Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₆ (as Pyridoxal 5-Phosphate)
2.5 mg
147%
Folate (800 mcg as 6S)-5MTHF-Methyltetrahydrofolate Glucosamine Salt)
1,360 mcg DFE‡
340%
Vitamin B12 (as Methylcobalamin)
5,000 mcg
208,330%
Top Medical Research Studies
9
We examined the effects of dietary folate intake on severe headaches by analyzing data from a large national health survey. The study involved nearly 10,000 participants over the age of 20, where individuals self-reported their experiences with severe headaches.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Read More
8
We explored how dietary folate intake might be linked to severe headaches or migraines through a comprehensive analysis of data from the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2004. By examining over 4,100 adults, we observed that around 17% reported experiencing severe headaches or migraines. Importantly, our study used advanced statistical methods to ensure accurate and meaningful results.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Read More
8
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
Read More
Most Useful Reviews
9
Headaches vanished
6 people found this helpful
Great vitamins! After several days of taking them, my well-being has greatly improved, and my headaches have disappeared. I am very pleased with this purchase, and the taste is quite pleasant.
Read More
9
Headaches resolved
I am very pleased with the fast delivery, high quality and convenient packaging. Nothing was damaged, and the dosage is excellent with a natural composition from herbal ingredients. The capsules are a bit large, but I have no issues swallowing them, and they have a citrus taste that I enjoy. I take one capsule daily with meals alongside vitamin D3+K2, magnesium, and vitamin B6. After ten days of usage, I have noticed improvements; I no longer suffer from frequent headaches, experience more energy, and my mood has greatly improved. I highly recommend this product, especially for sports enthusiasts and those on a diet. Omega-3 is revitalising and replenishes what the body lacks.
Read More
9
Headaches eliminated
The composition is good, with fast delivery and high-quality, convenient packaging. The capsules are slightly large, but I swallow them easily, and the citrus taste is enjoyable. I take one daily with meals, along with vitamin D3+K2, magnesium, and vitamin B6. Initially, I was concerned about frequent headaches and overall fatigue. After ten days, I feel energised, my headaches have ceased, and my mood is consistently excellent. I recommend this to anyone interested in fitness or dieting, as omega-3 replenishes what the body lacks.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.6
- All Researches
9
We explored the effects of vitamin B6 treatment in a unique case involving a 25-year-old man who experienced headaches and memory issues due to a specific genetic condition. This condition caused a build-up of branched-chain amino acids (BCAAs) like valine and leucine in the bloodstream, leading to neurological symptoms.
The patient had notable brain MRI findings, and metabolic tests revealed significantly high plasma levels of BCAAs. Interestingly, standard tests for a related disorder, maple syrup urine disease, came back normal, helping guide the investigation. Upon discovering mutations in the BCAT2 gene, which heavily influences BCAA metabolism, we were curious about the role of vitamin B6 in this scenario.
After the patient began taking vitamin B6, we observed impressive reductions in his BCAA levels, especially valine, and improvements in the brain MRI lesions. Although the initial focus was on his headaches, it's important to note that the study didn’t isolate the specific effects of vitamin B6 on headaches alone. Instead, the broader context of metabolic improvement is significant.
Ultimately, our findings highlight a new and rare amino acid metabolism disorder linked to genetic mutations. They also suggest that vitamin B6 supplementation may lead to beneficial outcomes in managing BCAA-related conditions, even if direct links to headache relief weren’t the sole focus of this particular case.
The patient had notable brain MRI findings, and metabolic tests revealed significantly high plasma levels of BCAAs. Interestingly, standard tests for a related disorder, maple syrup urine disease, came back normal, helping guide the investigation. Upon discovering mutations in the BCAT2 gene, which heavily influences BCAA metabolism, we were curious about the role of vitamin B6 in this scenario.
After the patient began taking vitamin B6, we observed impressive reductions in his BCAA levels, especially valine, and improvements in the brain MRI lesions. Although the initial focus was on his headaches, it's important to note that the study didn’t isolate the specific effects of vitamin B6 on headaches alone. Instead, the broader context of metabolic improvement is significant.
