' 
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.5
USERS' SCORE
Good
Based on 4 Reviews
8.8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₆ (as Pyridoxal 5-Phosphate)
2.5 mg
147%
Folate (800 mcg as 6S)-5MTHF-Methyltetrahydrofolate Glucosamine Salt)
1,360 mcg DFE‡
340%
Vitamin B12 (as Methylcobalamin)
5,000 mcg
208,330%
Top Medical Research Studies
9
Folate intake may reduce headaches
Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey.
Study directly examines folate effects
We examined the effects of dietary folate intake on severe headaches by analyzing data from a large national health survey. The study involved nearly 10,000 participants over the age of 20, where individuals self-reported their experiences with severe headaches.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Read More
8
Folate intake decreases migraine severity
Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey.
Directly evaluates folate effects
We explored how dietary folate intake might be linked to severe headaches or migraines through a comprehensive analysis of data from the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2004. By examining over 4,100 adults, we observed that around 17% reported experiencing severe headaches or migraines. Importantly, our study used advanced statistical methods to ensure accurate and meaningful results.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Read More
8
Vitamin B12 deficiency linked to migraines
The correlation between vitamin B12 serum levels and migraine: a case-control study.
Direct investigation of B12 effects
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
Read More
Most Useful Reviews
9.5
Headaches vanished
Great vitamins! After several days of taking them, my well-being has greatly improved, and my headaches have disappeared. I am very pleased with this purchase, and the taste is quite pleasant.
Read More
9.5
Headaches resolved
I am very pleased with the fast delivery, high quality and convenient packaging. Nothing was damaged, and the dosage is excellent with a natural composition from herbal ingredients. The capsules are a bit large, but I have no issues swallowing them, and they have a citrus taste that I enjoy. I take one capsule daily with meals alongside vitamin D3+K2, magnesium, and vitamin B6. After ten days of usage, I have noticed improvements; I no longer suffer from frequent headaches, experience more energy, and my mood has greatly improved. I highly recommend this product, especially for sports enthusiasts and those on a diet. Omega-3 is revitalising and replenishes what the body lacks.
Read More
9.5
Headaches eliminated
The composition is good, with fast delivery and high-quality, convenient packaging. The capsules are slightly large, but I swallow them easily, and the citrus taste is enjoyable. I take one daily with meals, along with vitamin D3+K2, magnesium, and vitamin B6. Initially, I was concerned about frequent headaches and overall fatigue. After ten days, I feel energised, my headaches have ceased, and my mood is consistently excellent. I recommend this to anyone interested in fitness or dieting, as omega-3 replenishes what the body lacks.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.5
- All Researches
9
Genetic metabolic disorder insights
Hypervalinemia and hyperleucine-isoleucinemia caused by mutations in the branched-chain-amino-acid aminotransferase gene.
Indicates limited headache connection
We explored the effects of vitamin B6 treatment in a unique case involving a 25-year-old man who experienced headaches and memory issues due to a specific genetic condition. This condition caused a build-up of branched-chain amino acids (BCAAs) like valine and leucine in the bloodstream, leading to neurological symptoms.
The patient had notable brain MRI findings, and metabolic tests revealed significantly high plasma levels of BCAAs. Interestingly, standard tests for a related disorder, maple syrup urine disease, came back normal, helping guide the investigation. Upon discovering mutations in the BCAT2 gene, which heavily influences BCAA metabolism, we were curious about the role of vitamin B6 in this scenario.
After the patient began taking vitamin B6, we observed impressive reductions in his BCAA levels, especially valine, and improvements in the brain MRI lesions. Although the initial focus was on his headaches, it's important to note that the study didn’t isolate the specific effects of vitamin B6 on headaches alone. Instead, the broader context of metabolic improvement is significant.
Ultimately, our findings highlight a new and rare amino acid metabolism disorder linked to genetic mutations. They also suggest that vitamin B6 supplementation may lead to beneficial outcomes in managing BCAA-related conditions, even if direct links to headache relief weren’t the sole focus of this particular case.
The patient had notable brain MRI findings, and metabolic tests revealed significantly high plasma levels of BCAAs. Interestingly, standard tests for a related disorder, maple syrup urine disease, came back normal, helping guide the investigation. Upon discovering mutations in the BCAT2 gene, which heavily influences BCAA metabolism, we were curious about the role of vitamin B6 in this scenario.
After the patient began taking vitamin B6, we observed impressive reductions in his BCAA levels, especially valine, and improvements in the brain MRI lesions. Although the initial focus was on his headaches, it's important to note that the study didn’t isolate the specific effects of vitamin B6 on headaches alone. Instead, the broader context of metabolic improvement is significant.
Ultimately, our findings highlight a new and rare amino acid metabolism disorder linked to genetic mutations. They also suggest that vitamin B6 supplementation may lead to beneficial outcomes in managing BCAA-related conditions, even if direct links to headache relief weren’t the sole focus of this particular case.
Read More
9
Migraine linked to folate genetics
[The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children].
Folate's role in headache relief
We examined the connection between genetic differences in folate metabolism and migraine experiences in children aged 7 to 18. The study involved 54 children with migraine symptoms and a control group of 115 others without neurological issues.
Focusing on four specific genetic variants linked to folate metabolism, we found that children with migraines were more likely to have a certain rare genetic variant that may increase plasma homocysteine levels, potentially indicating a hidden folate deficiency. In addition to genetic testing, we looked at vitamin B levels and the effectiveness of Cortexin, a treatment administered to the children.
After a 10-day course of Cortexin, many children reported significant improvements in their migraine symptoms, such as less headache pain, reduced fatigue, and better emotional stability. This suggests that while there’s a genetic connection to migraine, the treatment with Cortexin also plays a critical role in alleviating symptoms.
