Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 7 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Calcium (from Calcium-Magnesium Inositol Hexaphosphate)
100 mg
8%
Inositol Hexaphosphate (from Calcium-Magnesium Inositol Hexaphosphate)
500 mg
†
Top Medical Research Studies
9
We investigated how inositol supplementation could counteract heart issues caused by lithium in mice. Our study involved four groups of mice to explore the varying effects of inositol. One group received lithium alone, another received lithium followed by inositol, a third group had both lithium and inositol from the start, and a control group had no treatment at all.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
8
ITPP improves heart function in PH
We investigated the effects of myo-inositol trispyrophosphate (ITPP) on rats with pulmonary hypertension (PH), a condition that often leads to serious heart issues. To do this, we injected some rats with monocrotaline to induce PH and treated others with a placebo. For five weeks, we closely monitored their heart function using echocardiograms and other advanced techniques.
Our findings revealed that ITPP significantly reduced mortality linked to PH. While it didn't change the increasing resistance in the pulmonary vessels, ITPP importantly alleviated hypoxia within the right ventricle (RV), which is crucial for maintaining heart function. This reduction in RV hypoxia not only improved heart performance but also decreased stress on the heart’s structure.
Furthermore, we noticed that ITPP appeared to inhibit an increase in a specific protein associated with low oxygen levels, though it didn't affect the density of blood vessels in the RV. Overall, this suggests that enhancing oxygen delivery with ITPP could provide a crucial therapeutic avenue for improving heart health in patients suffering from pulmonary hypertension.
Our findings revealed that ITPP significantly reduced mortality linked to PH. While it didn't change the increasing resistance in the pulmonary vessels, ITPP importantly alleviated hypoxia within the right ventricle (RV), which is crucial for maintaining heart function. This reduction in RV hypoxia not only improved heart performance but also decreased stress on the heart’s structure.
Furthermore, we noticed that ITPP appeared to inhibit an increase in a specific protein associated with low oxygen levels, though it didn't affect the density of blood vessels in the RV. Overall, this suggests that enhancing oxygen delivery with ITPP could provide a crucial therapeutic avenue for improving heart health in patients suffering from pulmonary hypertension.
Most Useful Reviews
8.3
Remarkable results obtained
I took this to chelate excess iron from my liver, and I was astonished to find that it alleviated my palmar erythema almost immediately. Research reveals that low-dose IP6 (500-1000mg daily) reduces inflammatory TNF-a cytokines linked to liver disease and leaky gut. I am overjoyed daily to have discovered IP6, and I always take it on an empty stomach with a full glass of water.
8.8
Supports health effectively
Jarrow Formulas® IP6 provides 500mg of purified inositol hexaphosphate (IP6) sourced from Japanese rice bran. This phosphorylated inositol, commonly found in high-fibre plant foods, enhances immune and cardiovascular health by boosting K-cell activity and chelating iron, thereby protecting against harmful free radicals. I take it upon my doctor’s recommendation.
8.8
Antioxidant support provided
Jarrow Formulas® P6 offers 500mg of purified inositol hexaphosphate (IP6) from Japanese rice bran. This form of inositol, prevalent in fibre-rich plant foods, promotes immune and cardiovascular health by enhancing K-cell activity and chelating reactive iron. It serves as a defence against aggressive free radicals. We intend to give it a try.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
- All Researches
9
We investigated how inositol supplementation could counteract heart issues caused by lithium in mice. Our study involved four groups of mice to explore the varying effects of inositol. One group received lithium alone, another received lithium followed by inositol, a third group had both lithium and inositol from the start, and a control group had no treatment at all.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
8
ITPP improves heart function in PH
We investigated the effects of myo-inositol trispyrophosphate (ITPP) on rats with pulmonary hypertension (PH), a condition that often leads to serious heart issues. To do this, we injected some rats with monocrotaline to induce PH and treated others with a placebo. For five weeks, we closely monitored their heart function using echocardiograms and other advanced techniques.
