Last update
3/4/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 25 Researches
8
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.1
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Proprietary Probiotic BlendLacticaseibacillus rhamnosus R0011Lactobacillus helvetius R0052Pediococcus acidilactici R1001Lacticaseibacillus casei R0215Bifidobacterium longum BB536Lactiplantibacillus plantarum R1012Bifidobacterium breve R0070Lactococcus lactis subsp. lactis R1058
131 mg (10 Billion CFU)
†
Top Medical Research Studies
9
L. plantarum reduces heart disease risk
We set out to explore the effects of Lactobacillus plantarum ATCC 14917 on heart disease in ApoE-deficient mice. Over 12 weeks, these mice were given the probiotic, and we analyzed their heart health and inflammation levels.
The results were intriguing; while L. plantarum didn’t impact body weight or overall fat levels, it did significantly reduce atherosclerotic lesions. Additionally, markers of inflammation and oxidative stress improved, suggesting this probiotic might help slow heart disease progression.
The results were intriguing; while L. plantarum didn’t impact body weight or overall fat levels, it did significantly reduce atherosclerotic lesions. Additionally, markers of inflammation and oxidative stress improved, suggesting this probiotic might help slow heart disease progression.
Read More
9
Lactobacillus plantarum reduces cholesterol
We investigated how Lactobacillus plantarum ECGC 13110402 affects cholesterol levels in a group of 49 adults with normal to mildly high cholesterol. This double-blind, placebo-controlled study showed promising results. Specifically, we observed a notable decrease in LDL cholesterol and triglycerides after 12 weeks, alongside a rise in HDL cholesterol.
Additionally, systolic blood pressure reduced significantly in participants over 60 during the study. Importantly, the probiotic was well-tolerated with no gastrointestinal side effects. Overall, this strain shows potential as a natural option to help reduce heart disease risk.
Additionally, systolic blood pressure reduced significantly in participants over 60 during the study. Importantly, the probiotic was well-tolerated with no gastrointestinal side effects. Overall, this strain shows potential as a natural option to help reduce heart disease risk.
Read More
9
We explored how the gut microbiota influences atrial fibrillation (AF) caused by the cancer drug ibrutinib. Using advanced techniques like gene sequencing and microbiota transplantation, we identified that ibrutinib decreases the Lactobacillus gasseri levels, which raises AF risk in rats.
Remarkably, when we supplemented with L. gasseri or its byproduct, butyrate, we found it effectively prevented AF linked to ibrutinib. This study suggests targeting gut microbes could be a promising strategy to manage drug-related heart issues.
Remarkably, when we supplemented with L. gasseri or its byproduct, butyrate, we found it effectively prevented AF linked to ibrutinib. This study suggests targeting gut microbes could be a promising strategy to manage drug-related heart issues.
Read More
Most Useful Reviews
0
No improvement noted
1 people found this helpful
I initially thought this supplement was effective but soon developed a skin condition resembling atopy. After stopping the supplement and trying various remedies without success, I experienced intense itching on my neck, abdomen, and eyelids. Ceasing this supplement led to immediate improvement. Ultimately, it was not suitable for me. I am now seeing positive effects with a different lactic acid bacterium and no longer have any atopy.
Read More
0
Sharp stomach pain
6 people found this helpful
I had been searching for a good probiotic for some time, especially due to my chronic diseases and frequent antibiotics. However, I experienced severe stomach pain shortly after starting this product. Despite my efforts to persist, it wasn't worth it. I ended up giving it to a friend who suffers from constipation, and it proved beneficial for them.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 25 Researches
8
- All Researches
9
We explored how the gut microbiota influences atrial fibrillation (AF) caused by the cancer drug ibrutinib. Using advanced techniques like gene sequencing and microbiota transplantation, we identified that ibrutinib decreases the Lactobacillus gasseri levels, which raises AF risk in rats.
