5/16/2025
Last update
5/16/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.6
USERS' SCORE
Good
Based on 10 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Lactoferrin (as Apolactoferrin)
250 mg
†
Top Medical Research Studies
9
Lactoferrin reduces cholesterol levels
We explored how enteric lactoferrin (eLF) affects cholesterol levels and atherosclerosis in Microminipigs fed a high-fat and high-cholesterol diet. Over eight weeks, eLF significantly lowered total and low-density lipoprotein (LDL) cholesterol levels, while high-density lipoprotein (HDL) levels remained unchanged. Additionally, eLF helped reduce the formation of atherosclerotic lesions in arteries. This suggests that eLF might support cholesterol metabolism by maintaining homeostasis affected by unhealthy diets. Overall, our findings indicate that eLF has potential benefits for preventing high cholesterol and related cardiovascular issues.
Read More
8
We explored the impact of lactoferrin (LF) on cholesterol management in rats fed a high-cholesterol diet. By investigating how LF interacts with bile acids, we found that it significantly increased the levels of fecal cholesterol excretion by 22% while simultaneously lowering liver cholesterol by 17%.
This suggests that LF effectively promotes cholesterol elimination from the body through its interactions with bile acids, making it a potential natural treatment for managing high cholesterol.
This suggests that LF effectively promotes cholesterol elimination from the body through its interactions with bile acids, making it a potential natural treatment for managing high cholesterol.
Read More
9
We explored the impact of lactoferrin (LF) on cholesterol levels in a mouse study. Mice on a high-fat, high-cholesterol diet were given water containing LF for eight weeks.
Our findings revealed that LF significantly boosted good cholesterol while slashing harmful liver cholesterol levels. It also enhanced bile acid metabolism, promoting cholesterol excretion.
Overall, LF showed promise in managing cholesterol and improving lipid metabolism, although further studies are needed to understand its full effectiveness in humans.
Our findings revealed that LF significantly boosted good cholesterol while slashing harmful liver cholesterol levels. It also enhanced bile acid metabolism, promoting cholesterol excretion.
Overall, LF showed promise in managing cholesterol and improving lipid metabolism, although further studies are needed to understand its full effectiveness in humans.
Read More
Most Useful Reviews
9
No side effects
26 people found this helpful
Highly recommend! My ferritin level was at 15, and I tried various iron supplements, which caused stomach issues and led to a maximum ferritin of 42 that quickly decreased after stopping. Lactoferin works on a different principle and contains no iron. It raised my ferritin to 50 within a month without side effects, and my stomach felt fine. I have taken 2 packs, and after about 6 months, my ferritin remains stable! Highly recommend.
Read More
9
Improved hemoglobin
5 people found this helpful
These capsules work excellently for my anaemic condition. I noticed significant benefits during my last blood test, as they help retain iron and have greatly improved my haemoglobin count. My doctor prescribed one capsule in the morning and evening for two months alongside iron, and they are easy to swallow and tasteless, demonstrating the high quality of the ingredients.
Read More
9
Reduced symptoms
4 people found this helpful
I took colostrum and lactoferrin regularly but ran out during a recent parasite infection, which brought on painful stomach symptoms. After ordering more, the pain and bloating subsided significantly within a few days. I’ve read that parasites feed off excess iron, and lactoferrin helps prevent that. Highly recommend! Jarrow consistently provides high-quality products, and these pills are easy to swallow.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.6
- All Researches
9
We explored the impact of lactoferrin (LF) on cholesterol levels in a mouse study. Mice on a high-fat, high-cholesterol diet were given water containing LF for eight weeks.
Our findings revealed that LF significantly boosted good cholesterol while slashing harmful liver cholesterol levels. It also enhanced bile acid metabolism, promoting cholesterol excretion.
Overall, LF showed promise in managing cholesterol and improving lipid metabolism, although further studies are needed to understand its full effectiveness in humans.
Our findings revealed that LF significantly boosted good cholesterol while slashing harmful liver cholesterol levels. It also enhanced bile acid metabolism, promoting cholesterol excretion.
Overall, LF showed promise in managing cholesterol and improving lipid metabolism, although further studies are needed to understand its full effectiveness in humans.
Read More
9
We investigated the impact of bovine lactoferrin (bLF) on antioxidant activity and cholesterol levels in rats fed a high-cholesterol diet. The study involved 44 rats divided into four groups, including a control and a treatment group receiving bLF.
After four weeks, we observed that bLF treatment significantly lowered LDL cholesterol and total cholesterol while raising HDL cholesterol. Additionally, levels of the harmful 8-isoprostane decreased. Overall, these findings suggest that bLF can help counteract some adverse effects of high cholesterol.
After four weeks, we observed that bLF treatment significantly lowered LDL cholesterol and total cholesterol while raising HDL cholesterol. Additionally, levels of the harmful 8-isoprostane decreased. Overall, these findings suggest that bLF can help counteract some adverse effects of high cholesterol.