Ultimately, our findings highlight a new and rare amino acid metabolism disorder linked to genetic mutations. They also suggest that vitamin B6 supplementation may lead to beneficial outcomes in managing BCAA-related conditions, even if direct links to headache relief weren’t the sole focus of this particular case.
Read More
9
We examined the connection between genetic differences in folate metabolism and migraine experiences in children aged 7 to 18. The study involved 54 children with migraine symptoms and a control group of 115 others without neurological issues.
Focusing on four specific genetic variants linked to folate metabolism, we found that children with migraines were more likely to have a certain rare genetic variant that may increase plasma homocysteine levels, potentially indicating a hidden folate deficiency. In addition to genetic testing, we looked at vitamin B levels and the effectiveness of Cortexin, a treatment administered to the children.
After a 10-day course of Cortexin, many children reported significant improvements in their migraine symptoms, such as less headache pain, reduced fatigue, and better emotional stability. This suggests that while there’s a genetic connection to migraine, the treatment with Cortexin also plays a critical role in alleviating symptoms.
Focusing on four specific genetic variants linked to folate metabolism, we found that children with migraines were more likely to have a certain rare genetic variant that may increase plasma homocysteine levels, potentially indicating a hidden folate deficiency. In addition to genetic testing, we looked at vitamin B levels and the effectiveness of Cortexin, a treatment administered to the children.
After a 10-day course of Cortexin, many children reported significant improvements in their migraine symptoms, such as less headache pain, reduced fatigue, and better emotional stability. This suggests that while there’s a genetic connection to migraine, the treatment with Cortexin also plays a critical role in alleviating symptoms.
Read More
9
We examined the effects of dietary folate intake on severe headaches by analyzing data from a large national health survey. The study involved nearly 10,000 participants over the age of 20, where individuals self-reported their experiences with severe headaches.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Read More
9
We explored the case of a 14-year-old girl who faced severe headaches and nausea due to cerebral venous thrombosis (CVT) and high levels of homocysteine. After thorough examinations, including brain imaging and genetic testing, she underwent treatment that included anticoagulants and supplementation with folate, as well as vitamins B12 and B6.
The patient showed significant improvement in her condition within a month. She experienced relief from headaches, and her intracranial pressure decreased considerably. While the study indicates that folate was part of a comprehensive treatment approach, the specific contribution of folate alone to the relief of her headaches remains unclear due to the combined nature of the treatments.
This case highlights a unique instance of loss of heterozygosity at the methylenetetrahydrofolate reductase (MTHFR) gene and suggests that analyzing this genetic factor could be important in patients with CVT and hyperhomocysteinemia. However, we must interpret the efficacy of folate cautiously, as its isolated impact on headache resolution wasn't specifically tested.
The patient showed significant improvement in her condition within a month. She experienced relief from headaches, and her intracranial pressure decreased considerably. While the study indicates that folate was part of a comprehensive treatment approach, the specific contribution of folate alone to the relief of her headaches remains unclear due to the combined nature of the treatments.
This case highlights a unique instance of loss of heterozygosity at the methylenetetrahydrofolate reductase (MTHFR) gene and suggests that analyzing this genetic factor could be important in patients with CVT and hyperhomocysteinemia. However, we must interpret the efficacy of folate cautiously, as its isolated impact on headache resolution wasn't specifically tested.
Read More
We evaluated the effectiveness of vitamin B6 in alleviating headaches associated with premenstrual syndrome (PMS). In a real-world study, participants were assigned to different treatment groups, with one group receiving a combination of Ezedayz tablets containing vitamin B6, along with other ingredients, while others received traditional therapies.
Throughout the three-month study, participants rated their headache severity, among other PMS symptoms. Though all groups reported some improvements, the data indicated that those taking Ezedayz tablets, either alone or with standard treatments, enjoyed a more significant reduction in headaches and other PMS symptoms.
Notably, while the combined therapy appeared promising in enhancing overall quality of life, the specific impact of vitamin B6 on headaches couldn't be isolated due to the formulation's combination with other active ingredients. Overall, while we observed benefits, the direct effect of vitamin B6 alone remains unclear, emphasizing the need for further focused research.
