Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.1
USERS' SCORE
Good
Based on 6 Reviews
8.1
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Proprietary Probiotic BlendLacticaseibacillus rhamnosus R0011Lactobacillus helvetius R0052Pediococcus acidilactici R1001Lacticaseibacillus casei R0215Bifidobacterium longum BB536Lactiplantibacillus plantarum R1012Bifidobacterium breve R0070Lactococcus lactis subsp. lactis R1058
131 mg (10 Billion CFU)
†
Top Medical Research Studies
8
We examined the effects of Lactobacillus rhamnosus HN001 on eczema prevention among children with genetic predispositions. In our double-blind, randomized, placebo-controlled study involving 331 children, we discovered that those with specific high-risk gene variants experienced lower eczema rates when treated with HN001, compared to those receiving a placebo. This suggests Lactobacillus rhamnosus might be particularly beneficial for children at greater genetic risk of eczema and may even influence the severity of eczema and related allergic conditions.
Read More
2
We investigated whether taking the probiotic Lactobacillus rhamnosus GG during pregnancy could help lower the risk of eczema in infants. In a randomized controlled trial, 250 pregnant women, whose babies were at high risk for allergic diseases, took this probiotic from 36 weeks until delivery.
Unfortunately, we found that this prenatal treatment didn’t significantly reduce the incidence of eczema or any allergic reactions in their babies. This suggests that probiotics might need to be given after birth, or we may need to explore different strains for better results.
Unfortunately, we found that this prenatal treatment didn’t significantly reduce the incidence of eczema or any allergic reactions in their babies. This suggests that probiotics might need to be given after birth, or we may need to explore different strains for better results.
Read More
9
We explored the potential of Lactobacillus rhamnosus HN001 in reducing eczema among infants at high risk. Through a robust double-blind trial, expecting mothers took the probiotic from 35 weeks pregnant and continued while breastfeeding, while infants received it from birth to two years. Remarkably, this approach halved the prevalence of eczema by ages 2 and 4. Even better, the benefits seemed to last until age 6, showing promising potential in preventing eczema and associated allergic sensitization. However, another probiotic, HN019, did not show similar effects, suggesting specific benefits tied to HN001.
Read More
Most Useful Reviews
9
Eczema improvement
During early pregnancy, I struggled with severe atopic eczema. Since starting on these lactic acid bacteria, my eczema has noticeably improved. The discomfort has reduced significantly and I'm now much happier, hoping it continues to aid in preventing atopy for my baby as well.
Read More
9
Reduced eczema discomfort
After years of persistent scratching at night due to eczema, I’ve finally found relief. My routine now includes taking two capsules three times daily before meals. I'm also changing my diet to vegan, which is part of my overall healing process.
Read More
6
Improved gut health
9 people found this helpful
I've been taking this product for both vaginitis and chronic constipation. The combination of lactic acid bacteria and dietary fibre is beneficial. I’ve noticed improvements in my gut health and immunity, as well as reductions in yeast infections and chronic constipation. I'm now taking four capsules a day and have experienced better bowel movement regularity. I hope this will also help with my atopic eczema.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.1
- All Researches
9.5
We conducted a study to see if giving probiotics to mothers during pregnancy and breastfeeding could help reduce eczema in infants at risk. This double-blind, placebo-controlled trial involved 241 mother-infant pairs, where mothers were given either specific probiotics or a placebo.
Our findings showed that infants whose mothers took Lactobacillus rhamnosus and Bifidobacterium longum had a significantly lower risk of developing eczema in their first two years. This suggests that probiotics can be a safe and effective preventive measure for high-risk infants.
Our findings showed that infants whose mothers took Lactobacillus rhamnosus and Bifidobacterium longum had a significantly lower risk of developing eczema in their first two years. This suggests that probiotics can be a safe and effective preventive measure for high-risk infants.
Read More
9
We explored the potential of Lactobacillus rhamnosus HN001 in reducing eczema among infants at high risk. Through a robust double-blind trial, expecting mothers took the probiotic from 35 weeks pregnant and continued while breastfeeding, while infants received it from birth to two years. Remarkably, this approach halved the prevalence of eczema by ages 2 and 4. Even better, the benefits seemed to last until age 6, showing promising potential in preventing eczema and associated allergic sensitization. However, another probiotic, HN019, did not show similar effects, suggesting specific benefits tied to HN001.
Read More
9
Lactobacillus rhamnosus reduces eczema prevalence
We conducted a robust study using a double-blind randomized placebo-controlled trial to explore the impact of Lactobacillus rhamnosus HN001 on eczema in young children.
Mothers supplemented with HN001 from the 35th week of pregnancy until 6 months of breastfeeding, while infants continued taking the probiotic until age 2.