Read More
9
Lactoferrin reduces cholesterol levels
We explored how enteric lactoferrin (eLF) affects cholesterol levels and atherosclerosis in Microminipigs fed a high-fat and high-cholesterol diet. Over eight weeks, eLF significantly lowered total and low-density lipoprotein (LDL) cholesterol levels, while high-density lipoprotein (HDL) levels remained unchanged. Additionally, eLF helped reduce the formation of atherosclerotic lesions in arteries. This suggests that eLF might support cholesterol metabolism by maintaining homeostasis affected by unhealthy diets. Overall, our findings indicate that eLF has potential benefits for preventing high cholesterol and related cardiovascular issues.
Read More
8
Bovine lactoferrin reduces cholesterol
We explored how bovine lactoferrin (bLF) impacts cholesterol levels in rats fed a high-cholesterol diet. In a structured study, male rats were split into groups, with some receiving bLF daily.
After four weeks, we observed that bLF significantly lowered harmful cholesterol levels and improved other markers such as homocysteine and leptin. Additionally, it helped increase beneficial cholesterol levels.
These findings suggest that bLF may be a promising treatment for those struggling with high cholesterol and related issues.
After four weeks, we observed that bLF significantly lowered harmful cholesterol levels and improved other markers such as homocysteine and leptin. Additionally, it helped increase beneficial cholesterol levels.
These findings suggest that bLF may be a promising treatment for those struggling with high cholesterol and related issues.
Read More
8
We explored the impact of lactoferrin (LF) on cholesterol management in rats fed a high-cholesterol diet. By investigating how LF interacts with bile acids, we found that it significantly increased the levels of fecal cholesterol excretion by 22% while simultaneously lowering liver cholesterol by 17%.
This suggests that LF effectively promotes cholesterol elimination from the body through its interactions with bile acids, making it a potential natural treatment for managing high cholesterol.
This suggests that LF effectively promotes cholesterol elimination from the body through its interactions with bile acids, making it a potential natural treatment for managing high cholesterol.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
No side effects
26 people found this helpful
Highly recommend! My ferritin level was at 15, and I tried various iron supplements, which caused stomach issues and led to a maximum ferritin of 42 that quickly decreased after stopping. Lactoferin works on a different principle and contains no iron. It raised my ferritin to 50 within a month without side effects, and my stomach felt fine. I have taken 2 packs, and after about 6 months, my ferritin remains stable! Highly recommend.
Read More
9
Improved hemoglobin
5 people found this helpful
These capsules work excellently for my anaemic condition. I noticed significant benefits during my last blood test, as they help retain iron and have greatly improved my haemoglobin count. My doctor prescribed one capsule in the morning and evening for two months alongside iron, and they are easy to swallow and tasteless, demonstrating the high quality of the ingredients.
Read More
9
Reduced symptoms
4 people found this helpful
I took colostrum and lactoferrin regularly but ran out during a recent parasite infection, which brought on painful stomach symptoms. After ordering more, the pain and bloating subsided significantly within a few days. I’ve read that parasites feed off excess iron, and lactoferrin helps prevent that. Highly recommend! Jarrow consistently provides high-quality products, and these pills are easy to swallow.
Read More
7.5
Less fatigue
2 people found this helpful
Highly recommend! I’ve been struggling with long COVID, and lactoferrin has been one of the few supplements that has helped in alleviating my fatigue and brain fog.
Read More
6
Improved communication
2 people found this helpful
Excellent! After taking this supplement, my communication skills have improved. My blood test also showed an increase in good cholesterol.
Read More
Frequently Asked Questions
2
No positive effect
1 people found this helpful
I purchased this here as it was cheaper than the Japanese version. However, I am uncertain about its effects, as my cholesterol levels remain high following the assessment. I don't think I will purchase it again.
9
No side effects
26 people found this helpful
Highly recommend! My ferritin level was at 15, and I tried various iron supplements, which caused stomach issues and led to a maximum ferritin of 42 that quickly decreased after stopping. Lactoferin works on a different principle and contains no iron. It raised my ferritin to 50 within a month without side effects, and my stomach felt fine. I have taken 2 packs, and after about 6 months, my ferritin remains stable! Highly recommend.
9
Improved hemoglobin
5 people found this helpful
These capsules work excellently for my anaemic condition. I noticed significant benefits during my last blood test, as they help retain iron and have greatly improved my haemoglobin count. My doctor prescribed one capsule in the morning and evening for two months alongside iron, and they are easy to swallow and tasteless, demonstrating the high quality of the ingredients.
9
Reduced symptoms
4 people found this helpful
I took colostrum and lactoferrin regularly but ran out during a recent parasite infection, which brought on painful stomach symptoms. After ordering more, the pain and bloating subsided significantly within a few days. I’ve read that parasites feed off excess iron, and lactoferrin helps prevent that. Highly recommend! Jarrow consistently provides high-quality products, and these pills are easy to swallow.