Our findings revealed that ITPP significantly reduced mortality linked to PH. While it didn't change the increasing resistance in the pulmonary vessels, ITPP importantly alleviated hypoxia within the right ventricle (RV), which is crucial for maintaining heart function. This reduction in RV hypoxia not only improved heart performance but also decreased stress on the heart’s structure.
Furthermore, we noticed that ITPP appeared to inhibit an increase in a specific protein associated with low oxygen levels, though it didn't affect the density of blood vessels in the RV. Overall, this suggests that enhancing oxygen delivery with ITPP could provide a crucial therapeutic avenue for improving heart health in patients suffering from pulmonary hypertension.
Our findings revealed that ITPP significantly reduced mortality linked to PH. While it didn't change the increasing resistance in the pulmonary vessels, ITPP importantly alleviated hypoxia within the right ventricle (RV), which is crucial for maintaining heart function. This reduction in RV hypoxia not only improved heart performance but also decreased stress on the heart’s structure.
Furthermore, we noticed that ITPP appeared to inhibit an increase in a specific protein associated with low oxygen levels, though it didn't affect the density of blood vessels in the RV. Overall, this suggests that enhancing oxygen delivery with ITPP could provide a crucial therapeutic avenue for improving heart health in patients suffering from pulmonary hypertension.
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.3
Remarkable results obtained
I took this to chelate excess iron from my liver, and I was astonished to find that it alleviated my palmar erythema almost immediately. Research reveals that low-dose IP6 (500-1000mg daily) reduces inflammatory TNF-a cytokines linked to liver disease and leaky gut. I am overjoyed daily to have discovered IP6, and I always take it on an empty stomach with a full glass of water.
8.8
Supports health effectively
Jarrow Formulas® IP6 provides 500mg of purified inositol hexaphosphate (IP6) sourced from Japanese rice bran. This phosphorylated inositol, commonly found in high-fibre plant foods, enhances immune and cardiovascular health by boosting K-cell activity and chelating iron, thereby protecting against harmful free radicals. I take it upon my doctor’s recommendation.
8.8
Antioxidant support provided
Jarrow Formulas® P6 offers 500mg of purified inositol hexaphosphate (IP6) from Japanese rice bran. This form of inositol, prevalent in fibre-rich plant foods, promotes immune and cardiovascular health by enhancing K-cell activity and chelating reactive iron. It serves as a defence against aggressive free radicals. We intend to give it a try.
8.8
Quality product confirmed
I trust Jarrow Formulas entirely; I’ve purchased their products multiple times. Their quality is consistently top-notch. The ingredients used are always optimal. This product, derived from rice bran in Japan, is a form of inositol present in high-fibre foods, supporting immune and cardiovascular health through enhanced K-cell activity and iron chelation, providing protection against harmful free radicals. I take it on an empty stomach in the evening, separate from my daytime medications. The capsules are standard size and easy to swallow, and the benefits are noticeable.
8
Promotes cell protection
Jarrow Formulas® NSF IP6 certified contains 500mg of purified inositol hexaphosphate (IP6) from rice bran, made in Japan. IP6 supports immune and cardiovascular health by enhancing K-cell activity and chelating reactive iron, providing protection against aggressive hydroxyl free radicals. It's suitable for vegetarians and vegans, being a non-GMO product.
Frequently Asked Questions
8.3
Remarkable results obtained
I took this to chelate excess iron from my liver, and I was astonished to find that it alleviated my palmar erythema almost immediately. Research reveals that low-dose IP6 (500-1000mg daily) reduces inflammatory TNF-a cytokines linked to liver disease and leaky gut. I am overjoyed daily to have discovered IP6, and I always take it on an empty stomach with a full glass of water.
9.5
Prevents diseases
Excellent! This supplement supports immunity and prevents cardiovascular disease. I highly recommend it.
