' 
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₆ (as Pyridoxal 5-Phosphate)
2.5 mg
147%
Folate (800 mcg as 6S)-5MTHF-Methyltetrahydrofolate Glucosamine Salt)
1,360 mcg DFE‡
340%
Vitamin B12 (as Methylcobalamin)
5,000 mcg
208,330%
Top Medical Research Studies
4
Vitamin B6 risks in pregnancy
The potential hazards of high doses of vitamin B6 in treating nausea and vomiting in pregnancy: A systematic review.
Focus on vitamin B6 effects
We investigated the use of vitamin B6 as a common treatment for nausea and vomiting during pregnancy. There has been an ongoing discussion about how effective high doses of this vitamin actually are, and we wanted to shed light on this issue.
Through a systematic review of literature, we examined various studies, focusing on reports that highlighted the effects of high doses of vitamin B6 on pregnant women experiencing nausea. While we found that many women do turn to vitamin B6 to alleviate their symptoms, particularly during the challenging first trimester, the data also raised serious concerns about potential side effects.
A significant portion of the studies reviewed documented adverse reactions in women taking excessive amounts of vitamin B6. These included neurological symptoms such as burning sensations, tingling, and coordination problems. Alarmingly, we also noted a few cases of miscarriage and intrauterine demise among those studied.
Overall, while vitamin B6 is a widely used treatment for nausea during pregnancy, we must exercise caution. The risks associated with high doses cannot be overlooked, particularly when it comes to the health of both the mother and the developing fetus.
Through a systematic review of literature, we examined various studies, focusing on reports that highlighted the effects of high doses of vitamin B6 on pregnant women experiencing nausea. While we found that many women do turn to vitamin B6 to alleviate their symptoms, particularly during the challenging first trimester, the data also raised serious concerns about potential side effects.
A significant portion of the studies reviewed documented adverse reactions in women taking excessive amounts of vitamin B6. These included neurological symptoms such as burning sensations, tingling, and coordination problems. Alarmingly, we also noted a few cases of miscarriage and intrauterine demise among those studied.
Overall, while vitamin B6 is a widely used treatment for nausea during pregnancy, we must exercise caution. The risks associated with high doses cannot be overlooked, particularly when it comes to the health of both the mother and the developing fetus.
Read More
8
Pyridoxine reduces postoperative nausea
Pyridoxine Prevents Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery: A Double-blind Randomized Controlled Trial.
Combined medication limits assessment
We examined the effects of pyridoxine, or vitamin B6, in reducing postoperative nausea and vomiting (PONV) for patients undergoing elective gynecological laparoscopic surgery. In this study, patients aged 18 to 65 were randomly assigned to receive either pyridoxine or a placebo (normal saline) before anesthesia.
All patients also received a regimen that included dexamethasone and ondansetron, two well-known anti-nausea medications. Reports from the patients indicated that those who received pyridoxine experienced a reduced incidence of nausea and vomiting following their surgery compared to those who received the placebo.
While our findings are promising, it is important to note that pyridoxine was used in conjunction with other medications, making it difficult to ascertain its effect in isolation. Future multicenter studies will help us confirm the effectiveness of pyridoxine in more diverse settings and populations.
All patients also received a regimen that included dexamethasone and ondansetron, two well-known anti-nausea medications. Reports from the patients indicated that those who received pyridoxine experienced a reduced incidence of nausea and vomiting following their surgery compared to those who received the placebo.
While our findings are promising, it is important to note that pyridoxine was used in conjunction with other medications, making it difficult to ascertain its effect in isolation. Future multicenter studies will help us confirm the effectiveness of pyridoxine in more diverse settings and populations.
Read More
4
Nutrient supplements and nausea study
Prevalence of morbidity symptoms among pregnant and postpartum women receiving different nutrient supplements in Ghana and Malawi: A secondary outcome analysis of two randomised controlled trials.
Nausea linked to folate usage
We observed the effects of various nutrient supplements, including folate, on nausea in pregnant and postpartum women in Ghana and Malawi. Participants in our study were given different types of supplements, with some receiving iron and folic acid, while others received multiple micronutrients or small-quantity lipid-based nutrient supplements.
Throughout the study, which followed the women from early pregnancy to six months postpartum, we monitored symptoms like nausea and vomiting among the groups. Interestingly, we found that the overall prevalence of vomiting was lower in the group receiving lipid-based nutrient supplements compared to those taking multiple micronutrients. However, the mean number of days women experienced nausea was higher in those taking lipid-based nutrients and multiple micronutrients compared to the iron and folic acid group.
Importantly, while we gained insights into how nutrition affects maternal health, we did not find strong evidence that the type of nutrient supplements consistently influenced nausea during pregnancy or the postpartum period. This suggests that folate’s effects on nausea may not be significant in isolation or within the context of the supplements studied.
Throughout the study, which followed the women from early pregnancy to six months postpartum, we monitored symptoms like nausea and vomiting among the groups. Interestingly, we found that the overall prevalence of vomiting was lower in the group receiving lipid-based nutrient supplements compared to those taking multiple micronutrients. However, the mean number of days women experienced nausea was higher in those taking lipid-based nutrients and multiple micronutrients compared to the iron and folic acid group.
Importantly, while we gained insights into how nutrition affects maternal health, we did not find strong evidence that the type of nutrient supplements consistently influenced nausea during pregnancy or the postpartum period. This suggests that folate’s effects on nausea may not be significant in isolation or within the context of the supplements studied.
Read More
Most Useful Reviews
6.8
Nausea from vitamins
I’ve been taking single methylated B-vitamins for some time. Due to the MTHFR mutation, I struggle to methylate vitamins, feeling nauseated and somewhat hungover with regular multi-vitamins. Methylated versions may not cause nausea. If they don’t, you may also have this mutation. B vitamins are crucial for neurological health, especially folate for pregnant women. If you can’t process them, you miss out on their benefits. I prefer Jarrow for the consistent quality of their supplements.
Read More
0
Not suitable
My husband has the MTFHR gene mutation and was advised to take these. Each attempt resulted in headaches—unusual for him—along with nausea, irritability, and aches. Not sure if it’s an allergic reaction, but he’s stopping this and will try another brand.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6
- All Researches
8
Pyridoxine reduces postoperative nausea
Pyridoxine Prevents Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery: A Double-blind Randomized Controlled Trial.
Combined medication limits assessment
We examined the effects of pyridoxine, or vitamin B6, in reducing postoperative nausea and vomiting (PONV) for patients undergoing elective gynecological laparoscopic surgery. In this study, patients aged 18 to 65 were randomly assigned to receive either pyridoxine or a placebo (normal saline) before anesthesia.
All patients also received a regimen that included dexamethasone and ondansetron, two well-known anti-nausea medications. Reports from the patients indicated that those who received pyridoxine experienced a reduced incidence of nausea and vomiting following their surgery compared to those who received the placebo.
While our findings are promising, it is important to note that pyridoxine was used in conjunction with other medications, making it difficult to ascertain its effect in isolation. Future multicenter studies will help us confirm the effectiveness of pyridoxine in more diverse settings and populations.
All patients also received a regimen that included dexamethasone and ondansetron, two well-known anti-nausea medications. Reports from the patients indicated that those who received pyridoxine experienced a reduced incidence of nausea and vomiting following their surgery compared to those who received the placebo.
While our findings are promising, it is important to note that pyridoxine was used in conjunction with other medications, making it difficult to ascertain its effect in isolation. Future multicenter studies will help us confirm the effectiveness of pyridoxine in more diverse settings and populations.
Read More
8
Vitamin B12's role in nausea unclear
May headache be the first sign of mutation in the MTHFR gene?
Moderate relevance to nausea treatment
We explored the role of vitamin B12 in treating nausea related to cerebral venous thrombosis (CVT). In a case study involving a 28-year-old man, we noted that after undergoing treatment with heparin, warfarin, and vitamin B12, his nausea improved along with his persistent headache symptoms.
Although we observed positive outcomes associated with this vitamin, it was part of a broader treatment approach rather than a standalone intervention. The study indicated that the combination of these treatments effectively alleviated nausea, but we cannot draw firm conclusions on vitamin B12's isolated impact due to the lack of control or blinding in the study design.
Overall, while vitamin B12 may have contributed to symptom relief, we must recognize that its specific role remains uncertain within the context of CVT treatment. Further studies would be needed to better define its effectiveness solely for nausea.
Although we observed positive outcomes associated with this vitamin, it was part of a broader treatment approach rather than a standalone intervention. The study indicated that the combination of these treatments effectively alleviated nausea, but we cannot draw firm conclusions on vitamin B12's isolated impact due to the lack of control or blinding in the study design.
Overall, while vitamin B12 may have contributed to symptom relief, we must recognize that its specific role remains uncertain within the context of CVT treatment. Further studies would be needed to better define its effectiveness solely for nausea.
