Last update
3/6/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
USERS' SCORE
Good
Based on 9 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Lactoferrin (as Apolactoferrin)
250 mg
†
Top Medical Research Studies
9
We examined how KRDS, a peptide derived from human lactotransferrin, impacts platelet function and blood clot formation in dogs. The study demonstrated that KRDS effectively inhibited platelet aggregation and secretion, making it a powerful agent against clot formation.
During the experiment, KRDS reduced the weight of blood clots formed in the arteries by half compared to control groups, indicating its potential as an antithrombotic treatment. The findings suggest that KRDS may be a promising option for preventing harmful blood clots.
During the experiment, KRDS reduced the weight of blood clots formed in the arteries by half compared to control groups, indicating its potential as an antithrombotic treatment. The findings suggest that KRDS may be a promising option for preventing harmful blood clots.
Read More
9
We examined the effects of a specific lactoferrin peptide, KRDS, on blood clots compared to another peptide, RGDS. In controlled studies using rats and guinea pigs, we observed that KRDS significantly reduced platelet aggregation, showcasing its potential as an antithrombotic agent. Both in vitro and in vivo tests demonstrated that KRDS's impact was much stronger than another sequence, KRDR, which showed minimal effects on clot formation. This suggests that KRDS could play a vital role in preventing blood clots, with mechanisms that are distinct from RGDS.
Read More
8
We examined the effects of a peptide derived from lactoferrin, known as LF-LR, on blood clotting by targeting thrombin, a key factor in thrombosis. In our investigation, LF-LR significantly delayed various coagulation times, indicating its potential to hinder blood clot formation.
By altering thrombin's structure, LF-LR transformed its secondary forms, enhancing its functionality in anticoagulation. Molecular docking studies revealed that this peptide attaches to thrombin at critical sites, strengthening its role as an anticoagulant. These findings suggest that lactoferrin may be an interesting area for future research in blood clot management.
By altering thrombin's structure, LF-LR transformed its secondary forms, enhancing its functionality in anticoagulation. Molecular docking studies revealed that this peptide attaches to thrombin at critical sites, strengthening its role as an anticoagulant. These findings suggest that lactoferrin may be an interesting area for future research in blood clot management.
Read More
Most Useful Reviews
9
Effective, recommended product
34 people found this helpful
I took this alongside Solaray iron due to my low ferritin (27) after severe blood loss from childbirth. Over 1.5 months, it raised my ferritin to 70. No other iron supplement compares! I highly recommend it and it caused no gastrointestinal issues, unlike many iron products.
Read More
10
Improved iron levels
2 people found this helpful
This perfectly raises iron levels in the blood! According to the tests, my ferritin has increased threefold! I recommend it.
Read More
9
Significant increase
I took it for just one month, and it significantly increased my iron and ferritin levels in my blood. My ferritin went from 11 to 80, and my iron also rose from the lower limit to the upper limit.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
- All Researches
9
We examined how KRDS, a peptide derived from human lactotransferrin, impacts platelet function and blood clot formation in dogs. The study demonstrated that KRDS effectively inhibited platelet aggregation and secretion, making it a powerful agent against clot formation.
During the experiment, KRDS reduced the weight of blood clots formed in the arteries by half compared to control groups, indicating its potential as an antithrombotic treatment. The findings suggest that KRDS may be a promising option for preventing harmful blood clots.
During the experiment, KRDS reduced the weight of blood clots formed in the arteries by half compared to control groups, indicating its potential as an antithrombotic treatment. The findings suggest that KRDS may be a promising option for preventing harmful blood clots.
Read More
9
We examined the effects of a specific lactoferrin peptide, KRDS, on blood clots compared to another peptide, RGDS. In controlled studies using rats and guinea pigs, we observed that KRDS significantly reduced platelet aggregation, showcasing its potential as an antithrombotic agent. Both in vitro and in vivo tests demonstrated that KRDS's impact was much stronger than another sequence, KRDR, which showed minimal effects on clot formation. This suggests that KRDS could play a vital role in preventing blood clots, with mechanisms that are distinct from RGDS.
Read More
8
We examined the effects of a peptide derived from lactoferrin, known as LF-LR, on blood clotting by targeting thrombin, a key factor in thrombosis. In our investigation, LF-LR significantly delayed various coagulation times, indicating its potential to hinder blood clot formation.
By altering thrombin's structure, LF-LR transformed its secondary forms, enhancing its functionality in anticoagulation. Molecular docking studies revealed that this peptide attaches to thrombin at critical sites, strengthening its role as an anticoagulant. These findings suggest that lactoferrin may be an interesting area for future research in blood clot management.
By altering thrombin's structure, LF-LR transformed its secondary forms, enhancing its functionality in anticoagulation. Molecular docking studies revealed that this peptide attaches to thrombin at critical sites, strengthening its role as an anticoagulant. These findings suggest that lactoferrin may be an interesting area for future research in blood clot management.
