We examined how acetyl-L-carnitine affects stress responses in rats exposed to cold swimming. Over ten days, we compared the effects of two stress types and found that cold-swimming significantly increased beta-endorphin levels in both the pituitary and plasma. Notably, acetyl-L-carnitine treatment appeared to offset these changes induced by cold stress. However, it’s essential to highlight that while there were improvements observed with acetyl-L-carnitine, the overall effectiveness for treating cold-related symptoms remains uncertain based on these findings.
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8
ALC maintains testosterone under stress
Effect of different chronic intermittent stressors and acetyl-l-carnitine on hypothalamic beta-endorphin and GnRH and on plasma testosterone levels in male rats.
This study explored the impact of stress and acetyl-l-carnitine (ALC) on hormone levels in male rats. We found that chronic swimming stress decreased reproductive hormones and testosterone levels.
However, ALC treatment appeared to counteract this decline, helping maintain testosterone during stress. This suggests ALC may play a protective role against stress-induced hormonal disruptions.
In contrast, ether stress did not show the same effects on testosterone, highlighting the unique responses to different stressors.
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Most Useful Reviews
9
Prevents illness
This medication should be taken at the first sign of a cold or after contact with a sick person. It helps prevent illness, and I would prefer to take it regularly, but it’s rather costly.
Read More
9
Reduced cold susceptibility
Absolutely brilliant! It comes in a convenient size, has no taste, and can be taken daily. Since I started using it, I’ve felt well, less susceptible to colds, and think it’s very effective.
Read More
7.5
Enhanced recovery post-cold
Carnitine is essential not only for sports but also during recovery after a cold. I began taking carnitine after suffering from a coronavirus infection when I felt weak. After 1.5 months of 500 units daily, I regained my previous energy and felt revitalised!
Effect of different chronic intermittent stressors and acetyl-l-carnitine on hypothalamic beta-endorphin and GnRH and on plasma testosterone levels in male rats.
This study explored the impact of stress and acetyl-l-carnitine (ALC) on hormone levels in male rats. We found that chronic swimming stress decreased reproductive hormones and testosterone levels.
However, ALC treatment appeared to counteract this decline, helping maintain testosterone during stress. This suggests ALC may play a protective role against stress-induced hormonal disruptions.
In contrast, ether stress did not show the same effects on testosterone, highlighting the unique responses to different stressors.
Read More
7
Acetyl-L-carnitine's mixed effectiveness
Acetyl-L-carnitine effect on pituitary and plasma beta-endorphin responsiveness to different chronic intermittent stressors.
We examined how acetyl-L-carnitine affects stress responses in rats exposed to cold swimming. Over ten days, we compared the effects of two stress types and found that cold-swimming significantly increased beta-endorphin levels in both the pituitary and plasma. Notably, acetyl-L-carnitine treatment appeared to offset these changes induced by cold stress. However, it’s essential to highlight that while there were improvements observed with acetyl-L-carnitine, the overall effectiveness for treating cold-related symptoms remains uncertain based on these findings.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.8
All Reviews
Positive Reviews
Negative Reviews
9
Prevents illness
This medication should be taken at the first sign of a cold or after contact with a sick person. It helps prevent illness, and I would prefer to take it regularly, but it’s rather costly.
Read More
9
Reduced cold susceptibility
Absolutely brilliant! It comes in a convenient size, has no taste, and can be taken daily. Since I started using it, I’ve felt well, less susceptible to colds, and think it’s very effective.
Read More
7.5
Enhanced recovery post-cold
Carnitine is essential not only for sports but also during recovery after a cold. I began taking carnitine after suffering from a coronavirus infection when I felt weak. After 1.5 months of 500 units daily, I regained my previous energy and felt revitalised!
Read More
9
Effective for weight loss
5 people found this helpful
Stay warm in winter and lose weight by sweating in summer! When I took acetyl carnitine in winter, I didn't feel cold at night. In summer, I noticed a significant increase in sweating. It seems effective for weight loss. I no longer feel drowsy upon waking; I feel truly alert.
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6
Improved cold tolerance
5 people found this helpful
I believe there is an effect! I started taking it and found it easier to sweat. Last year, at my workplace in cold weather, I felt chilly even in midsummer. This year, however, it feels just right. I've even asked my colleagues, "Have you been feeling cold recently?" I plan to continue since my body feels slightly tighter.
