Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.9
USERS' SCORE
Good
Based on 4 Reviews
8.8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₆ (as Pyridoxal 5-Phosphate)
2.5 mg
147%
Folate (800 mcg as 6S)-5MTHF-Methyltetrahydrofolate Glucosamine Salt)
1,360 mcg DFE‡
340%
Vitamin B12 (as Methylcobalamin)
5,000 mcg
208,330%
Top Medical Research Studies
9
We investigated how folic acid affects blood clotting, particularly when exposed to carbon black (CB), a common industrial substance. In our study with adult C57BL/6 mice, we found that prolonged exposure to CB led to increased blood clotting potential due to changes in the spleen, where extra blood cell production occurs.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
8
We examined the case of a healthy 12-year-old girl who experienced a central retinal vein occlusion. This incident was particularly notable because she later developed retinal neovascularization at the age of 24. This timing marks the longest gap reported between such a pediatric event and subsequent complications.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
8
We observed a 74-year-old female patient who sought help for unilateral vision reduction attributed to cystoid macular edema and retinal venous stasis. During our examination, we noted her visual acuity was reduced in the affected left eye. Further investigation through imaging techniques confirmed her diagnosis and revealed systemic issues related to elevated homocysteine levels.
The relationship between homocysteine and vascular complications made us consider hyperhomocysteinemia as a significant risk factor for her condition. We were particularly interested in how addressing her elevated homocysteine with folate—commonly known for its role in blood health—could impact her treatment.
The patient was treated with anti-vascular endothelial growth factor (VEGF) injections and prescribed oral folic acid for life to manage her condition. We were pleased to see her vision improve significantly and maintain stability for an extended period. However, when cystoid macular edema returned, she received additional intravitreal injections, indicating ongoing vigilance was necessary.
Ultimately, our findings suggest that while folate may contribute positively to managing blood clot risks, particularly in the context of hyperhomocysteinemia, its effects can be complicated by the combined treatment of anti-VEGF injections, highlighting the complexity of such cases.
The relationship between homocysteine and vascular complications made us consider hyperhomocysteinemia as a significant risk factor for her condition. We were particularly interested in how addressing her elevated homocysteine with folate—commonly known for its role in blood health—could impact her treatment.
The patient was treated with anti-vascular endothelial growth factor (VEGF) injections and prescribed oral folic acid for life to manage her condition. We were pleased to see her vision improve significantly and maintain stability for an extended period. However, when cystoid macular edema returned, she received additional intravitreal injections, indicating ongoing vigilance was necessary.
Ultimately, our findings suggest that while folate may contribute positively to managing blood clot risks, particularly in the context of hyperhomocysteinemia, its effects can be complicated by the combined treatment of anti-VEGF injections, highlighting the complexity of such cases.
Most Useful Reviews
9.5
Preventing blood clots
My husband takes this supplement an hour after breakfast to reduce homocysteine levels. It combines active folate and vitamin B12 in one pill. The sublingual form is ideal for B vitamins, as excess homocysteine can lead to blood clots. Therefore, we keep a close eye on it and take steps to prevent any serious issues like strokes or heart attacks.
9.5
Restored health
This supplement transformed my life! I discovered my B12 and folate levels were critically low. After starting this, I noticed a significant improvement; my libido returned, and hair loss decreased. Despite initially disliking the cherry taste, I've grown fond of it and reordered. I haven't retested my levels yet, but I'm confident in this product's effectiveness against blood clots.
9.5
Effective for clots
I purchased this for my elderly father, who has issues with blood clots and elevated homocysteine levels. He finds it sweet like candy, and it caused no negative reactions, even with his liver problems. The dosage of active folate is excellent, and the absorption method enhances vitamin assimilation. I will definitely order more.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.9
- All Researches
9.5
We explored the effects of high serum homocysteine levels on blood clot risks within a group of 1,014 patients who experienced thrombotic events. This group underwent a thorough evaluation for various thrombophilic conditions. Notably, we found that 12% of these patients had treatable high homocysteine levels.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
9
We explored the connection between vitamin levels and cerebral venous sinus thrombosis (CVST), particularly focusing on vitamin B6. Our case series documented three instances of CVST where patients presented with headaches, and two experienced additional symptoms like visual disturbances.
In our findings, we noted that two of these patients had notably low levels of vitamin B12, alongside the presence of hyperhomocysteinemia (hHcy). Treatment included low-molecular-weight heparin and supplements of vitamins B6, B9, and B12.