Focusing on four specific genetic variants linked to folate metabolism, we found that children with migraines were more likely to have a certain rare genetic variant that may increase plasma homocysteine levels, potentially indicating a hidden folate deficiency. In addition to genetic testing, we looked at vitamin B levels and the effectiveness of Cortexin, a treatment administered to the children.
After a 10-day course of Cortexin, many children reported significant improvements in their migraine symptoms, such as less headache pain, reduced fatigue, and better emotional stability. This suggests that while there’s a genetic connection to migraine, the treatment with Cortexin also plays a critical role in alleviating symptoms.
Read More
9
Folate intake may reduce headaches
Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey.
Study directly examines folate effects
We examined the effects of dietary folate intake on severe headaches by analyzing data from a large national health survey. The study involved nearly 10,000 participants over the age of 20, where individuals self-reported their experiences with severe headaches.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Read More
9
Folate's unclear role in headaches
Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report.
Moderate relevance; mixed treatment effects
We explored the case of a 14-year-old girl who faced severe headaches and nausea due to cerebral venous thrombosis (CVT) and high levels of homocysteine. After thorough examinations, including brain imaging and genetic testing, she underwent treatment that included anticoagulants and supplementation with folate, as well as vitamins B12 and B6.
The patient showed significant improvement in her condition within a month. She experienced relief from headaches, and her intracranial pressure decreased considerably. While the study indicates that folate was part of a comprehensive treatment approach, the specific contribution of folate alone to the relief of her headaches remains unclear due to the combined nature of the treatments.
This case highlights a unique instance of loss of heterozygosity at the methylenetetrahydrofolate reductase (MTHFR) gene and suggests that analyzing this genetic factor could be important in patients with CVT and hyperhomocysteinemia. However, we must interpret the efficacy of folate cautiously, as its isolated impact on headache resolution wasn't specifically tested.
The patient showed significant improvement in her condition within a month. She experienced relief from headaches, and her intracranial pressure decreased considerably. While the study indicates that folate was part of a comprehensive treatment approach, the specific contribution of folate alone to the relief of her headaches remains unclear due to the combined nature of the treatments.
This case highlights a unique instance of loss of heterozygosity at the methylenetetrahydrofolate reductase (MTHFR) gene and suggests that analyzing this genetic factor could be important in patients with CVT and hyperhomocysteinemia. However, we must interpret the efficacy of folate cautiously, as its isolated impact on headache resolution wasn't specifically tested.
Read More
8
Vitamin B6's effect on headaches
Efficacy and Tolerability Evaluation of a Nutraceutical Composition Containing Vitex agnus-castus Extract (EVX40™), Pyridoxine, and Magnesium in Premenstrual Syndrome: A Real-World, Interventional, Comparative Study.
Some relevance, unclear outcomes
We evaluated the effectiveness of vitamin B6 in alleviating headaches associated with premenstrual syndrome (PMS). In a real-world study, participants were assigned to different treatment groups, with one group receiving a combination of Ezedayz tablets containing vitamin B6, along with other ingredients, while others received traditional therapies.
Throughout the three-month study, participants rated their headache severity, among other PMS symptoms. Though all groups reported some improvements, the data indicated that those taking Ezedayz tablets, either alone or with standard treatments, enjoyed a more significant reduction in headaches and other PMS symptoms.
Notably, while the combined therapy appeared promising in enhancing overall quality of life, the specific impact of vitamin B6 on headaches couldn't be isolated due to the formulation's combination with other active ingredients. Overall, while we observed benefits, the direct effect of vitamin B6 alone remains unclear, emphasizing the need for further focused research.
Throughout the three-month study, participants rated their headache severity, among other PMS symptoms. Though all groups reported some improvements, the data indicated that those taking Ezedayz tablets, either alone or with standard treatments, enjoyed a more significant reduction in headaches and other PMS symptoms.
Notably, while the combined therapy appeared promising in enhancing overall quality of life, the specific impact of vitamin B6 on headaches couldn't be isolated due to the formulation's combination with other active ingredients. Overall, while we observed benefits, the direct effect of vitamin B6 alone remains unclear, emphasizing the need for further focused research.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.8
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Headaches vanished
Great vitamins! After several days of taking them, my well-being has greatly improved, and my headaches have disappeared. I am very pleased with this purchase, and the taste is quite pleasant.
9.5
Headaches resolved
I am very pleased with the fast delivery, high quality and convenient packaging. Nothing was damaged, and the dosage is excellent with a natural composition from herbal ingredients. The capsules are a bit large, but I have no issues swallowing them, and they have a citrus taste that I enjoy. I take one capsule daily with meals alongside vitamin D3+K2, magnesium, and vitamin B6. After ten days of usage, I have noticed improvements; I no longer suffer from frequent headaches, experience more energy, and my mood has greatly improved. I highly recommend this product, especially for sports enthusiasts and those on a diet. Omega-3 is revitalising and replenishes what the body lacks.
Read More
9.5
Headaches eliminated
The composition is good, with fast delivery and high-quality, convenient packaging. The capsules are slightly large, but I swallow them easily, and the citrus taste is enjoyable. I take one daily with meals, along with vitamin D3+K2, magnesium, and vitamin B6. Initially, I was concerned about frequent headaches and overall fatigue. After ten days, I feel energised, my headaches have ceased, and my mood is consistently excellent. I recommend this to anyone interested in fitness or dieting, as omega-3 replenishes what the body lacks.
Read More
8.8
Effective absorption
This product is amazing; I love it! I can really feel it absorbing well and helping with my headaches and deficiencies.