7.5
Less fatigue
2 people found this helpful
Highly recommend! I’ve been struggling with long COVID, and lactoferrin has been one of the few supplements that has helped in alleviating my fatigue and brain fog.
6
Improved communication
2 people found this helpful
Excellent! After taking this supplement, my communication skills have improved. My blood test also showed an increase in good cholesterol.
7.5
Boosted energy
7 people found this helpful
This additive is quite significant—though pricey, it's well worth it. I purchased it for an iron-boosting programme, taking it with iron and copper for better absorption. I suffer from low iron and feel immediate weakness when levels drop. I constantly follow programmes to enhance iron and accumulate ferritin reserves. My tests show a steady increase in ferritin, my health has improved, and I've regained energy.
9
We investigated the impact of bovine lactoferrin (bLF) on antioxidant activity and cholesterol levels in rats fed a high-cholesterol diet. The study involved 44 rats divided into four groups, including a control and a treatment group receiving bLF.
After four weeks, we observed that bLF treatment significantly lowered LDL cholesterol and total cholesterol while raising HDL cholesterol. Additionally, levels of the harmful 8-isoprostane decreased. Overall, these findings suggest that bLF can help counteract some adverse effects of high cholesterol.
After four weeks, we observed that bLF treatment significantly lowered LDL cholesterol and total cholesterol while raising HDL cholesterol. Additionally, levels of the harmful 8-isoprostane decreased. Overall, these findings suggest that bLF can help counteract some adverse effects of high cholesterol.
8
Bovine lactoferrin reduces cholesterol
We explored how bovine lactoferrin (bLF) impacts cholesterol levels in rats fed a high-cholesterol diet. In a structured study, male rats were split into groups, with some receiving bLF daily.
After four weeks, we observed that bLF significantly lowered harmful cholesterol levels and improved other markers such as homocysteine and leptin. Additionally, it helped increase beneficial cholesterol levels.
These findings suggest that bLF may be a promising treatment for those struggling with high cholesterol and related issues.
After four weeks, we observed that bLF significantly lowered harmful cholesterol levels and improved other markers such as homocysteine and leptin. Additionally, it helped increase beneficial cholesterol levels.
These findings suggest that bLF may be a promising treatment for those struggling with high cholesterol and related issues.
8
We explored the impact of lactoferrin (LF) on cholesterol management in rats fed a high-cholesterol diet. By investigating how LF interacts with bile acids, we found that it significantly increased the levels of fecal cholesterol excretion by 22% while simultaneously lowering liver cholesterol by 17%.
This suggests that LF effectively promotes cholesterol elimination from the body through its interactions with bile acids, making it a potential natural treatment for managing high cholesterol.
This suggests that LF effectively promotes cholesterol elimination from the body through its interactions with bile acids, making it a potential natural treatment for managing high cholesterol.
9
Lactoferrin reduces cholesterol levels
We explored how enteric lactoferrin (eLF) affects cholesterol levels and atherosclerosis in Microminipigs fed a high-fat and high-cholesterol diet. Over eight weeks, eLF significantly lowered total and low-density lipoprotein (LDL) cholesterol levels, while high-density lipoprotein (HDL) levels remained unchanged. Additionally, eLF helped reduce the formation of atherosclerotic lesions in arteries. This suggests that eLF might support cholesterol metabolism by maintaining homeostasis affected by unhealthy diets. Overall, our findings indicate that eLF has potential benefits for preventing high cholesterol and related cardiovascular issues.
References
- Ling CJ, Xu JY, Li YH, Tong X, Yang HH, et al. Lactoferrin promotes bile acid metabolism and reduces hepatic cholesterol deposition by inhibiting the farnesoid X receptor (FXR)-mediated enterohepatic axis. Food Funct. 2019;10:7299. 10.1039/c9fo01616c
- Faridvand Y, Nozari S, Asoudeh-Fard A, Karimi MA, Pezeshkian M, et al. Bovine lactoferrin ameliorates antioxidant esterase activity and 8-isoprostane levels in high-cholesterol-diet fed rats. Int J Vitam Nutr Res. 2017;87:201. 10.1024/0300-9831/a000516
- Nozari S, Fathi Maroufi N, Nouri M, Paytakhti Oskouei M, Shiralizade J, et al. Decreasing serum homocysteine and hypocholesterolemic effects of Bovine lactoferrin in male rat fed with high-cholesterol diet. J Cardiovasc Thorac Res. 2018;10:203. 10.15171/jcvtr.2018.35
- Nakamura K, Morishita S, Ono T, Murakoshi M, Sugiyama K, et al. Lactoferrin interacts with bile acids and increases fecal cholesterol excretion in rats. Biochem Cell Biol. 2017;95:142. 10.1139/bcb-2016-0052
- Morishita S, Kawaguchi H, Ono T, Miura N, Murakoshi M, et al. Enteric lactoferrin attenuates the development of high-fat and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis in Microminipigs. Biosci Biotechnol Biochem. 2016;80:295. 10.1080/09168451.2015.1091713