Read More
8
We explored the effects of lactoferrin on neutrophil extracellular traps (NETs), which play a role in both defense and the formation of harmful blood clots. Our findings indicate that lactoferrin suppresses the release of NETs in the bloodstream, reducing potential clot formation in inflammatory conditions. This suppression may hinge on lactoferrin's positive charge interacting with NETs, as removing this charge diminished its effectiveness. Although these results are promising for using lactoferrin in treating autoimmune and inflammatory diseases, they reveal no immediate benefits for directly preventing blood clots.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective, recommended product
34 people found this helpful
I took this alongside Solaray iron due to my low ferritin (27) after severe blood loss from childbirth. Over 1.5 months, it raised my ferritin to 70. No other iron supplement compares! I highly recommend it and it caused no gastrointestinal issues, unlike many iron products.
Read More
10
Improved iron levels
2 people found this helpful
This perfectly raises iron levels in the blood! According to the tests, my ferritin has increased threefold! I recommend it.
Read More
9
Significant increase
I took it for just one month, and it significantly increased my iron and ferritin levels in my blood. My ferritin went from 11 to 80, and my iron also rose from the lower limit to the upper limit.
Read More
9
Boosted ferritin level
17 people found this helpful
I believe that this supplement well boosted my ferritin levels. I took it with iron at night. After finishing the iron, I will finish another jar of lactoferrin. Then, I plan to take iron with lactoferrin once a month for 5-7 days during periods of blood loss.
Read More
9
Effective delivery vehicle
8 people found this helpful
I bought this because of my low haemoglobin and ferritin levels, as I read it is the best for raising them. Lactoferrin is valuable because it delivers iron where it is needed, preventing harm from free iron. It is particularly relevant with COVID, as free iron can lead to severe complications. Lactoferrin acts as a delivery vehicle, preventing the virus from entering cells and inhibiting viral replication. I ordered another one for myself, as it raises haemoglobin effectively and has no side effects.
Read More
Frequently Asked Questions
9
Significant increase
I took it for just one month, and it significantly increased my iron and ferritin levels in my blood. My ferritin went from 11 to 80, and my iron also rose from the lower limit to the upper limit.
9
Effective, recommended product
34 people found this helpful
I took this alongside Solaray iron due to my low ferritin (27) after severe blood loss from childbirth. Over 1.5 months, it raised my ferritin to 70. No other iron supplement compares! I highly recommend it and it caused no gastrointestinal issues, unlike many iron products.
9
Boosted ferritin level
17 people found this helpful
I believe that this supplement well boosted my ferritin levels. I took it with iron at night. After finishing the iron, I will finish another jar of lactoferrin. Then, I plan to take iron with lactoferrin once a month for 5-7 days during periods of blood loss.
9
We examined how KRDS, a peptide derived from human lactotransferrin, impacts platelet function and blood clot formation in dogs. The study demonstrated that KRDS effectively inhibited platelet aggregation and secretion, making it a powerful agent against clot formation.
During the experiment, KRDS reduced the weight of blood clots formed in the arteries by half compared to control groups, indicating its potential as an antithrombotic treatment. The findings suggest that KRDS may be a promising option for preventing harmful blood clots.
During the experiment, KRDS reduced the weight of blood clots formed in the arteries by half compared to control groups, indicating its potential as an antithrombotic treatment. The findings suggest that KRDS may be a promising option for preventing harmful blood clots.
9
We examined the effects of a specific lactoferrin peptide, KRDS, on blood clots compared to another peptide, RGDS. In controlled studies using rats and guinea pigs, we observed that KRDS significantly reduced platelet aggregation, showcasing its potential as an antithrombotic agent. Both in vitro and in vivo tests demonstrated that KRDS's impact was much stronger than another sequence, KRDR, which showed minimal effects on clot formation. This suggests that KRDS could play a vital role in preventing blood clots, with mechanisms that are distinct from RGDS.
8
We explored the effects of lactoferrin on neutrophil extracellular traps (NETs), which play a role in both defense and the formation of harmful blood clots. Our findings indicate that lactoferrin suppresses the release of NETs in the bloodstream, reducing potential clot formation in inflammatory conditions. This suppression may hinge on lactoferrin's positive charge interacting with NETs, as removing this charge diminished its effectiveness. Although these results are promising for using lactoferrin in treating autoimmune and inflammatory diseases, they reveal no immediate benefits for directly preventing blood clots.
References
- Xu S, Fan F, Liu H, Cheng S, Tu M, et al. Novel Anticoagulant Peptide from Lactoferrin Binding Thrombin at the Active Site and Exosite-I. J Agric Food Chem. 2020;68:3132. 10.1021/acs.jafc.9b08094
- Okubo K, Kamiya M, Urano Y, Nishi H, Herter JM, et al. Lactoferrin Suppresses Neutrophil Extracellular Traps Release in Inflammation. EBioMedicine. 2016;10:204. 10.1016/j.ebiom.2016.07.012
- Wu G, Ruan C, Drouet L, Caen J. Inhibition effects of KRDS, a peptide derived from lactotransferrin, on platelet function and arterial thrombus formation in dogs. Haemostasis. 1992;22:1.
- Drouet L, Bal dit Sollier C, Cisse M, Pignaud G, Mazoyer E, et al. The antithrombotic effect of KRDS, a lactotransferrin peptide, compared with RGDS. Nouv Rev Fr Hematol (1978). 1990;32:59.
Data last updated:
