' 
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
5.6
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
8
Maternal Folate and Child Asthma
Interaction of maternal asthma history and plasma folate levels on child asthma risk in the Boston Birth Cohort.
Significant interplay identified
We examined the link between maternal folate levels and the risk of asthma in children, particularly focusing on whether this relationship varies according to whether the mother has a history of asthma. In a comprehensive study involving 1,948 mother-child pairs from the Boston Birth Cohort, we found that both maternal asthma history and lower levels of folate together increased the risk for childhood asthma.
Interestingly, for children whose mothers had asthma, there was a notable L-shaped relationship with folate levels. This means that those with low maternal folate levels had a dramatically higher risk of asthma, presenting an odds ratio of 5.93 compared to kids with asthma-free mothers and sufficient folate levels. Our findings suggest that when a mother has asthma, ensuring adequate folate during pregnancy could be crucial for reducing the chance of developing asthma in their children.
If further research supports our findings, optimizing maternal folate levels could serve as an important step in asthma prevention, especially for moms with a history of the condition.
Interestingly, for children whose mothers had asthma, there was a notable L-shaped relationship with folate levels. This means that those with low maternal folate levels had a dramatically higher risk of asthma, presenting an odds ratio of 5.93 compared to kids with asthma-free mothers and sufficient folate levels. Our findings suggest that when a mother has asthma, ensuring adequate folate during pregnancy could be crucial for reducing the chance of developing asthma in their children.
If further research supports our findings, optimizing maternal folate levels could serve as an important step in asthma prevention, especially for moms with a history of the condition.
Read More
8
Folate levels influence asthma symptoms
Potential role of folate status on pulmonary function in pediatric asthma.
Addresses pediatric asthma and folate
We explored the link between folate levels in the blood and asthma symptoms in children, particularly in those following a traditional Mediterranean diet. Our study involved 64 children with mild asthma from Athens, Greece, where we conducted clinical assessments including spirometry to measure lung function and analyzed plasma folate levels.
Through this research, we found that 45.3% of the children exhibited folate deficiency. Notably, we observed a positive correlation between higher folate levels and better lung function, specifically in girls. For instance, girls with low folate concentrations showed significantly lower forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and peak expiratory flow (PEF) than those with higher folate concentrations.
These results highlight the potential detrimental impact of folate deficiency on lung function in girls with asthma. They suggest that monitoring folate status could be vital for managing asthma in children, indicating a need for early interventions to prevent deficiencies.
Through this research, we found that 45.3% of the children exhibited folate deficiency. Notably, we observed a positive correlation between higher folate levels and better lung function, specifically in girls. For instance, girls with low folate concentrations showed significantly lower forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and peak expiratory flow (PEF) than those with higher folate concentrations.
These results highlight the potential detrimental impact of folate deficiency on lung function in girls with asthma. They suggest that monitoring folate status could be vital for managing asthma in children, indicating a need for early interventions to prevent deficiencies.
Read More
7
Folate's role in asthma management
Association between serum folate levels and blood eosinophil counts in American adults with asthma: Results from NHANES 2011-2018.
Highly relevant to asthma research
We explored how serum folate levels might relate to blood eosinophil counts in adults with asthma using data from the National Health and Nutrition Examination Survey (NHANES) spanning 2011 to 2018. Over 2,300 adults with asthma participated, allowing us to analyze the impact of folate on asthma severity and control.
Our findings revealed an intriguing inverse relationship: as serum folate levels increased, blood eosinophil counts tended to decrease. Specifically, we observed a reduction of about 0.20 cells per microliter of blood for each unit increase in serum folate concentration. This suggests that higher folate levels could play a role in modulating the immune response in asthmatic patients.
We utilized various statistical models, including regression analyses and the XGBoost algorithm, to reinforce our conclusions. These methods helped us confirm that the correlation between folate and eosinophil counts is consistent across different models and remains significant even when accounting for other influencing factors.
We hope these insights shed light on the potential benefits of folate in managing asthma, encouraging a broader conversation regarding its role in asthma care and treatment. This emphasizes the importance of recognizing nutritional elements, like folate, in understanding and potentially controlling asthma.
Our findings revealed an intriguing inverse relationship: as serum folate levels increased, blood eosinophil counts tended to decrease. Specifically, we observed a reduction of about 0.20 cells per microliter of blood for each unit increase in serum folate concentration. This suggests that higher folate levels could play a role in modulating the immune response in asthmatic patients.