Throughout the three-month study, participants rated their headache severity, among other PMS symptoms. Though all groups reported some improvements, the data indicated that those taking Ezedayz tablets, either alone or with standard treatments, enjoyed a more significant reduction in headaches and other PMS symptoms.
Notably, while the combined therapy appeared promising in enhancing overall quality of life, the specific impact of vitamin B6 on headaches couldn't be isolated due to the formulation's combination with other active ingredients. Overall, while we observed benefits, the direct effect of vitamin B6 alone remains unclear, emphasizing the need for further focused research.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Headaches vanished
6 people found this helpful
Great vitamins! After several days of taking them, my well-being has greatly improved, and my headaches have disappeared. I am very pleased with this purchase, and the taste is quite pleasant.
Read More
9
Headaches resolved
I am very pleased with the fast delivery, high quality and convenient packaging. Nothing was damaged, and the dosage is excellent with a natural composition from herbal ingredients. The capsules are a bit large, but I have no issues swallowing them, and they have a citrus taste that I enjoy. I take one capsule daily with meals alongside vitamin D3+K2, magnesium, and vitamin B6. After ten days of usage, I have noticed improvements; I no longer suffer from frequent headaches, experience more energy, and my mood has greatly improved. I highly recommend this product, especially for sports enthusiasts and those on a diet. Omega-3 is revitalising and replenishes what the body lacks.
Read More
9
Headaches eliminated
The composition is good, with fast delivery and high-quality, convenient packaging. The capsules are slightly large, but I swallow them easily, and the citrus taste is enjoyable. I take one daily with meals, along with vitamin D3+K2, magnesium, and vitamin B6. Initially, I was concerned about frequent headaches and overall fatigue. After ten days, I feel energised, my headaches have ceased, and my mood is consistently excellent. I recommend this to anyone interested in fitness or dieting, as omega-3 replenishes what the body lacks.
Read More
7.5
Effective absorption
This product is amazing; I love it! I can really feel it absorbing well and helping with my headaches and deficiencies.
Read More
Frequently Asked Questions
9
Headaches resolved
I am very pleased with the fast delivery, high quality and convenient packaging. Nothing was damaged, and the dosage is excellent with a natural composition from herbal ingredients. The capsules are a bit large, but I have no issues swallowing them, and they have a citrus taste that I enjoy. I take one capsule daily with meals alongside vitamin D3+K2, magnesium, and vitamin B6. After ten days of usage, I have noticed improvements; I no longer suffer from frequent headaches, experience more energy, and my mood has greatly improved. I highly recommend this product, especially for sports enthusiasts and those on a diet. Omega-3 is revitalising and replenishes what the body lacks.
9
Headaches eliminated
The composition is good, with fast delivery and high-quality, convenient packaging. The capsules are slightly large, but I swallow them easily, and the citrus taste is enjoyable. I take one daily with meals, along with vitamin D3+K2, magnesium, and vitamin B6. Initially, I was concerned about frequent headaches and overall fatigue. After ten days, I feel energised, my headaches have ceased, and my mood is consistently excellent. I recommend this to anyone interested in fitness or dieting, as omega-3 replenishes what the body lacks.
9
Headaches vanished
6 people found this helpful
Great vitamins! After several days of taking them, my well-being has greatly improved, and my headaches have disappeared. I am very pleased with this purchase, and the taste is quite pleasant.
7.5
Effective absorption
This product is amazing; I love it! I can really feel it absorbing well and helping with my headaches and deficiencies.
8
We explored how vitamin B6, along with other B vitamins like folate and B12, might help in preventing migraines. Through a thorough review of existing research, we discovered that while vitamin B6 showed some promise in reducing migraines with aura in adults, the results aren’t as clear-cut for individuals suffering from other forms of headaches. In fact, in the context of treating acute migraine attacks, the benefits of these vitamins have not been supported by strong evidence from studies.
We found several trials that looked specifically at vitamin B6 for migraine prevention. The results were generally positive, especially for those experiencing migraines with aura, where vitamin B6 exhibited significant benefits against placebo in multiple studies. However, when it comes to folate, using it alone didn’t show improved outcomes compared to placebo. Limited data on children and those suffering from migraines without aura prevented us from making definitive conclusions about vitamin B6’s effectiveness across different demographics.
