Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7
USERS' SCORE
Good
Based on 26 Reviews
8
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
9
Folic acid improves rheumatoid arthritis treatment
We explored the use of ginger-derived extracellular vesicles modified with folic acid to treat rheumatoid arthritis, a painful autoimmune condition. By enhancing these vesicles to target the inflammatory cells in affected joints, we found that they help shift the immune response towards healing. Our in vitro and in vivo studies showed promising results: these folic acid-infused vesicles not only concentrated in the inflamed areas but also significantly reduced RA symptoms. This suggests that folic acid-modified vesicles could be a safe and effective alternative treatment option for RA.
Read More
8
Methotrexate withdrawal and folic acid
We examined a long-term study focusing on elderly patients with rheumatoid arthritis (RA) using methotrexate (MTX).
While higher MTX doses increased the risk of needing to stop treatment due to adverse effects, adding folic acid seemed to lower that risk significantly.
In fact, around 51.7% of patients had to discontinue MTX within 15 years, but those on folic acid had a much better outcome.
This suggests that doctors should consider lower MTX doses combined with folic acid for better results in elderly RA management.
While higher MTX doses increased the risk of needing to stop treatment due to adverse effects, adding folic acid seemed to lower that risk significantly.
In fact, around 51.7% of patients had to discontinue MTX within 15 years, but those on folic acid had a much better outcome.
This suggests that doctors should consider lower MTX doses combined with folic acid for better results in elderly RA management.
Read More
7
We aimed to understand how folate receptor alpha autoantibodies (FRAAs) relate to symptoms in children diagnosed with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) and Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). We analyzed serum samples from 47 children, aged 6 to 18, who carried these diagnoses.
Our results showed that a significant number of these children—about 63.8%—had binding or blocking FRAAs. Additionally, certain symptoms, like severe tics, linked with higher FRAA binding titers. Notably, we observed that kids with autism spectrum disorder (ASD) had lower binding titers of FRAAs.
A remarkable case highlighted how treatment with leucovorin, a form of folate, resulted in symptom improvements in a child with PANS/PANDAS who tested positive for FRAAs. These findings suggest that abnormalities in folate metabolism could play a role in the symptomatology of PANS/PANDAS, presenting the potential for folate-based therapies to be a viable treatment option.
Overall, this study sheds light on the connection between folate-related factors and pediatric neuropsychiatric disorders, calling for further research into leucovorin as a targeted treatment.
Our results showed that a significant number of these children—about 63.8%—had binding or blocking FRAAs. Additionally, certain symptoms, like severe tics, linked with higher FRAA binding titers. Notably, we observed that kids with autism spectrum disorder (ASD) had lower binding titers of FRAAs.
A remarkable case highlighted how treatment with leucovorin, a form of folate, resulted in symptom improvements in a child with PANS/PANDAS who tested positive for FRAAs. These findings suggest that abnormalities in folate metabolism could play a role in the symptomatology of PANS/PANDAS, presenting the potential for folate-based therapies to be a viable treatment option.
Overall, this study sheds light on the connection between folate-related factors and pediatric neuropsychiatric disorders, calling for further research into leucovorin as a targeted treatment.
Read More
Most Useful Reviews
9
Hormonal balance restored
115 people found this helpful
My wife, who has an autoimmune disorder related to hormonal imbalance, was prescribed folic acid and vitamin E. After trying a "pharmacy course", we sought a better quality supplement from iHerb, which proved beneficial, resulting in her improved health.
Read More
9
Affordable efficiency
68 people found this helpful
If you have an autoimmune disorder and an MTFR gene mutation, this has been one of the few effective methylfolate supplements I've tried. It's economical and small in size, fulfilling the necessary levels for conception and healthy development.
Read More
9
Pregnancy prepared
36 people found this helpful
After two purchases, I can confidently say that this methylfolate is excellent for those with an autoimmune disorder. I began taking it while planning to get pregnant, and I've noticed significant improvements in my hair health.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7
- All Researches
9
Folic acid improves rheumatoid arthritis treatment
We explored the use of ginger-derived extracellular vesicles modified with folic acid to treat rheumatoid arthritis, a painful autoimmune condition. By enhancing these vesicles to target the inflammatory cells in affected joints, we found that they help shift the immune response towards healing. Our in vitro and in vivo studies showed promising results: these folic acid-infused vesicles not only concentrated in the inflamed areas but also significantly reduced RA symptoms. This suggests that folic acid-modified vesicles could be a safe and effective alternative treatment option for RA.
Read More
8
Prodrug shows promise for arthritis
We explored a promising new approach to treating inflammatory arthritis, focusing on a modified form of methotrexate (MTX) that uses folic acid to target inflamed joints. The study found that this prodrug could release the medication in a controlled way while reducing side effects common with traditional treatments.