We utilized various statistical models, including regression analyses and the XGBoost algorithm, to reinforce our conclusions. These methods helped us confirm that the correlation between folate and eosinophil counts is consistent across different models and remains significant even when accounting for other influencing factors.
We hope these insights shed light on the potential benefits of folate in managing asthma, encouraging a broader conversation regarding its role in asthma care and treatment. This emphasizes the importance of recognizing nutritional elements, like folate, in understanding and potentially controlling asthma.
Read More
Most Useful Reviews
9.5
Immediate relief
This product was great for my asthma! Within 30 minutes of taking it, my lungs felt open. I'm grateful for a solution that addresses nutrient deficiencies rather than relying on pharmaceutical drugs.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
5.6
- All Researches
8
Maternal Folate and Child Asthma
Interaction of maternal asthma history and plasma folate levels on child asthma risk in the Boston Birth Cohort.
Significant interplay identified
We examined the link between maternal folate levels and the risk of asthma in children, particularly focusing on whether this relationship varies according to whether the mother has a history of asthma. In a comprehensive study involving 1,948 mother-child pairs from the Boston Birth Cohort, we found that both maternal asthma history and lower levels of folate together increased the risk for childhood asthma.
Interestingly, for children whose mothers had asthma, there was a notable L-shaped relationship with folate levels. This means that those with low maternal folate levels had a dramatically higher risk of asthma, presenting an odds ratio of 5.93 compared to kids with asthma-free mothers and sufficient folate levels. Our findings suggest that when a mother has asthma, ensuring adequate folate during pregnancy could be crucial for reducing the chance of developing asthma in their children.
If further research supports our findings, optimizing maternal folate levels could serve as an important step in asthma prevention, especially for moms with a history of the condition.
Interestingly, for children whose mothers had asthma, there was a notable L-shaped relationship with folate levels. This means that those with low maternal folate levels had a dramatically higher risk of asthma, presenting an odds ratio of 5.93 compared to kids with asthma-free mothers and sufficient folate levels. Our findings suggest that when a mother has asthma, ensuring adequate folate during pregnancy could be crucial for reducing the chance of developing asthma in their children.
If further research supports our findings, optimizing maternal folate levels could serve as an important step in asthma prevention, especially for moms with a history of the condition.
Read More
8
Folate levels influence asthma symptoms
Potential role of folate status on pulmonary function in pediatric asthma.
Addresses pediatric asthma and folate
We explored the link between folate levels in the blood and asthma symptoms in children, particularly in those following a traditional Mediterranean diet. Our study involved 64 children with mild asthma from Athens, Greece, where we conducted clinical assessments including spirometry to measure lung function and analyzed plasma folate levels.
Through this research, we found that 45.3% of the children exhibited folate deficiency. Notably, we observed a positive correlation between higher folate levels and better lung function, specifically in girls. For instance, girls with low folate concentrations showed significantly lower forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and peak expiratory flow (PEF) than those with higher folate concentrations.
These results highlight the potential detrimental impact of folate deficiency on lung function in girls with asthma. They suggest that monitoring folate status could be vital for managing asthma in children, indicating a need for early interventions to prevent deficiencies.
Through this research, we found that 45.3% of the children exhibited folate deficiency. Notably, we observed a positive correlation between higher folate levels and better lung function, specifically in girls. For instance, girls with low folate concentrations showed significantly lower forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and peak expiratory flow (PEF) than those with higher folate concentrations.
These results highlight the potential detrimental impact of folate deficiency on lung function in girls with asthma. They suggest that monitoring folate status could be vital for managing asthma in children, indicating a need for early interventions to prevent deficiencies.
Read More
8
Folate impacts asthma and lung function
Serum folate metabolites, asthma, and lung function in a nationwide US study.
High relevance in asthma research
We explored the relationship between serum folate levels and asthma outcomes in a large-scale study conducted across the United States. The focus was on a specific measure called the 5-MTHF to UMFA ratio, and we found that a higher ratio is linked to lower odds of asthma.
Interestingly, this same ratio was also correlated with improvements in lung function, showing increased forced expiratory volume (FEV) in both children and adults, as well as a rise in forced vital capacity (FVC) among adults.
While these findings suggest a positive association between folate levels and asthma control, it's essential to recognize that the isolated effect of folate wasn’t rigorously determined. This means that while there is a connection, it could also be influenced by other factors that impact metabolic processes.