Read More
4
Vitamin B6 risks in pregnancy
The potential hazards of high doses of vitamin B6 in treating nausea and vomiting in pregnancy: A systematic review.
Focus on vitamin B6 effects
We investigated the use of vitamin B6 as a common treatment for nausea and vomiting during pregnancy. There has been an ongoing discussion about how effective high doses of this vitamin actually are, and we wanted to shed light on this issue.
Through a systematic review of literature, we examined various studies, focusing on reports that highlighted the effects of high doses of vitamin B6 on pregnant women experiencing nausea. While we found that many women do turn to vitamin B6 to alleviate their symptoms, particularly during the challenging first trimester, the data also raised serious concerns about potential side effects.
A significant portion of the studies reviewed documented adverse reactions in women taking excessive amounts of vitamin B6. These included neurological symptoms such as burning sensations, tingling, and coordination problems. Alarmingly, we also noted a few cases of miscarriage and intrauterine demise among those studied.
Overall, while vitamin B6 is a widely used treatment for nausea during pregnancy, we must exercise caution. The risks associated with high doses cannot be overlooked, particularly when it comes to the health of both the mother and the developing fetus.
Through a systematic review of literature, we examined various studies, focusing on reports that highlighted the effects of high doses of vitamin B6 on pregnant women experiencing nausea. While we found that many women do turn to vitamin B6 to alleviate their symptoms, particularly during the challenging first trimester, the data also raised serious concerns about potential side effects.
A significant portion of the studies reviewed documented adverse reactions in women taking excessive amounts of vitamin B6. These included neurological symptoms such as burning sensations, tingling, and coordination problems. Alarmingly, we also noted a few cases of miscarriage and intrauterine demise among those studied.
Overall, while vitamin B6 is a widely used treatment for nausea during pregnancy, we must exercise caution. The risks associated with high doses cannot be overlooked, particularly when it comes to the health of both the mother and the developing fetus.
Read More
4
Nutrient supplements and nausea study
Prevalence of morbidity symptoms among pregnant and postpartum women receiving different nutrient supplements in Ghana and Malawi: A secondary outcome analysis of two randomised controlled trials.
Nausea linked to folate usage
We observed the effects of various nutrient supplements, including folate, on nausea in pregnant and postpartum women in Ghana and Malawi. Participants in our study were given different types of supplements, with some receiving iron and folic acid, while others received multiple micronutrients or small-quantity lipid-based nutrient supplements.
Throughout the study, which followed the women from early pregnancy to six months postpartum, we monitored symptoms like nausea and vomiting among the groups. Interestingly, we found that the overall prevalence of vomiting was lower in the group receiving lipid-based nutrient supplements compared to those taking multiple micronutrients. However, the mean number of days women experienced nausea was higher in those taking lipid-based nutrients and multiple micronutrients compared to the iron and folic acid group.
Importantly, while we gained insights into how nutrition affects maternal health, we did not find strong evidence that the type of nutrient supplements consistently influenced nausea during pregnancy or the postpartum period. This suggests that folate’s effects on nausea may not be significant in isolation or within the context of the supplements studied.
Throughout the study, which followed the women from early pregnancy to six months postpartum, we monitored symptoms like nausea and vomiting among the groups. Interestingly, we found that the overall prevalence of vomiting was lower in the group receiving lipid-based nutrient supplements compared to those taking multiple micronutrients. However, the mean number of days women experienced nausea was higher in those taking lipid-based nutrients and multiple micronutrients compared to the iron and folic acid group.
Importantly, while we gained insights into how nutrition affects maternal health, we did not find strong evidence that the type of nutrient supplements consistently influenced nausea during pregnancy or the postpartum period. This suggests that folate’s effects on nausea may not be significant in isolation or within the context of the supplements studied.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
6.8
Nausea from vitamins
I’ve been taking single methylated B-vitamins for some time. Due to the MTHFR mutation, I struggle to methylate vitamins, feeling nauseated and somewhat hungover with regular multi-vitamins. Methylated versions may not cause nausea. If they don’t, you may also have this mutation. B vitamins are crucial for neurological health, especially folate for pregnant women. If you can’t process them, you miss out on their benefits. I prefer Jarrow for the consistent quality of their supplements.
Read More
0
Not suitable
My husband has the MTFHR gene mutation and was advised to take these. Each attempt resulted in headaches—unusual for him—along with nausea, irritability, and aches. Not sure if it’s an allergic reaction, but he’s stopping this and will try another brand.
