Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Proprietary Probiotic BlendLacticaseibacillus rhamnosus R0011Lactobacillus helvetius R0052Pediococcus acidilactici R1001Lacticaseibacillus casei R0215Bifidobacterium longum BB536Lactiplantibacillus plantarum R1012Bifidobacterium breve R0070Lactococcus lactis subsp. lactis R1058
131 mg (10 Billion CFU)
†
Top Medical Research Studies
9
We investigated how the probiotic strain CCFM1274 can help alleviate allergic asthma symptoms. Using a mouse model, we administered CCFM1274 alongside ovalbumin, a common allergen, and observed positive results.
This treatment not only reduced weight loss and mortality but also improved inflammatory responses in the lungs. Notably, there was a decrease in specific immune markers, indicating CCFM1274 might adjust gut tryptophan metabolism beneficially, highlighting potential new strategies for asthma management.
This treatment not only reduced weight loss and mortality but also improved inflammatory responses in the lungs. Notably, there was a decrease in specific immune markers, indicating CCFM1274 might adjust gut tryptophan metabolism beneficially, highlighting potential new strategies for asthma management.
Read More
9
Bifidobacterium lactis reduces asthma symptoms
We explored how Bifidobacterium lactis, a probiotic, might impact asthma symptoms. In a mice study, newborns were given this probiotic every other day for eight weeks while being exposed to allergens. The results showed that this treatment effectively reduced airway inflammation and allergic reactions associated with asthma.
Although both Bifidobacterium lactis and another probiotic demonstrated benefits, the exact mechanisms remain to be fully understood. Nevertheless, it appears that these probiotics could play a role in fostering a healthier immune response against asthma.
Although both Bifidobacterium lactis and another probiotic demonstrated benefits, the exact mechanisms remain to be fully understood. Nevertheless, it appears that these probiotics could play a role in fostering a healthier immune response against asthma.
Read More
9
We aimed to investigate whether Lactococcus lactis NZ9000 could reduce asthmatic airway inflammation and lung tissue changes in rats while also supporting gut health.
Through careful testing, we found that L. lactis lowered pro-inflammatory cells in the lungs and improved the intestinal barrier. The treatment led to less collagen buildup in lung tissue and enhanced immune function.
Overall, while L. lactis showed promising results in improving asthma symptoms in rats, further research is needed to confirm its effectiveness in humans.
Through careful testing, we found that L. lactis lowered pro-inflammatory cells in the lungs and improved the intestinal barrier. The treatment led to less collagen buildup in lung tissue and enhanced immune function.
Overall, while L. lactis showed promising results in improving asthma symptoms in rats, further research is needed to confirm its effectiveness in humans.
Read More
Most Useful Reviews
9
Sick less often
1 people found this helpful
I was sceptical about supplements, but this one significantly improved my health. With asthma and bronchitis, I found that during a recent cold, I only had a stuffy nose and no mucus buildup in my lungs. I can't believe how effective it is!
Read More
9
Astonishing infection relief
I read the reviews and thought, I hope this works. I had a severe cold, developed bronchial-asthma, and ended up on antibiotics which caused further issues. After taking this product for 5 days, the infections disappeared. I'm thrilled and have recommended it for my elderly aunt who struggles with UTIs. This is truly remarkable!
Read More
7.5
Improved asthma condition
4 people found this helpful
Very handy, the blister-packs are convenient to take out. The gluten-free aspect is a plus. I first bought these for my daughter following a sudden exacerbation of asthma after 7 years. She’d been on various antibiotics for about a month, and after reading about antibiotics/asthma, she improved almost immediately after starting the probiotics.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
- All Researches
9
We investigated how the probiotic strain CCFM1274 can help alleviate allergic asthma symptoms. Using a mouse model, we administered CCFM1274 alongside ovalbumin, a common allergen, and observed positive results.
This treatment not only reduced weight loss and mortality but also improved inflammatory responses in the lungs. Notably, there was a decrease in specific immune markers, indicating CCFM1274 might adjust gut tryptophan metabolism beneficially, highlighting potential new strategies for asthma management.
This treatment not only reduced weight loss and mortality but also improved inflammatory responses in the lungs. Notably, there was a decrease in specific immune markers, indicating CCFM1274 might adjust gut tryptophan metabolism beneficially, highlighting potential new strategies for asthma management.