Remarkably, when we supplemented with L. gasseri or its byproduct, butyrate, we found it effectively prevented AF linked to ibrutinib. This study suggests targeting gut microbes could be a promising strategy to manage drug-related heart issues.
Remarkably, when we supplemented with L. gasseri or its byproduct, butyrate, we found it effectively prevented AF linked to ibrutinib. This study suggests targeting gut microbes could be a promising strategy to manage drug-related heart issues.
Read More
9
We explored the impact of Shenxiang Suhe pill (SXSH) on heart health by examining its effects on gut bacteria and blood metabolites in rats with acute myocardial infarction.
Using a controlled study setup, we found that administering a specific dose of SXSH improved heart function significantly, as indicated by increased ejection fraction and reduced heart damage markers.
However, the benefits were diminished when antibiotics were introduced, highlighting the importance of gut microbiota in this process.
Using a controlled study setup, we found that administering a specific dose of SXSH improved heart function significantly, as indicated by increased ejection fraction and reduced heart damage markers.
However, the benefits were diminished when antibiotics were introduced, highlighting the importance of gut microbiota in this process.
Read More
9
We examined how Qianshan Huoxue Gao (QS) affects acute coronary syndrome (ACS) using an experimental model with rats. These rats underwent a surgical procedure to induce heart problems and were treated with QS, alongside a control group for comparison.
After 28 days of treatment, we observed that QS improved heart function and restored a healthier balance of gut bacteria, similar to results seen with atorvastatin, a conventional medication. Our findings suggest that ethanolamine, a metabolite linked to QS, plays a significant role in helping manage ACS.
After 28 days of treatment, we observed that QS improved heart function and restored a healthier balance of gut bacteria, similar to results seen with atorvastatin, a conventional medication. Our findings suggest that ethanolamine, a metabolite linked to QS, plays a significant role in helping manage ACS.
Read More
9
We investigated whether adding Lactobacillus plantarum to standard simvastatin treatment could reduce cardiovascular risk in dyslipidemic patients. In a study with 77 participants aged 40-74, we found that the combination therapy significantly lowered total cholesterol and LDL levels after 8 and 12 weeks.
The results showed not only a noteworthy decline in lipid levels but also in cardiovascular risk scores for those receiving the probiotic. This suggests that Lactobacillus plantarum may enhance heart health when used alongside traditional medications.
The results showed not only a noteworthy decline in lipid levels but also in cardiovascular risk scores for those receiving the probiotic. This suggests that Lactobacillus plantarum may enhance heart health when used alongside traditional medications.
Read More
9
L. plantarum reduces heart disease risk
We set out to explore the effects of Lactobacillus plantarum ATCC 14917 on heart disease in ApoE-deficient mice. Over 12 weeks, these mice were given the probiotic, and we analyzed their heart health and inflammation levels.
The results were intriguing; while L. plantarum didn’t impact body weight or overall fat levels, it did significantly reduce atherosclerotic lesions. Additionally, markers of inflammation and oxidative stress improved, suggesting this probiotic might help slow heart disease progression.
The results were intriguing; while L. plantarum didn’t impact body weight or overall fat levels, it did significantly reduce atherosclerotic lesions. Additionally, markers of inflammation and oxidative stress improved, suggesting this probiotic might help slow heart disease progression.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.1
- All Reviews
- Positive Reviews
- Negative Reviews
0
No improvement noted
1 people found this helpful
I initially thought this supplement was effective but soon developed a skin condition resembling atopy. After stopping the supplement and trying various remedies without success, I experienced intense itching on my neck, abdomen, and eyelids. Ceasing this supplement led to immediate improvement. Ultimately, it was not suitable for me. I am now seeing positive effects with a different lactic acid bacterium and no longer have any atopy.