Overall, there’s a potential positive effect of vitamin B6 in managing migraines, particularly in adults with aura. While the safety profile appears favorable, we advocate for more high-quality research to clarify its role in treating various types of migraines.
We found several trials that looked specifically at vitamin B6 for migraine prevention. The results were generally positive, especially for those experiencing migraines with aura, where vitamin B6 exhibited significant benefits against placebo in multiple studies. However, when it comes to folate, using it alone didn’t show improved outcomes compared to placebo. Limited data on children and those suffering from migraines without aura prevented us from making definitive conclusions about vitamin B6’s effectiveness across different demographics.
Overall, there’s a potential positive effect of vitamin B6 in managing migraines, particularly in adults with aura. While the safety profile appears favorable, we advocate for more high-quality research to clarify its role in treating various types of migraines.
7
Vitamin B6's mixed effects on headaches
We explored the effects of a nutritional supplement, including vitamin B6, on children suffering from chronic headaches, some of whom also experienced sleep disorders. In our study, 34 children were closely monitored for one month without any treatment. After this initial period, we divided them into two groups. One group received melatonin alone, while the other group received a combination of melatonin, tryptophan, and vitamin B6 for an additional two months.
While we observed positive changes in headache frequency for both groups, the results didn't clearly identify a strong benefit solely attributable to vitamin B6. In fact, while 91.7% of children in the melatonin-only group reported fewer headaches, only 66.7% in the group that received both vitamin B6 and tryptophan saw similar improvements.
When we looked at the number of night awakenings, both groups showed a decrease over time. However, those receiving the combination treatment with tryptophan and vitamin B6 experienced a significant decrease, while those on melatonin alone did not show marked improvements. This suggests that while vitamin B6 is part of an effective treatment combination, the overall effect on headache management was less distinct.
While we observed positive changes in headache frequency for both groups, the results didn't clearly identify a strong benefit solely attributable to vitamin B6. In fact, while 91.7% of children in the melatonin-only group reported fewer headaches, only 66.7% in the group that received both vitamin B6 and tryptophan saw similar improvements.
When we looked at the number of night awakenings, both groups showed a decrease over time. However, those receiving the combination treatment with tryptophan and vitamin B6 experienced a significant decrease, while those on melatonin alone did not show marked improvements. This suggests that while vitamin B6 is part of an effective treatment combination, the overall effect on headache management was less distinct.
7
We conducted a study to evaluate the effectiveness of vitamin B6 in easing headache symptoms associated with a low-dose oral contraceptive. In this randomized and triple-blinded trial, 124 women participated, taking either 150 mg of vitamin B6 daily or a placebo for 30 days.
We measured the severity of headaches, along with several other symptoms, on a scale from 0 to 3, with evaluations occurring a month after starting the treatment. Interestingly, while both groups reported reductions in overall symptom severity, there was no significant difference between the vitamin B6 group and the placebo group.
That said, we did notice that the B6 group experienced somewhat greater reductions in headache and dizziness symptoms specifically. Nevertheless, the overall decrease in symptoms could be attributed more to a placebo effect rather than a strong clinical benefit of the vitamin B6 treatment itself. Overall, these findings suggest that vitamin B6 may not have a notable impact on headache relief for those starting low-dose birth control.
We measured the severity of headaches, along with several other symptoms, on a scale from 0 to 3, with evaluations occurring a month after starting the treatment. Interestingly, while both groups reported reductions in overall symptom severity, there was no significant difference between the vitamin B6 group and the placebo group.
That said, we did notice that the B6 group experienced somewhat greater reductions in headache and dizziness symptoms specifically. Nevertheless, the overall decrease in symptoms could be attributed more to a placebo effect rather than a strong clinical benefit of the vitamin B6 treatment itself. Overall, these findings suggest that vitamin B6 may not have a notable impact on headache relief for those starting low-dose birth control.