In tests involving mouse models and human joint fluid samples, we observed that the prodrug not only accumulated in areas of inflammation but also matched the effectiveness of standard weekly MTX with much less dosage. While this treatment is still in the early stages, it shows exciting potential for improving care in those suffering from arthritis.
In tests involving mouse models and human joint fluid samples, we observed that the prodrug not only accumulated in areas of inflammation but also matched the effectiveness of standard weekly MTX with much less dosage. While this treatment is still in the early stages, it shows exciting potential for improving care in those suffering from arthritis.
Read More
8
Methotrexate withdrawal and folic acid
We examined a long-term study focusing on elderly patients with rheumatoid arthritis (RA) using methotrexate (MTX).
While higher MTX doses increased the risk of needing to stop treatment due to adverse effects, adding folic acid seemed to lower that risk significantly.
In fact, around 51.7% of patients had to discontinue MTX within 15 years, but those on folic acid had a much better outcome.
This suggests that doctors should consider lower MTX doses combined with folic acid for better results in elderly RA management.
While higher MTX doses increased the risk of needing to stop treatment due to adverse effects, adding folic acid seemed to lower that risk significantly.
In fact, around 51.7% of patients had to discontinue MTX within 15 years, but those on folic acid had a much better outcome.
This suggests that doctors should consider lower MTX doses combined with folic acid for better results in elderly RA management.
Read More
8
We explored the effectiveness of a folic acid-targeted liposomal drug delivery system, known as FA-LP-GCK, for treating rheumatoid arthritis (RA). Ginsenoside compound K, while promising due to its immune-boosting and anti-inflammatory properties, faces challenges like poor solubility and absorption.
Our study found that FA-LP-GCK showed significant improvements, such as reduced joint swelling and lower levels of inflammatory markers in rat models of RA. This suggests FA-LP-GCK could be a promising new treatment option for patients struggling with this debilitating condition.
Our study found that FA-LP-GCK showed significant improvements, such as reduced joint swelling and lower levels of inflammatory markers in rat models of RA. This suggests FA-LP-GCK could be a promising new treatment option for patients struggling with this debilitating condition.
Read More
8
We investigated the effects of a new treatment approach for rheumatoid arthritis (RA) that combines Methotrexate (MTX) with folate-liposomal delivery of RELA siRNA. This innovative method aims to target macrophages in the body, which play a critical role in inflammation, especially in autoimmune disorders.
In our study, we observed that using folate-liposomes to deliver both MTX and RELA siRNA leads to a notable reduction in synovial inflammation and improved mobility in a rat model of collagen-induced arthritis (CIA). This dual approach not only helps lower inflammatory markers in the body, like cytokines and C-reactive protein, but also appears to shift the behavior of macrophages from a pro-inflammatory state towards a more healing one.
Additionally, extensive tests showed that this therapy is stable and compatible with biological systems. It highlights the potential of using folate as a targeting agent in the treatment of RA, albeit we did not focus solely on folate’s effect on autoimmune disorders in isolation.
Overall, this research suggests a promising pathway for more effective RA treatments by tackling the root causes of inflammation and preventing further joint damage.
In our study, we observed that using folate-liposomes to deliver both MTX and RELA siRNA leads to a notable reduction in synovial inflammation and improved mobility in a rat model of collagen-induced arthritis (CIA). This dual approach not only helps lower inflammatory markers in the body, like cytokines and C-reactive protein, but also appears to shift the behavior of macrophages from a pro-inflammatory state towards a more healing one.
Additionally, extensive tests showed that this therapy is stable and compatible with biological systems. It highlights the potential of using folate as a targeting agent in the treatment of RA, albeit we did not focus solely on folate’s effect on autoimmune disorders in isolation.
Overall, this research suggests a promising pathway for more effective RA treatments by tackling the root causes of inflammation and preventing further joint damage.
Read More
User Reviews
USERS' SCORE
Good
Based on 26 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Hormonal balance restored
115 people found this helpful
My wife, who has an autoimmune disorder related to hormonal imbalance, was prescribed folic acid and vitamin E. After trying a "pharmacy course", we sought a better quality supplement from iHerb, which proved beneficial, resulting in her improved health.
Read More
9
Affordable efficiency
68 people found this helpful
If you have an autoimmune disorder and an MTFR gene mutation, this has been one of the few effective methylfolate supplements I've tried. It's economical and small in size, fulfilling the necessary levels for conception and healthy development.
Read More
9
Pregnancy prepared
36 people found this helpful
After two purchases, I can confidently say that this methylfolate is excellent for those with an autoimmune disorder. I began taking it while planning to get pregnant, and I've noticed significant improvements in my hair health.
