Last update
5/26/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 5 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Lactoferrin (as Apolactoferrin)
250 mg
†
Top Medical Research Studies
8
Lactoferrin may treat stress-induced IBS
We explored how lactoferrin might alleviate symptoms of irritable bowel syndrome (IBS) by examining its effects on stress-induced colitis in Wistar rats. In our study, we used a chronic wrap-restraint stress model to simulate the psychological stress that contributes to IBS.
The rats were divided into four groups: naïve rats, those subjected to stress, and two groups that received either vitamin D or lactoferrin. Our findings indicated that both lactoferrin and vitamin D improved various health markers compared to the stressed rats. Notably, lactoferrin treatment resulted in enhanced social behavior, increased levels of beneficial interleukin-10, and improved autophagy in the colon.
Furthermore, lactoferrin demonstrated a remarkable ability to decrease inflammatory markers and stress levels, suggesting it may modulate the body’s response to the inflammation linked with IBS. The results indicate that lactoferrin could be more effective than vitamin D for treating stress-induced colitis, making it a promising nutritional supplement for those struggling with IBS.
The rats were divided into four groups: naïve rats, those subjected to stress, and two groups that received either vitamin D or lactoferrin. Our findings indicated that both lactoferrin and vitamin D improved various health markers compared to the stressed rats. Notably, lactoferrin treatment resulted in enhanced social behavior, increased levels of beneficial interleukin-10, and improved autophagy in the colon.
Furthermore, lactoferrin demonstrated a remarkable ability to decrease inflammatory markers and stress levels, suggesting it may modulate the body’s response to the inflammation linked with IBS. The results indicate that lactoferrin could be more effective than vitamin D for treating stress-induced colitis, making it a promising nutritional supplement for those struggling with IBS.
Read More
Most Useful Reviews
9
Comfortable digestion
10 people found this helpful
This supplement is excellent. After taking it with mastic gum, my stomach felt comfortable and my bowel movements became regular. For anyone struggling with bowel issues, I recommend taking lactoferrin, mastic gum, and butyrate on an empty stomach.
Read More
10
Great IBS Relief
5 people found this helpful
Combining Jarrow Formulas Lactoferrin with broccoli sprout extract has significantly improved my irritable bowel syndrome symptoms. I wholeheartedly recommend both for effective relief!
Read More
6
Moderate success
18 people found this helpful
This product, alongside goat colostrum, has aided in alleviating some bowel issues related to leaky gut, although I did not see an improvement in my iron levels, which was my primary concern initially.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
Lactoferrin may treat stress-induced IBS
We explored how lactoferrin might alleviate symptoms of irritable bowel syndrome (IBS) by examining its effects on stress-induced colitis in Wistar rats. In our study, we used a chronic wrap-restraint stress model to simulate the psychological stress that contributes to IBS.
The rats were divided into four groups: naïve rats, those subjected to stress, and two groups that received either vitamin D or lactoferrin. Our findings indicated that both lactoferrin and vitamin D improved various health markers compared to the stressed rats. Notably, lactoferrin treatment resulted in enhanced social behavior, increased levels of beneficial interleukin-10, and improved autophagy in the colon.
Furthermore, lactoferrin demonstrated a remarkable ability to decrease inflammatory markers and stress levels, suggesting it may modulate the body’s response to the inflammation linked with IBS. The results indicate that lactoferrin could be more effective than vitamin D for treating stress-induced colitis, making it a promising nutritional supplement for those struggling with IBS.
The rats were divided into four groups: naïve rats, those subjected to stress, and two groups that received either vitamin D or lactoferrin. Our findings indicated that both lactoferrin and vitamin D improved various health markers compared to the stressed rats. Notably, lactoferrin treatment resulted in enhanced social behavior, increased levels of beneficial interleukin-10, and improved autophagy in the colon.
Furthermore, lactoferrin demonstrated a remarkable ability to decrease inflammatory markers and stress levels, suggesting it may modulate the body’s response to the inflammation linked with IBS. The results indicate that lactoferrin could be more effective than vitamin D for treating stress-induced colitis, making it a promising nutritional supplement for those struggling with IBS.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Comfortable digestion
10 people found this helpful
This supplement is excellent. After taking it with mastic gum, my stomach felt comfortable and my bowel movements became regular. For anyone struggling with bowel issues, I recommend taking lactoferrin, mastic gum, and butyrate on an empty stomach.
Read More
10
Great IBS Relief
5 people found this helpful
Combining Jarrow Formulas Lactoferrin with broccoli sprout extract has significantly improved my irritable bowel syndrome symptoms. I wholeheartedly recommend both for effective relief!
Read More
6
Moderate success
18 people found this helpful
This product, alongside goat colostrum, has aided in alleviating some bowel issues related to leaky gut, although I did not see an improvement in my iron levels, which was my primary concern initially.
Read More
9
Consistency yields results
1 people found this helpful
I found this product effective for regular bowel movements and have been satisfied since switching from a higher dose. My bowel movements are now consistent thanks to this supplement, which has relieved some digestive issues.
Read More
2
Limited effectiveness observed
I started taking this to enhance my bowel movements and immunity; however, the results have been underwhelming. I felt increased hunger but noticed no impactful effects. I will monitor my progress and might give it another attempt if needed.
Read More
Frequently Asked Questions
9
Comfortable digestion
10 people found this helpful
This supplement is excellent. After taking it with mastic gum, my stomach felt comfortable and my bowel movements became regular. For anyone struggling with bowel issues, I recommend taking lactoferrin, mastic gum, and butyrate on an empty stomach.
8
Lactoferrin may treat stress-induced IBS
We explored how lactoferrin might alleviate symptoms of irritable bowel syndrome (IBS) by examining its effects on stress-induced colitis in Wistar rats. In our study, we used a chronic wrap-restraint stress model to simulate the psychological stress that contributes to IBS.
The rats were divided into four groups: naïve rats, those subjected to stress, and two groups that received either vitamin D or lactoferrin. Our findings indicated that both lactoferrin and vitamin D improved various health markers compared to the stressed rats. Notably, lactoferrin treatment resulted in enhanced social behavior, increased levels of beneficial interleukin-10, and improved autophagy in the colon.
Furthermore, lactoferrin demonstrated a remarkable ability to decrease inflammatory markers and stress levels, suggesting it may modulate the body’s response to the inflammation linked with IBS. The results indicate that lactoferrin could be more effective than vitamin D for treating stress-induced colitis, making it a promising nutritional supplement for those struggling with IBS.
The rats were divided into four groups: naïve rats, those subjected to stress, and two groups that received either vitamin D or lactoferrin. Our findings indicated that both lactoferrin and vitamin D improved various health markers compared to the stressed rats. Notably, lactoferrin treatment resulted in enhanced social behavior, increased levels of beneficial interleukin-10, and improved autophagy in the colon.
Furthermore, lactoferrin demonstrated a remarkable ability to decrease inflammatory markers and stress levels, suggesting it may modulate the body’s response to the inflammation linked with IBS. The results indicate that lactoferrin could be more effective than vitamin D for treating stress-induced colitis, making it a promising nutritional supplement for those struggling with IBS.
References
- Abdelmalak MFL, Abdelrahim DS, George Michael TMA, Abdel-Maksoud OM, Labib JMW. Vitamin D and lactoferrin attenuate stress-induced colitis in Wistar rats via enhancing AMPK expression with inhibiting mTOR-STAT3 signaling and modulating autophagy. Cell Biochem Funct. 2023;41:211. 10.1002/cbf.3774
