' 
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 13 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Calcium (from Calcium-Magnesium Inositol Hexaphosphate)
100 mg
8%
Inositol Hexaphosphate (from Calcium-Magnesium Inositol Hexaphosphate)
500 mg
†
Top Medical Research Studies
9
SCI offers safe anticoagulant potential
A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding.
Highly relevant to anticoagulant development
We explored the effects of a synthetic heparin mimetic known as sulfated chiro-inositol (SCI) on blood clotting mechanisms. This innovative treatment aims to inhibit human factor XIa (FXIa), a key player in the clotting process, while minimizing bleeding risks typically associated with anticoagulants.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
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Most Useful Reviews
10
Normalised iron levels
This supplement effectively reduces excess iron from the liver, particularly in men. I've been using it for a month, and my iron levels have returned to normal. It's crucial to follow the label instructions and not to take it for more than 4 to 6 weeks. I find it quite effective.
Read More
9.5
Supports blood sugar
The best quality from Jarrow Formulas. I use it to manage insulin resistance, lower sugar levels, and reduce inflammatory ferritin, as it binds and removes iron. It’s effective for up to six months. Together with Berberine, it has helped my patients lower their sugar levels significantly.
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8.8
Effective iron reduction
Really works! My Naturopath recommended this product for iron chelation. My ferritin count dropped from 819 to 634 after starting on February 11. I have made no other changes besides taking IP6 on an empty stomach at night, so it must be the IP6 doing its job. I'm pleased and will continue using it alongside my phlebotomies every 84 days.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
- All Researches
9
SCI offers safe anticoagulant potential
A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding.
Highly relevant to anticoagulant development
We explored the effects of a synthetic heparin mimetic known as sulfated chiro-inositol (SCI) on blood clotting mechanisms. This innovative treatment aims to inhibit human factor XIa (FXIa), a key player in the clotting process, while minimizing bleeding risks typically associated with anticoagulants.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
Normalised iron levels
This supplement effectively reduces excess iron from the liver, particularly in men. I've been using it for a month, and my iron levels have returned to normal. It's crucial to follow the label instructions and not to take it for more than 4 to 6 weeks. I find it quite effective.
Read More
9.5
Supports blood sugar
The best quality from Jarrow Formulas. I use it to manage insulin resistance, lower sugar levels, and reduce inflammatory ferritin, as it binds and removes iron. It’s effective for up to six months. Together with Berberine, it has helped my patients lower their sugar levels significantly.
Read More
8.8
Effective iron reduction
Really works! My Naturopath recommended this product for iron chelation. My ferritin count dropped from 819 to 634 after starting on February 11. I have made no other changes besides taking IP6 on an empty stomach at night, so it must be the IP6 doing its job. I'm pleased and will continue using it alongside my phlebotomies every 84 days.
Read More
8.8
Lowered blood iron
Excellent! This product significantly lowered my iron levels from 32 to 25 in just 3 months. I took 2 capsules twice daily, along with milk thistle drops and curcumin.
9.5
Useful for detox
UPDATE - I initially wasn't sure about its effects, hoping to help my immune system. It’s challenging to take daily with empty stomach requirements and timing away from other medications. In June 2023, I purchased it again to help lower high iron levels from recent blood tests. Taking it at night worked; my next test showed significant improvement in my iron levels. This supplement may also help with heavy metals.
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