Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.5
USERS' SCORE
Good
Based on 10 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Calcium (from Calcium-Magnesium Inositol Hexaphosphate)
100 mg
8%
Inositol Hexaphosphate (from Calcium-Magnesium Inositol Hexaphosphate)
500 mg
†
Top Medical Research Studies
8
We explored the impact of inositol on cold stress in rapeseed, an essential oilseed crop affected by low temperatures. Notably, we found that inositol plays a significant role in enhancing cold tolerance in these plants by boosting calcium ion (Ca) influx.
Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.
Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.
Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.
Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.
Read More
9
We explored how myo-inositol oxygenase (MIOX), an important enzyme, might help alfalfa, a type of forage crop, adapt to challenging cold conditions. The study identified ten MsMIOX genes in the alfalfa genome, which were found distributed across three chromosomes.
Through analysis, we noted that these genes exhibited similarities in structure and conserved features, hinting at a functional role important for the plant's survival under stress.
Our qRT-PCR tests showed that different MsMIOX genes could be triggered by cold and other abiotic stress factors like drought and salinity. Notably, the activity of MIOX in alfalfa significantly increased under these harsh conditions.
By overexpressing the MsMIOX2 gene in yeast, we found that it notably enhanced resistance to cold stresses. Additionally, when MsMIOX2 was overexpressed in alfalfa’s hairy roots, it reduced reactive oxygen species and improved the plant's resilience against cold.
This study provides valuable insights into how inositol plays a part in helping alfalfa thrive even in cold weather, presenting a candidate for future efforts to enhance the plant’s stress tolerance.
Through analysis, we noted that these genes exhibited similarities in structure and conserved features, hinting at a functional role important for the plant's survival under stress.
Our qRT-PCR tests showed that different MsMIOX genes could be triggered by cold and other abiotic stress factors like drought and salinity. Notably, the activity of MIOX in alfalfa significantly increased under these harsh conditions.
By overexpressing the MsMIOX2 gene in yeast, we found that it notably enhanced resistance to cold stresses. Additionally, when MsMIOX2 was overexpressed in alfalfa’s hairy roots, it reduced reactive oxygen species and improved the plant's resilience against cold.
This study provides valuable insights into how inositol plays a part in helping alfalfa thrive even in cold weather, presenting a candidate for future efforts to enhance the plant’s stress tolerance.
Read More
9
We explored how low red to far-red light ratios influence cold tolerance in tomato plants. The focus was on two key proteins, SlFHY3 and SlHY5, which play a role in increasing the accumulation of myo-inositol, a compound linked with cold resistance.
Our findings revealed that when tomato plants experienced low light ratios, it encouraged the production of SlFHY3 under cold stress. Knocking out this gene led to lower myo-inositol levels and made the plants more vulnerable to cold, while overexpressing it had the opposite effect.
Moreover, we found that SlFHY3 works closely with SlHY5 to boost writing activity for a particular gene involved in myo-inositol synthesis. This interaction is crucial, as it significantly enhances both myo-inositol levels and the plants' ability to withstand cold conditions. Without these proteins or the inositol synthesis gene, the cold resistance we observed was diminished.
Ultimately, our study shines a light on the important relationship between light signals, inositol accumulation, and cold tolerance in tomatoes, unveiling how plants manage environmental stress.
Our findings revealed that when tomato plants experienced low light ratios, it encouraged the production of SlFHY3 under cold stress. Knocking out this gene led to lower myo-inositol levels and made the plants more vulnerable to cold, while overexpressing it had the opposite effect.
Moreover, we found that SlFHY3 works closely with SlHY5 to boost writing activity for a particular gene involved in myo-inositol synthesis. This interaction is crucial, as it significantly enhances both myo-inositol levels and the plants' ability to withstand cold conditions. Without these proteins or the inositol synthesis gene, the cold resistance we observed was diminished.
Ultimately, our study shines a light on the important relationship between light signals, inositol accumulation, and cold tolerance in tomatoes, unveiling how plants manage environmental stress.
Read More
Most Useful Reviews
9
Keeps shingles away
11 people found this helpful
I take this daily to keep cold sores and shingles at bay!
Read More
9
No cold sores
9 people found this helpful
Love these for cold sores. I have been taking these for about 9 months and haven't had a single cold sore yet! I usually get cold sores when stressed or with changes in weather and they have troubled me every few months since I was young. These really work.
Read More
10
Ideal remedy
2 people found this helpful
With a cold, there is nothing better than this remedy!!!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.5
- All Researches
9
We explored the effects of myo-inositol and corn steep liquor (CSL) on cucumber and tomato seedlings, particularly focusing on their ability to withstand cold temperatures. Through our research, we found that applying these substances led to noticeable improvements in seedling growth during low-temperature stress.
Our treatments not only increased the levels of photosynthetic pigments, enhancing photosynthesis, but also reduced harmful compounds like malondialdehyde (MDA) and electrolyte leakage. This suggests that the combination of inositol and CSL helps to protect plant cells under stress.
Additionally, we confirmed these findings by analyzing the expression of important genes that relate to cold tolerance in cucumbers. The most effective mix we identified was 0.6 mL L of CSL together with 72 mg L of myo-inositol. Overall, this study gives us valuable insights into how we can use inositol and maize leachate to foster early growth in crops and improve their resilience against cold weather.
Our treatments not only increased the levels of photosynthetic pigments, enhancing photosynthesis, but also reduced harmful compounds like malondialdehyde (MDA) and electrolyte leakage. This suggests that the combination of inositol and CSL helps to protect plant cells under stress.
Additionally, we confirmed these findings by analyzing the expression of important genes that relate to cold tolerance in cucumbers. The most effective mix we identified was 0.6 mL L of CSL together with 72 mg L of myo-inositol. Overall, this study gives us valuable insights into how we can use inositol and maize leachate to foster early growth in crops and improve their resilience against cold weather.
Read More
9
We explored how myo-inositol oxygenase (MIOX), an important enzyme, might help alfalfa, a type of forage crop, adapt to challenging cold conditions. The study identified ten MsMIOX genes in the alfalfa genome, which were found distributed across three chromosomes.
Through analysis, we noted that these genes exhibited similarities in structure and conserved features, hinting at a functional role important for the plant's survival under stress.
Our qRT-PCR tests showed that different MsMIOX genes could be triggered by cold and other abiotic stress factors like drought and salinity. Notably, the activity of MIOX in alfalfa significantly increased under these harsh conditions.
By overexpressing the MsMIOX2 gene in yeast, we found that it notably enhanced resistance to cold stresses. Additionally, when MsMIOX2 was overexpressed in alfalfa’s hairy roots, it reduced reactive oxygen species and improved the plant's resilience against cold.
This study provides valuable insights into how inositol plays a part in helping alfalfa thrive even in cold weather, presenting a candidate for future efforts to enhance the plant’s stress tolerance.
Through analysis, we noted that these genes exhibited similarities in structure and conserved features, hinting at a functional role important for the plant's survival under stress.
Our qRT-PCR tests showed that different MsMIOX genes could be triggered by cold and other abiotic stress factors like drought and salinity. Notably, the activity of MIOX in alfalfa significantly increased under these harsh conditions.
By overexpressing the MsMIOX2 gene in yeast, we found that it notably enhanced resistance to cold stresses. Additionally, when MsMIOX2 was overexpressed in alfalfa’s hairy roots, it reduced reactive oxygen species and improved the plant's resilience against cold.
This study provides valuable insights into how inositol plays a part in helping alfalfa thrive even in cold weather, presenting a candidate for future efforts to enhance the plant’s stress tolerance.
Read More
9
We explored how low red to far-red light ratios influence cold tolerance in tomato plants. The focus was on two key proteins, SlFHY3 and SlHY5, which play a role in increasing the accumulation of myo-inositol, a compound linked with cold resistance.
Our findings revealed that when tomato plants experienced low light ratios, it encouraged the production of SlFHY3 under cold stress. Knocking out this gene led to lower myo-inositol levels and made the plants more vulnerable to cold, while overexpressing it had the opposite effect.
Moreover, we found that SlFHY3 works closely with SlHY5 to boost writing activity for a particular gene involved in myo-inositol synthesis. This interaction is crucial, as it significantly enhances both myo-inositol levels and the plants' ability to withstand cold conditions. Without these proteins or the inositol synthesis gene, the cold resistance we observed was diminished.