While vitamin B6 was used as part of the supplementation strategy, the specific impact of vitamin B6 alone on blood clotting wasn't thoroughly isolated in this study. All patients showed positive responses to the treatment, with follow-up imaging indicating resolution of the thrombosis in two cases.
This suggests that addressing vitamin deficiencies, particularly in those on vegetarian diets, is vital. Nevertheless, further dedicated research is necessary to determine the isolated effect of vitamin B6 on blood clots.
In our findings, we noted that two of these patients had notably low levels of vitamin B12, alongside the presence of hyperhomocysteinemia (hHcy). Treatment included low-molecular-weight heparin and supplements of vitamins B6, B9, and B12.
While vitamin B6 was used as part of the supplementation strategy, the specific impact of vitamin B6 alone on blood clotting wasn't thoroughly isolated in this study. All patients showed positive responses to the treatment, with follow-up imaging indicating resolution of the thrombosis in two cases.
This suggests that addressing vitamin deficiencies, particularly in those on vegetarian diets, is vital. Nevertheless, further dedicated research is necessary to determine the isolated effect of vitamin B6 on blood clots.
9
We explored the intriguing case of a 30-year-old woman who experienced severe headaches and neurological symptoms, later linked to blood clotting issues. Initially diagnosed with suspected viral encephalopathy, she faced multiple health challenges including a pulmonary embolism and persistent migraines.
After undergoing various investigations, her doctors discovered she had a dangerously high homocysteine level of over 350 μmol/L, indicating a metabolic disorder known as homocystinuria due to cystathionine β-synthase deficiency. This condition is typically identified in childhood, making her case particularly unusual.
To tackle her elevated homocysteine, a treatment plan involving vitamin B6 (pyridoxine) and betaine was implemented. Remarkably, this approach successfully normalized her homocysteine levels, and she has since avoided any further thrombotic events. Though vitamin B6 is a key player in her treatment, it was administered alongside betaine, which complicates isolating the effects of B6 on blood clot prevention alone.
After undergoing various investigations, her doctors discovered she had a dangerously high homocysteine level of over 350 μmol/L, indicating a metabolic disorder known as homocystinuria due to cystathionine β-synthase deficiency. This condition is typically identified in childhood, making her case particularly unusual.
To tackle her elevated homocysteine, a treatment plan involving vitamin B6 (pyridoxine) and betaine was implemented. Remarkably, this approach successfully normalized her homocysteine levels, and she has since avoided any further thrombotic events. Though vitamin B6 is a key player in her treatment, it was administered alongside betaine, which complicates isolating the effects of B6 on blood clot prevention alone.
9
We observed a fascinating case involving a 14-year-old girl who experienced severe headaches and nausea, leading to the discovery of cerebral venous thrombosis (CVT) and significantly elevated plasma homocysteine levels. Through comprehensive genetic testing, we identified a rare genetic change called loss of heterozygosity (LOH) affecting the methylenetetrahydrofolate reductase (MTHFR) gene, which plays a crucial role in processing folate in the body.
In treating the patient, we included supplementary folate along with anticoagulants to manage the thrombosis. While we noted improvements in her symptoms and a decrease in thrombosis severity, it is essential to recognize that the isolated effect of folate on blood clotting cannot be fully established due to the concurrent use of anticoagulants and other vitamin supplements. Therefore, while folate forms part of the treatment, its direct impact on clot formation requires further investigation.
The combination of anticoagulants, nutritional supplements, and genetic insights showcases an integrated approach to managing complex medical issues, highlighting that while folate is beneficial, its role is part of a broader strategy.
In treating the patient, we included supplementary folate along with anticoagulants to manage the thrombosis. While we noted improvements in her symptoms and a decrease in thrombosis severity, it is essential to recognize that the isolated effect of folate on blood clotting cannot be fully established due to the concurrent use of anticoagulants and other vitamin supplements. Therefore, while folate forms part of the treatment, its direct impact on clot formation requires further investigation.
The combination of anticoagulants, nutritional supplements, and genetic insights showcases an integrated approach to managing complex medical issues, highlighting that while folate is beneficial, its role is part of a broader strategy.
9
We investigated how folic acid affects blood clotting, particularly when exposed to carbon black (CB), a common industrial substance. In our study with adult C57BL/6 mice, we found that prolonged exposure to CB led to increased blood clotting potential due to changes in the spleen, where extra blood cell production occurs.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.8
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Preventing blood clots
My husband takes this supplement an hour after breakfast to reduce homocysteine levels. It combines active folate and vitamin B12 in one pill. The sublingual form is ideal for B vitamins, as excess homocysteine can lead to blood clots. Therefore, we keep a close eye on it and take steps to prevent any serious issues like strokes or heart attacks.
