Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.7
USERS' SCORE
Good
Based on 13 Reviews
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₆ (as Pyridoxal 5-Phosphate)
2.5 mg
147%
Folate (800 mcg as 6S)-5MTHF-Methyltetrahydrofolate Glucosamine Salt)
1,360 mcg DFE‡
340%
Vitamin B12 (as Methylcobalamin)
5,000 mcg
208,330%
Top Medical Research Studies
9
We explored the impact of vitamin B12 treatment on individuals suffering from pernicious anemia, an autoimmune disorder that affects the body’s ability to absorb this essential vitamin. In a recent case report, a 51-year-old man from Uganda presented with lower limb weakness, which had returned after an earlier bout of vitamin B12 deficiency.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
Read More
9
We explored the intriguing case of a 56-year-old man diagnosed with Biermer's disease, also known as pernicious anemia, an autoimmune condition that leads to a lack of intrinsic factor and, consequently, vitamin B12 malabsorption. This patient presented with unusual symptoms: not just digestive concerns like melena, but also notable neurological effects such as memory issues and gait disturbances.
During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis—including gastroscopy, ultrasound, and blood tests—we initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.
The outcome of our intervention was promising, with significant clinical improvement observed in the patient’s condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.
During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis—including gastroscopy, ultrasound, and blood tests—we initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.
The outcome of our intervention was promising, with significant clinical improvement observed in the patient’s condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.
Read More
8
Vitamin B6 improves cognitive function
We conducted an intriguing study that looked into how vitamin B6 affects cognitive function in patients with Neuromyelitis Optica Spectrum Disorder (NMOSD). This autoimmune disorder often brings along cognitive challenges, so understanding potential dietary influences could be beneficial.
By surveying 24 NMOSD patients at Sina Hospital in Tehran, we gathered detailed dietary habits through a comprehensive food frequency questionnaire. The cognitive abilities of participants were assessed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery, which allowed us to evaluate their mental performance thoroughly.
Our findings were particularly interesting: we observed a positive correlation between the amount of dietary vitamin B6 consumed and cognitive function. Specifically, higher intake was linked to better performance in verbal and learning memory, as well as working memory and processing speed. This suggests that boosting vitamin B6 intake might help enhance cognitive functioning in NMOSD patients, which is encouraging given the prevalence of cognitive issues in this group.
Overall, our study opens up promising pathways for dietary intervention in managing cognitive impairment related to autoimmune disorders like NMOSD.
By surveying 24 NMOSD patients at Sina Hospital in Tehran, we gathered detailed dietary habits through a comprehensive food frequency questionnaire. The cognitive abilities of participants were assessed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery, which allowed us to evaluate their mental performance thoroughly.
Our findings were particularly interesting: we observed a positive correlation between the amount of dietary vitamin B6 consumed and cognitive function. Specifically, higher intake was linked to better performance in verbal and learning memory, as well as working memory and processing speed. This suggests that boosting vitamin B6 intake might help enhance cognitive functioning in NMOSD patients, which is encouraging given the prevalence of cognitive issues in this group.
Overall, our study opens up promising pathways for dietary intervention in managing cognitive impairment related to autoimmune disorders like NMOSD.
Read More
Most Useful Reviews
9
Normal homocysteine levels
10 people found this helpful
Reduced my homocysteine from 12 to 5.5. I'm very pleased as it's now perfect! I took these vitamins after a recommendation, and the results were remarkable. My mother is now trying them, as she also suffers from high homocysteine. I hope for her positive results too!
Read More
9
Enhanced mental health
2 people found this helpful
I’ve ordered these many times. They significantly helped raise my and my friends' B12 levels. One friend, who had been depressed for years, found that a lack of B12 and vitamin D was the issue. I’ve been taking them for three years now.
Read More
9
Balanced folate levels
1 people found this helpful
I took this medication during my pregnancy for a diagnosed folate cycle disorder and high homocysteine levels. Within three months, everything returned to normal, which was a relief.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.7
- All Researches
9.5
Vitamin B12 supplementation benefits autoimmune patients
We explored the impact of vitamin B12 on patients with autoimmune disorders, particularly those experiencing symptoms often attributed to their underlying conditions. The study presented three cases of individuals with neuropathic pain, depression, fatigue, and muscle weakness, who had their symptoms initially misattributed to rheumatic diseases.
Upon starting vitamin B12 supplementation, these patients showed nearly complete resolution of their symptoms, highlighting the potential benefits of this vitamin in treating related health issues. Interestingly, several participants did not display obvious deficiencies in vitamin B12 levels according to lab tests, suggesting that even those who appear to have sufficient levels could still benefit from supplementation.
Furthermore, we delved into research indicating the nerve-protective properties of vitamin B12, which could play a crucial role in managing pain and neuropathy associated with long-standing rheumatic diseases. Therefore, we recommend that healthcare providers consider checking vitamin B12 levels early in the diagnostic journey for autoimmune conditions, and think about offering supplementation regardless of laboratory findings.
Upon starting vitamin B12 supplementation, these patients showed nearly complete resolution of their symptoms, highlighting the potential benefits of this vitamin in treating related health issues. Interestingly, several participants did not display obvious deficiencies in vitamin B12 levels according to lab tests, suggesting that even those who appear to have sufficient levels could still benefit from supplementation.
Furthermore, we delved into research indicating the nerve-protective properties of vitamin B12, which could play a crucial role in managing pain and neuropathy associated with long-standing rheumatic diseases. Therefore, we recommend that healthcare providers consider checking vitamin B12 levels early in the diagnostic journey for autoimmune conditions, and think about offering supplementation regardless of laboratory findings.
Read More
9
We aimed to understand how high doses of vitamins B1, B6, and B12 might help improve vision in people suffering from relapsing-remitting multiple sclerosis (RRMS) who face persistent visual loss after acute optic neuritis. In our pilot study, we included sixteen patients who had been diagnosed with RRMS and had visual disabilities resulting from an earlier bout of optic neuritis. Each participant received a daily regimen of high-dose vitamins for 90 days, alongside their regular disease-modifying therapies.
Over the three-month follow-up, we noticed a significant improvement in visual acuity and foveal sensitivity threshold, suggesting that high doses of these B vitamins could play a role in enhancing visual function. The trends for other measures, such as mean deviation and pattern standard deviation in visual testing, were also promising. We found an interesting correlation: older patients had longer latency times in their visual processing but lower visual acuity at the follow-up. Crucially, we determined that the foveal sensitivity threshold was the main predictor of visual acuity improvement.
Although vitamin B6 was part of the combination treatment, it was challenging to pinpoint its individual effects. However, the collective results indicated that high-dose vitamin B treatment can be beneficial for visual function parameters in patients with MS-related visual issues.
Over the three-month follow-up, we noticed a significant improvement in visual acuity and foveal sensitivity threshold, suggesting that high doses of these B vitamins could play a role in enhancing visual function. The trends for other measures, such as mean deviation and pattern standard deviation in visual testing, were also promising. We found an interesting correlation: older patients had longer latency times in their visual processing but lower visual acuity at the follow-up. Crucially, we determined that the foveal sensitivity threshold was the main predictor of visual acuity improvement.
Although vitamin B6 was part of the combination treatment, it was challenging to pinpoint its individual effects. However, the collective results indicated that high-dose vitamin B treatment can be beneficial for visual function parameters in patients with MS-related visual issues.
Read More
9
We investigated the potential benefits of a treatment composed of advanced glycation end products inhibitors, which included vitamin B6, on patients with rheumatoid arthritis (RA). The study focused on how this combination therapy could enhance endothelial function in individuals suffering from this autoimmune disorder.
