Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.1
USERS' SCORE
Good
Based on 16 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
8
We explored a unique case of recurrent fainting after hysteroscopy, ultimately revealed as cerebral venous sinus thrombosis (CVST). This rare condition can mimic symptoms of more common complications like TURP syndrome, making diagnosis tricky.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
Read More
8
We examined the case of a healthy 12-year-old girl who experienced a central retinal vein occlusion. This incident was particularly notable because she later developed retinal neovascularization at the age of 24. This timing marks the longest gap reported between such a pediatric event and subsequent complications.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Read More
7
We investigated how folic acid supplementation affects blood clots in patients with end-stage kidney disease (ESKD) undergoing hemodialysis. Our research used patient data from the Chang Gung Medical Foundation and compared daily versus weekly folic acid dosages.
Interestingly, patients taking daily folic acid showed a lower rate of arteriovenous access thrombosis compared to those on weekly supplements. However, both groups had similar rates of other serious cardiovascular events, suggesting that while daily supplementation may help with thrombosis, it does not significantly impact overall cardiovascular health.
Interestingly, patients taking daily folic acid showed a lower rate of arteriovenous access thrombosis compared to those on weekly supplements. However, both groups had similar rates of other serious cardiovascular events, suggesting that while daily supplementation may help with thrombosis, it does not significantly impact overall cardiovascular health.
Read More
Most Useful Reviews
9
Lowered homocysteine level
27 people found this helpful
Understanding my homocysteine level is crucial as I plan my pregnancy. After discovering it was high, I switched to methyl folate due to allergies with regular folic acid. Within a month, my levels decreased significantly, and I felt more energetic with clearer thoughts—definitely effective.
Read More
9
Monitored effectiveness
1 people found this helpful
The correct form of methyl folate raised my B9 levels and reduced homocysteine alongside B12. I plan to continue taking it while monitoring my blood tests.
Read More
9
Thins blood well
1 people found this helpful
The best form of folic acid is as folates. It is especially beneficial for those with a blood clot condition. I am planning a pregnancy and have thrombophilia; my doctor recommended this particular form as it aids in thinning the blood effectively.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.1
- All Researches
9
Supplementation improves health outcomes
We conducted a multi-center trial in Romania to explore how vitamin B12, folic acid, and vitamin D3 supplements could help lower homocysteine levels in Parkinson's disease patients on levodopa treatment.
Over six months, we observed that participants who took these supplements experienced a significant reduction in homocysteine levels and an improvement in their overall quality of life.
The findings suggest that nutritional support can play a vital role in managing Parkinson's disease, potentially reducing risks associated with elevated homocysteine, such as blood clots and other complications.
Over six months, we observed that participants who took these supplements experienced a significant reduction in homocysteine levels and an improvement in their overall quality of life.
The findings suggest that nutritional support can play a vital role in managing Parkinson's disease, potentially reducing risks associated with elevated homocysteine, such as blood clots and other complications.
Read More
8
We explored a unique case of recurrent fainting after hysteroscopy, ultimately revealed as cerebral venous sinus thrombosis (CVST). This rare condition can mimic symptoms of more common complications like TURP syndrome, making diagnosis tricky.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
Read More
8
We examined a unique case of cerebral venous thrombosis in a 14-year-old girl, associated with hyperhomocysteinemia and a rare mutation at the MTHFR locus. The patient displayed symptoms like headaches and nausea, with significantly elevated homocysteine levels.
After receiving a combination of anticoagulation therapy and supplementation with folate, B12, and B6, her condition improved remarkably over a month, reducing intracranial pressure and alleviating symptoms. This case emphasizes the importance of such genetic analysis in similar thrombotic cases.
After receiving a combination of anticoagulation therapy and supplementation with folate, B12, and B6, her condition improved remarkably over a month, reducing intracranial pressure and alleviating symptoms. This case emphasizes the importance of such genetic analysis in similar thrombotic cases.
Read More
8
We explored how folic acid (FA) affects blood clotting in a study that examined the impact of carbon black (CB) on mice. Over 28 days, mice exposed to CB showed increased blood clotting due to changes in spleen activity and elevated platelet counts.
Interestingly, lower levels of folic acid were noted after CB exposure. However, administering folic acid helped restore normal blood coagulation levels by inhibiting certain inflammatory pathways. Despite these findings, it’s important to state that this study primarily exposes potential mechanisms rather than confirming definitive benefits of folic acid for humans.