Remarkably, we found that this approach halved the prevalence of eczema by age 2, and its protective effects persisted up to age 4. HN001 may be a promising preventive measure for infants at high risk of allergic diseases.
Mothers supplemented with HN001 from the 35th week of pregnancy until 6 months of breastfeeding, while infants continued taking the probiotic until age 2.
Remarkably, we found that this approach halved the prevalence of eczema by age 2, and its protective effects persisted up to age 4. HN001 may be a promising preventive measure for infants at high risk of allergic diseases.
Read More
9
Probiotic intervention lowers eczema risk
We investigated if a mixture of probiotics could prevent eczema in infants at risk due to family history of allergies. In a double-blind, randomized, placebo-controlled trial, pregnant women took the probiotics leading to noteworthy results.
Infants whose mothers took the probiotics had a lower prevalence of eczema—18.2% compared to 40% in the placebo group. Additionally, the cumulative incidence of eczema was significantly reduced during the first year.
However, no notable differences in allergen sensitivity or total IgE levels were found between the two groups.
Infants whose mothers took the probiotics had a lower prevalence of eczema—18.2% compared to 40% in the placebo group. Additionally, the cumulative incidence of eczema was significantly reduced during the first year.
However, no notable differences in allergen sensitivity or total IgE levels were found between the two groups.
Read More
8
Probiotic formula benefits allergy management
We examined the impact of several infant formulas on allergies in children with cow's milk allergy over 36 months.
Our findings showed that the extensively hydrolyzed casein formula containing Lactobacillus rhamnosus GG led to a significantly lower rate of eczema and other allergic issues compared to other formula types.
Children treated with this particular formula also exhibited a faster development of immune tolerance.
It appears that incorporating this probiotic could be beneficial for managing allergies in infants.
Our findings showed that the extensively hydrolyzed casein formula containing Lactobacillus rhamnosus GG led to a significantly lower rate of eczema and other allergic issues compared to other formula types.
Children treated with this particular formula also exhibited a faster development of immune tolerance.
It appears that incorporating this probiotic could be beneficial for managing allergies in infants.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Eczema improvement
During early pregnancy, I struggled with severe atopic eczema. Since starting on these lactic acid bacteria, my eczema has noticeably improved. The discomfort has reduced significantly and I'm now much happier, hoping it continues to aid in preventing atopy for my baby as well.
Read More
9
Reduced eczema discomfort
After years of persistent scratching at night due to eczema, I’ve finally found relief. My routine now includes taking two capsules three times daily before meals. I'm also changing my diet to vegan, which is part of my overall healing process.
Read More
6
Improved gut health
9 people found this helpful
I've been taking this product for both vaginitis and chronic constipation. The combination of lactic acid bacteria and dietary fibre is beneficial. I’ve noticed improvements in my gut health and immunity, as well as reductions in yeast infections and chronic constipation. I'm now taking four capsules a day and have experienced better bowel movement regularity. I hope this will also help with my atopic eczema.
Read More
8
Calmed eczema symptoms
Having taken this for a week, I’m already seeing significant improvements in my eczema. It has also assisted with my constipation, making me feel better overall.
Read More
7.5
Eczema significantly better
This probiotic has been effective for my eczema, improving my skin condition considerably. I highly recommend it for anyone dealing with similar issues.
Read More
Frequently Asked Questions
8
Calmed eczema symptoms
Having taken this for a week, I’m already seeing significant improvements in my eczema. It has also assisted with my constipation, making me feel better overall.
9
Eczema improvement
During early pregnancy, I struggled with severe atopic eczema. Since starting on these lactic acid bacteria, my eczema has noticeably improved. The discomfort has reduced significantly and I'm now much happier, hoping it continues to aid in preventing atopy for my baby as well.
7.5
Eczema significantly better
This probiotic has been effective for my eczema, improving my skin condition considerably. I highly recommend it for anyone dealing with similar issues.
6
Improved gut health
9 people found this helpful
I've been taking this product for both vaginitis and chronic constipation. The combination of lactic acid bacteria and dietary fibre is beneficial. I’ve noticed improvements in my gut health and immunity, as well as reductions in yeast infections and chronic constipation. I'm now taking four capsules a day and have experienced better bowel movement regularity. I hope this will also help with my atopic eczema.
9
Reduced eczema discomfort
After years of persistent scratching at night due to eczema, I’ve finally found relief. My routine now includes taking two capsules three times daily before meals. I'm also changing my diet to vegan, which is part of my overall healing process.
8
This study looked into how two probiotics, Lactobacillus rhamnosus HN001 and Bifidobacterium animalis HN019, could affect the risk of eczema in genetically predisposed infants. Using a double-blind, randomized, placebo-controlled trial with 331 participants, we found that HN001 significantly reduced eczema risks linked to genetic variations, while HN019 had minimal impact.
Our results indicate that HN001 is particularly effective, addressing multiple genetic factors that contribute to eczema development. This opens new avenues for preventive strategies in at-risk populations.
Our results indicate that HN001 is particularly effective, addressing multiple genetic factors that contribute to eczema development. This opens new avenues for preventive strategies in at-risk populations.
9
We explored the potential of Lactobacillus rhamnosus HN001 in reducing eczema among infants at high risk. Through a robust double-blind trial, expecting mothers took the probiotic from 35 weeks pregnant and continued while breastfeeding, while infants received it from birth to two years. Remarkably, this approach halved the prevalence of eczema by ages 2 and 4. Even better, the benefits seemed to last until age 6, showing promising potential in preventing eczema and associated allergic sensitization. However, another probiotic, HN019, did not show similar effects, suggesting specific benefits tied to HN001.
8
Eczema prevention linked to probiotics
We explored the effectiveness of probiotics, particularly Lactobacillus rhamnosus, in preventing eczema and food allergies. The research highlights that combining prenatal and postnatal probiotic treatment can significantly reduce eczema prevalence in infants up to 2 years old, with some benefits lasting until age 4. However, not all studies are consistent—while many show promising results, others do not find any significant effects. This suggests that the timing and specific strain of probiotics play a crucial role in their potential benefits.
8
In a double-blind, placebo-controlled trial, we evaluated the effect of Lactobacillus rhamnosus alongside Bifidobacterium on eczema development in infants.
Over 290 participants received either the probiotic mixture or a placebo. Notably, at the end of the six-month intervention, only 4.2% of the probiotic group developed eczema, compared to 11.5% in the placebo group.
Other allergic conditions like asthma and rhinitis showed no significant differences, indicating that while probiotics may help with eczema, they don’t necessarily prevent other common allergies.
Over 290 participants received either the probiotic mixture or a placebo. Notably, at the end of the six-month intervention, only 4.2% of the probiotic group developed eczema, compared to 11.5% in the placebo group.
Other allergic conditions like asthma and rhinitis showed no significant differences, indicating that while probiotics may help with eczema, they don’t necessarily prevent other common allergies.
8
We examined the effects of Lactobacillus rhamnosus HN001 on eczema prevention among children with genetic predispositions. In our double-blind, randomized, placebo-controlled study involving 331 children, we discovered that those with specific high-risk gene variants experienced lower eczema rates when treated with HN001, compared to those receiving a placebo. This suggests Lactobacillus rhamnosus might be particularly beneficial for children at greater genetic risk of eczema and may even influence the severity of eczema and related allergic conditions.
References
- Voigt J, Lele M. Lactobacillus rhamnosus Used in the Perinatal Period for the Prevention of Atopic Dermatitis in Infants: A Systematic Review and Meta-Analysis of Randomized Trials. Am J Clin Dermatol. 2022;23:801. doi:10.1007/s40257-022-00723-x
- Nocerino R, Bedogni G, Carucci L, Cosenza L, Cozzolino T, et al. The Impact of Formula Choice for the Management of Pediatric Cow's Milk Allergy on the Occurrence of Other Allergic Manifestations: The Atopic March Cohort Study. J Pediatr. 2021;232:183. doi:10.1016/j.jpeds.2021.01.059
- Schmidt RM, Pilmann Laursen R, Bruun S, Larnkjaer A, Mølgaard C, et al. Probiotics in late infancy reduce the incidence of eczema: A randomized controlled trial. Pediatr Allergy Immunol. 2019;30:335. doi:10.1111/pai.13018
- Murphy R, Morgan XC, Wang XY, Wickens K, Purdie G, et al. Eczema-protective probiotic alters infant gut microbiome functional capacity but not composition: sub-sample analysis from a RCT. Benef Microbes. 2019;10:5. doi:10.3920/BM2017.0191
- Wickens K, Barthow C, Mitchell EA, Kang J, van Zyl N, et al. Effects of Lactobacillus rhamnosus HN001 in early life on the cumulative prevalence of allergic disease to 11 years. Pediatr Allergy Immunol. 2018;29:808. doi:10.1111/pai.12982
- Gulliver WP, Hutton AS, Ship N. Investigating the therapeutic potential of a probiotic in a clinical population with chronic hand dermatitis. Clin Cosmet Investig Dermatol. 2018;11:265. doi:10.2147/CCID.S164748
- Wickens K, Barthow C, Mitchell EA, Stanley TV, Purdie G, et al. Maternal supplementation alone with Lactobacillus rhamnosus HN001 during pregnancy and breastfeeding does not reduce infant eczema. Pediatr Allergy Immunol. 2018;29:296. doi:10.1111/pai.12874
- Berni Canani R, Di Costanzo M, Bedogni G, Amoroso A, Cosenza L, et al. Extensively hydrolyzed casein formula containing Lactobacillus rhamnosus GG reduces the occurrence of other allergic manifestations in children with cow's milk allergy: 3-year randomized controlled trial. J Allergy Clin Immunol. 2017;139:1906. doi:10.1016/j.jaci.2016.10.050
- Marlow G, Han DY, Wickens K, Stanley T, Crane J, et al. Differential effects of two probiotics on the risks of eczema and atopy associated with single nucleotide polymorphisms to Toll-like receptors. Pediatr Allergy Immunol. 2015;26:262. doi:10.1111/pai.12371
- Ismail IH, Boyle RJ, Mah LJ, Licciardi PV, Tang ML. Reduced neonatal regulatory T cell response to microbial stimuli associates with subsequent eczema in high-risk infants. Pediatr Allergy Immunol. 2014;25:674. doi:10.1111/pai.12303
- Morgan AR, Han DY, Wickens K, Barthow C, Mitchell EA, et al. Differential modification of genetic susceptibility to childhood eczema by two probiotics. Clin Exp Allergy. 2014;44:1255. doi:10.1111/cea.12394
- Wickens K, Stanley TV, Mitchell EA, Barthow C, Fitzharris P, et al. Early supplementation with Lactobacillus rhamnosus HN001 reduces eczema prevalence to 6 years: does it also reduce atopic sensitization?. Clin Exp Allergy. 2013;43:1048. doi:10.1111/cea.12154
- Kuitunen M. Probiotics and prebiotics in preventing food allergy and eczema. Curr Opin Allergy Clin Immunol. 2013;13:280. doi:10.1097/ACI.0b013e328360ed66
- Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130:1355. doi:10.1016/j.jaci.2012.09.003
- Wickens K, Black P, Stanley TV, Mitchell E, Barthow C, et al. A protective effect of Lactobacillus rhamnosus HN001 against eczema in the first 2 years of life persists to age 4 years. Clin Exp Allergy. 2012;42:1071. doi:10.1111/j.1365-2222.2012.03975.x
- Boyle RJ, Ismail IH, Kivivuori S, Licciardi PV, Robins-Browne RM, et al. Lactobacillus GG treatment during pregnancy for the prevention of eczema: a randomized controlled trial. Allergy. 2011;66:509. doi:10.1111/j.1398-9995.2010.02507.x
- Puisto R, Gómez-Gallego C, Collado MC, Turta O, Isolauri E, et al. The Role of Infant Gut Microbiota Modulation by Perinatal Maternal Probiotic Intervention in Atopic Eczema Risk Reduction. Neonatology. 2025;122:84. doi:10.1159/000540075
- Enomoto T, Sowa M, Nishimori K, Shimazu S, Yoshida A, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int. 2014;63:575. doi:10.2332/allergolint.13-OA-0683
- Adjibade M, Vigneron L, Delvert R, Adel-Patient K, Divaret-Chauveau A, et al. Characteristics of infant formula consumed in the first months of life and allergy in the EDEN mother-child cohort. Matern Child Nutr. 2024;20:e13673. doi:10.1111/mcn.13673
- Kim HK, Rutten NB, Besseling-van der Vaart I, Niers LE, Choi YH, et al. Probiotic supplementation influences faecal short chain fatty acids in infants at high risk for eczema. Benef Microbes. 2015;6:783. doi:10.3920/BM2015.0056
- Dotterud CK, Storrø O, Johnsen R, Oien T. Probiotics in pregnant women to prevent allergic disease: a randomized, double-blind trial. Br J Dermatol. 2010;163:616. doi:10.1111/j.1365-2133.2010.09889.x
- Kim JY, Kwon JH, Ahn SH, Lee SI, Han YS, et al. Effect of probiotic mix (Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double-blind, randomized, placebo-controlled trial. Pediatr Allergy Immunol. 2010;21:e386. doi:10.1111/j.1399-3038.2009.00958.x
- Niers L, Martín R, Rijkers G, Sengers F, Timmerman H, et al. The effects of selected probiotic strains on the development of eczema (the PandA study). Allergy. 2009;64:1349. doi:10.1111/j.1398-9995.2009.02021.x
- Wickens K, Black PN, Stanley TV, Mitchell E, Fitzharris P, et al. A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol. 2008;122:788. doi:10.1016/j.jaci.2008.07.011
- Kirjavainen PV, Arvola T, Salminen SJ, Isolauri E. Aberrant composition of gut microbiota of allergic infants: a target of bifidobacterial therapy at weaning?. Gut. 2002;51:51.
- Isolauri E, Arvola T, Sütas Y, Moilanen E, Salminen S. Probiotics in the management of atopic eczema. Clin Exp Allergy. 2000;30:1604.