In a controlled research setup, 24 patients experiencing active RA despite standard treatments were given an AGEs inhibitor containing vitamins and other compounds. Over 12 weeks, we monitored various health indicators, including inflammatory markers and measures of endothelial function.
The results were promising. We noticed significant improvements in endothelial function, as indicated by enhanced vasodilation measures. Additionally, levels of inflammatory markers like ESR and CRP decreased notably, along with reductions in RA activity scores.
While vitamin B6 is included in the treatment mix, the study highlights the collective impact of the entire formulation on managing RA symptoms. This indicates the potential role that AGEs inhibitors, with vitamin B6 among other ingredients, can play in treating this challenging condition.
In a controlled research setup, 24 patients experiencing active RA despite standard treatments were given an AGEs inhibitor containing vitamins and other compounds. Over 12 weeks, we monitored various health indicators, including inflammatory markers and measures of endothelial function.
The results were promising. We noticed significant improvements in endothelial function, as indicated by enhanced vasodilation measures. Additionally, levels of inflammatory markers like ESR and CRP decreased notably, along with reductions in RA activity scores.
While vitamin B6 is included in the treatment mix, the study highlights the collective impact of the entire formulation on managing RA symptoms. This indicates the potential role that AGEs inhibitors, with vitamin B6 among other ingredients, can play in treating this challenging condition.
Read More
9
Folate's Role in Rheumatoid Arthritis
We explored the potential of folate-modified ginger-derived extracellular vesicles (FA-GDEVs) in treating rheumatoid arthritis (RA). This innovative approach aims to tackle the ongoing inflammation and joint damage that characterizes this autoimmune disorder. By using folate, which selectively targets specific receptors on inflammatory cells, we specifically directed these vesicles to M1 macrophages in inflamed joints.
Our findings show that FA-GDEVs can help encourage a shift from harmful M1 macrophages to a healing M2 phenotype. This shift is significant because M2 macrophages play a role in tissue repair and reducing inflammation. We also investigated how these vesicles activate the PI3K-AKT pathway, a crucial cellular pathway involved in regulating immune response.
In our in vivo studies, we noted that these folate-modified vesicles successfully concentrated in affected joints and led to a marked reduction in RA symptoms. Overall, it’s clear that FA-GDEVs present a promising therapeutic option for those suffering from rheumatoid arthritis, bringing together safety, affordability, and effectiveness in one approach.
Our findings show that FA-GDEVs can help encourage a shift from harmful M1 macrophages to a healing M2 phenotype. This shift is significant because M2 macrophages play a role in tissue repair and reducing inflammation. We also investigated how these vesicles activate the PI3K-AKT pathway, a crucial cellular pathway involved in regulating immune response.
In our in vivo studies, we noted that these folate-modified vesicles successfully concentrated in affected joints and led to a marked reduction in RA symptoms. Overall, it’s clear that FA-GDEVs present a promising therapeutic option for those suffering from rheumatoid arthritis, bringing together safety, affordability, and effectiveness in one approach.
Read More
9
We explored the impact of vitamin B12 treatment on individuals suffering from pernicious anemia, an autoimmune disorder that affects the body’s ability to absorb this essential vitamin. In a recent case report, a 51-year-old man from Uganda presented with lower limb weakness, which had returned after an earlier bout of vitamin B12 deficiency.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Normal homocysteine levels
10 people found this helpful
Reduced my homocysteine from 12 to 5.5. I'm very pleased as it's now perfect! I took these vitamins after a recommendation, and the results were remarkable. My mother is now trying them, as she also suffers from high homocysteine. I hope for her positive results too!
Read More
9
Enhanced mental health
2 people found this helpful
I’ve ordered these many times. They significantly helped raise my and my friends' B12 levels. One friend, who had been depressed for years, found that a lack of B12 and vitamin D was the issue. I’ve been taking them for three years now.
Read More
9
Balanced folate levels
1 people found this helpful
I took this medication during my pregnancy for a diagnosed folate cycle disorder and high homocysteine levels. Within three months, everything returned to normal, which was a relief.