References
- Sureja VP, Kheni DB, Dubey VP, Kansagra J, Soni ZK, et al. Efficacy and Tolerability Evaluation of a Nutraceutical Composition Containing Vitex agnus-castus Extract (EVX40™), Pyridoxine, and Magnesium in Premenstrual Syndrome: A Real-World, Interventional, Comparative Study. Cureus. 2023;15:e42832. 10.7759/cureus.42832
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. 10.1111/ane.13251
- Bravaccio C, Terrone G, Rizzo R, Gulisano M, Tosi M, et al. Use of nutritional supplements based on melatonin, tryptophan and vitamin B6 (Melamil Tripto®) in children with primary chronic headache, with or without sleep disorders: a pilot study. Minerva Pediatr. 2020;72:30. 10.23736/S0026-4946.19.05533-6
- Askari G, Nasiri M, Mozaffari-Khosravi H, Rezaie M, Bagheri-Bidakhavidi M, et al. The effects of folic acid and pyridoxine supplementation on characteristics of migraine attacks in migraine patients with aura: A double-blind, randomized placebo-controlled, clinical trial. Nutrition. 2017;38:74. 10.1016/j.nut.2017.01.007
- Woods E, Dawson C, Senthil L, Geberhiwot T. Cerebral venous thrombosis as the first presentation of classical homocystinuria in an adult patient. BMJ Case Rep. 2017;2017. 10.1136/bcr-2016-217477
- Menon S, Nasir B, Avgan N, Ghassabian S, Oliver C, et al. The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients. J Headache Pain. 2016;17:60. 10.1186/s10194-016-0652-7
- Wang XL, Li CJ, Xing Y, Yang YH, Jia JP. Hypervalinemia and hyperleucine-isoleucinemia caused by mutations in the branched-chain-amino-acid aminotransferase gene. J Inherit Metab Dis. 2015;38:855. 10.1007/s10545-015-9814-z
- Menon S, Lea RA, Roy B, Hanna M, Wee S, et al. Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation. Pharmacogenet Genomics. 2012;22:741. 10.1097/FPC.0b013e3283576b6b
- Lea R, Colson N, Quinlan S, Macmillan J, Griffiths L. The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability. Pharmacogenet Genomics. 2009;19:422. 10.1097/FPC.0b013e32832af5a3
- Villegas-Salas E, Ponce de León R, Juárez-Perez MA, Grubb GS. Effect of vitamin B6 on the side effects of a low-dose combined oral contraceptive. Contraception. 1997;55:245.
- Jarisch R, Wantke F. Wine and headache. Int Arch Allergy Immunol. 1996;110:7.
- Bernstein AL. Vitamin B6 in clinical neurology. Ann N Y Acad Sci. 1990;585:250.
- Strozenko LA, Ponomaryov VS, Sanina OO, Lobanov YF. [The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children]. Zh Nevrol Psikhiatr Im S S Korsakova. 2025;125:47. 10.17116/jnevro202512501147
- Zhao D, Long X, Wang J. Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey. Front Nutr. 2024;11:1456502. 10.3389/fnut.2024.1456502
- Luwen H, Ping C, Qing-Rong O, Lei X, Linlin L, et al. Association between serum folate levels and migraine or severe headaches: A nationwide cross-sectional study. Medicine (Baltimore). 2024;103:e40458. 10.1097/MD.0000000000040458
- Tian S, Yu X, Wu L, Zheng H, Zhong X, et al. Vitamin B and folate intake are associated with lower risk of severe headache or migraine in adults: An analysis based on NHANES 1999-2004. Nutr Res. 2024;121:51. 10.1016/j.nutres.2023.11.008
- Tian S, Wu L, Zheng H, Zhong X, Liu M, et al. Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey. Br J Nutr. 2024;131:438. 10.1017/S000711452300137X
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. 10.1186/s12883-023-03200-y
- Lin SS, Fan IW, Chen CY, Su YJ. A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report. Med Int (Lond). 2022;2:20. 10.3892/mi.2022.45
- Aydin H, Bucak IH, Geyik M. Vitamin B12 and folic acid levels in pediatric migraine patients. Acta Neurol Belg. 2021;121:1741. 10.1007/s13760-020-01491-3
- Abdelsadek SE, Tahoun SA, Mansour FM, Abdulsalam MF, Ahmed AM. The correlation between vitamin B12 serum levels and migraine: a case-control study. Neurol Res. 2025;47:195. 10.1080/01616412.2025.2462735