Read More
9
Heightened energy noted
14 people found this helpful
I've been using this for a few years after discovering my MTHFR gene mutation related to my autoimmune disorder. It's revitalised me, providing energy and mental clarity. I started with a lower dose and gradually increased it, noticing remarkable improvements in my health.
Read More
7.5
Improved mental clarity
13 people found this helpful
This has helped me feel much better mentally and detox at a faster rate than normal. Caffeine no longer bothers me, and I can sleep and wake up early. I will definitely order again when it runs out. Thank you.
Read More
Frequently Asked Questions
9
Reduced homocysteine levels
221 people found this helpful
I found that my homocysteine levels were elevated, indicating that I have an autoimmune disorder. After being prescribed Methylfolate, my levels dropped from 14 to 5.8 within two weeks. I then reduced my intake to 800 micrograms daily. I feel it's essential for my health.
7.5
Sustained compatibility
149 people found this helpful
I've been taking methylfolate for four years due to an autoimmune disorder, as regular forms are not well absorbed. I switched to this brand for cost-effectiveness and am pleased; it perfectly suits my needs and I manage my vitamin intake carefully.
7.5
Reduces homocysteine levels
1 people found this helpful
Methylfolate is an effective bioactive folate form. Due to limited conversion of synthetic folic acid, 5-MTHF should be taken for proper absorption, especially for pregnant women or those with elevated homocysteine levels linked to an autoimmune disorder. This affordable methylfolate may help in addressing those deficiencies.
9
Hormonal balance restored
115 people found this helpful
My wife, who has an autoimmune disorder related to hormonal imbalance, was prescribed folic acid and vitamin E. After trying a "pharmacy course", we sought a better quality supplement from iHerb, which proved beneficial, resulting in her improved health.
9
Heightened energy noted
14 people found this helpful
I've been using this for a few years after discovering my MTHFR gene mutation related to my autoimmune disorder. It's revitalised me, providing energy and mental clarity. I started with a lower dose and gradually increased it, noticing remarkable improvements in my health.
9
Enhanced communication skills
10 people found this helpful
I ordered this for my child with an autoimmune disorder as prescribed by a doctor. He had no allergic reactions. After taking methyl folate, his understanding of speech improved, communication flourished, and protest behaviours decreased.
4
Mixed results
80 people found this helpful
An endocrinologist prescribed this supplement to lower my homocysteine levels related to my autoimmune disorder, but I didn’t see results. It did work for my girlfriend, so I conclude that effects may vary.
7.5
Essential for conception
286 people found this helpful
Methyl folate is vital for anyone over 40 planning to conceive as it is much better absorbed than synthetic folic acid. I use it as part of a comprehensive regimen to support a healthy cycle before pregnancy.
9
Effective for rheumatoid arthritis
1 people found this helpful
My son, diagnosed with rheumatoid arthritis, struggled on folic acid previously. Methyl folate works well; he takes it daily as recommended by his doctor, helping manage the impact of immunosuppressants that deplete vitamin B9.
9
Affordable efficiency
68 people found this helpful
If you have an autoimmune disorder and an MTFR gene mutation, this has been one of the few effective methylfolate supplements I've tried. It's economical and small in size, fulfilling the necessary levels for conception and healthy development.
9
Folic acid improves rheumatoid arthritis treatment
We explored the use of ginger-derived extracellular vesicles modified with folic acid to treat rheumatoid arthritis, a painful autoimmune condition. By enhancing these vesicles to target the inflammatory cells in affected joints, we found that they help shift the immune response towards healing. Our in vitro and in vivo studies showed promising results: these folic acid-infused vesicles not only concentrated in the inflamed areas but also significantly reduced RA symptoms. This suggests that folic acid-modified vesicles could be a safe and effective alternative treatment option for RA.
8
Prodrug shows promise for arthritis
We explored a promising new approach to treating inflammatory arthritis, focusing on a modified form of methotrexate (MTX) that uses folic acid to target inflamed joints. The study found that this prodrug could release the medication in a controlled way while reducing side effects common with traditional treatments.
In tests involving mouse models and human joint fluid samples, we observed that the prodrug not only accumulated in areas of inflammation but also matched the effectiveness of standard weekly MTX with much less dosage. While this treatment is still in the early stages, it shows exciting potential for improving care in those suffering from arthritis.
In tests involving mouse models and human joint fluid samples, we observed that the prodrug not only accumulated in areas of inflammation but also matched the effectiveness of standard weekly MTX with much less dosage. While this treatment is still in the early stages, it shows exciting potential for improving care in those suffering from arthritis.