8
Promotes cell protection
Jarrow Formulas® NSF IP6 certified contains 500mg of purified inositol hexaphosphate (IP6) from rice bran, made in Japan. IP6 supports immune and cardiovascular health by enhancing K-cell activity and chelating reactive iron, providing protection against aggressive hydroxyl free radicals. It's suitable for vegetarians and vegans, being a non-GMO product.
8
Tangible benefits noted
Inositol was suggested to me by my nutritionist as a supplement for immune support and cardiovascular health. It’s a B vitamin derived from rice bran. I take it on an empty stomach in the evening, separate from daily medications. The capsule size is standard, making them easy to swallow, and I’ve noticed significant benefits.
8.8
Supports health effectively
Jarrow Formulas® IP6 provides 500mg of purified inositol hexaphosphate (IP6) sourced from Japanese rice bran. This phosphorylated inositol, commonly found in high-fibre plant foods, enhances immune and cardiovascular health by boosting K-cell activity and chelating iron, thereby protecting against harmful free radicals. I take it upon my doctor’s recommendation.
8.8
Quality product confirmed
I trust Jarrow Formulas entirely; I’ve purchased their products multiple times. Their quality is consistently top-notch. The ingredients used are always optimal. This product, derived from rice bran in Japan, is a form of inositol present in high-fibre foods, supporting immune and cardiovascular health through enhanced K-cell activity and iron chelation, providing protection against harmful free radicals. I take it on an empty stomach in the evening, separate from my daytime medications. The capsules are standard size and easy to swallow, and the benefits are noticeable.
9
We investigated how inositol supplementation could counteract heart issues caused by lithium in mice. Our study involved four groups of mice to explore the varying effects of inositol. One group received lithium alone, another received lithium followed by inositol, a third group had both lithium and inositol from the start, and a control group had no treatment at all.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
8
ITPP improves heart function in PH
We investigated the effects of myo-inositol trispyrophosphate (ITPP) on rats with pulmonary hypertension (PH), a condition that often leads to serious heart issues. To do this, we injected some rats with monocrotaline to induce PH and treated others with a placebo. For five weeks, we closely monitored their heart function using echocardiograms and other advanced techniques.
Our findings revealed that ITPP significantly reduced mortality linked to PH. While it didn't change the increasing resistance in the pulmonary vessels, ITPP importantly alleviated hypoxia within the right ventricle (RV), which is crucial for maintaining heart function. This reduction in RV hypoxia not only improved heart performance but also decreased stress on the heart’s structure.
Furthermore, we noticed that ITPP appeared to inhibit an increase in a specific protein associated with low oxygen levels, though it didn't affect the density of blood vessels in the RV. Overall, this suggests that enhancing oxygen delivery with ITPP could provide a crucial therapeutic avenue for improving heart health in patients suffering from pulmonary hypertension.
Our findings revealed that ITPP significantly reduced mortality linked to PH. While it didn't change the increasing resistance in the pulmonary vessels, ITPP importantly alleviated hypoxia within the right ventricle (RV), which is crucial for maintaining heart function. This reduction in RV hypoxia not only improved heart performance but also decreased stress on the heart’s structure.
Furthermore, we noticed that ITPP appeared to inhibit an increase in a specific protein associated with low oxygen levels, though it didn't affect the density of blood vessels in the RV. Overall, this suggests that enhancing oxygen delivery with ITPP could provide a crucial therapeutic avenue for improving heart health in patients suffering from pulmonary hypertension.
References
- L'Abbate S, Nicolini G, Forini F, Lepore E, Marchetti S, et al. Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice. Biomed Pharmacother. 2024;178:117287. doi:10.1016/j.biopha.2024.117287
- Oknińska M, Paterek A, Grzanka M, Zajda K, Surzykiewicz M, et al. Myo-inositol trispyrophosphate prevents right ventricular failure and improves survival in monocrotaline-induced pulmonary hypertension in the rat. Br J Pharmacol. 2024;181:4050. doi:10.1111/bph.16482