Read More
0
Sharp stomach pain
6 people found this helpful
I had been searching for a good probiotic for some time, especially due to my chronic diseases and frequent antibiotics. However, I experienced severe stomach pain shortly after starting this product. Despite my efforts to persist, it wasn't worth it. I ended up giving it to a friend who suffers from constipation, and it proved beneficial for them.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Shi L, Duan Y, Fang N, Zhang N, Yan S, et al. Lactobacillus gasseri prevents ibrutinib-associated atrial fibrillation through butyrate. Europace. 2025;27. 10.1093/europace/euaf018
- Peña-Ocaña BA, Silva-Flores M, Shotaro T, García-Gálvez L, Hernández-Esquivel L, et al. Transplant of gut microbiota ameliorates metabolic and heart disorders in rats fed with a hypercaloric diet by modulating microbial metabolism and diversity. Biomed Pharmacother. 2024;181:117667. 10.1016/j.biopha.2024.117667
- Bonab SF, Tahmasebi S, Ghafouri-Fard S, Eslami S. Preventive impact of probiotic supplements on heart injury and inflammatory indices in a rat model of myocardial infarction: histopathological and gene expression evaluation. APMIS. 2025;133:e13479. 10.1111/apm.13479
- Wu G, Liao J, Zhu X, Zhang Y, Lin Y, et al. Shexiang Baoxin Pill enriches Lactobacillus to regulate purine metabolism in patients with stable coronary artery disease. Phytomedicine. 2024;130:155727. 10.1016/j.phymed.2024.155727
- Li Y, Liu Y, Cui J, Zhu M, Wang W, et al. Oral-gut microbial transmission promotes diabetic coronary heart disease. Cardiovasc Diabetol. 2024;23:123. 10.1186/s12933-024-02217-y
- Wang J, Zhang H, Yuan H, Chen S, Yu Y, et al. Prophylactic Supplementation with Lactobacillus Reuteri or Its Metabolite GABA Protects Against Acute Ischemic Cardiac Injury. Adv Sci (Weinh). 2024;11:e2307233. 10.1002/advs.202307233
- Zhong X, Yan J, Wei X, Xie T, Zhang Z, et al. Shenxiang Suhe pill improves cardiac function through modulating gut microbiota and serum metabolites in rats after acute myocardial infarction. Pharm Biol. 2024;62:1. 10.1080/13880209.2023.2289577
- Zhao N, Ma Y, Liang X, Zhang Y, Hong D, et al. Efficacy and Mechanism of Qianshan Huoxue Gao in Acute Coronary Syndrome via Regulation of Intestinal Flora and Metabolites. Drug Des Devel Ther. 2023;17:579. 10.2147/DDDT.S396649
- Huang YL, Xiang Q, Zou JJ, Wu Y, Yu R. Zuogui Jiangtang Shuxin formula Ameliorates diabetic cardiomyopathy mice modulating gut-heart axis. Front Endocrinol (Lausanne). 2023;14:1106812. 10.3389/fendo.2023.1106812
- Tian Y, Wu G, Zhao X, Zhang H, Ren M, et al. Probiotics combined with atorvastatin administration in the treatment of hyperlipidemia: A randomized, double-blind, placebo-controlled clinical trial. Medicine (Baltimore). 2024;103:e37883. 10.1097/MD.0000000000037883
- Neverovskyi A, Chernyavskyi V, Shypulin V, Hvozdetska L, Tishchenko V, et al. Probiotic Lactobacillus plantarum may reduce cardiovascular risk: An experimental study. ARYA Atheroscler. 2021;17:1. 10.22122/arya.v17i0.2156
- Aboulgheit A, Karbasiafshar C, Zhang Z, Sabra M, Shi G, et al. probiotic induces Nrf2-mediated antioxidant signaling and eNOS expression resulting in improvement of myocardial diastolic function. Am J Physiol Heart Circ Physiol. 2021;321:H839. 10.1152/ajpheart.00278.2021
