Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 4 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Calcium (from Calcium-Magnesium Inositol Hexaphosphate)
100 mg
8%
Inositol Hexaphosphate (from Calcium-Magnesium Inositol Hexaphosphate)
500 mg
†
Top Medical Research Studies
7
We examined how INPP5E influences Sonic Hedgehog (SHH) signaling in medulloblastoma, a common pediatric brain tumor. By using a murine model, we found that deleting INPP5E reduced tumor growth, cell proliferation, and SHH signaling while causing a loss of cilia on tumor cells.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Read More
8
We explored the effects of inositol treatment on medulloblastoma, which is a leading cause of brain tumors in children. Specifically, we found that some medulloblastoma cells showed a unique sensitivity to changes in inositol metabolism due to the presence of the BMI1 gene.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Read More
Most Useful Reviews
7.5
Speedy delivery service
4 people found this helpful
I ordered Jarrow Formulas IP6, and the immediate delivery impressed me. The capsules help chelate and remove the iron accumulation in my brain due to CCSVI, and I believe they are making a difference. I'm extremely happy with both the effectiveness and the swift service provided.
Read More
9
Cancer prevention benefits
Inositol hexaphosphate (IP6) is a carbohydrate that occurs naturally in many plant foods. I've understood its importance in cancer prevention and controlling tumour growth. IP6 acts as an antioxidant and has showcased remarkable benefits for human health, including immune system enhancement and reducing cholesterol levels. Some studies even indicate that it can enhance conventional chemotherapy's effects and improve quality of life for cancer patients.
Read More
6
Effective brain support
4 people found this helpful
I've been taking inositol as per my doctor's advice and found it to be a beneficial dietary supplement. It plays an essential role in various bodily processes, particularly for the brain and hormonal system. I've noticed effects develop steadily after completing the course, showcasing its positive influence on overall well-being.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
We explored the effects of inositol treatment on medulloblastoma, which is a leading cause of brain tumors in children. Specifically, we found that some medulloblastoma cells showed a unique sensitivity to changes in inositol metabolism due to the presence of the BMI1 gene.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Read More
7
We examined how INPP5E influences Sonic Hedgehog (SHH) signaling in medulloblastoma, a common pediatric brain tumor. By using a murine model, we found that deleting INPP5E reduced tumor growth, cell proliferation, and SHH signaling while causing a loss of cilia on tumor cells.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Speedy delivery service
4 people found this helpful
I ordered Jarrow Formulas IP6, and the immediate delivery impressed me. The capsules help chelate and remove the iron accumulation in my brain due to CCSVI, and I believe they are making a difference. I'm extremely happy with both the effectiveness and the swift service provided.
Read More
9
Cancer prevention benefits
Inositol hexaphosphate (IP6) is a carbohydrate that occurs naturally in many plant foods. I've understood its importance in cancer prevention and controlling tumour growth. IP6 acts as an antioxidant and has showcased remarkable benefits for human health, including immune system enhancement and reducing cholesterol levels. Some studies even indicate that it can enhance conventional chemotherapy's effects and improve quality of life for cancer patients.
Read More
6
Effective brain support
4 people found this helpful
I've been taking inositol as per my doctor's advice and found it to be a beneficial dietary supplement. It plays an essential role in various bodily processes, particularly for the brain and hormonal system. I've noticed effects develop steadily after completing the course, showcasing its positive influence on overall well-being.
Read More
7.5
Mood enhancement properties
2 people found this helpful
Inositol is a trace mineral that has a vital role in balancing brain chemicals like serotonin and dopamine, which are crucial for mood and well-being. Scientific studies suggest that individuals suffering from depression and anxiety often have low inositol levels. Its potential to support mental health cannot be underestimated.
Read More
Frequently Asked Questions
6
Effective brain support
4 people found this helpful
I've been taking inositol as per my doctor's advice and found it to be a beneficial dietary supplement. It plays an essential role in various bodily processes, particularly for the brain and hormonal system. I've noticed effects develop steadily after completing the course, showcasing its positive influence on overall well-being.
7.5
Speedy delivery service
4 people found this helpful
I ordered Jarrow Formulas IP6, and the immediate delivery impressed me. The capsules help chelate and remove the iron accumulation in my brain due to CCSVI, and I believe they are making a difference. I'm extremely happy with both the effectiveness and the swift service provided.
9
Cancer prevention benefits
Inositol hexaphosphate (IP6) is a carbohydrate that occurs naturally in many plant foods. I've understood its importance in cancer prevention and controlling tumour growth. IP6 acts as an antioxidant and has showcased remarkable benefits for human health, including immune system enhancement and reducing cholesterol levels. Some studies even indicate that it can enhance conventional chemotherapy's effects and improve quality of life for cancer patients.
7.5
Mood enhancement properties
2 people found this helpful
Inositol is a trace mineral that has a vital role in balancing brain chemicals like serotonin and dopamine, which are crucial for mood and well-being. Scientific studies suggest that individuals suffering from depression and anxiety often have low inositol levels. Its potential to support mental health cannot be underestimated.
8
We explored the effects of inositol treatment on medulloblastoma, which is a leading cause of brain tumors in children. Specifically, we found that some medulloblastoma cells showed a unique sensitivity to changes in inositol metabolism due to the presence of the BMI1 gene.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
7
We examined how INPP5E influences Sonic Hedgehog (SHH) signaling in medulloblastoma, a common pediatric brain tumor. By using a murine model, we found that deleting INPP5E reduced tumor growth, cell proliferation, and SHH signaling while causing a loss of cilia on tumor cells.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
References
- Badodi S, Pomella N, Zhang X, Rosser G, Whittingham J, et al. Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation. Nat Commun. 2021;12:2148. 10.1038/s41467-021-22379-7
- Conduit SE, Ramaswamy V, Remke M, Watkins DN, Wainwright BJ, et al. A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma. Oncogene. 2017;36:5969. 10.1038/onc.2017.208