Read More
9
Improved vitamin levels
They raised my B12 and B9 levels; the doctor prescribed them through the pharmacy, and I ordered from here. After the course, my analysis showed a good level of these vitamins. They performed wonderfully. I recommend it.
Read More
9
Good progress noted
I've been using this product for 1.5 years; my bloodwork shows good progress, and I feel excellent. iHerb shipped the order the day after I placed it, and it arrived promptly.
Read More
Frequently Asked Questions
9
Balanced folate levels
1 people found this helpful
I took this medication during my pregnancy for a diagnosed folate cycle disorder and high homocysteine levels. Within three months, everything returned to normal, which was a relief.
7.5
Improved energy levels
8 people found this helpful
I had a B12 deficiency, with levels as low as 150. After taking B12 capsules for 2 months, my level rose to 250. Following my doctor's advice, I continued with these vitamins for another 2 months, bringing my B12 to 800. My health improved significantly; I no longer suffer from daily headaches and feel much more energetic.
9
Good progress noted
I've been using this product for 1.5 years; my bloodwork shows good progress, and I feel excellent. iHerb shipped the order the day after I placed it, and it arrived promptly.
9
Normal homocysteine levels
10 people found this helpful
Reduced my homocysteine from 12 to 5.5. I'm very pleased as it's now perfect! I took these vitamins after a recommendation, and the results were remarkable. My mother is now trying them, as she also suffers from high homocysteine. I hope for her positive results too!
7.5
Restored wellbeing
3 people found this helpful
During a stressful period, I discovered my B12 was critically low at 112. After starting these vitamins, I noticed an improvement; my hair loss diminished, and my libido returned. I also learned to appreciate the cherry flavour. I intend to reorder and highly recommend them!
9
Enhanced mental health
2 people found this helpful
I’ve ordered these many times. They significantly helped raise my and my friends' B12 levels. One friend, who had been depressed for years, found that a lack of B12 and vitamin D was the issue. I’ve been taking them for three years now.
7.5
Effective methyl folate
1 people found this helpful
I previously ordered a different product with a lower dosage but needed these with a higher dosage for my elevated homocysteine. The methyl folate is well absorbed, unlike ordinary folic acid. After taking them, I observed noticeable results and am thoroughly satisfied.
8
We explored the effects of vitamin B6 on inflammation, particularly in relation to autoimmune disorders. The study focused on macrophages, which play a crucial role in our immune response. It found that vitamin B6 can significantly reduce the buildup of a substance called sphingosine-1-phosphate (S1P) in a way that depends on an enzyme known as sphingosine-1-phosphate lyase (SPL).
By promoting the activity of SPL, vitamin B6 helps lower the level of S1P in macrophages, which leads to decreased expression of pro-inflammatory cytokines. This means that vitamin B6 can effectively suppress some key signaling pathways in the body that drive inflammation.
In terms of practical benefits, we observed that mice receiving vitamin B6 supplementation were protected from severe endotoxic shock, a condition often tied to autoimmune reactions. Furthermore, it was noted that vitamin B6 can slow the progression of experimental autoimmune encephalomyelitis, a model for studying multiple sclerosis in humans.
Overall, these findings suggest that vitamin B6 has a promising role in managing excessive inflammation associated with autoimmune disorders, providing valuable insights for potential clinical applications.
By promoting the activity of SPL, vitamin B6 helps lower the level of S1P in macrophages, which leads to decreased expression of pro-inflammatory cytokines. This means that vitamin B6 can effectively suppress some key signaling pathways in the body that drive inflammation.
In terms of practical benefits, we observed that mice receiving vitamin B6 supplementation were protected from severe endotoxic shock, a condition often tied to autoimmune reactions. Furthermore, it was noted that vitamin B6 can slow the progression of experimental autoimmune encephalomyelitis, a model for studying multiple sclerosis in humans.