- O'Morain VL, Chan YH, Williams JO, Alotibi R, Alahmadi A, et al. The Lab4P Consortium of Probiotics Attenuates Atherosclerosis in LDL Receptor Deficient Mice Fed a High Fat Diet and Causes Plaque Stabilization by Inhibiting Inflammation and Several Pro-Atherogenic Processes. Mol Nutr Food Res. 2021;65:e2100214. 10.1002/mnfr.202100214
- Hofeld BC, Puppala VK, Tyagi S, Ahn KW, Anger A, et al. Lactobacillus plantarum 299v probiotic supplementation in men with stable coronary artery disease suppresses systemic inflammation. Sci Rep. 2021;11:3972. 10.1038/s41598-021-83252-7
- Hassan A, Din AU, Zhu Y, Zhang K, Li T, et al. Anti-atherosclerotic effects of Lactobacillus plantarum ATCC 14917 in ApoE mice through modulation of proinflammatory cytokines and oxidative stress. Appl Microbiol Biotechnol. 2020;104:6337. 10.1007/s00253-020-10693-x
- Malik M, Suboc TM, Tyagi S, Salzman N, Wang J, et al. Lactobacillus plantarum 299v Supplementation Improves Vascular Endothelial Function and Reduces Inflammatory Biomarkers in Men With Stable Coronary Artery Disease. Circ Res. 2018;123:1091. 10.1161/CIRCRESAHA.118.313565
- Martinic A, Barouei J, Bendiks Z, Mishchuk D, Heeney DD, et al. Supplementation of Lactobacillus plantarum Improves Markers of Metabolic Dysfunction Induced by a High Fat Diet. J Proteome Res. 2018;17:2790. 10.1021/acs.jproteome.8b00282
- Costabile A, Buttarazzi I, Kolida S, Quercia S, Baldini J, et al. An in vivo assessment of the cholesterol-lowering efficacy of Lactobacillus plantarum ECGC 13110402 in normal to mildly hypercholesterolaemic adults. PLoS One. 2017;12:e0187964. 10.1371/journal.pone.0187964
- Yang G, Jiang Y, Yang W, Du F, Yao Y, et al. Effective treatment of hypertension by recombinant Lactobacillus plantarum expressing angiotensin converting enzyme inhibitory peptide. Microb Cell Fact. 2015;14:202. 10.1186/s12934-015-0394-2
- Mirjani R, Faramarzi MA, Sharifzadeh M, Setayesh N, Khoshayand MR, et al. Biosynthesis of tellurium nanoparticles by Lactobacillus plantarum and the effect of nanoparticle-enriched probiotics on the lipid profiles of mice. IET Nanobiotechnol. 2015;9:300. 10.1049/iet-nbt.2014.0057
- Ahrén IL, Xu J, Önning G, Olsson C, Ahrné S, et al. Antihypertensive activity of blueberries fermented by Lactobacillus plantarum DSM 15313 and effects on the gut microbiota in healthy rats. Clin Nutr. 2015;34:719. 10.1016/j.clnu.2014.08.009
- Barreto FM, Colado Simão AN, Morimoto HK, Batisti Lozovoy MA, Dichi I, et al. Beneficial effects of Lactobacillus plantarum on glycemia and homocysteine levels in postmenopausal women with metabolic syndrome. Nutrition. 2014;30:939. 10.1016/j.nut.2013.12.004
- Gorenjak M, Gradišnik L, Trapečar M, Pistello M, Kozmus CP, et al. Improvement of lipid profile by probiotic/protective cultures: study in a non-carcinogenic small intestinal cell model. New Microbiol. 2014;37:51.
- Huang Y, Wang X, Wang J, Wu F, Sui Y, et al. Lactobacillus plantarum strains as potential probiotic cultures with cholesterol-lowering activity. J Dairy Sci. 2013;96:2746. 10.3168/jds.2012-6123
- Lam V, Su J, Koprowski S, Hsu A, Tweddell JS, et al. Intestinal microbiota determine severity of myocardial infarction in rats. FASEB J. 2012;26:1727. 10.1096/fj.11-197921
Data last updated:
