Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
USERS' SCORE
Good
Based on 14 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Calcium (from Calcium-Magnesium Inositol Hexaphosphate)
100 mg
8%
Inositol Hexaphosphate (from Calcium-Magnesium Inositol Hexaphosphate)
500 mg

Top Medical Research Studies

9
IP6 improves cholesterol levels
We examined the effects of inositol hexakisphosphate (IP6) and myo-inositol on high cholesterol in rats. In our study, we found that dietary IP6 effectively reduced increased cholesterol levels caused by a specific chemical exposure, while myo-inositol did not show significant benefits.

Additionally, IP6 also contributed to body weight gain, regardless of other dietary factors. Overall, while both inositol types helped prevent fatty liver, only IP6 demonstrated a clear advantage in managing hypercholesterolemia.
Read More
9
Inositol boosts growth and health
We explored how inositol affects growth performance and cholesterol levels in largemouth bass through a systematic diet study. By preparing six different diets with varying inositol concentrations, we fed the fish for eight weeks and closely monitored their progress. The results showed that our group consuming 250 mg/kg of inositol enjoyed significantly better weight gain, growth rates, and feed efficiency compared to the control group.

Interestingly, as we increased the inositol levels, we noticed a rise in serum triglycerides and cholesterol, particularly peaking in the 250 mg/kg group. It appeared that while inositol helped improve overall growth, it also influenced cholesterol levels in a complex way. However, the high-density lipoprotein cholesterol (HDL-C), often considered "good" cholesterol, remained unaffected across all treatment groups.

Furthermore, our analysis revealed that inositol supplementation not only reduced fat deposition in the liver but also enhanced the fish's antioxidant capacity by lowering harmful enzymes and increasing beneficial antioxidant markers. This suggests that while inositol modified cholesterol dynamics, it also supported the general health and performance of the fish.

Overall, the findings indicate that dietary inositol can significantly improve growth and antioxidant capacity in largemouth bass, with an optimal dosage around 250 mg/kg to harness these benefits effectively.
Read More
9
D--Inositol reduces cholesterol levels
We examined how D--Inositol (DCI), a natural compound found in many living organisms, influences high cholesterol and obesity, especially when combined with a high-fat diet. In our study involving mice over a 12-week period, we observed that DCI supplementation led to noticeable reductions in body weight, triglycerides, total cholesterol, insulin, and fasting glucose levels when given at doses of 50 and 100 mg per kg daily.

The findings were encouraging as DCI not only diminished body weight but also helped lower fat accumulation in the liver and fat tissue. Importantly, we noted a significant increase in serum adiponectin levels, a beneficial hormone linked to improved lipid metabolism. This increase was accompanied by enhanced activity of adiponectin receptors in the liver, which play a key role in regulating fat and energy metabolism.

Additionally, DCI was shown to activate a critical pathway involving AMPKα and PPARs, further promoting healthy fat management in the body. These results suggest that DCI could be a valuable ally in addressing cholesterol and obesity issues, potentially through its influence on adiponectin synthesis and its related metabolic pathways.
Read More

Most Useful Reviews

10
Significant ferritin reduction
8 people found this helpful
This product helped me effectively reduce my ferritin levels, and my body’s inflammation vastly improved without affecting my sleep. Previously, I was troubled for two weeks by high ferritin levels that led to unrestful nights, even landing me in the emergency room. This product helps me absorb iron effectively, preventing bad retention that causes inflammation.
Read More
9
Pleasant ferritin decrease
4 people found this helpful
A wonderful product I bought for my mother, whose ferritin was high at 223. After three months of usage, her levels dropped to 157. With continued use, everything should return to normal.
Read More
9
Effective iron chelation
3 people found this helpful
I wasn't sure what this product would do, but I hoped it would support my immune system. It was challenging to take the required amount since it must be on an empty stomach. I purchased it again due to high iron levels, taking it at night. One month later, my iron had significantly lowered! I believe this supplement could effectively remove iron from my system and help with heavy metal build-up.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
  • All Researches
9
Inositol boosts growth and health
We explored how inositol affects growth performance and cholesterol levels in largemouth bass through a systematic diet study. By preparing six different diets with varying inositol concentrations, we fed the fish for eight weeks and closely monitored their progress. The results showed that our group consuming 250 mg/kg of inositol enjoyed significantly better weight gain, growth rates, and feed efficiency compared to the control group.

Interestingly, as we increased the inositol levels, we noticed a rise in serum triglycerides and cholesterol, particularly peaking in the 250 mg/kg group. It appeared that while inositol helped improve overall growth, it also influenced cholesterol levels in a complex way. However, the high-density lipoprotein cholesterol (HDL-C), often considered "good" cholesterol, remained unaffected across all treatment groups.

