Last update
4/7/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.4
USERS' SCORE
Good
Based on 10 Reviews
8.3
Supplement Facts
Serving Size: 2 Softgels
Serving Per Container: 60
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%‡
Cholesterol
11 mg
4%‡
Protein
<1 g
Fish Oil Concentrate^
2,000 mg
†
Omega-3 Fatty Acids^
1,200 mg
†
EPA (Eicosapentaenoic acid)^
800 mg
†
DHA (Docosahexaenoic acid)^
400 mg
†
Top Medical Research Studies
8
Eicosapentaenoic acid shows potential
We assessed how eicosapentaenoic acid, an essential fatty acid, impacts chronic fatigue syndrome (CFS). A group of CFS patients took a specific supplement rich in this fatty acid. Remarkably, every participant reported symptom improvement within eight to twelve weeks.
These findings align with other research that shows the positive effects of eicosapentaenoic acid, hinting that it could be a promising treatment option for some individuals living with CFS.
These findings align with other research that shows the positive effects of eicosapentaenoic acid, hinting that it could be a promising treatment option for some individuals living with CFS.
Read More
9
Effective treatment for fatigue syndrome
We conducted a thorough investigation into the effects of essential fatty acids, including eicosapentaenoic acid (EPA), on individuals suffering from postviral fatigue syndrome. In a well-structured trial, 63 adults with this condition participated in a double-blind, placebo-controlled study. They had been living with severe fatigue and other troubling symptoms for one to three years following a viral infection.
Patients received either an active treatment containing EPA and other essential fatty acids or a placebo for three months. Their overall health, fatigue levels, and other symptoms were assessed at the beginning, after one month, and at the end of the study. Strikingly, we observed that 74% of those taking the essential fatty acids reported improvements after one month, rising to 85% after three months. In contrast, only 23% and 17% of the placebo group noted any benefit at those respective time points.
Notably, the fatty acid levels in the participants' red blood cells, which were abnormal at the beginning of the trial, showed significant improvement with the active treatment. Importantly, we found no adverse side effects from the treatment, leading us to conclude that essential fatty acids can be a safe and effective option for people dealing with postviral fatigue syndrome.
Patients received either an active treatment containing EPA and other essential fatty acids or a placebo for three months. Their overall health, fatigue levels, and other symptoms were assessed at the beginning, after one month, and at the end of the study. Strikingly, we observed that 74% of those taking the essential fatty acids reported improvements after one month, rising to 85% after three months. In contrast, only 23% and 17% of the placebo group noted any benefit at those respective time points.
Notably, the fatty acid levels in the participants' red blood cells, which were abnormal at the beginning of the trial, showed significant improvement with the active treatment. Importantly, we found no adverse side effects from the treatment, leading us to conclude that essential fatty acids can be a safe and effective option for people dealing with postviral fatigue syndrome.
Read More
8
Eicosapentaenoic acid's potential in CFS
We explored the connection between eicosapentaenoic acid (EPA) and chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis. The research indicates that individuals suffering from CFS may experience complications linked to persistent viral infections, which could hinder their body's ability to produce necessary fatty acids.
Specifically, the issue revolves around the enzyme delta-6 desaturase, which plays a critical role in the conversion of essential fatty acids like alpha-linolenic acid and linoleic acid into longer chain polyunsaturated fatty acids. These fatty acids are vital for maintaining healthy cell membranes and proper cell signaling. If their production is inhibited, it could explain many symptoms associated with CFS.
One intriguing aspect we observed is the potential therapeutic role that EPA could play. By providing EPA directly, we may bypass some of the metabolic restrictions caused by viral infections. This not only aids in generating essential fatty acids needed for bodily functions but also shows promise as a treatment option that could alleviate certain symptoms of CFS.
While the exact impact of EPA treatment on CFS warrants further investigation, the findings suggest that it might offer some benefits worth considering for those affected by this challenging condition.
Specifically, the issue revolves around the enzyme delta-6 desaturase, which plays a critical role in the conversion of essential fatty acids like alpha-linolenic acid and linoleic acid into longer chain polyunsaturated fatty acids. These fatty acids are vital for maintaining healthy cell membranes and proper cell signaling. If their production is inhibited, it could explain many symptoms associated with CFS.
One intriguing aspect we observed is the potential therapeutic role that EPA could play. By providing EPA directly, we may bypass some of the metabolic restrictions caused by viral infections. This not only aids in generating essential fatty acids needed for bodily functions but also shows promise as a treatment option that could alleviate certain symptoms of CFS.