Cold is a term that refers to a state of low temperature, often associated with a perceptibly chilly environment or the sensation of being cool to the touch. Scientifically, cold is relative to the presence and movement of heat, which is a measure of energy within matter. In everyday terms, we experience cold through weather changes, such as during winter months, and it can also be described in the context of specific temperature ranges – for example, temperatures below 32 degrees Fahrenheit (0 degrees Celsius) generally signify freezing conditions, which can impact outdoor activities, personal comfort, and various ecological systems.
Moreover, the sensation of cold is not solely dependent on temperature; factors like humidity and wind chill can enhance the feeling of coldness. When discussing cold in terms of human health, prolonged exposure to cold conditions can lead to hypothermia or frostbite if body heat is not effectively maintained. Hence, it's crucial to dress appropriately and take necessary precautions during colder months to prevent adverse effects. Understanding the concept of cold can help individuals better prepare for seasonal changes and ensure their comfort and safety.
Acetyl L-Carnitine (ALCAR) is a naturally occurring compound derived from L-Carnitine, an amino acid that plays a vital role in energy metabolism. It is synthesized in the body from the amino acids lysine and methionine and is found in high concentrations in the mitochondria of cells, where it assists in the transport of fatty acids into the mitochondria for energy production. This process makes ALCAR popular among athletes and fitness enthusiasts who are looking to enhance their physical performance and energy levels.
In addition to its role in energy metabolism, Acetyl L-Carnitine is also studied for its potential cognitive benefits. Some research suggests it may help improve memory and overall brain function, making it a supplement of interest for those seeking mental clarity or support for age-related cognitive decline. Commonly available in capsule or powder form, ALCAR is often used as a dietary supplement, and while it's generally considered safe, it's always wise to consult with a healthcare provider before starting any new supplement regimen.
Based on user reviews, the time it takes to see results from this supplement can vary significantly. Some users report feeling improvements relatively quickly, often within a few days to a week. For instance, one reviewer mentioned they began to feel less susceptible to colds almost immediately after starting the supplement Read Review. Another user suggested that they experienced noticeable effects after taking the supplement for a few weeks, feeling more energetic and less sensitive to cold after about 1.5 months Read Review.
It's also noted that regular intake is recommended for better results. For example, several users indicated ongoing use helps maintain their improved sensitivity to cold, suggesting that benefits might continue to increase with consistent use Read Review. Overall, while some users may feel immediate effects, a common theme is that consistent use over several weeks enhances the supplement's effectiveness.
The research surrounding acetyl-L-carnitine (ALC) offers some insights into its potential effects on cold stress, particularly in animal models. A study investigated how ALC treated rats exposed to cold swimming stress, revealing that while ALC seemed to mitigate certain stress-induced hormone changes, its overall efficacy in treating cold-related symptoms is still not fully established [2]. Notably, there were indications that ALC could offset increases in beta-endorphin levels related to cold stress, a promising sign for its protective properties during such conditions.
Users have reported a range of improvements in symptoms after using the supplement, particularly regarding sensitivity to cold and overall energy levels. Many reviewers noted a decrease in their susceptibility to cold, feeling warmer and more comfortable in chilly environments. One user mentioned, "I started taking it and found it easier to sweat...this year, however, it feels just right" Read Review. Another user echoed this sentiment, stating that their sensitivity to cold has improved significantly while taking the supplement Read Review.
Additionally, users have observed enhanced energy levels, especially following periods of illness or fatigue. A reviewer recovering from a coronavirus infection reported, "I regained my previous energy and felt revitalised!" Read Review. Others have mentioned feeling more alert and less drowsy upon waking Read Review. Overall, while individual results can vary, the common theme in user feedback is that consistent use of the supplement may lead to significant improvements in both cold sensitivity and energy levels.
Users have reported a positive experience when combining this supplement with other supplements for handling cold symptoms. Many have noted that taking the supplement alongside carnitine can enhance overall energy levels, particularly during recovery from illness. For instance, one user suggested that after suffering from a coronavirus infection, ingesting carnitine resulted in a revitalizing effect and a significant boost in energy levels after just 1.5 months of regular use Read Review. This combination seems particularly effective in bolstering the immune response and maintaining warmth in cold conditions.