Furthermore, our analysis revealed that inositol supplementation not only reduced fat deposition in the liver but also enhanced the fish's antioxidant capacity by lowering harmful enzymes and increasing beneficial antioxidant markers. This suggests that while inositol modified cholesterol dynamics, it also supported the general health and performance of the fish.

Overall, the findings indicate that dietary inositol can significantly improve growth and antioxidant capacity in largemouth bass, with an optimal dosage around 250 mg/kg to harness these benefits effectively.
Read More
9
Food supplement aids cholesterol management
We tested the effectiveness of a food supplement combining glucomannan, D-chiro-inositol, blume, and inulin in managing high cholesterol levels among individuals with metabolic syndrome. Fifty-eight participants, each dealing with either type 2 diabetes or impaired glucose tolerance, took this supplement daily for four months alongside their metformin medication.

Over the course of the study, we observed significant improvements in several key health markers. The participants experienced a marked reduction in their body weight and body mass index (BMI). More importantly for those dealing with high cholesterol, the supplement contributed to noteworthy enhancements in their lipid profiles. Levels of total cholesterol reduced significantly, alongside improvements in triglycerides and low-density lipoprotein (LDL).

Our findings suggest that this food supplement may be a beneficial addition to traditional treatments for managing cholesterol levels and other risk factors associated with metabolic syndrome. This study highlights the potential of inositol as part of a multi-ingredient supplement, although the specific effect of inositol alone wasn't isolated.
Read More
9
D--Inositol reduces cholesterol levels
We examined how D--Inositol (DCI), a natural compound found in many living organisms, influences high cholesterol and obesity, especially when combined with a high-fat diet. In our study involving mice over a 12-week period, we observed that DCI supplementation led to noticeable reductions in body weight, triglycerides, total cholesterol, insulin, and fasting glucose levels when given at doses of 50 and 100 mg per kg daily.

The findings were encouraging as DCI not only diminished body weight but also helped lower fat accumulation in the liver and fat tissue. Importantly, we noted a significant increase in serum adiponectin levels, a beneficial hormone linked to improved lipid metabolism. This increase was accompanied by enhanced activity of adiponectin receptors in the liver, which play a key role in regulating fat and energy metabolism.

Additionally, DCI was shown to activate a critical pathway involving AMPKα and PPARs, further promoting healthy fat management in the body. These results suggest that DCI could be a valuable ally in addressing cholesterol and obesity issues, potentially through its influence on adiponectin synthesis and its related metabolic pathways.
Read More
9
IP6 improves cholesterol levels
We examined the effects of inositol hexakisphosphate (IP6) and myo-inositol on high cholesterol in rats. In our study, we found that dietary IP6 effectively reduced increased cholesterol levels caused by a specific chemical exposure, while myo-inositol did not show significant benefits.

Additionally, IP6 also contributed to body weight gain, regardless of other dietary factors. Overall, while both inositol types helped prevent fatty liver, only IP6 demonstrated a clear advantage in managing hypercholesterolemia.
Read More
8
Myo-inositol reduces cholesterol levels
We wanted to understand how myo-inositol (MI), a compound found in many foods, influences cholesterol levels and overall metabolic health in db/db mice, a commonly used model for type 2 diabetes. Our findings revealed that providing MI significantly reduced high cholesterol and triglyceride levels in these mice, making a noticeable impact on their lipid profiles.

In addition to lowering cholesterol levels, MI improved insulin resistance, suggesting it might offer a dual benefit for those struggling with metabolic disorders. Interestingly, while MI showed promising effects on cholesterol and glucose levels, it did not help with obesity in the treated mice.

Overall, our study highlights myo-inositol as a potential adjunct therapy for managing high cholesterol and related metabolic challenges in diabetes. These results indicate that incorporating this accessible compound into dietary strategies might benefit patients dealing with these issues.
Read More

User Reviews

USERS' SCORE
Good
Based on 14 Reviews
8.2
  • All Reviews
  • Positive Reviews
  • Negative Reviews
10
Significant ferritin reduction
8 people found this helpful
This product helped me effectively reduce my ferritin levels, and my body’s inflammation vastly improved without affecting my sleep. Previously, I was troubled for two weeks by high ferritin levels that led to unrestful nights, even landing me in the emergency room. This product helps me absorb iron effectively, preventing bad retention that causes inflammation.
Read More
9
Pleasant ferritin decrease
4 people found this helpful
A wonderful product I bought for my mother, whose ferritin was high at 223. After three months of usage, her levels dropped to 157. With continued use, everything should return to normal.
Read More
9
Effective iron chelation
3 people found this helpful
I wasn't sure what this product would do, but I hoped it would support my immune system. It was challenging to take the required amount since it must be on an empty stomach. I purchased it again due to high iron levels, taking it at night. One month later, my iron had significantly lowered! I believe this supplement could effectively remove iron from my system and help with heavy metal build-up.
Read More
9
Improved immune support
3 people found this helpful
The best quality product from Jarrow formulas. I use it to manage insulin resistance and lower high inflammatory ferritin levels as it binds and removes iron. It can be taken for up to six months for optimal results. Used alongside Berberine, it significantly lowers blood sugar levels. My patients report reductions from 7 to 5, and from 8 to 6, showing excellent results.
Read More
9
Cholesterol management
2 people found this helpful
I suffer from chronic dyslipidaemia. I have used this product for over five years, consistently keeping my triglyceride and cholesterol levels at an acceptable level.
Read More

Frequently Asked Questions

9
Pleasant ferritin decrease
4 people found this helpful
A wonderful product I bought for my mother, whose ferritin was high at 223. After three months of usage, her levels dropped to 157. With continued use, everything should return to normal.
6
Iron level drop
I tried this due to high iron levels in my blood, and it worked. With the right diet, my levels dropped slightly.
7.5
Notable ferritin decrease
6 people found this helpful
I started taking this after finding high ferritin levels. I aimed to eliminate the inflammatory factor and drive iron into my cells. After four months, my ferritin levels decreased from 146 to 93. However, it did wash out some calcium too.
2
Need for research
I bought IP6 to manage high ferritin but have not seen improvements in my lab results. I need to research it further to understand its effects better.
7.5
Notable ferritin drop
2 people found this helpful
This product seems to be bringing down my ferritin levels. I discovered two years ago my ferritin was 575, and despite my GP's lack of concern, I grew worried. After starting this product three months before my annual check-up, my latest lab test showed a drop to 515. I plan to continue using it and have purchased more. Highly recommend it!
7.5
Good blood sugar results
10 people found this helpful
This company offers the best quality. I bought for my mother to manage insulin resistance and reduce sugar levels as well as high inflammatory ferritin. Our doctor prescribed this drug. He said it binds and removes iron. After three months, her sugar levels decreased from 7 to 5. She finds it palatable and, as advised by the doctor, adheres to the diet. A useful product with great results; we've ordered a second batch.
9
Improved immune support
3 people found this helpful
The best quality product from Jarrow formulas. I use it to manage insulin resistance and lower high inflammatory ferritin levels as it binds and removes iron. It can be taken for up to six months for optimal results. Used alongside Berberine, it significantly lowers blood sugar levels. My patients report reductions from 7 to 5, and from 8 to 6, showing excellent results.
7.5
Effective inflammation reduction
13 people found this helpful
This drug is excellent for reducing inflammation and lowering ferritin levels within the cells. IP-6 should be taken separately from all other supplements, maintaining an interval of 3-4 hours. I give my husband this to reduce high ferritin post-COVID, taking 2 capsules 30-40 minutes before lunch. Be healthy!
9
Food supplement aids cholesterol management
We tested the effectiveness of a food supplement combining glucomannan, D-chiro-inositol, blume, and inulin in managing high cholesterol levels among individuals with metabolic syndrome. Fifty-eight participants, each dealing with either type 2 diabetes or impaired glucose tolerance, took this supplement daily for four months alongside their metformin medication.

Over the course of the study, we observed significant improvements in several key health markers. The participants experienced a marked reduction in their body weight and body mass index (BMI). More importantly for those dealing with high cholesterol, the supplement contributed to noteworthy enhancements in their lipid profiles. Levels of total cholesterol reduced significantly, alongside improvements in triglycerides and low-density lipoprotein (LDL).

Our findings suggest that this food supplement may be a beneficial addition to traditional treatments for managing cholesterol levels and other risk factors associated with metabolic syndrome. This study highlights the potential of inositol as part of a multi-ingredient supplement, although the specific effect of inositol alone wasn't isolated.
8
Inositol and cholesterol management
This study aimed to explore how a combination of myo-inositol and d-chiro-inositol, along with α-lactalbumin, Gymnema sylvestre, and zinc, impacts cholesterol levels in patients with type 2 diabetes mellitus (T2DM).

We evaluated 75 participants who were randomly assigned to either the supplement group or a placebo group. While we found no significant improvements in blood glucose levels between the two groups overall, the results for cholesterol were more promising.

After three months of supplementation, those taking the combination of nutrients experienced a noticeable reduction in total cholesterol and LDL (or bad cholesterol) levels. In a subgroup of patients who kept their diabetes medications unchanged, cholesterol improvements continued to show after six months.

Additionally, members of the supplement group also saw better weight management and enhancements in their HDL (good cholesterol) and triglyceride levels after three months. These findings suggest that combining these specific nutrients could be beneficial in managing cholesterol levels for those with T2DM.
7
Inositol's cholesterol effects unclear
We explored the effects of combining metformin with two forms of inositol—myoinositol and D-chiro-inositol—on high cholesterol levels in women with polycystic ovary syndrome (PCOS). This study involved 72 participants who were randomly assigned to either metformin alone or the combination therapy for six months.

While we did observe significant improvements in other areas, such as cycle regularity and various hormonal levels, the specific impact of inositol on cholesterol was less clear. For instance, the combination therapy resulted in notable changes in average cholesterol and other metabolic parameters, but it’s important to highlight that the isolated effect of inositol on cholesterol was not explicitly measured.

Our findings suggest that while there are some benefits to this combined treatment, further research is necessary to fully understand how effective inositol alone might be on cholesterol management in women with PCOS.
8
Nutraceutical improves cholesterol management
We enrolled 148 patients experiencing issues with high fasting glucose levels and glucose tolerance to explore the effects of a nutraceutical combination containing Berberine, Curcumin, Inositol, Banaba, and Chromium Picolinate. Over three months, participants were divided into two groups, with one taking the nutraceutical and the other a placebo. This randomized, double-blind study helped ensure the results were reliable and unbiased.

Our findings indicated that the nutraceutical combination led to improvements in metrics related to blood sugar levels and cholesterol. Specifically, we noted reductions in fasting plasma glucose, glycated hemoglobin, and total cholesterol levels. However, while inositol was one of the ingredients, the complex nature of the combination makes it difficult to isolate its individual effect on cholesterol reduction specifically.

Overall, it seems that the nutraceutical can positively impact metabolic health and may assist those with dysglycemia in improving their cholesterol levels. As we sift through the results, the potential benefits of using inositol in this blend point towards a promising avenue in managing cholesterol, though further research would be necessary to clarify its distinct role.

References

  1. Long L, Huang Q, Song T, Dai Z. Myo-inositol rescued insulin resistance and dyslipidemia in db/db mice. J Appl Biomed. 2024;22:74. 10.32725/jab.2024.009
  2. Xu Y, Gong Y, Li S, Zhou Y, Ma Z, et al. Inositol Inclusion Affects Growth, Body Composition, Antioxidant Performance, and Lipid Metabolism of Largemouth Bass (). Aquac Nutr. 2024;2024:9944159. 10.1155/2024/9944159
  3. Citarrella R, Chianetta R, Amodeo S, Mirarchi L, Licata A, et al. Effectiveness of a Food Supplement Based on Glucomannan, D-Chiro-Inositol, Blume and Inulin in Patients with Metabolic Syndrome. Nutrients. 2024;16. 10.3390/nu16020249
  4. Nani A, Bertuzzi F, Meneghini E, Mion E, Pintaudi B. Combined Inositols, α-Lactalbumin, Gymnema Sylvestre and Zinc Improve the Lipid Metabolic Profile of Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial. J Clin Med. 2023;12. 10.3390/jcm12247650
  5. Tutunchi H, Arefhosseini S, Ebrahimi-Mameghani M. Clinical effectiveness of α-lipoic acid, myo-inositol and propolis supplementation on metabolic profiles and liver function in obese patients with NAFLD: A randomized controlled clinical trial. Clin Nutr ESPEN. 2023;54:412. 10.1016/j.clnesp.2023.02.016
  6. Yang Q, Zhang Y, Li L, Li J, Li Y, et al. D--Inositol facilitates adiponectin biosynthesis and activates the AMPKα/PPARs pathway to inhibit high-fat diet-induced obesity and liver lipid deposition. Food Funct. 2022;13:7192. 10.1039/d2fo00869f
  7. Bahadur A, Arora H, Ravi AK, Naithani M, Bahurupi Y, et al. Comparison of Clinical, Metabolic and Hormonal Effects of Metformin Versus Combined Therapy of Metformin With Myoinositol Plus D-Chiro-Inositol in Women With Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial. Cureus. 2021;13:e15510. 10.7759/cureus.15510
  8. Derosa G, D'Angelo A, Vanelli A, Maffioli P. An Evaluation of a Nutraceutical with Berberine, Curcumin, Inositol, Banaba and Chromium Picolinate in Patients with Fasting Dysglycemia. Diabetes Metab Syndr Obes. 2020;13:653. 10.2147/DMSO.S232791
  9. Choi MS, Lee MK, Jung UJ, Kim HJ, Do GM, et al. Metabolic response of soy pinitol on lipid-lowering, antioxidant and hepatoprotective action in hamsters fed-high fat and high cholesterol diet. Mol Nutr Food Res. 2009;53:751. 10.1002/mnfr.200800241
  10. Okazaki Y, Katayama T. Dietary inositol hexakisphosphate, but not myo-inositol, clearly improves hypercholesterolemia in rats fed casein-type amino acid mixtures and 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane. Nutr Res. 2008;28:714. 10.1016/j.nutres.2008.07.003
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