9.5
Restored health
This supplement transformed my life! I discovered my B12 and folate levels were critically low. After starting this, I noticed a significant improvement; my libido returned, and hair loss decreased. Despite initially disliking the cherry taste, I've grown fond of it and reordered. I haven't retested my levels yet, but I'm confident in this product's effectiveness against blood clots.
9.5
Effective for clots
I purchased this for my elderly father, who has issues with blood clots and elevated homocysteine levels. He finds it sweet like candy, and it caused no negative reactions, even with his liver problems. The dosage of active folate is excellent, and the absorption method enhances vitamin assimilation. I will definitely order more.
9.5
Life-changing treatment
No more insomnia, anxiety or depression!!! I have homozygous MTHFR C677T, blood clots, anxiety, depression, and insomnia. After trying countless medicines and herbs, I decided to try methylated B vitamins in despair. After ONE WEEK, I am sleeping! My mood has drastically improved, and the leg that had DVTs feels normal. This is the only treatment that has made such a significant change to my life, and I believe it's truly what I needed. Thank you, Jarrow – I am now a customer for life!
Frequently Asked Questions
9.5
Restored health
This supplement transformed my life! I discovered my B12 and folate levels were critically low. After starting this, I noticed a significant improvement; my libido returned, and hair loss decreased. Despite initially disliking the cherry taste, I've grown fond of it and reordered. I haven't retested my levels yet, but I'm confident in this product's effectiveness against blood clots.
9.5
Effective for clots
I purchased this for my elderly father, who has issues with blood clots and elevated homocysteine levels. He finds it sweet like candy, and it caused no negative reactions, even with his liver problems. The dosage of active folate is excellent, and the absorption method enhances vitamin assimilation. I will definitely order more.
9.5
Preventing blood clots
My husband takes this supplement an hour after breakfast to reduce homocysteine levels. It combines active folate and vitamin B12 in one pill. The sublingual form is ideal for B vitamins, as excess homocysteine can lead to blood clots. Therefore, we keep a close eye on it and take steps to prevent any serious issues like strokes or heart attacks.
8
We looked into the effects of Vitamin B6, along with B12 and folic acid, on the risk of blood clots among Indian soldiers stationed at high altitudes. This study aimed to find out if these vitamins could lower homocysteine levels—an amino acid linked to an increased risk of thrombosis.
In a well-structured randomized field trial, 12,000 soldiers taking these vitamins were compared to another group receiving no intervention. After one year, we saw promising results: the soldiers who took the Vitamin B complex maintained healthier levels of homocysteine, plasminogen activator inhibitor (PAI 1), and fibrinogen, while their nitric oxide levels increased.
Most importantly, over two years, only five thrombotic episodes occurred in the intervention group compared to 17 in the control group. This indicates a clear protective effect of the vitamin regimen against thrombosis. Although the study did assess Vitamin B6 alongside B12 and folic acid, it points to its potential relevance in reducing blood clot risks in high-altitude conditions.
In a well-structured randomized field trial, 12,000 soldiers taking these vitamins were compared to another group receiving no intervention. After one year, we saw promising results: the soldiers who took the Vitamin B complex maintained healthier levels of homocysteine, plasminogen activator inhibitor (PAI 1), and fibrinogen, while their nitric oxide levels increased.
Most importantly, over two years, only five thrombotic episodes occurred in the intervention group compared to 17 in the control group. This indicates a clear protective effect of the vitamin regimen against thrombosis. Although the study did assess Vitamin B6 alongside B12 and folic acid, it points to its potential relevance in reducing blood clot risks in high-altitude conditions.
9
We explored the intriguing case of a 30-year-old woman who experienced severe headaches and neurological symptoms, later linked to blood clotting issues. Initially diagnosed with suspected viral encephalopathy, she faced multiple health challenges including a pulmonary embolism and persistent migraines.
After undergoing various investigations, her doctors discovered she had a dangerously high homocysteine level of over 350 μmol/L, indicating a metabolic disorder known as homocystinuria due to cystathionine β-synthase deficiency. This condition is typically identified in childhood, making her case particularly unusual.
To tackle her elevated homocysteine, a treatment plan involving vitamin B6 (pyridoxine) and betaine was implemented. Remarkably, this approach successfully normalized her homocysteine levels, and she has since avoided any further thrombotic events. Though vitamin B6 is a key player in her treatment, it was administered alongside betaine, which complicates isolating the effects of B6 on blood clot prevention alone.
