Last update
5/3/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Sodium (from Sodium Hyaluronate)
8 mg
<1%
Hyaluronic Acid (from Sodium Hyaluronate)
120 mg
†
Top Medical Research Studies
8
We engaged in a pilot study comparing the effectiveness of polynucleotide sodium with sodium hyaluronate for knee osteoarthritis pain relief. With 15 patients divided into three groups, all received ultrasound-guided injections over three weeks.
Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.
Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.
Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.
Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.
Read More
Most Useful Reviews
10
Enhanced exercise ability
7 people found this helpful
A nurse friend recommended this, and it has significantly aided my bone-on-bone arthritic knee. I can now exercise regularly without pain. I take it twice a day and have endorsed it to many friends.
Read More
9
Significant improvement
I really feel the difference; I used to have pain in my knees, but when I take this supplement, I feel much better.
Read More
6
Reduced daily pain
It helps a lot with disc disease. I'm able to do daily activities with less pain.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
We engaged in a pilot study comparing the effectiveness of polynucleotide sodium with sodium hyaluronate for knee osteoarthritis pain relief. With 15 patients divided into three groups, all received ultrasound-guided injections over three weeks.
Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.
Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.
Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.
Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
10
Enhanced exercise ability
7 people found this helpful
A nurse friend recommended this, and it has significantly aided my bone-on-bone arthritic knee. I can now exercise regularly without pain. I take it twice a day and have endorsed it to many friends.
Read More
9
Significant improvement
I really feel the difference; I used to have pain in my knees, but when I take this supplement, I feel much better.
Read More
6
Reduced daily pain
It helps a lot with disc disease. I'm able to do daily activities with less pain.
Read More
6
Notable pain relief
I've just started taking hyaluronic acid and have noticed some relief in pain. Your service was outstanding; thank you.
Read More
Frequently Asked Questions
9
Significant improvement
I really feel the difference; I used to have pain in my knees, but when I take this supplement, I feel much better.
6
Reduced daily pain
It helps a lot with disc disease. I'm able to do daily activities with less pain.
6
Notable pain relief
I've just started taking hyaluronic acid and have noticed some relief in pain. Your service was outstanding; thank you.
8
We engaged in a pilot study comparing the effectiveness of polynucleotide sodium with sodium hyaluronate for knee osteoarthritis pain relief. With 15 patients divided into three groups, all received ultrasound-guided injections over three weeks.
Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.
Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.
Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.
Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.
References
- Kim JY, Kim YN, Lee YJ, Sim SE, Ko YR, et al. Pilot Study to Evaluate the Efficacy of Polynucleotide Sodium Compared to Sodium Hyaluronate and Crosslinked Sodium Hyaluronate in Patients with Knee Osteoarthritis. J Clin Med. 2021;10. 10.3390/jcm10051138