Read More
9
Bifidobacterium lactis reduces asthma symptoms
We explored how Bifidobacterium lactis, a probiotic, might impact asthma symptoms. In a mice study, newborns were given this probiotic every other day for eight weeks while being exposed to allergens. The results showed that this treatment effectively reduced airway inflammation and allergic reactions associated with asthma.
Although both Bifidobacterium lactis and another probiotic demonstrated benefits, the exact mechanisms remain to be fully understood. Nevertheless, it appears that these probiotics could play a role in fostering a healthier immune response against asthma.
Although both Bifidobacterium lactis and another probiotic demonstrated benefits, the exact mechanisms remain to be fully understood. Nevertheless, it appears that these probiotics could play a role in fostering a healthier immune response against asthma.
Read More
9
We aimed to investigate whether Lactococcus lactis NZ9000 could reduce asthmatic airway inflammation and lung tissue changes in rats while also supporting gut health.
Through careful testing, we found that L. lactis lowered pro-inflammatory cells in the lungs and improved the intestinal barrier. The treatment led to less collagen buildup in lung tissue and enhanced immune function.
Overall, while L. lactis showed promising results in improving asthma symptoms in rats, further research is needed to confirm its effectiveness in humans.
Through careful testing, we found that L. lactis lowered pro-inflammatory cells in the lungs and improved the intestinal barrier. The treatment led to less collagen buildup in lung tissue and enhanced immune function.
Overall, while L. lactis showed promising results in improving asthma symptoms in rats, further research is needed to confirm its effectiveness in humans.
Read More
9
We explored the impact of Lactococcus lactis producing mycobacterial heat shock protein 65 (LLHsp65) on allergic asthma using a mouse model. Over ten days, OVA-challenged mice received oral LLHsp65, which showed promising results.
The treatment notably reduced airway inflammation, mucus production, and eosinophil levels. It also shifted immune responses to favor protective responses while increasing regulatory T cells and cytokines like IL-6 and IL-10.
These outcomes suggest that LLHsp65 offers a hopeful new strategy for managing allergic asthma effectively.
The treatment notably reduced airway inflammation, mucus production, and eosinophil levels. It also shifted immune responses to favor protective responses while increasing regulatory T cells and cytokines like IL-6 and IL-10.
These outcomes suggest that LLHsp65 offers a hopeful new strategy for managing allergic asthma effectively.
Read More
9
We examined the potential of a genetically engineered Lactococcus lactis to tackle allergic asthma caused by house dust mites. The study focused on a hypoallergenic version of a major allergen, which showed reduced IgE reactivity.
When administered orally, this novel approach significantly lessened airway inflammation in mice. Notably, it increased levels of protective IgG2a and regulatory T cells, which could help manage allergic responses more effectively.
Overall, our findings suggest that Lactococcus lactis, in combination with this hypoallergenic derivative, may offer a new avenue for treating allergic diseases.
When administered orally, this novel approach significantly lessened airway inflammation in mice. Notably, it increased levels of protective IgG2a and regulatory T cells, which could help manage allergic responses more effectively.
Overall, our findings suggest that Lactococcus lactis, in combination with this hypoallergenic derivative, may offer a new avenue for treating allergic diseases.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Sick less often
1 people found this helpful
I was sceptical about supplements, but this one significantly improved my health. With asthma and bronchitis, I found that during a recent cold, I only had a stuffy nose and no mucus buildup in my lungs. I can't believe how effective it is!
Read More
9
Astonishing infection relief
I read the reviews and thought, I hope this works. I had a severe cold, developed bronchial-asthma, and ended up on antibiotics which caused further issues. After taking this product for 5 days, the infections disappeared. I'm thrilled and have recommended it for my elderly aunt who struggles with UTIs. This is truly remarkable!
Read More
7.5
Improved asthma condition
4 people found this helpful
Very handy, the blister-packs are convenient to take out. The gluten-free aspect is a plus. I first bought these for my daughter following a sudden exacerbation of asthma after 7 years. She’d been on various antibiotics for about a month, and after reading about antibiotics/asthma, she improved almost immediately after starting the probiotics.
Read More
Frequently Asked Questions
9
Astonishing infection relief
I read the reviews and thought, I hope this works. I had a severe cold, developed bronchial-asthma, and ended up on antibiotics which caused further issues. After taking this product for 5 days, the infections disappeared. I'm thrilled and have recommended it for my elderly aunt who struggles with UTIs. This is truly remarkable!