After undergoing various investigations, her doctors discovered she had a dangerously high homocysteine level of over 350 μmol/L, indicating a metabolic disorder known as homocystinuria due to cystathionine β-synthase deficiency. This condition is typically identified in childhood, making her case particularly unusual.
To tackle her elevated homocysteine, a treatment plan involving vitamin B6 (pyridoxine) and betaine was implemented. Remarkably, this approach successfully normalized her homocysteine levels, and she has since avoided any further thrombotic events. Though vitamin B6 is a key player in her treatment, it was administered alongside betaine, which complicates isolating the effects of B6 on blood clot prevention alone.
9.5
We explored the effects of high serum homocysteine levels on blood clot risks within a group of 1,014 patients who experienced thrombotic events. This group underwent a thorough evaluation for various thrombophilic conditions. Notably, we found that 12% of these patients had treatable high homocysteine levels.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
8
We explored the effectiveness of vitamin B6 in treating patients suffering from pulmonary thromboembolism linked to deficiencies in protein C (PC) and protein S (PS). In our analysis of two male patients, we found that they presented with common symptoms such as lower limb pain, chest pain, and even decreased vision.
Using color Doppler flow imaging, we identified lower deep venous thrombosis in both cases, while multislice CT angiography revealed pulmonary embolism. Interestingly, both patients had decreased levels of plasma PC and PS alongside elevated homocysteine levels. After recognizing their deficiencies, we introduced vitamin B6 along with anticoagulant therapy to manage their symptoms.
The incorporation of vitamin B6 appeared to significantly improve the patients’ conditions, indicating a potentially beneficial role in such cases. It highlights the importance of considering congenital thrombophilia and its treatment options for young patients experiencing recurrent blood clots without clear causes. Overall, vitamin B6 might enhance treatment outcomes in managing blood clots associated with these specific deficiencies.
Using color Doppler flow imaging, we identified lower deep venous thrombosis in both cases, while multislice CT angiography revealed pulmonary embolism. Interestingly, both patients had decreased levels of plasma PC and PS alongside elevated homocysteine levels. After recognizing their deficiencies, we introduced vitamin B6 along with anticoagulant therapy to manage their symptoms.
The incorporation of vitamin B6 appeared to significantly improve the patients’ conditions, indicating a potentially beneficial role in such cases. It highlights the importance of considering congenital thrombophilia and its treatment options for young patients experiencing recurrent blood clots without clear causes. Overall, vitamin B6 might enhance treatment outcomes in managing blood clots associated with these specific deficiencies.
References
- Baby N, George M, Rajasekharan A, Ajith S, Zabeer M, et al. Cerebral Venous Sinus Thrombosis Secondary to Vitamin B12 Deficiency - A Case Series with Emphasis on Food Fortification. Ann Afr Med. 2024;23:496. doi:10.4103/aam.aam_138_23
- Woods E, Dawson C, Senthil L, Geberhiwot T. Cerebral venous thrombosis as the first presentation of classical homocystinuria in an adult patient. BMJ Case Rep. 2017;2017. doi:10.1136/bcr-2016-217477
- Kotwal J, Kotwal A, Bhalla S, Singh PK, Nair V. Effectiveness of homocysteine lowering vitamins in prevention of thrombotic tendency at high altitude area: A randomized field trial. Thromb Res. 2015;136:758. doi:10.1016/j.thromres.2015.08.001
- Glueck CJ, Smith D, Gandhi N, Hemachandra K, Shah P, et al. Treatable high homocysteine alone or in concert with five other thrombophilias in 1014 patients with thrombotic events. Blood Coagul Fibrinolysis. 2015;26:736. doi:10.1097/MBC.0000000000000276
- Awan Z, Aljenedil S, Rosenblatt DS, Cusson J, Gilfix BM, et al. Severe hyperhomocysteinemia due to cystathionine β-synthase deficiency, and Factor V Leiden mutation in a patient with recurrent venous thrombosis. Thromb J. 2014;12:30. doi:10.1186/s12959-014-0030-0
- Liu F, Zhu L, Chen P, Shi Z, Liu S. [Two cases of pulmonary thromboembolism associated with protein C and protein S deficiency and literature review]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013;38:971. doi:10.3969/j.issn.1672-7347.2013.09.018
- Mendiratta V, Prakash A, Jain A, Jain M. Isolated distal cutaneous thrombosis: an unusual presentation and an interesting etiology. Indian J Dermatol Venereol Leprol. 2011;77:494. doi:10.4103/0378-6323.82412
- Dworakowska D, Kazimierska E, Weyer-Hepka J, Dworakowski R, Jakóbiewicz-Banecka J, et al. [Hyperhomocysteinemia complicated by myocardial infarction and portal vein thrombosis--case report]. Pol Arch Med Wewn. 2006;115:234.
