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In a study involving over 94,000 veterans, we found that those taking magnesium supplements experienced a lower risk of heart failure compared to nonusers. Specifically, 8.0% of supplement users developed heart failure, versus 9.7% of nonusers.
Furthermore, magnesium intake was linked to a reduced chance of major adverse cardiac events. However, it’s important to note that these findings need further investigation through randomized controlled trials.
Interestingly, we found that magnesium intake was linked to a significant reduction in 28-day mortality rates. This effect was most notable in older adults, women, and patients with high blood pressure. Despite these positive findings, magnesium treatment did lead to longer hospital and ICU stays.
Overall, magnesium shows promise as a supportive treatment for HFpEF, but further investigation is necessary to better understand its benefits and implications.
This suggests that maintaining adequate magnesium levels may help improve health outcomes for individuals with advanced kidney issues and an increased risk of cardiovascular problems.
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Interestingly, we found that magnesium intake was linked to a significant reduction in 28-day mortality rates. This effect was most notable in older adults, women, and patients with high blood pressure. Despite these positive findings, magnesium treatment did lead to longer hospital and ICU stays.
Overall, magnesium shows promise as a supportive treatment for HFpEF, but further investigation is necessary to better understand its benefits and implications.
This suggests that maintaining adequate magnesium levels may help improve health outcomes for individuals with advanced kidney issues and an increased risk of cardiovascular problems.
Our findings suggest that higher magnesium intake is associated with a lower risk of future cardiovascular issues and non-HDL cholesterol problems. This suggests that including magnesium-rich foods in our diets could promote heart health early in life.
However, both supplements showed promise in lowering SBP but did not seem to drastically change heart disease risk directly. Further studies will help confirm our results and refine dosage recommendations for better health outcomes.
By categorizing patients based on their calcium-magnesium levels at admission, we discovered that a higher calcium-to-magnesium ratio correlated with worse outcomes.
Our findings suggest that monitoring this ratio could help predict the prognosis for those dealing with ACS, emphasizing the importance of maintaining a balanced mineral intake for heart health.
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Frequently Asked Questions
Heart disease refers to a range of conditions that affect the heart's function and overall health. This umbrella term includes various cardiovascular issues such as coronary artery disease, which is caused by the buildup of plaque in the arteries; heart rhythm problems (arrhythmias); and heart defects present at birth (congenital heart defects). Additionally, heart disease encompasses conditions related to the heart muscle, such as cardiomyopathy, and the heart's valves, which might not open or close properly. The effects of heart disease can be significant, impacting not only physical health but also quality of life, making prevention and timely medical intervention crucial.
Several risk factors contribute to the development of heart disease, including high blood pressure, high cholesterol levels, diabetes, obesity, poor diet, physical inactivity, and smoking. Genetics also play a role, as heart disease can run in families. To mitigate the risks, healthcare professionals typically recommend lifestyle changes such as adopting a heart-healthy diet, engaging in regular physical activity, and avoiding tobacco use. For those already diagnosed with heart disease, treatment options can vary widely, ranging from lifestyle modifications to medications and, in severe cases, surgical interventions. Understanding the nature of heart disease and its risk factors is an essential step toward prevention and effective management.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium is an essential mineral that plays a critical role in cardiovascular health. Research suggests that adequate magnesium intake may help reduce the risk of heart disease by maintaining normal heart rhythm, regulating blood pressure, and supporting overall vascular health. Some studies have shown that higher magnesium levels are associated with lower rates of heart attack and stroke, indicating that this mineral might have a protective effect on the heart. Additionally, magnesium helps with the transport of potassium and calcium, both of which are vital for proper heart function.
However, while magnesium supplementation may benefit those who are deficient, it is important to note that it should not be seen as a standalone treatment for heart disease. Individuals with existing heart conditions should consult their healthcare providers before making any changes to their diet or supplementation regimen. Overall, maintaining a balanced diet rich in magnesium through food sources like leafy greens, nuts, seeds, and whole grains, combined with regular physical activity, may contribute to better heart health.
Based on user reviews, individuals taking magnesium supplements for heart health tend to report noticeable improvements in their condition within a few weeks of consistent use. One user noted that after a few weeks, they found it easier to focus, sleep better, and experienced an uplift in mood, which may indirectly influence heart health (Read Review). Another reviewer mentioned that regular use led to significant health improvements for their grandfather, though specific timelines were not outlined (Read Review).
Additionally, the benefits of magnesium are supported by its crucial role in various bodily functions, including blood pressure regulation and overall well-being, which suggests that users might start to feel better as the supplement begins to correct any deficiencies. Therefore, while results can vary, a period of a few weeks seems typical for users to begin feeling the positive effects of magnesium on heart health and general wellness.
Magnesium supplementation has garnered attention in recent studies concerning heart disease, particularly its potential benefits for specific populations. A significant study involving over 94,000 veterans indicated that diabetic patients taking magnesium supplements had a reduced risk of heart failure, reporting an incidence of 8.0% among users compared to 9.7% among nonusers. This suggests that magnesium might play a protective role against major cardiac issues, albeit further randomized controlled trials are necessary to solidify these findings [1]. Additionally, higher serum magnesium levels were associated with lower mortality from heart disease-related causes in patients with chronic kidney disease, again indicating a possible heart health benefit [2].
Further research shows that magnesium may improve blood sugar control and has a link to lower abnormal HbA1c levels in patients with coronary artery disease, suggesting a multifaceted benefit for heart health [3]. Moreover, in heart failure patients, magnesium supplementation has been linked to a significant reduction in short-term mortality rates, particularly in vulnerable groups such as older adults and those with high blood pressure [4]. While these findings are promising, the relationship between magnesium and heart disease is complex and requires more in-depth investigation to determine optimal dosages and treatment protocols.
Based on user reviews, many individuals report significant improvements in symptoms after incorporating magnesium supplements into their routines. One user noted that their persistent head shaking ceased and their sleep quality improved dramatically after adjusting their dosage to two capsules at night and one in the morning. They also felt calmer and more emotionally resilient, indicating a broader impact on their mental well-being (Read Review). Another reviewer highlighted cognitive benefits, stating that after a few weeks of taking magnesium, they found it easier to focus and also experienced an uplift in mood, which suggests that magnesium may enhance overall cognitive functionality as well (Read Review).
Additionally, users have reported improvements in physical health conditions, such as hypertension. One reviewer mentioned noticeable health improvements in their grandfather after he began taking magnesium regularly, reinforcing the idea that consistent use can lead to significant health benefits (Read Review). Users also commonly highlight magnesium's role in boosting energy and aiding memory and brain function, making it appealing for those seeking enhanced physical and cognitive health (Read Review). However, it's important to note that individual results can vary based on factors such as personal health status and supplement dosage.
Based on user reviews, there seems to be a consensus that combining magnesium supplements with other heart health strategies can lead to significant improvements. For instance, one user specifically mentioned that after their grandfather started taking magnesium regularly, his health markedly improved, highlighting magnesium's beneficial impact on hypertension and overall heart health (Read Review). Another user emphasized that magnesium plays a vital role in various bodily functions related to heart health, suggesting that individuals who are deficient may experience heightened risks of heart disease and other ailments (Read Review).
Users also reported cognitive and emotional benefits when incorporating magnesium into their routines, which may indirectly support heart health by reducing stress and anxiety levels (Read Review). Moreover, additional users pointed out that magnesium not only aids in energy production but also assists with muscle function and memory, which can be particularly advantageous for those on statin medications, making it a versatile supplement in conjunction with other heart disease management strategies (Read Review). Overall, users indicate that magnesium can be a complementary addition to other supplements targeted at heart disease.
Users report varying doses of Magnesium tailored to individual needs when it comes to treating heart disease and overall health. One user found success with a regimen of two capsules at night and one in the morning, indicating that starting with a lower dose and gradually increasing it may be effective (Read Review). Another user specifically pointed out that taking one to two capsules in the evening can aid in managing hypertension, suggesting that evening dosing might have particular benefits for heart health (Read Review).
Additionally, users emphasize the importance of magnesium in regulating bodily functions, such as blood pressure and muscle contraction, which are vital for heart health (Read Review). There’s a consensus that magnesium supplementation can be beneficial for those with dietary deficiencies, potentially reducing the risks associated with heart disease (Read Review). With proper dosing, users report not only improved heart health but also enhancements in mental well-being (Read Review).
In a study involving over 94,000 veterans, we found that those taking magnesium supplements experienced a lower risk of heart failure compared to nonusers. Specifically, 8.0% of supplement users developed heart failure, versus 9.7% of nonusers.
Furthermore, magnesium intake was linked to a reduced chance of major adverse cardiac events. However, it’s important to note that these findings need further investigation through randomized controlled trials.
This suggests that maintaining adequate magnesium levels may help improve health outcomes for individuals with advanced kidney issues and an increased risk of cardiovascular problems.
Interestingly, we found that magnesium intake was linked to a significant reduction in 28-day mortality rates. This effect was most notable in older adults, women, and patients with high blood pressure. Despite these positive findings, magnesium treatment did lead to longer hospital and ICU stays.
Overall, magnesium shows promise as a supportive treatment for HFpEF, but further investigation is necessary to better understand its benefits and implications.
References
- Cheng Y, Zullo AR, Yin Y, Shao Y, Liu S, et al. Nonprescription Magnesium Supplement Use and Risk of Heart Failure in Patients With Diabetes: A Target Trial Emulation. J Am Heart Assoc. 2025;14:e038870. doi:10.1161/JAHA.124.038870
- Moyano-Peregrin C, Rodelo-Haad C, Martín-Malo A, Muñoz-Castañeda JR, Ojeda R, et al. Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5. Clin Kidney J. 2025;18:sfae390. doi:10.1093/ckj/sfae390
- Dong H, Lu N, Wang J, Hu P. Serum magnesium, not calcium, is inversely associated with abnormal HbA1c concentrations in adults with coronary artery disease. Asia Pac J Clin Nutr. 2025;34:104. doi:10.6133/apjcn.202502_34(1).0010
- Song L, Ying J, Li M, Ying L, Zhao C. Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF. Sci Rep. 2025;15:1944. doi:10.1038/s41598-025-85931-1
- Sun L, Du J. Magnesium status, serum vitamin D concentration and mortality among congestive heart failure patients: a cohort study from NHANES 2007-2018. Magnes Res. 2024;37:61. doi:10.1684/mrh.2024.0528
- Song Q, Song L, Liu H, Tan H, Yang B, et al. Association of magnesium intake with predicted atherosclerotic lesions and cardiovascular risk in young adults based on PDAY score: a cross-sectional study. BMC Public Health. 2024;24:3232. doi:10.1186/s12889-024-20785-2
- Behers BJ, Behers BM, Stephenson-Moe CA, Vargas IA, Meng Z, et al. Magnesium and Potassium Supplementation for Systolic Blood Pressure Reduction in the General Normotensive Population: A Systematic Review and Subgroup Meta-Analysis for Optimal Dosage and Treatment Length. Nutrients. 2024;16. doi:10.3390/nu16213617
- Jiang Y, Luo B, Chen Y, Lu W, Peng Y, et al. Serum calcium-magnesium ratio at admission predicts adverse outcomes in patients with acute coronary syndrome. PLoS One. 2024;19:e0313352. doi:10.1371/journal.pone.0313352
- Wyss C, Gündling PW, Kostev K. Real world effectiveness of Hawthorn special extract WS 1442 in a retrospective cohort study from Germany. Sci Rep. 2024;14:22986. doi:10.1038/s41598-024-74325-4
- Seguchi M, Aytekin A, Xhepa E, Haude M, Wlodarczak A, et al. Vascular response following implantation of the third-generation drug-eluting resorbable coronary magnesium scaffold: an intravascular imaging analysis of the BIOMAG-I first-in-human study. EuroIntervention. 2024;20:e1173. doi:10.4244/EIJ-D-24-00055
- Zhang J, Chen Z, Rao L, He Y. Coronary bioresorbable metallic stents: Advancements and future perspectives. J Cardiol. 2025;85:69. doi:10.1016/j.jjcc.2024.08.003
- Copp KL, Steffen LM, Yi SY, Lutsey PL, Rebholz CM, et al. Magnesium-rich diet score is inversely associated with incident cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study. Eur J Prev Cardiol. 2025;32:386. doi:10.1093/eurjpc/zwae251
- Zhuang J, Zhang Q, Wang H, Su PH, Chen PY. Association between short-term changes in serum magnesium and in-hospital mortality following acute myocardial infarction: a cohort study based on the MIMIC database. Magnes Res. 2024;37:45. doi:10.1684/mrh.2024.0517
- Fruh V, Babalola T, Sears C, Wellenius GA, Webster TF, et al. Dietary Minerals and Incident Cardiovascular Outcomes among Never-Smokers in a Danish Case-Cohort Study. Int J Environ Res Public Health. 2024;21. doi:10.3390/ijerph21070932
- Tao J, Wang J, Peng H, Yuan Y, Lai H, et al. Association between serum phosphate, magnesium, calcium and aortic valve sclerosis: a propensity score-matched case-control study. Acta Cardiol. 2024;79:522. doi:10.1080/00015385.2024.2379682
- Zhang J, Sun D, Guo Y, Tong J, Liu Q, et al. Targeted delivery of black phosphorus nanosheets by ROS responsive complex hydrogel based on angiogenesis and antioxidant promotes myocardial infarction repair. J Nanobiotechnology. 2024;22:433. doi:10.1186/s12951-024-02685-0