We looked into how folate, an essential nutrient in our diet, might influence the health of individuals with systemic lupus erythematosus (SLE), an autoimmune disorder that carries a heightened risk of cardiovascular disease. Our investigation involved a case-control study with 394 Mexican-mestizo women, where we sought to find connections between certain genetic variants related to folate metabolism and heart health in SLE patients.
Surprisingly, our results showed that the overall levels of folate and homocysteine—both important in the context of heart health—didn't differ significantly between those with SLE and healthy controls. However, we did observe that the genetic variant c.+677 C>T (known as the CC genotype) appeared to offer some protective benefit against cardiovascular issues, suggesting that people with this genetic makeup might have a lower risk of heart disease.
On the flip side, two specific haplotypes from the c.+677 and c.+1298 genetic variants were linked to an increased risk for SLE itself. This suggests that while folate's role in the body is vital and its genetic connections intricate, treating SLE patients with folate alone may not yield significant improvements in their condition based on these findings.
Overall, while we documented interesting associations between genetic variants and disease risk in SLE, we didn't find strong evidence supporting direct benefits of folate treatment in mitigating the disorder's impact.
Surprisingly, our results showed that the overall levels of folate and homocysteine—both important in the context of heart health—didn't differ significantly between those with SLE and healthy controls. However, we did observe that the genetic variant c.+677 C>T (known as the CC genotype) appeared to offer some protective benefit against cardiovascular issues, suggesting that people with this genetic makeup might have a lower risk of heart disease.
On the flip side, two specific haplotypes from the c.+677 and c.+1298 genetic variants were linked to an increased risk for SLE itself. This suggests that while folate's role in the body is vital and its genetic connections intricate, treating SLE patients with folate alone may not yield significant improvements in their condition based on these findings.
Overall, while we documented interesting associations between genetic variants and disease risk in SLE, we didn't find strong evidence supporting direct benefits of folate treatment in mitigating the disorder's impact.
References
- Han R, Zhou D, Ji N, Yin Z, Wang J, et al. Folic acid-modified ginger-derived extracellular vesicles for targeted treatment of rheumatoid arthritis by remodeling immune microenvironment via the PI3K-AKT pathway. J Nanobiotechnology. 2025;23:41. 10.1186/s12951-025-03096-5
- Nosrati Z, Chen YA, Bergamo M, Rodríguez-Rodríguez C, Chan J, et al. Prodrug Nanomedicine for Synovium Targeted Therapy of Inflammatory Arthritis: Insights from Animal Model and Human Synovial Joint Fluid. Adv Healthc Mater. 2024;13:e2401936. 10.1002/adhm.202401936
- Avalos-Salgado FA, Gonzalez-Lopez L, Gonzalez-Vazquez S, Ponce-Guarneros JM, Santiago-Garcia AP, et al. Risk Factors Associated with Adverse Events Leading to Methotrexate Withdrawal in Elderly Rheumatoid Arthritis Patients: A Retrospective Cohort Study. J Clin Med. 2024;13. 10.3390/jcm13071863
- Liu K, Li X, Li D. Connective tissue disease as a challenge in heart failure: Three case reports. Medicine (Baltimore). 2024;103:e36885. 10.1097/MD.0000000000036885
- Li Z, Han S, Cui G, Xue B, Li J, et al. Oral liposomes encapsulating ginsenoside compound K for rheumatoid arthritis therapy. Int J Pharm. 2023;643:123247. 10.1016/j.ijpharm.2023.123247
- Nasra S, Bhatia D, Kumar A. Targeted Macrophage Re-Programming: Synergistic Therapy With Methotrexate and RELA siRNA Folate-Liposome in RAW264.7 Cells and Arthritic Rats. Adv Healthc Mater. 2024;13:e2400679. 10.1002/adhm.202400679
- Pesqueda-Cendejas K, Parra-Rojas I, Campos-López B, Mora-García PE, Ruiz-Ballesteros AI, et al. Association of c.+677 C>T (rs1801133) and c.+1298 A>C (rs1801131) genetic variants with cardiometabolic and disease risk in systemic lupus erythematosus patients: A cross-sectional study. Lupus. 2024;33:918. 10.1177/09612033241257158
- Patel AV, Morgan SL, Green R, Danila MI, Merriman TR, et al. Vitamin B12 status and hyperhomocysteinemia in patients with Rheumatoid arthritis treated with methotrexate and folic acid. Am J Med Sci. 2024;368:33. 10.1016/j.amjms.2024.03.020
- Wells L, O'Hara N, Frye RE, Hullavard N, Smith E. Folate Receptor Alpha Autoantibodies in the Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) Population. J Pers Med. 2024;14. 10.3390/jpm14020166