While the exact impact of EPA treatment on CFS warrants further investigation, the findings suggest that it might offer some benefits worth considering for those affected by this challenging condition.
Read More
Most Useful Reviews
9
Less fatigue
1 people found this helpful
On my doctor’s advice, I began taking these to enhance my well-being and alleviate lethargy. I'm pleased to say it has helped!
Read More
9
Supports joint health
Omega-3s are vital for the stable functioning of the nervous, cardiovascular and immune systems. They also help alleviate inflammatory processes and improve joint and skin conditions, as well as emotional wellbeing, assisting in the fight against Chronic Fatigue Syndrome. This supplement, made from anchovy and sardine, has no unpleasant fishy aftertaste and offers great value for money. I take it regularly.
Read More
9
Optimal source selected
I chose EPA-DHA Balance from Jarrow Formulas for its perfect component ratio. Omega-3s are essential for the stable functioning of our nervous, cardiovascular, and immune systems. They minimise inflammation, enhance joint and skin health, improve emotional states, and help in the fight against Chronic Fatigue Syndrome. The large plastic jar contains 240 soft gel tablets without a typical fishy smell.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.4
- All Researches
9
Effective treatment for fatigue syndrome
We conducted a thorough investigation into the effects of essential fatty acids, including eicosapentaenoic acid (EPA), on individuals suffering from postviral fatigue syndrome. In a well-structured trial, 63 adults with this condition participated in a double-blind, placebo-controlled study. They had been living with severe fatigue and other troubling symptoms for one to three years following a viral infection.
Patients received either an active treatment containing EPA and other essential fatty acids or a placebo for three months. Their overall health, fatigue levels, and other symptoms were assessed at the beginning, after one month, and at the end of the study. Strikingly, we observed that 74% of those taking the essential fatty acids reported improvements after one month, rising to 85% after three months. In contrast, only 23% and 17% of the placebo group noted any benefit at those respective time points.
Notably, the fatty acid levels in the participants' red blood cells, which were abnormal at the beginning of the trial, showed significant improvement with the active treatment. Importantly, we found no adverse side effects from the treatment, leading us to conclude that essential fatty acids can be a safe and effective option for people dealing with postviral fatigue syndrome.
Patients received either an active treatment containing EPA and other essential fatty acids or a placebo for three months. Their overall health, fatigue levels, and other symptoms were assessed at the beginning, after one month, and at the end of the study. Strikingly, we observed that 74% of those taking the essential fatty acids reported improvements after one month, rising to 85% after three months. In contrast, only 23% and 17% of the placebo group noted any benefit at those respective time points.
Notably, the fatty acid levels in the participants' red blood cells, which were abnormal at the beginning of the trial, showed significant improvement with the active treatment. Importantly, we found no adverse side effects from the treatment, leading us to conclude that essential fatty acids can be a safe and effective option for people dealing with postviral fatigue syndrome.
Read More
8
We investigated the effects of a daily eicosapentaenoic acid (EPA)-rich supplement on a woman suffering from chronic fatigue syndrome for six years. After 16 weeks of treatment, she experienced significant symptom relief starting within the first 6-8 weeks.
Additionally, brain scans revealed a notable reduction in the size of her lateral ventricles, which is promising. This early-stage observation suggests that EPA supplementation might offer benefits for individuals dealing with chronic fatigue syndrome.
Additionally, brain scans revealed a notable reduction in the size of her lateral ventricles, which is promising. This early-stage observation suggests that EPA supplementation might offer benefits for individuals dealing with chronic fatigue syndrome.
Read More
8
Eicosapentaenoic acid shows potential
We assessed how eicosapentaenoic acid, an essential fatty acid, impacts chronic fatigue syndrome (CFS). A group of CFS patients took a specific supplement rich in this fatty acid. Remarkably, every participant reported symptom improvement within eight to twelve weeks.
These findings align with other research that shows the positive effects of eicosapentaenoic acid, hinting that it could be a promising treatment option for some individuals living with CFS.
These findings align with other research that shows the positive effects of eicosapentaenoic acid, hinting that it could be a promising treatment option for some individuals living with CFS.
Read More
8
Eicosapentaenoic acid's potential in CFS
We explored the connection between eicosapentaenoic acid (EPA) and chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis. The research indicates that individuals suffering from CFS may experience complications linked to persistent viral infections, which could hinder their body's ability to produce necessary fatty acids.
Specifically, the issue revolves around the enzyme delta-6 desaturase, which plays a critical role in the conversion of essential fatty acids like alpha-linolenic acid and linoleic acid into longer chain polyunsaturated fatty acids. These fatty acids are vital for maintaining healthy cell membranes and proper cell signaling. If their production is inhibited, it could explain many symptoms associated with CFS.
One intriguing aspect we observed is the potential therapeutic role that EPA could play. By providing EPA directly, we may bypass some of the metabolic restrictions caused by viral infections. This not only aids in generating essential fatty acids needed for bodily functions but also shows promise as a treatment option that could alleviate certain symptoms of CFS.
While the exact impact of EPA treatment on CFS warrants further investigation, the findings suggest that it might offer some benefits worth considering for those affected by this challenging condition.
Specifically, the issue revolves around the enzyme delta-6 desaturase, which plays a critical role in the conversion of essential fatty acids like alpha-linolenic acid and linoleic acid into longer chain polyunsaturated fatty acids. These fatty acids are vital for maintaining healthy cell membranes and proper cell signaling. If their production is inhibited, it could explain many symptoms associated with CFS.
One intriguing aspect we observed is the potential therapeutic role that EPA could play. By providing EPA directly, we may bypass some of the metabolic restrictions caused by viral infections. This not only aids in generating essential fatty acids needed for bodily functions but also shows promise as a treatment option that could alleviate certain symptoms of CFS.
While the exact impact of EPA treatment on CFS warrants further investigation, the findings suggest that it might offer some benefits worth considering for those affected by this challenging condition.
Read More
4
We explored the connection between omega-3 fatty acids and chronic fatigue syndrome (CFS) by examining serum levels in 22 CFS patients and 12 healthy controls. Our findings revealed that CFS patients had lower omega-3 levels compared to controls, along with higher omega-6 levels.
Interestingly, we observed that these imbalances correlated with the severity of fatigue and other symptoms. Additionally, lower omega-3 availability linked to poorer immune function was noted. These results suggest that omega-3 supplementation could be beneficial for those suffering from CFS.
Interestingly, we observed that these imbalances correlated with the severity of fatigue and other symptoms. Additionally, lower omega-3 availability linked to poorer immune function was noted. These results suggest that omega-3 supplementation could be beneficial for those suffering from CFS.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Less fatigue
1 people found this helpful
On my doctor’s advice, I began taking these to enhance my well-being and alleviate lethargy. I'm pleased to say it has helped!
Read More
9
Supports joint health
Omega-3s are vital for the stable functioning of the nervous, cardiovascular and immune systems. They also help alleviate inflammatory processes and improve joint and skin conditions, as well as emotional wellbeing, assisting in the fight against Chronic Fatigue Syndrome. This supplement, made from anchovy and sardine, has no unpleasant fishy aftertaste and offers great value for money. I take it regularly.
Read More
9
Optimal source selected
I chose EPA-DHA Balance from Jarrow Formulas for its perfect component ratio. Omega-3s are essential for the stable functioning of our nervous, cardiovascular, and immune systems. They minimise inflammation, enhance joint and skin health, improve emotional states, and help in the fight against Chronic Fatigue Syndrome. The large plastic jar contains 240 soft gel tablets without a typical fishy smell.
Read More
9
Effective source recommended
Omega-3 is crucial for protecting cell membranes and organs. It's needed for the proper functioning of the nervous, cardiovascular, and immune systems, while also combating inflammation and improving the condition of joints and skin, emotional wellbeing, and aiding in Chronic Fatigue Syndrome. I highly recommend EPA-DHA Balance from TM Jarrow Formulas as an effective Omega-3 source.
Read More
7.5
Enhances overall health
Omega-3 fatty acids are vital for cell and brain function. They significantly improve brain, cardiovascular, and gastrointestinal functioning, normalise emotional states, and help reduce chronic fatigue, irritation, and depression. They also decrease inflammation and pain, boost sexual function in men, lower cholesterol, strengthen the immune system, and enhance regeneration capabilities. Omega-3 is also beneficial for skin and hair health.
Read More
Frequently Asked Questions
7.5
Reduced tiredness
I can't tell yet how effective this is, but I've noticed a significant reduction in fatigue. It would be nice to have more energy.
4
We explored the connection between omega-3 fatty acids and chronic fatigue syndrome (CFS) by examining serum levels in 22 CFS patients and 12 healthy controls. Our findings revealed that CFS patients had lower omega-3 levels compared to controls, along with higher omega-6 levels.
Interestingly, we observed that these imbalances correlated with the severity of fatigue and other symptoms. Additionally, lower omega-3 availability linked to poorer immune function was noted. These results suggest that omega-3 supplementation could be beneficial for those suffering from CFS.
Interestingly, we observed that these imbalances correlated with the severity of fatigue and other symptoms. Additionally, lower omega-3 availability linked to poorer immune function was noted. These results suggest that omega-3 supplementation could be beneficial for those suffering from CFS.
8
Eicosapentaenoic acid shows potential
We assessed how eicosapentaenoic acid, an essential fatty acid, impacts chronic fatigue syndrome (CFS). A group of CFS patients took a specific supplement rich in this fatty acid. Remarkably, every participant reported symptom improvement within eight to twelve weeks.
These findings align with other research that shows the positive effects of eicosapentaenoic acid, hinting that it could be a promising treatment option for some individuals living with CFS.
These findings align with other research that shows the positive effects of eicosapentaenoic acid, hinting that it could be a promising treatment option for some individuals living with CFS.
8
We investigated the effects of a daily eicosapentaenoic acid (EPA)-rich supplement on a woman suffering from chronic fatigue syndrome for six years. After 16 weeks of treatment, she experienced significant symptom relief starting within the first 6-8 weeks.
Additionally, brain scans revealed a notable reduction in the size of her lateral ventricles, which is promising. This early-stage observation suggests that EPA supplementation might offer benefits for individuals dealing with chronic fatigue syndrome.
Additionally, brain scans revealed a notable reduction in the size of her lateral ventricles, which is promising. This early-stage observation suggests that EPA supplementation might offer benefits for individuals dealing with chronic fatigue syndrome.
8
Eicosapentaenoic acid's potential in CFS
We explored the connection between eicosapentaenoic acid (EPA) and chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis. The research indicates that individuals suffering from CFS may experience complications linked to persistent viral infections, which could hinder their body's ability to produce necessary fatty acids.
Specifically, the issue revolves around the enzyme delta-6 desaturase, which plays a critical role in the conversion of essential fatty acids like alpha-linolenic acid and linoleic acid into longer chain polyunsaturated fatty acids. These fatty acids are vital for maintaining healthy cell membranes and proper cell signaling. If their production is inhibited, it could explain many symptoms associated with CFS.
One intriguing aspect we observed is the potential therapeutic role that EPA could play. By providing EPA directly, we may bypass some of the metabolic restrictions caused by viral infections. This not only aids in generating essential fatty acids needed for bodily functions but also shows promise as a treatment option that could alleviate certain symptoms of CFS.
While the exact impact of EPA treatment on CFS warrants further investigation, the findings suggest that it might offer some benefits worth considering for those affected by this challenging condition.
Specifically, the issue revolves around the enzyme delta-6 desaturase, which plays a critical role in the conversion of essential fatty acids like alpha-linolenic acid and linoleic acid into longer chain polyunsaturated fatty acids. These fatty acids are vital for maintaining healthy cell membranes and proper cell signaling. If their production is inhibited, it could explain many symptoms associated with CFS.
One intriguing aspect we observed is the potential therapeutic role that EPA could play. By providing EPA directly, we may bypass some of the metabolic restrictions caused by viral infections. This not only aids in generating essential fatty acids needed for bodily functions but also shows promise as a treatment option that could alleviate certain symptoms of CFS.
While the exact impact of EPA treatment on CFS warrants further investigation, the findings suggest that it might offer some benefits worth considering for those affected by this challenging condition.
References
- Maes M, Mihaylova I, Leunis JC. In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation. Neuro Endocrinol Lett. 2005;26:745. PubMed
- Puri BK, Holmes J, Hamilton G. Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes. Int J Clin Pract. 2004;58:297. PubMed
- Puri BK. The use of eicosapentaenoic acid in the treatment of chronic fatigue syndrome. Prostaglandins Leukot Essent Fatty Acids. 2004;70:399. PubMed
- Puri BK. Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome). J Clin Pathol. 2007;60:122. PubMed
- Behan PO, Behan WM, Horrobin D. Effect of high doses of essential fatty acids on the postviral fatigue syndrome. Acta Neurol Scand. 1990;82:209. PubMed
