Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.7
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
†
Top Medical Research Studies
2
We focused on how turmeric, specifically curcumin, might influence allergies. Our study involved 34 participants who were allergic to certain antigens. To assess the effect of curcumin, we randomly assigned participants to receive either curcumin or a placebo for one week, all while keeping the study double-blind to eliminate bias.
After this week, we conducted skin-prick tests to measure reactions before and after the treatment. We compared the size of the skin test reactions, or wheals and flares, to see if there were any significant changes.
The results were clear: curcumin did not show a statistically significant impact on the size of these reactions. Although earlier studies suggested that curcumin may help reduce allergic symptoms, our findings indicate that it does not change the immediate response measured through skin tests. Thus, there's no need to stop using curcumin before allergy testing since it doesn't interfere with the results.
After this week, we conducted skin-prick tests to measure reactions before and after the treatment. We compared the size of the skin test reactions, or wheals and flares, to see if there were any significant changes.
The results were clear: curcumin did not show a statistically significant impact on the size of these reactions. Although earlier studies suggested that curcumin may help reduce allergic symptoms, our findings indicate that it does not change the immediate response measured through skin tests. Thus, there's no need to stop using curcumin before allergy testing since it doesn't interfere with the results.
Read More
9
Turmeric extract alleviates atopic dermatitis
We aimed to understand how turmeric, particularly its leaves and pseudostems, impacts allergies, specifically atopic dermatitis (AD). In our study, we utilized the BALB/c mouse model to mimic the symptoms of AD by applying a chemical called DNCB to the skin.
After introducing the symptoms, we divided the mice into groups, with some receiving daily doses of turmeric extract for three weeks. Throughout this time, we carefully observed various factors, such as skin condition, moisture loss, scratching behavior, and overall health indicators, including serum levels of antibodies and immune responses.
Our findings revealed that the turmeric extract significantly alleviated the AD-like symptoms in the treated mice. The skin's severity scores improved, and we noticed decreased, itchy scratching and moisture loss. Moreover, there were lower serum immunoglobulin levels and less inflammation compared to untreated mice. This highlights turmeric's potential as a natural remedy for managing allergic reactions related to atopic dermatitis.
After introducing the symptoms, we divided the mice into groups, with some receiving daily doses of turmeric extract for three weeks. Throughout this time, we carefully observed various factors, such as skin condition, moisture loss, scratching behavior, and overall health indicators, including serum levels of antibodies and immune responses.
Our findings revealed that the turmeric extract significantly alleviated the AD-like symptoms in the treated mice. The skin's severity scores improved, and we noticed decreased, itchy scratching and moisture loss. Moreover, there were lower serum immunoglobulin levels and less inflammation compared to untreated mice. This highlights turmeric's potential as a natural remedy for managing allergic reactions related to atopic dermatitis.
Read More
9
This study examines the potential of turmeric leaves and pseudostems extract to ease allergic responses, particularly in how it affects mast cells. We analyzed its impact on specific immune reactions triggered by allergens, focusing on the release of various chemicals known to play roles in allergy symptoms.
By assessing mast cell degranulation, we observed that the extract significantly reduced the release of important mediators like histamine. This suggests that turmeric might help control allergic reactions at the cellular level.
Furthermore, in our exploration, we noticed that turmeric extract downregulated key signaling pathways involved in allergic responses. This helped to diminish the release of allergy-related cytokines and chemokines.
Additionally, in an in vivo setting, we tested turmeric’s effect on mice experiencing IgE-mediated passive cutaneous anaphylaxis, finding it successfully attenuated the allergic reactions. Overall, these findings indicate turmeric's potential as a powerful ally in managing allergies.
By assessing mast cell degranulation, we observed that the extract significantly reduced the release of important mediators like histamine. This suggests that turmeric might help control allergic reactions at the cellular level.
Furthermore, in our exploration, we noticed that turmeric extract downregulated key signaling pathways involved in allergic responses. This helped to diminish the release of allergy-related cytokines and chemokines.
Additionally, in an in vivo setting, we tested turmeric’s effect on mice experiencing IgE-mediated passive cutaneous anaphylaxis, finding it successfully attenuated the allergic reactions. Overall, these findings indicate turmeric's potential as a powerful ally in managing allergies.
Read More
Most Useful Reviews
6
Slight improvement
When allergy symptoms arise, I give this to my child when they have a runny nose. I believe it helps alleviate the issue somewhat.
Read More
2
No improvement
I have allergies and rosacea, so I hoped this would enhance my skin, but it didn't have any effect.