Overall, these findings suggest that vitamin B6 has a promising role in managing excessive inflammation associated with autoimmune disorders, providing valuable insights for potential clinical applications.
8
Vitamin B6 improves cognitive function
We conducted an intriguing study that looked into how vitamin B6 affects cognitive function in patients with Neuromyelitis Optica Spectrum Disorder (NMOSD). This autoimmune disorder often brings along cognitive challenges, so understanding potential dietary influences could be beneficial.
By surveying 24 NMOSD patients at Sina Hospital in Tehran, we gathered detailed dietary habits through a comprehensive food frequency questionnaire. The cognitive abilities of participants were assessed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery, which allowed us to evaluate their mental performance thoroughly.
Our findings were particularly interesting: we observed a positive correlation between the amount of dietary vitamin B6 consumed and cognitive function. Specifically, higher intake was linked to better performance in verbal and learning memory, as well as working memory and processing speed. This suggests that boosting vitamin B6 intake might help enhance cognitive functioning in NMOSD patients, which is encouraging given the prevalence of cognitive issues in this group.
Overall, our study opens up promising pathways for dietary intervention in managing cognitive impairment related to autoimmune disorders like NMOSD.
By surveying 24 NMOSD patients at Sina Hospital in Tehran, we gathered detailed dietary habits through a comprehensive food frequency questionnaire. The cognitive abilities of participants were assessed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery, which allowed us to evaluate their mental performance thoroughly.
Our findings were particularly interesting: we observed a positive correlation between the amount of dietary vitamin B6 consumed and cognitive function. Specifically, higher intake was linked to better performance in verbal and learning memory, as well as working memory and processing speed. This suggests that boosting vitamin B6 intake might help enhance cognitive functioning in NMOSD patients, which is encouraging given the prevalence of cognitive issues in this group.
Overall, our study opens up promising pathways for dietary intervention in managing cognitive impairment related to autoimmune disorders like NMOSD.
9
We explored a unique case involving a 54-year-old man who experienced symptoms that indicated both Guillain-Barré syndrome (GBS) and complications from autoimmune gastritis (AIG). Notably, he displayed progressive numbness and weakness along with gastrointestinal symptoms, which are often linked to vitamin B12 deficiency.
As part of his treatment, we utilized intravenous immunoglobulin alongside methylcobalamin, a form of vitamin B12. What was particularly interesting is that while the immunoglobulin treatment is typically aimed at addressing GBS, vitamin B12 was also administered to combat the neurological effects stemming from the deficiency due to AIG.
Our findings revealed that following these treatments, the patient showed significant clinical improvement before discharge. However, it's crucial to note that while vitamin B12 is commonly understood to aid neurological functions, the specific impact of its isolated use in this case remains unclear without additional studies focusing solely on its effectiveness in autoimmune disorders like GBS.
Overall, the integration of vitamin B12 treatment, particularly in the context of GBS and AIG, opens up discussions about managing similar cases in the future, although further research is necessary to firmly establish its benefits.
As part of his treatment, we utilized intravenous immunoglobulin alongside methylcobalamin, a form of vitamin B12. What was particularly interesting is that while the immunoglobulin treatment is typically aimed at addressing GBS, vitamin B12 was also administered to combat the neurological effects stemming from the deficiency due to AIG.
Our findings revealed that following these treatments, the patient showed significant clinical improvement before discharge. However, it's crucial to note that while vitamin B12 is commonly understood to aid neurological functions, the specific impact of its isolated use in this case remains unclear without additional studies focusing solely on its effectiveness in autoimmune disorders like GBS.
Overall, the integration of vitamin B12 treatment, particularly in the context of GBS and AIG, opens up discussions about managing similar cases in the future, although further research is necessary to firmly establish its benefits.