7.5
Improved asthma condition
4 people found this helpful
Very handy, the blister-packs are convenient to take out. The gluten-free aspect is a plus. I first bought these for my daughter following a sudden exacerbation of asthma after 7 years. She’d been on various antibiotics for about a month, and after reading about antibiotics/asthma, she improved almost immediately after starting the probiotics.
8
We conducted a study to understand how Bifidobacterium lactis, a type of probiotic, influences asthma management. In this three-month trial, 55 asthmatic patients were either given Bifidobacterium lactis along with traditional asthma medication or a placebo.
We saw positive changes in those taking probiotics, including a noteworthy decrease in certain asthma-related markers and improvements in asthma control scores. Also, the gut microbiome of probiotic users showed enhanced diversity and resilience. Overall, our findings suggest that adding probiotics might offer additional relief for asthma sufferers, potentially improving the effectiveness of standard treatments.
We saw positive changes in those taking probiotics, including a noteworthy decrease in certain asthma-related markers and improvements in asthma control scores. Also, the gut microbiome of probiotic users showed enhanced diversity and resilience. Overall, our findings suggest that adding probiotics might offer additional relief for asthma sufferers, potentially improving the effectiveness of standard treatments.
7
Postnatal probiotics benefit asthma care
We delved into whether postnatal probiotics are as effective as prenatal probiotics in preventing or treating childhood asthma and related conditions. By reviewing recent randomized controlled trials, we found that certain strains of postnatal probiotics can indeed help prevent and improve asthma symptoms. While results varied across studies, evidence suggests that specific probiotics positively impact asthma outcomes and atopic disorders. Importantly, further research is needed to pinpoint the most effective strains for these health issues.
8
We explored the effectiveness of different probiotic strains in combating asthma symptoms in a study involving mice. The researchers administered various strains, including Bifidobacterium breve M-16V and Lactobacillus plantarum NumRes8, to ovalbumin-sensitized mice.
B. breve M-16V stood out as the most effective, showcasing the ability to reduce allergic responses, including specific immunoglobulin levels and inflammatory markers. However, while there was a significant impact observed with this strain, it’s essential to note that the trial’s focus was distinctly on animal models, meaning results may not directly translate to humans.
B. breve M-16V stood out as the most effective, showcasing the ability to reduce allergic responses, including specific immunoglobulin levels and inflammatory markers. However, while there was a significant impact observed with this strain, it’s essential to note that the trial’s focus was distinctly on animal models, meaning results may not directly translate to humans.
9
Bifidobacterium lactis reduces asthma symptoms
We explored how Bifidobacterium lactis, a probiotic, might impact asthma symptoms. In a mice study, newborns were given this probiotic every other day for eight weeks while being exposed to allergens. The results showed that this treatment effectively reduced airway inflammation and allergic reactions associated with asthma.
Although both Bifidobacterium lactis and another probiotic demonstrated benefits, the exact mechanisms remain to be fully understood. Nevertheless, it appears that these probiotics could play a role in fostering a healthier immune response against asthma.
Although both Bifidobacterium lactis and another probiotic demonstrated benefits, the exact mechanisms remain to be fully understood. Nevertheless, it appears that these probiotics could play a role in fostering a healthier immune response against asthma.
9
We aimed to investigate whether Lactococcus lactis NZ9000 could reduce asthmatic airway inflammation and lung tissue changes in rats while also supporting gut health.
Through careful testing, we found that L. lactis lowered pro-inflammatory cells in the lungs and improved the intestinal barrier. The treatment led to less collagen buildup in lung tissue and enhanced immune function.
Overall, while L. lactis showed promising results in improving asthma symptoms in rats, further research is needed to confirm its effectiveness in humans.
Through careful testing, we found that L. lactis lowered pro-inflammatory cells in the lungs and improved the intestinal barrier. The treatment led to less collagen buildup in lung tissue and enhanced immune function.
Overall, while L. lactis showed promising results in improving asthma symptoms in rats, further research is needed to confirm its effectiveness in humans.