Read More
4
Tension relief
6 people found this helpful
Works excellently for my headaches, neck and back pain. I have numerous health issues, and while this supplement has alleviated my pain, I have noticed a slight increase in my allergy symptoms. However, I would choose the relief from pain over mild allergy discomfort any day.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.7
- All Researches
9
Turmeric extract alleviates atopic dermatitis
We aimed to understand how turmeric, particularly its leaves and pseudostems, impacts allergies, specifically atopic dermatitis (AD). In our study, we utilized the BALB/c mouse model to mimic the symptoms of AD by applying a chemical called DNCB to the skin.
After introducing the symptoms, we divided the mice into groups, with some receiving daily doses of turmeric extract for three weeks. Throughout this time, we carefully observed various factors, such as skin condition, moisture loss, scratching behavior, and overall health indicators, including serum levels of antibodies and immune responses.
Our findings revealed that the turmeric extract significantly alleviated the AD-like symptoms in the treated mice. The skin's severity scores improved, and we noticed decreased, itchy scratching and moisture loss. Moreover, there were lower serum immunoglobulin levels and less inflammation compared to untreated mice. This highlights turmeric's potential as a natural remedy for managing allergic reactions related to atopic dermatitis.
After introducing the symptoms, we divided the mice into groups, with some receiving daily doses of turmeric extract for three weeks. Throughout this time, we carefully observed various factors, such as skin condition, moisture loss, scratching behavior, and overall health indicators, including serum levels of antibodies and immune responses.
Our findings revealed that the turmeric extract significantly alleviated the AD-like symptoms in the treated mice. The skin's severity scores improved, and we noticed decreased, itchy scratching and moisture loss. Moreover, there were lower serum immunoglobulin levels and less inflammation compared to untreated mice. This highlights turmeric's potential as a natural remedy for managing allergic reactions related to atopic dermatitis.
Read More
9
We explored the effects of turmeric extract (CLE) on airway inflammation, particularly in relation to asthma and allergies. Using an asthmatic mouse model that was sensitized with ovalbumin (OVA), we observed how different doses of CLE (100 or 300 mg/kg/day) impacted inflammation. Dexamethasone was used as a positive control to compare its effects.
Our findings revealed that both doses of CLE significantly reduced eosinophil counts, cytokine levels, and immunoglobulin-E levels associated with allergic responses. This suggests that turmeric extract has a promising role in managing allergy-related symptoms. Additionally, we noted that CLE effectively decreased oxidative stress and inflammation in lung tissues.
On a cellular level, when we treated human airway epithelial cells (A549) with CLE, we saw reductions in proinflammatory cytokines and a decrease in the activity of certain proteins that contribute to inflammation, specifically matrix metalloproteinases (MMPs). Curcumin, a compound found in turmeric, also demonstrated similar anti-inflammatory effects at lower concentrations.
Overall, our research indicates that turmeric extract could be a beneficial treatment option for individuals struggling with asthma and related allergies, thanks to its ability to target inflammation on multiple fronts.
Our findings revealed that both doses of CLE significantly reduced eosinophil counts, cytokine levels, and immunoglobulin-E levels associated with allergic responses. This suggests that turmeric extract has a promising role in managing allergy-related symptoms. Additionally, we noted that CLE effectively decreased oxidative stress and inflammation in lung tissues.
On a cellular level, when we treated human airway epithelial cells (A549) with CLE, we saw reductions in proinflammatory cytokines and a decrease in the activity of certain proteins that contribute to inflammation, specifically matrix metalloproteinases (MMPs). Curcumin, a compound found in turmeric, also demonstrated similar anti-inflammatory effects at lower concentrations.
Overall, our research indicates that turmeric extract could be a beneficial treatment option for individuals struggling with asthma and related allergies, thanks to its ability to target inflammation on multiple fronts.
Read More
9
Curcumin shows promise for allergies
We focused on how curcumin, a natural compound found in turmeric, could help treat allergic rhinitis when combined with an allergen. To investigate this, we utilized nanofibers infused with curcumin and ovalbumin—an allergen commonly associated with allergies. We prepared these nanofibers using electrospinning and then tested their effects in a mouse model of allergic rhinitis.
The results were promising! When we administered sublingual immunotherapy (SLIT) using these nanofibers, we observed a noteworthy reduction in serum IgE levels, which are often elevated in allergic reactions. Specifically, the formulation containing 2.5 µg of curcumin per mouse showed a significant decrease in IL-4—a marker associated with allergic responses—while levels of INF-γ, which helps modulate immune responses, increased.
Additionally, the analysis of nasal lavage fluid revealed fewer allergic cells and eosinophils in the treated groups. Histological examinations showed that the nasal tissue health approached normal, with less inflammation and cellular infiltration. Overall, these findings suggest that the combination of curcumin and the allergen in our nanofiber treatments could be a promising route for improving allergic rhinitis management.