Ultimately, our study shines a light on the important relationship between light signals, inositol accumulation, and cold tolerance in tomatoes, unveiling how plants manage environmental stress.
Our findings revealed that when tomato plants experienced low light ratios, it encouraged the production of SlFHY3 under cold stress. Knocking out this gene led to lower myo-inositol levels and made the plants more vulnerable to cold, while overexpressing it had the opposite effect.
Moreover, we found that SlFHY3 works closely with SlHY5 to boost writing activity for a particular gene involved in myo-inositol synthesis. This interaction is crucial, as it significantly enhances both myo-inositol levels and the plants' ability to withstand cold conditions. Without these proteins or the inositol synthesis gene, the cold resistance we observed was diminished.
Ultimately, our study shines a light on the important relationship between light signals, inositol accumulation, and cold tolerance in tomatoes, unveiling how plants manage environmental stress.
Read More
8
We examined how inositol, a key component in the production of raffinose, plays a role in helping sugar beet plants withstand cold stress. In the study, researchers identified the vacuolar inositol transporter BvINT1;1, which seems to be critical for the synthesis of raffinose under chilly conditions.
When plants were exposed to cold, BvINT1;1 was found to be highly active, ensuring adequate inositol was available for raffinose production. Interestingly, sugar beet mutants that lacked functional BvINT1;1 not only had higher levels of inositol but also lower amounts of raffinose when subjected to cold stress.
This reduction in raffinose was significant because raffinose can help neutralize harmful reactive oxygen species (ROS), which accumulate when plants are stressed. As a result, these mutants showed increased expression of genes related to ROS, pointing out a potential risk for them during cold weather.
Overall, our findings suggest that the transporter BvINT1;1 is not just about moving inositol; it plays a vital role in boosting the plant's cold resilience by facilitating raffinose biosynthesis and maintaining balance against oxidative stress.
When plants were exposed to cold, BvINT1;1 was found to be highly active, ensuring adequate inositol was available for raffinose production. Interestingly, sugar beet mutants that lacked functional BvINT1;1 not only had higher levels of inositol but also lower amounts of raffinose when subjected to cold stress.
This reduction in raffinose was significant because raffinose can help neutralize harmful reactive oxygen species (ROS), which accumulate when plants are stressed. As a result, these mutants showed increased expression of genes related to ROS, pointing out a potential risk for them during cold weather.
Overall, our findings suggest that the transporter BvINT1;1 is not just about moving inositol; it plays a vital role in boosting the plant's cold resilience by facilitating raffinose biosynthesis and maintaining balance against oxidative stress.
Read More
8
We delved into the fascinating world of white water lilies and their remarkable ability to withstand cold temperatures. This study aimed to understand how certain compounds, particularly myo-inositol, contribute to the plant's cold resilience.
Through a comprehensive examination, we learned that the water lily effectively copes with winter by entering a state called ecodormancy. During this time, the plant reallocates resources and enhances its defenses against cold stress.
One of our key findings was the significance of myo-inositol. This compound helps bolster the plant’s cold tolerance, although it works alongside various other factors. It plays a role in regulating metabolic activities, especially in relation to amino acids, which are crucial for overcoming chilly conditions.
Although our study highlighted the importance of myo-inositol, it did not isolate its effects from other treatments, which limits our understanding of its specific impact. Nevertheless, the insights we gained about the water lily’s adaptive strategies provide valuable information for future agricultural practices in cold climates.
Through a comprehensive examination, we learned that the water lily effectively copes with winter by entering a state called ecodormancy. During this time, the plant reallocates resources and enhances its defenses against cold stress.
One of our key findings was the significance of myo-inositol. This compound helps bolster the plant’s cold tolerance, although it works alongside various other factors. It plays a role in regulating metabolic activities, especially in relation to amino acids, which are crucial for overcoming chilly conditions.
Although our study highlighted the importance of myo-inositol, it did not isolate its effects from other treatments, which limits our understanding of its specific impact. Nevertheless, the insights we gained about the water lily’s adaptive strategies provide valuable information for future agricultural practices in cold climates.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Keeps shingles away
11 people found this helpful
I take this daily to keep cold sores and shingles at bay!
Read More
9
No cold sores
9 people found this helpful
Love these for cold sores. I have been taking these for about 9 months and haven't had a single cold sore yet! I usually get cold sores when stressed or with changes in weather and they have troubled me every few months since I was young. These really work.
Read More
10
Ideal remedy
2 people found this helpful
With a cold, there is nothing better than this remedy!!!
Read More
9
Prevents cold sore
2 people found this helpful
Big but effective! I got these for cold sores and canker sores. They are larger but go down easily! I take 2, three times a day during an active cold sore until a day after, and my cold sore NEVER formed, even though I could feel it trying to break through daily! I really like these and plan to always have a bottle on hand!
Read More
6
High-quality product
6 people found this helpful
These capsules are not hard pills and are high quality and effective. They help me with cold sores; I don’t need them all the time.
Read More
Frequently Asked Questions
7.5
Immunity boost
2 people found this helpful
Bullet proof! I've been taking IP6 for several years now, and during this time, when exposed to colds of all shapes and sizes, they have either skirted around me, or the impact, if any, is short-lived and not as severe. It helps maintain a high level of immunity. Highly recommend!
7.5
Resilient immunity
1 people found this helpful
I started taking Jarrow Formulas Vegan IP6 and my impressions of the supplement are positive. I noticed that my immune system became more resilient. With the start of autumn, I was often sick, but with IP6 I felt better able to cope with seasonal colds. I appreciate its antioxidant properties, which have helped maintain my energy and overall well-being. The capsules are easy to take, and I didn't experience any side effects.
7.5
Effective immune support
1 people found this helpful
Good price! This is GREAT for my immune system. No side effects. Great if you get colds this time of the year.
9
Cold sore prevention
2 people found this helpful
Big but they work! I got these for cold sores and canker sores! They are larger but go down easily. I take 2, three times a day with an active cold sore and my cold sore NEVER formed, although I could feel it trying to break through. I really like these and plan to ALWAYS have a bottle on hand!
9
We explored the effects of myo-inositol and corn steep liquor (CSL) on cucumber and tomato seedlings, particularly focusing on their ability to withstand cold temperatures. Through our research, we found that applying these substances led to noticeable improvements in seedling growth during low-temperature stress.
Our treatments not only increased the levels of photosynthetic pigments, enhancing photosynthesis, but also reduced harmful compounds like malondialdehyde (MDA) and electrolyte leakage. This suggests that the combination of inositol and CSL helps to protect plant cells under stress.
Additionally, we confirmed these findings by analyzing the expression of important genes that relate to cold tolerance in cucumbers. The most effective mix we identified was 0.6 mL L of CSL together with 72 mg L of myo-inositol. Overall, this study gives us valuable insights into how we can use inositol and maize leachate to foster early growth in crops and improve their resilience against cold weather.
Our treatments not only increased the levels of photosynthetic pigments, enhancing photosynthesis, but also reduced harmful compounds like malondialdehyde (MDA) and electrolyte leakage. This suggests that the combination of inositol and CSL helps to protect plant cells under stress.
Additionally, we confirmed these findings by analyzing the expression of important genes that relate to cold tolerance in cucumbers. The most effective mix we identified was 0.6 mL L of CSL together with 72 mg L of myo-inositol. Overall, this study gives us valuable insights into how we can use inositol and maize leachate to foster early growth in crops and improve their resilience against cold weather.
8
We delved into the fascinating world of white water lilies and their remarkable ability to withstand cold temperatures. This study aimed to understand how certain compounds, particularly myo-inositol, contribute to the plant's cold resilience.
Through a comprehensive examination, we learned that the water lily effectively copes with winter by entering a state called ecodormancy. During this time, the plant reallocates resources and enhances its defenses against cold stress.
One of our key findings was the significance of myo-inositol. This compound helps bolster the plant’s cold tolerance, although it works alongside various other factors. It plays a role in regulating metabolic activities, especially in relation to amino acids, which are crucial for overcoming chilly conditions.
Although our study highlighted the importance of myo-inositol, it did not isolate its effects from other treatments, which limits our understanding of its specific impact. Nevertheless, the insights we gained about the water lily’s adaptive strategies provide valuable information for future agricultural practices in cold climates.
Through a comprehensive examination, we learned that the water lily effectively copes with winter by entering a state called ecodormancy. During this time, the plant reallocates resources and enhances its defenses against cold stress.
One of our key findings was the significance of myo-inositol. This compound helps bolster the plant’s cold tolerance, although it works alongside various other factors. It plays a role in regulating metabolic activities, especially in relation to amino acids, which are crucial for overcoming chilly conditions.
Although our study highlighted the importance of myo-inositol, it did not isolate its effects from other treatments, which limits our understanding of its specific impact. Nevertheless, the insights we gained about the water lily’s adaptive strategies provide valuable information for future agricultural practices in cold climates.
9
We explored how myo-inositol oxygenase (MIOX), an important enzyme, might help alfalfa, a type of forage crop, adapt to challenging cold conditions. The study identified ten MsMIOX genes in the alfalfa genome, which were found distributed across three chromosomes.
Through analysis, we noted that these genes exhibited similarities in structure and conserved features, hinting at a functional role important for the plant's survival under stress.
Our qRT-PCR tests showed that different MsMIOX genes could be triggered by cold and other abiotic stress factors like drought and salinity. Notably, the activity of MIOX in alfalfa significantly increased under these harsh conditions.
By overexpressing the MsMIOX2 gene in yeast, we found that it notably enhanced resistance to cold stresses. Additionally, when MsMIOX2 was overexpressed in alfalfa’s hairy roots, it reduced reactive oxygen species and improved the plant's resilience against cold.
This study provides valuable insights into how inositol plays a part in helping alfalfa thrive even in cold weather, presenting a candidate for future efforts to enhance the plant’s stress tolerance.
Through analysis, we noted that these genes exhibited similarities in structure and conserved features, hinting at a functional role important for the plant's survival under stress.
Our qRT-PCR tests showed that different MsMIOX genes could be triggered by cold and other abiotic stress factors like drought and salinity. Notably, the activity of MIOX in alfalfa significantly increased under these harsh conditions.
By overexpressing the MsMIOX2 gene in yeast, we found that it notably enhanced resistance to cold stresses. Additionally, when MsMIOX2 was overexpressed in alfalfa’s hairy roots, it reduced reactive oxygen species and improved the plant's resilience against cold.
This study provides valuable insights into how inositol plays a part in helping alfalfa thrive even in cold weather, presenting a candidate for future efforts to enhance the plant’s stress tolerance.
8
We explored the impact of inositol on cold stress in rapeseed, an essential oilseed crop affected by low temperatures. Notably, we found that inositol plays a significant role in enhancing cold tolerance in these plants by boosting calcium ion (Ca) influx.
Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.
Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.
Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.
Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.
References
- Berg J, Rodrigues CM, Scheid C, Pirrotte Y, Picco C, et al. The Vacuolar Inositol Transporter BvINT1;1 Contributes to Raffinose Biosynthesis and Reactive Oxygen Species Scavenging During Cold Stress in Sugar Beet. Plant Cell Environ. 2025. 10.1111/pce.15367
- Sun S, Zhang X, Wang C, Yu Q, Yang H, et al. Combined application of myo-inositol and corn steep liquor enhances seedling growth and cold tolerance in cucumber and tomato. Physiol Plant. 2024;176:e14422. 10.1111/ppl.14422
- Qiu P, Liu T, Xu Y, Ye C, Zhang R, et al. Multi-omic dissection of the cold resistance traits of white water lily. Hortic Res. 2024;11:uhae093. 10.1093/hr/uhae093
- Guo W, Yu D, Zhang R, Zhao W, Zhang L, et al. Genome-wide identification of the myo-inositol oxygenase gene family in alfalfa (Medicago sativa L.) and expression analysis under abiotic stress. Plant Physiol Biochem. 2023;200:107787. 10.1016/j.plaphy.2023.107787
- Yan L, Zeng L, Raza A, Lv Y, Ding X, et al. Inositol Improves Cold Tolerance Through Inhibiting and Increasing Ca Influx in Rapeseed ( L.). Front Plant Sci. 2022;13:775692. 10.3389/fpls.2022.775692
- Wang F, Wang X, Zhang Y, Yan J, Ahammed GJ, et al. SlFHY3 and SlHY5 act compliantly to enhance cold tolerance through the integration of myo-inositol and light signaling in tomato. New Phytol. 2022;233:2127. 10.1111/nph.17934