7
We explored the relationship between folate treatment and vitamin B12 status in patients with rheumatoid arthritis (RA) who were being treated with methotrexate. This study involved 50 RA patients on methotrexate and folic acid, compared against 49 patients receiving other treatments. The aim was to see how well these treatments supported vitamin B12 levels and affected homocysteine, a marker associated with cardiovascular risk.
Our findings revealed that while plasma vitamin B12 levels remained comparable between the two groups, those treated with methotrexate and folic acid exhibited higher plasma homocysteine levels. Elevated homocysteine can signal a potential vitamin B12 deficiency, which is a concern for those on methotrexate due to the medication's known side effects. This suggests that while folate is being administered, some patients might still be at risk of complications related to vitamin B12 levels.
In conclusion, the treatment regimen combining methotrexate with folic acid may not be enough to fully mitigate the risks associated with vitamin B12 deficiency in RA patients. Hence, additional research is essential to understand these interactions better and to assess the clinical signs that could arise from low B12 levels and hyperhomocysteinemia among this group.
Our findings revealed that while plasma vitamin B12 levels remained comparable between the two groups, those treated with methotrexate and folic acid exhibited higher plasma homocysteine levels. Elevated homocysteine can signal a potential vitamin B12 deficiency, which is a concern for those on methotrexate due to the medication's known side effects. This suggests that while folate is being administered, some patients might still be at risk of complications related to vitamin B12 levels.
In conclusion, the treatment regimen combining methotrexate with folic acid may not be enough to fully mitigate the risks associated with vitamin B12 deficiency in RA patients. Hence, additional research is essential to understand these interactions better and to assess the clinical signs that could arise from low B12 levels and hyperhomocysteinemia among this group.
References
- Du X, Yang Y, Zhan X, Huang Y, Fu Y, et al. Vitamin B6 prevents excessive inflammation by reducing accumulation of sphingosine-1-phosphate in a sphingosine-1-phosphate lyase-dependent manner. J Cell Mol Med. 2020;24:13129. 10.1111/jcmm.15917
- Mallone F, Lucchino L, Franzone F, Marenco M, Carlesimo SC, et al. High-dose vitamin B supplementation for persistent visual deficit in multiple sclerosis: a pilot study. Drug Discov Ther. 2020;14:122. 10.5582/ddt.2020.03031
- Rezaeimanesh N, Saeedi R, Sahraian MA, Razeghi Jahromi S, Naser Moghadasi A. The possible beneficial effects of higher vitamin B6 intake from diet on cognitive function of patients with neuromyelitis optica spectrum disorder. Mult Scler Relat Disord. 2020;42:102132. 10.1016/j.msard.2020.102132
- Sande JS, Ulvik A, Midttun Ø, Ueland PM, Hammer HB, et al. Vitamin B-6 Status Correlates with Disease Activity in Rheumatoid Arthritis Patients During Treatment with TNFα Inhibitors. J Nutr. 2019;149:770. 10.1093/jn/nxz001
- Syngle A, Vohra K, Garg N, Kaur L, Chand P. Advanced glycation end-products inhibition improves endothelial dysfunction in rheumatoid arthritis. Int J Rheum Dis. 2012;15:45. 10.1111/j.1756-185X.2011.01679.x
- Han R, Zhou D, Ji N, Yin Z, Wang J, et al. Folic acid-modified ginger-derived extracellular vesicles for targeted treatment of rheumatoid arthritis by remodeling immune microenvironment via the PI3K-AKT pathway. J Nanobiotechnology. 2025;23:41. 10.1186/s12951-025-03096-5
- Nasra S, Bhatia D, Kumar A. Targeted Macrophage Re-Programming: Synergistic Therapy With Methotrexate and RELA siRNA Folate-Liposome in RAW264.7 Cells and Arthritic Rats. Adv Healthc Mater. 2024;13:e2400679. 10.1002/adhm.202400679
- Pesqueda-Cendejas K, Parra-Rojas I, Campos-López B, Mora-García PE, Ruiz-Ballesteros AI, et al. Association of c.+677 C>T (rs1801133) and c.+1298 A>C (rs1801131) genetic variants with cardiometabolic and disease risk in systemic lupus erythematosus patients: A cross-sectional study. Lupus. 2024;33:918. 10.1177/09612033241257158
- Avalos-Salgado FA, Gonzalez-Lopez L, Gonzalez-Vazquez S, Ponce-Guarneros JM, Santiago-Garcia AP, et al. Risk Factors Associated with Adverse Events Leading to Methotrexate Withdrawal in Elderly Rheumatoid Arthritis Patients: A Retrospective Cohort Study. J Clin Med. 2024;13. 10.3390/jcm13071863
- Patel AV, Morgan SL, Green R, Danila MI, Merriman TR, et al. Vitamin B12 status and hyperhomocysteinemia in patients with Rheumatoid arthritis treated with methotrexate and folic acid. Am J Med Sci. 2024;368:33. 10.1016/j.amjms.2024.03.020
- Wells L, O'Hara N, Frye RE, Hullavard N, Smith E. Folate Receptor Alpha Autoantibodies in the Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) Population. J Pers Med. 2024;14. 10.3390/jpm14020166
- Ma XY, Hao Y, Xie YH, Cao Q, Sun DF, et al. Risk Factors Analysis and Predictive Model Construction for Autoimmune Gastritis: A Nationwide Multicenter Case-Control Study in China. J Gastroenterol Hepatol. 2025. 10.1111/jgh.16912
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. 10.1186/s13256-025-05095-4
- Subtil J, Carvalho R, Rebelo AF, Subtil P. Autoimmune Polyglandular Syndrome Type 3: A Case Report. Cureus. 2024;16:e76152. 10.7759/cureus.76152
- Mansour M, Shamasnah A, Alsaadi D, Abu Saif S, Krama A. Evans syndrome as a presentation in systemic lupus erythematous, coexisting with Hashimoto's thyroiditis and pernicious anemia: a case report. J Med Case Rep. 2024;18:643. 10.1186/s13256-024-05002-3
- Hijjawi N, Tout FS, Azaizeh B, Aljaafreh B. The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review. Clin Rheumatol. 2025;44:591. 10.1007/s10067-024-07285-9
- Lang C, Huang P, Gao J, Chen Y, He Z. Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review. BMC Pediatr. 2024;24:817. 10.1186/s12887-024-05262-4
- Xiang H, Cai M. Coexistence of Guillain-Barré Syndrome and Subacute Combined Degeneration of the Spinal Cord Due to Autoimmune Gastritis: A Case Report and Literature Review. Cureus. 2024;16:e63084. 10.7759/cureus.63084
- Pluvinage JV, Ngo T, Fouassier C, McDonagh M, Holmes BB, et al. Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency. Sci Transl Med. 2024;16:eadl3758. 10.1126/scitranslmed.adl3758
- Haddad F, Boukhal Z, El Rhaoussi FZ, Tahiri M, Hliwa W, et al. Neurological and Cardiovascular Complications Revealing Biermer's Disease: A Case Report. Cureus. 2024;16:e58601. 10.7759/cureus.58601
- Fernandez I, Touzot F. Looking for ALPS: The value of a combined assessment of biochemical markers. Pediatr Allergy Immunol. 2024;35:e14135. 10.1111/pai.14135
- Yamada H, Toko M, Nakamori M, Ueno H, Aoki S, et al. Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging. J Neurovirol. 2024;30:197. 10.1007/s13365-024-01203-0
- Yang CW, Hsu HY, Lee YZ, Lee SJ. Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice. Biochem Biophys Res Commun. 2024;704:149668. 10.1016/j.bbrc.2024.149668
- Dułak NA, Rytlewska M, Jaskólska M, Chmielewski M. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review. Rheumatol Int. 2024;44:737. 10.1007/s00296-024-05539-y