References
- Wang H, He Y, Dang D, Feng L, Huang L, et al. subsp. CCFM1274 relieved allergic asthma symptoms by modifying intestinal tryptophan metabolism in mice. Food Funct. 2024;15:8810. doi:10.1039/d4fo01079e
- Uwaezuoke SN, Ayuk AC, Eze JN, Odimegwu CL, Ndiokwelu CO, et al. Postnatal probiotic supplementation can prevent and optimize treatment of childhood asthma and atopic disorders: A systematic review of randomized controlled trials. Front Pediatr. 2022;10:956141. doi:10.3389/fped.2022.956141
- Liu A, Ma T, Xu N, Jin H, Zhao F, et al. Adjunctive Probiotics Alleviates Asthmatic Symptoms via Modulating the Gut Microbiome and Serum Metabolome. Microbiol Spectr. 2021;9:e0085921. doi:10.1128/Spectrum.00859-21
- Lundelin K, Poussa T, Salminen S, Isolauri E. Long-term safety and efficacy of perinatal probiotic intervention: Evidence from a follow-up study of four randomized, double-blind, placebo-controlled trials. Pediatr Allergy Immunol. 2017;28:170. doi:10.1111/pai.12675
- Hougee S, Vriesema AJ, Wijering SC, Knippels LM, Folkerts G, et al. Oral treatment with probiotics reduces allergic symptoms in ovalbumin-sensitized mice: a bacterial strain comparative study. Int Arch Allergy Immunol. 2010;151:107. doi:10.1159/000236000
- Feleszko W, Jaworska J, Rha RD, Steinhausen S, Avagyan A, et al. Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthma. Clin Exp Allergy. 2007;37:498.
- Lee DH, Park HK, Lee HR, Sohn H, Sim S, et al. Immunoregulatory effects of Lactococcus lactis-derived extracellular vesicles in allergic asthma. Clin Transl Allergy. 2022;12:e12138. doi:10.1002/clt2.12138
- Lee MF, Chiang CH, Lin SJ, Wu CS, Chen YH. Effectiveness and safety of oral lactococci-based vaccine encoding triple common allergens to prevent airway allergy in mice. PLoS One. 2021;16:e0261333. doi:10.1371/journal.pone.0261333
- Cervantes-García D, Jiménez M, Rivas-Santiago CE, Gallegos-Alcalá P, Hernández-Mercado A, et al. Lactococcus lactis NZ9000 Prevents Asthmatic Airway Inflammation and Remodelling in Rats through the Improvement of Intestinal Barrier Function and Systemic TGF-β Production. Int Arch Allergy Immunol. 2021;182:277. doi:10.1159/000511146
- de Lacerda LB, Rios WM, Masson AP, Brandão IT, Milani TM, et al. Oral administration of Hsp65-producing Lactococcus lactis attenuates allergic asthma in a murine model. J Appl Microbiol. 2021;130:2075. doi:10.1111/jam.14913
- Ghasemi Z, Varasteh AR, Moghadam M, Jalali SA, Anissian A, et al. Sublingual Immunotherapy with Sal k1 Expressing Lactococcus lactis Down-regulates Th2 Immune Responses in Balb/c Mice. Iran J Allergy Asthma Immunol. 2018;17:281.
- Ai C, Zhang Q, Ding J, Ren C, Wang G, et al. Suppression of dust mite allergy by mucosal delivery of a hypoallergenic derivative in a mouse model. Appl Microbiol Biotechnol. 2015;99:4309. doi:10.1007/s00253-015-6407-6
- Fischer K, Vinogradov E, Lindner B, Heine H, Holst O. The structure of the extracellular teichoic acids from the allergy-protective bacterium Lactococcus lactis G121. Biol Chem. 2012;393:749. doi:10.1515/hsz-2012-0142
- Marinho FA, Pacífico LG, Miyoshi A, Azevedo V, Le Loir Y, et al. An intranasal administration of Lactococcus lactis strains expressing recombinant interleukin-10 modulates acute allergic airway inflammation in a murine model. Clin Exp Allergy. 2010;40:1541. doi:10.1111/j.1365-2222.2010.03502.x
- Daniel C, Repa A, Wild C, Pollak A, Pot B, et al. Modulation of allergic immune responses by mucosal application of recombinant lactic acid bacteria producing the major birch pollen allergen Bet v 1. Allergy. 2006;61:812.
- Wu C, Yang G, Bermúdez-Humarán LG, Pang Q, Zeng Y, et al. Immunomodulatory effects of IL-12 secreted by Lactococcus lactis on Th1/Th2 balance in ovalbumin (OVA)-induced asthma model mice. Int Immunopharmacol. 2006;6:610.