The results were promising! When we administered sublingual immunotherapy (SLIT) using these nanofibers, we observed a noteworthy reduction in serum IgE levels, which are often elevated in allergic reactions. Specifically, the formulation containing 2.5 µg of curcumin per mouse showed a significant decrease in IL-4—a marker associated with allergic responses—while levels of INF-γ, which helps modulate immune responses, increased.
Additionally, the analysis of nasal lavage fluid revealed fewer allergic cells and eosinophils in the treated groups. Histological examinations showed that the nasal tissue health approached normal, with less inflammation and cellular infiltration. Overall, these findings suggest that the combination of curcumin and the allergen in our nanofiber treatments could be a promising route for improving allergic rhinitis management.
Read More
9
This study examines the potential of turmeric leaves and pseudostems extract to ease allergic responses, particularly in how it affects mast cells. We analyzed its impact on specific immune reactions triggered by allergens, focusing on the release of various chemicals known to play roles in allergy symptoms.
By assessing mast cell degranulation, we observed that the extract significantly reduced the release of important mediators like histamine. This suggests that turmeric might help control allergic reactions at the cellular level.
Furthermore, in our exploration, we noticed that turmeric extract downregulated key signaling pathways involved in allergic responses. This helped to diminish the release of allergy-related cytokines and chemokines.
Additionally, in an in vivo setting, we tested turmeric’s effect on mice experiencing IgE-mediated passive cutaneous anaphylaxis, finding it successfully attenuated the allergic reactions. Overall, these findings indicate turmeric's potential as a powerful ally in managing allergies.
By assessing mast cell degranulation, we observed that the extract significantly reduced the release of important mediators like histamine. This suggests that turmeric might help control allergic reactions at the cellular level.
Furthermore, in our exploration, we noticed that turmeric extract downregulated key signaling pathways involved in allergic responses. This helped to diminish the release of allergy-related cytokines and chemokines.
Additionally, in an in vivo setting, we tested turmeric’s effect on mice experiencing IgE-mediated passive cutaneous anaphylaxis, finding it successfully attenuated the allergic reactions. Overall, these findings indicate turmeric's potential as a powerful ally in managing allergies.
Read More
9
We examined how curcumin, a natural compound found in turmeric, affects allergic reactions, particularly in asthma models. In our study, we used mice that were sensitized and exposed to allergens to mimic asthma symptoms, followed by treatment with curcumin and sodium butyrate. This approach helped us investigate whether these compounds could alleviate allergic inflammation by inhibiting histone deacetylase (HDAC1), which plays a role in modifying protein functions related to asthma.
Our findings indicated that curcumin and sodium butyrate significantly reduced markers of inflammation in the airways, specifically by modulating the PI3K/Akt signaling pathway. Notably, we observed that treatment with these compounds led to lower levels of proteins associated with inflammation. Moreover, curcumin and sodium butyrate restored levels of antioxidant proteins that were diminished during asthma.
Overall, these results suggest that curcumin, especially when combined with sodium butyrate, has potential as a treatment for reducing allergic airway inflammation. This could open up new avenues for managing conditions like asthma in the future, highlighting the importance of understanding natural compounds in allergy treatment.
Our findings indicated that curcumin and sodium butyrate significantly reduced markers of inflammation in the airways, specifically by modulating the PI3K/Akt signaling pathway. Notably, we observed that treatment with these compounds led to lower levels of proteins associated with inflammation. Moreover, curcumin and sodium butyrate restored levels of antioxidant proteins that were diminished during asthma.
Overall, these results suggest that curcumin, especially when combined with sodium butyrate, has potential as a treatment for reducing allergic airway inflammation. This could open up new avenues for managing conditions like asthma in the future, highlighting the importance of understanding natural compounds in allergy treatment.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.5
- All Reviews
- Positive Reviews
- Negative Reviews
6
Slight improvement
When allergy symptoms arise, I give this to my child when they have a runny nose. I believe it helps alleviate the issue somewhat.
Read More
2
No improvement
I have allergies and rosacea, so I hoped this would enhance my skin, but it didn't have any effect.
Read More
4
Tension relief
6 people found this helpful
Works excellently for my headaches, neck and back pain. I have numerous health issues, and while this supplement has alleviated my pain, I have noticed a slight increase in my allergy symptoms. However, I would choose the relief from pain over mild allergy discomfort any day.
Read More
Frequently Asked Questions
6
Slight improvement
When allergy symptoms arise, I give this to my child when they have a runny nose. I believe it helps alleviate the issue somewhat.
2
No improvement
I have allergies and rosacea, so I hoped this would enhance my skin, but it didn't have any effect.
9
Turmeric extract alleviates atopic dermatitis
We aimed to understand how turmeric, particularly its leaves and pseudostems, impacts allergies, specifically atopic dermatitis (AD). In our study, we utilized the BALB/c mouse model to mimic the symptoms of AD by applying a chemical called DNCB to the skin.
After introducing the symptoms, we divided the mice into groups, with some receiving daily doses of turmeric extract for three weeks. Throughout this time, we carefully observed various factors, such as skin condition, moisture loss, scratching behavior, and overall health indicators, including serum levels of antibodies and immune responses.
Our findings revealed that the turmeric extract significantly alleviated the AD-like symptoms in the treated mice. The skin's severity scores improved, and we noticed decreased, itchy scratching and moisture loss. Moreover, there were lower serum immunoglobulin levels and less inflammation compared to untreated mice. This highlights turmeric's potential as a natural remedy for managing allergic reactions related to atopic dermatitis.
After introducing the symptoms, we divided the mice into groups, with some receiving daily doses of turmeric extract for three weeks. Throughout this time, we carefully observed various factors, such as skin condition, moisture loss, scratching behavior, and overall health indicators, including serum levels of antibodies and immune responses.
Our findings revealed that the turmeric extract significantly alleviated the AD-like symptoms in the treated mice. The skin's severity scores improved, and we noticed decreased, itchy scratching and moisture loss. Moreover, there were lower serum immunoglobulin levels and less inflammation compared to untreated mice. This highlights turmeric's potential as a natural remedy for managing allergic reactions related to atopic dermatitis.
8
We explored the potential of curcumin, a natural compound found in turmeric, to alleviate symptoms of allergic asthma. Despite curcumin's known anti-inflammatory and antioxidant properties, its use has been limited due to its poor solubility and stability.
To overcome these challenges, researchers developed a unique deep eutectic solvent (DES) microemulsion system designed for intranasal delivery of curcumin. By optimizing this formulation, the team aimed to ensure curcumin's effective absorption into the body, which is crucial for treating asthma.
The study evaluated the microemulsion's ability to dissolve curcumin and enhance its permeability while also assessing any potential toxicity to mucosal cells. Additionally, the effectiveness of this curcumin delivery system was tested in a mouse model of allergic asthma. Although the results pointed towards promising advancements in curcumin's bioavailability, the overall therapeutic impact specific to treating allergies requires further examination.
Overall, while curcumin holds potential due to its beneficial properties, its effectiveness for allergy treatment in this study is still being established and may demand additional research for conclusive outcomes.
To overcome these challenges, researchers developed a unique deep eutectic solvent (DES) microemulsion system designed for intranasal delivery of curcumin. By optimizing this formulation, the team aimed to ensure curcumin's effective absorption into the body, which is crucial for treating asthma.
The study evaluated the microemulsion's ability to dissolve curcumin and enhance its permeability while also assessing any potential toxicity to mucosal cells. Additionally, the effectiveness of this curcumin delivery system was tested in a mouse model of allergic asthma. Although the results pointed towards promising advancements in curcumin's bioavailability, the overall therapeutic impact specific to treating allergies requires further examination.
Overall, while curcumin holds potential due to its beneficial properties, its effectiveness for allergy treatment in this study is still being established and may demand additional research for conclusive outcomes.
7
We conducted a comprehensive study to understand how turmeric, alongside ashwagandha, might alleviate symptoms of mild allergic rhinitis (AR). This study involved a randomized, double-blind, placebo-controlled setup with participants taking either a turmeric and ashwagandha combination (CQAB), a bioavailable curcumin (CGM), or a placebo for 28 days.
Throughout the study, we monitored various symptoms commonly associated with AR, such as nasal congestion, sneezing, and itching, to see if the participants reported any improvement. The findings suggest that the CQAB combination could indeed help ease discomfort associated with AR, pointing to its potential as a dietary supplement.
While we observed some benefits, it’s essential to note that attributing these effects solely to turmeric is challenging since the CQAB also includes ashwagandha. Nonetheless, our results offer promising insight into natural ways of managing mild allergic rhinitis, a condition affecting millions worldwide.
Throughout the study, we monitored various symptoms commonly associated with AR, such as nasal congestion, sneezing, and itching, to see if the participants reported any improvement. The findings suggest that the CQAB combination could indeed help ease discomfort associated with AR, pointing to its potential as a dietary supplement.
While we observed some benefits, it’s essential to note that attributing these effects solely to turmeric is challenging since the CQAB also includes ashwagandha. Nonetheless, our results offer promising insight into natural ways of managing mild allergic rhinitis, a condition affecting millions worldwide.
9
This study examines the potential of turmeric leaves and pseudostems extract to ease allergic responses, particularly in how it affects mast cells. We analyzed its impact on specific immune reactions triggered by allergens, focusing on the release of various chemicals known to play roles in allergy symptoms.
By assessing mast cell degranulation, we observed that the extract significantly reduced the release of important mediators like histamine. This suggests that turmeric might help control allergic reactions at the cellular level.
Furthermore, in our exploration, we noticed that turmeric extract downregulated key signaling pathways involved in allergic responses. This helped to diminish the release of allergy-related cytokines and chemokines.
Additionally, in an in vivo setting, we tested turmeric’s effect on mice experiencing IgE-mediated passive cutaneous anaphylaxis, finding it successfully attenuated the allergic reactions. Overall, these findings indicate turmeric's potential as a powerful ally in managing allergies.
By assessing mast cell degranulation, we observed that the extract significantly reduced the release of important mediators like histamine. This suggests that turmeric might help control allergic reactions at the cellular level.
Furthermore, in our exploration, we noticed that turmeric extract downregulated key signaling pathways involved in allergic responses. This helped to diminish the release of allergy-related cytokines and chemokines.
Additionally, in an in vivo setting, we tested turmeric’s effect on mice experiencing IgE-mediated passive cutaneous anaphylaxis, finding it successfully attenuated the allergic reactions. Overall, these findings indicate turmeric's potential as a powerful ally in managing allergies.
References
- Jayasinghe AMK, Kirindage KGIS, Kim SH, Lee S, Jung K, et al. Protective effect of Curcuma longa L. leaves and pseudostems extract against 1-chloro-2,4-dinitrobenzene-induced atopic dermatitis in BALB/c mice. J Ethnopharmacol. 2025;338:119138. 10.1016/j.jep.2024.119138
- Liu Y, Liu R, Yang Q, Yang G. DES/O microemulsion for solubilizing and delivering curcumin via the nasal administration to treat acute asthma. Int J Pharm. 2024;667:124900. 10.1016/j.ijpharm.2024.124900
- K M, Aryan MK, Prabhakaran P, Mulakal JN, Das S S, et al. Short-term influence of Immufen™ on mild allergic rhinitis: a randomized, double-blind, placebo-controlled study. Front Allergy. 2024;5:1390813. 10.3389/falgy.2024.1390813
- Kim JW, Jeong JS, Kim JH, Kim CY, Chung EH, et al. Turmeric extract alleviates airway inflammation via oxidative stress-driven MAPKs/MMPs pathway. Int Immunopharmacol. 2024;141:113018. 10.1016/j.intimp.2024.113018
- Ansari B, Abbaspour MR, Estajy A, Haghnavaz N, Pordel S, et al. Development of fast-dissolving sublingual nanofibers containing allergen and curcumin for immune response modulation in a mouse model of allergic rhinitis. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:7839. 10.1007/s00210-024-03139-y
- Jayasinghe AMK, Kirindage KGIS, Kim SH, Lee S, Kim KN, et al. Leaves and pseudostems extract of Curcuma longa attenuates immunoglobulin E/bovine serum albumin-stimulated bone marrow-derived cultured mast cell activation and passive cutaneous anaphylaxis in BALB/c mice. J Ethnopharmacol. 2024;321:117529. 10.1016/j.jep.2023.117529
- Islam R, Dash D, Singh R. An antioxidant ameliorates allergic airway inflammation by inhibiting HDAC 1 via HIF-1α/VEGF axis suppression in mice. Sci Rep. 2023;13:9637. 10.1038/s41598-023-36678-0
- Zeng J, Hao J, Yang Z, Ma C, Gao L, et al. Anti-Allergic Effect of Dietary Polyphenols Curcumin and Epigallocatechin Gallate via Anti-Degranulation in IgE/Antigen-Stimulated Mast Cell Model: A Lipidomics Perspective. Metabolites. 2023;13. 10.3390/metabo13050628
- Ceylan E, Turgut Cosan D, Bayar Muluk N, Cingi C. Investigation of the effect of the curcumin component as an alternative to the local treatment of nasal diseases. Eur Rev Med Pharmacol Sci. 2023;27:39. 10.26355/eurrev_202303_31700
- Gross LM, Nelson HS, Khatiwada A, Hoyte FCL. Curcumin does not significantly affect immediate skin tests. Allergy Asthma Proc. 2022;43:543. 10.2500/aap.2022.43.220067