In addition to carnitine, users have highlighted that regular supplementation can lead to improvements in cold sensitivity and metabolic rate. One reviewer remarked how taking the supplement consistently helped them experience less cold and improved their overall warmth, explicitly mentioning the benefits of using it in conjunction with exercise Read Review. The consensus among users suggests that combining this supplement with other effective ingredients, like carnitine, not only aids in recovery but also enhances the body’s ability to cope with cold environments.
Based on user reviews, individuals report varying doses of Acetyl L Carnitine for managing cold sensitivity. Many users highlight a regular intake, with one user specifically noting a daily dosage of 500 units for over a month as beneficial for their recovery after illness and overall energy levels Read Review. Another user suggests that this supplement should be taken at the first sign of cold symptoms or after exposure to illness Read Review.
Additionally, several users recommend taking it consistently, mentioning that regular use has contributed to their improved sensitivity to cold and enhanced warmth Read Review. While some reviewers highlight the positive effects of the supplement on their body temperature regulation, they don't specify exact dose recommendations other than suggesting that daily intake might be effective Read Review. Overall, it seems that users value the convenient daily intake of Acetyl L Carnitine for supporting their immune response and improving their sensitivity to cold.
9
Reduced cold susceptibility
Absolutely brilliant! It comes in a convenient size, has no taste, and can be taken daily. Since I started using it, I’ve felt well, less susceptible to colds, and think it’s very effective.
7.5
Enhanced recovery post-cold
Carnitine is essential not only for sports but also during recovery after a cold. I began taking carnitine after suffering from a coronavirus infection when I felt weak. After 1.5 months of 500 units daily, I regained my previous energy and felt revitalised!
6
Better cold tolerance
I've been taking this supplement for quite some time. I read that daily intake is recommended. I'm not sure about its effects on weight loss, but it has certainly improved my cold body. I continue to take it for my health management, and I don't have an issue with the taste or smell.
6
Improved cold tolerance
5 people found this helpful
I believe there is an effect! I started taking it and found it easier to sweat. Last year, at my workplace in cold weather, I felt chilly even in midsummer. This year, however, it feels just right. I've even asked my colleagues, "Have you been feeling cold recently?" I plan to continue since my body feels slightly tighter.
6
Improved cold sensitivity
It seems my sensitivity to cold is improving. I take it in the morning and before exercising, and I have noticed a positive change.
9
Effective for weight loss
5 people found this helpful
Stay warm in winter and lose weight by sweating in summer! When I took acetyl carnitine in winter, I didn't feel cold at night. In summer, I noticed a significant increase in sweating. It seems effective for weight loss. I no longer feel drowsy upon waking; I feel truly alert.
9
Prevents illness
This medication should be taken at the first sign of a cold or after contact with a sick person. It helps prevent illness, and I would prefer to take it regularly, but it’s rather costly.
7
Acetyl-L-carnitine's mixed effectiveness
Acetyl-L-carnitine effect on pituitary and plasma beta-endorphin responsiveness to different chronic intermittent stressors.
We examined how acetyl-L-carnitine affects stress responses in rats exposed to cold swimming. Over ten days, we compared the effects of two stress types and found that cold-swimming significantly increased beta-endorphin levels in both the pituitary and plasma. Notably, acetyl-L-carnitine treatment appeared to offset these changes induced by cold stress. However, it’s essential to highlight that while there were improvements observed with acetyl-L-carnitine, the overall effectiveness for treating cold-related symptoms remains uncertain based on these findings.
References
Bidzinska B, Petraglia F, Angioni S, Genazzani AD, Criscuolo M, et al. Effect of different chronic intermittent stressors and acetyl-l-carnitine on hypothalamic beta-endorphin and GnRH and on plasma testosterone levels in male rats. Neuroendocrinology. 1993;57:985.
Bidzinska B, Petraglia F, Angioni S, Genazzani AD, Criscuolo M, et al. Acetyl-L-carnitine effect on pituitary and plasma beta-endorphin responsiveness to different chronic intermittent stressors. J Neuroendocrinol. 1993;5:151.