Overall, this study highlights the potential importance of serum folate in respiratory health, paving the way for further investigations into how we might leverage nutritional interventions in asthma management.
Interestingly, this same ratio was also correlated with improvements in lung function, showing increased forced expiratory volume (FEV) in both children and adults, as well as a rise in forced vital capacity (FVC) among adults.
While these findings suggest a positive association between folate levels and asthma control, it's essential to recognize that the isolated effect of folate wasn’t rigorously determined. This means that while there is a connection, it could also be influenced by other factors that impact metabolic processes.
Overall, this study highlights the potential importance of serum folate in respiratory health, paving the way for further investigations into how we might leverage nutritional interventions in asthma management.
Read More
7
Folate's role in asthma management
Association between serum folate levels and blood eosinophil counts in American adults with asthma: Results from NHANES 2011-2018.
Highly relevant to asthma research
We explored how serum folate levels might relate to blood eosinophil counts in adults with asthma using data from the National Health and Nutrition Examination Survey (NHANES) spanning 2011 to 2018. Over 2,300 adults with asthma participated, allowing us to analyze the impact of folate on asthma severity and control.
Our findings revealed an intriguing inverse relationship: as serum folate levels increased, blood eosinophil counts tended to decrease. Specifically, we observed a reduction of about 0.20 cells per microliter of blood for each unit increase in serum folate concentration. This suggests that higher folate levels could play a role in modulating the immune response in asthmatic patients.
We utilized various statistical models, including regression analyses and the XGBoost algorithm, to reinforce our conclusions. These methods helped us confirm that the correlation between folate and eosinophil counts is consistent across different models and remains significant even when accounting for other influencing factors.
We hope these insights shed light on the potential benefits of folate in managing asthma, encouraging a broader conversation regarding its role in asthma care and treatment. This emphasizes the importance of recognizing nutritional elements, like folate, in understanding and potentially controlling asthma.
Our findings revealed an intriguing inverse relationship: as serum folate levels increased, blood eosinophil counts tended to decrease. Specifically, we observed a reduction of about 0.20 cells per microliter of blood for each unit increase in serum folate concentration. This suggests that higher folate levels could play a role in modulating the immune response in asthmatic patients.
We utilized various statistical models, including regression analyses and the XGBoost algorithm, to reinforce our conclusions. These methods helped us confirm that the correlation between folate and eosinophil counts is consistent across different models and remains significant even when accounting for other influencing factors.
We hope these insights shed light on the potential benefits of folate in managing asthma, encouraging a broader conversation regarding its role in asthma care and treatment. This emphasizes the importance of recognizing nutritional elements, like folate, in understanding and potentially controlling asthma.
Read More
7
Folate levels inversely affect asthma
Association between Serum Folic Acid Levels and Asthma in the Korean Population: A Study Based on the 2016-2018 Korea National Health and Nutrition Examination Survey.
Direct examination of folate and asthma
We explored the relationship between serum folic acid levels and asthma in a study involving over 6,600 individuals from the Korea National Health and Nutrition Examination Survey conducted between 2016 and 2018. Our key goal was to understand if there's an association between folate levels and the prevalence of asthma, a common allergic condition.
Through a series of analyses, including logistic regression, we found that higher serum folic acid levels were indeed linked to a lower risk of having physician-diagnosed asthma. Specifically, for every 1 ng/mL increase in serum folic acid, the odds of acquiring asthma decreased significantly, even after adjusting for factors like age, sex, body mass index, and smoking status.
This finding suggests that maintaining adequate folate levels might play a beneficial role in managing or preventing asthma among individuals, particularly within the Korean population. However, further research is necessary to confirm these results and deepen our understanding of how folate influences asthma severity and management.
Through a series of analyses, including logistic regression, we found that higher serum folic acid levels were indeed linked to a lower risk of having physician-diagnosed asthma. Specifically, for every 1 ng/mL increase in serum folic acid, the odds of acquiring asthma decreased significantly, even after adjusting for factors like age, sex, body mass index, and smoking status.
This finding suggests that maintaining adequate folate levels might play a beneficial role in managing or preventing asthma among individuals, particularly within the Korean population. However, further research is necessary to confirm these results and deepen our understanding of how folate influences asthma severity and management.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Immediate relief
This product was great for my asthma! Within 30 minutes of taking it, my lungs felt open. I'm grateful for a solution that addresses nutrient deficiencies rather than relying on pharmaceutical drugs.