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. doi:10.1186/s12883-023-03200-y
- Cao Y, Yao T, Chen H, Liu H, Li C, et al. The association of serum folate and homocysteine on venous thromboembolism in patients with colorectal cancer: a cross-sectional study. Transl Cancer Res. 2023;12:125. doi:10.21037/tcr-22-2839
- Lin SS, Fan IW, Chen CY, Su YJ. A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report. Med Int (Lond). 2022;2:20. doi:10.3892/mi.2022.45
- Sikora M, Skrzydlewski P, Perła-Kaján J, Jakubowski H. Homocysteine thiolactone contributes to the prognostic value of fibrin clot structure/function in coronary artery disease. PLoS One. 2022;17:e0275956. doi:10.1371/journal.pone.0275956
- Tu YR, Tu KH, Lee CC, Fan PC, Yen CL, et al. Supplementation with Folic Acid and Cardiovascular Outcomes in End-Stage Kidney Disease: A Multi-Institution Cohort Study. Nutrients. 2022;14. doi:10.3390/nu14194162
- Hudson JL, Laura DM, Berrocal AM. CENTRAL RETINAL VEIN OCCLUSION IN 12-YEAR-OLD GIRL WITH METHYLENETETRAHYDROFOLATE REDUCTASE MUTATION: A CASE REPORT AND REVIEW OF THE LITERATURE. Retin Cases Brief Rep. 2023;17:734. doi:10.1097/ICB.0000000000001283
- Chaloulis SK, Tsaousis KT. Cystoid Macular Edema Associated With Venous Stasis in a Patient With Previously Undiagnosed Hyperhomocysteinemia. Cureus. 2021;13:e20782. doi:10.7759/cureus.20782
- Meng Q, Li B, Huang N, Wei S, Ren Q, et al. Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential. J Hazard Mater. 2022;424:127354. doi:10.1016/j.jhazmat.2021.127354
- Mohamed Yile MEH, Berteau E, Ramdani N, Mouyen T, Ferrier N. Uncommon Thromboembolic Events in Young Adults: A Rare Cause Uncovered. Cureus. 2025;17:e76962. doi:10.7759/cureus.76962
- Baby N, George M, Rajasekharan A, Ajith S, Zabeer M, et al. Cerebral Venous Sinus Thrombosis Secondary to Vitamin B12 Deficiency - A Case Series with Emphasis on Food Fortification. Ann Afr Med. 2024;23:496. doi:10.4103/aam.aam_138_23
- Haddad F, Boukhal Z, El Rhaoussi FZ, Tahiri M, Hliwa W, et al. Neurological and Cardiovascular Complications Revealing Biermer's Disease: A Case Report. Cureus. 2024;16:e58601. doi:10.7759/cureus.58601
- Khaliq L, Kabir KF, Pyai K, Hadid T, Collins-Hamel B. A Simple Vitamin Deficiency With Life-Threatening Complications: A Case of B12 Deficiency and Hyperhomocysteinemia-Induced Thrombosis. Cureus. 2023;15:e42908. doi:10.7759/cureus.42908
- Banjongjit A, Sutamnartpong P, Mahanupap P, Phanachet P, Thanakitcharu S. Nitrous Oxide-Induced Cerebral Venous Thrombosis: A Case Report, Potential Mechanisms, and Literature Review. Cureus. 2023;15:e41428. doi:10.7759/cureus.41428
- Lin SS, Fan IW, Chen CY, Su YJ. A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report. Med Int (Lond). 2022;2:20. doi:10.3892/mi.2022.45
- Mochizuki T, Ryu B, Kushi K, Shima S, Sato S, et al. Cerebral venous thrombosis associated with hyperhomocysteinemia and iron-deficiency anemia induced by autoimmune gastritis: A case report and literature review. Neuroradiol J. 2023;36:491. doi:10.1177/19714009221147224
- Landry I, Chowdhury T, Hussein S, Thomas L. Life-Threatening Microangiopathy or Vitamin Deficiency: A Case Report of the Clinical Manifestations of Pseudo-Thrombotic Microangiopathic Anemia. Cureus. 2021;13:e20228. doi:10.7759/cureus.20228
