest that diet could play a role in headache management.
References
- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. 10.1007/s11916-025-01358-3
- Tian S, Yu X, Wu L, Zheng H, Zhong X, et al. Vitamin B and folate intake are associated with lower risk of severe headache or migraine in adults: An analysis based on NHANES 1999-2004. Nutr Res. 2024;121:51. 10.1016/j.nutres.2023.11.008
- Sadeghvand S, Barzegar M, Shiva S, Tarmahi V, Hamed H, et al. The Effects of Vitamin B-Complex Supplementation on Serum Homocysteine Levels and Migraine Severity in Children A Randomized Controlled Trial. Iran J Child Neurol. 2023;17:143. 10.22037/ijcn.v17i3.40053
- Tian S, Wu L, Zheng H, Zhong X, Liu M, et al. Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey. Br J Nutr. 2024;131:438. 10.1017/S000711452300137X
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. 10.1186/s12883-023-03200-y
- Li D, Guo Y, Xia M, Zhang J, Zang W. Dietary intake of thiamine and riboflavin in relation to severe headache or migraine: A cross-sectional survey. Headache. 2022;62:1133. 10.1111/head.14384
- Nematgorgani S, Razeghi-Jahromi S, Jafari E, Togha M, Rafiee P, et al. B vitamins and their combination could reduce migraine headaches: A randomized double-blind controlled trial. Curr J Neurol. 2022;21:105. 10.18502/cjn.v21i2.10494
- Chen YS, Lee HF, Tsai CH, Hsu YY, Fang CJ, et al. Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis. Nutr Neurosci. 2022;25:1801. 10.1080/1028415X.2021.1904542
- Das R, Qubty W. Retrospective Observational Study on Riboflavin Prophylaxis in Child and Adolescent Migraine. Pediatr Neurol. 2021;114:5. 10.1016/j.pediatrneurol.2020.09.009
- Yamanaka G, Suzuki S, Takeshita M, Go S, Morishita N, et al. Effectiveness of low-dose riboflavin as a prophylactic agent in pediatric migraine. Brain Dev. 2020;42:523. 10.1016/j.braindev.2020.04.002
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. 10.1111/ane.13251
- Chutko LS, Surushkina SY, Yakovenko EA, Rozhkova AV, Volov MB, et al. [Possibilities of using Cytoflavin in the treatment of cognitive and emotional disorders in patients with tension headaches]. Zh Nevrol Psikhiatr Im S S Korsakova. 2019;119:32. 10.17116/jnevro201911911132
- Bravaccio C, Terrone G, Rizzo R, Gulisano M, Tosi M, et al. Use of nutritional supplements based on melatonin, tryptophan and vitamin B6 (Melamil Tripto®) in children with primary chronic headache, with or without sleep disorders: a pilot study. Minerva Pediatr. 2020;72:30. 10.23736/S0026-4946.19.05533-6
- Togha M, Razeghi Jahromi S, Ghorbani Z, Martami F, Seifishahpar M. Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study. Headache. 2019;59:1492. 10.1111/head.13618
- Moscano F, Guiducci M, Maltoni L, Striano P, Ledda MG, et al. An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache. Ital J Pediatr. 2019;45:36. 10.1186/s13052-019-0624-z