Interestingly, lower levels of folic acid were noted after CB exposure. However, administering folic acid helped restore normal blood coagulation levels by inhibiting certain inflammatory pathways. Despite these findings, it’s important to state that this study primarily exposes potential mechanisms rather than confirming definitive benefits of folic acid for humans.
Read More
8
We examined the case of a healthy 12-year-old girl who experienced a central retinal vein occlusion. This incident was particularly notable because she later developed retinal neovascularization at the age of 24. This timing marks the longest gap reported between such a pediatric event and subsequent complications.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Read More
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Lowered homocysteine level
27 people found this helpful
Understanding my homocysteine level is crucial as I plan my pregnancy. After discovering it was high, I switched to methyl folate due to allergies with regular folic acid. Within a month, my levels decreased significantly, and I felt more energetic with clearer thoughts—definitely effective.
Read More
9
Monitored effectiveness
1 people found this helpful
The correct form of methyl folate raised my B9 levels and reduced homocysteine alongside B12. I plan to continue taking it while monitoring my blood tests.
Read More
9
Thins blood well
1 people found this helpful
The best form of folic acid is as folates. It is especially beneficial for those with a blood clot condition. I am planning a pregnancy and have thrombophilia; my doctor recommended this particular form as it aids in thinning the blood effectively.
Read More
7.5
Decreased homocysteine
30 people found this helpful
Folic acid in the form of methyl folate is better absorbed, leading to decreased homocysteine in my blood. I take it in preparation for pregnancy, as it supports my nervous system and provides energy. The taste is neutral, and the capsule size is convenient.
Read More
7
Improved blood levels
2 people found this helpful
This product effectively raised my vitamin B9 levels as part of my anaemia treatment.
Read More
Frequently Asked Questions
9
Lowered homocysteine level
27 people found this helpful
Understanding my homocysteine level is crucial as I plan my pregnancy. After discovering it was high, I switched to methyl folate due to allergies with regular folic acid. Within a month, my levels decreased significantly, and I felt more energetic with clearer thoughts—definitely effective.
7.5
Reduced homocysteine levels
2 people found this helpful
Hyperhomocysteinemia can damage blood vessels and lead to blood clots. As half the population struggles to absorb folic acid properly, I tailored my dosage after a test. I decreased my levels significantly in a short time and consulted experts on my progress. Methylfolate is a highly active form and effective.
7.5
Relieved leg pain
1 people found this helpful
I experienced an annoying pain in my legs, feeling as though my blood vessels ached at night. After taking methylfolate, these painful episodes disappeared, although I remain concerned they might return once I stop taking it. Other than that, I have not noticed significant changes in my body.
7.5
Effective for recovery
1 people found this helpful
I purchased this to lower my homocysteine levels after recovering from Covid. It’s an effective formulation, especially since some need B12 alongside it. I find this form safer, particularly for those with mutations in the folate cycle.
9
Improved blood fluidity
I found methylfolate excellent when preparing for pregnancy, especially when combined with niacin. I started with small doses initially. It improved my blood vessel condition and fluidity. During pregnancy, I continued with methylfolate only, and it met my needs despite my genetic issues.
9
Thins blood well
1 people found this helpful
The best form of folic acid is as folates. It is especially beneficial for those with a blood clot condition. I am planning a pregnancy and have thrombophilia; my doctor recommended this particular form as it aids in thinning the blood effectively.
7
We investigated how folic acid supplementation affects blood clots in patients with end-stage kidney disease (ESKD) undergoing hemodialysis. Our research used patient data from the Chang Gung Medical Foundation and compared daily versus weekly folic acid dosages.
Interestingly, patients taking daily folic acid showed a lower rate of arteriovenous access thrombosis compared to those on weekly supplements. However, both groups had similar rates of other serious cardiovascular events, suggesting that while daily supplementation may help with thrombosis, it does not significantly impact overall cardiovascular health.
Interestingly, patients taking daily folic acid showed a lower rate of arteriovenous access thrombosis compared to those on weekly supplements. However, both groups had similar rates of other serious cardiovascular events, suggesting that while daily supplementation may help with thrombosis, it does not significantly impact overall cardiovascular health.
8
We examined a unique case of cerebral venous thrombosis in a 14-year-old girl, associated with hyperhomocysteinemia and a rare mutation at the MTHFR locus. The patient displayed symptoms like headaches and nausea, with significantly elevated homocysteine levels.
After receiving a combination of anticoagulation therapy and supplementation with folate, B12, and B6, her condition improved remarkably over a month, reducing intracranial pressure and alleviating symptoms. This case emphasizes the importance of such genetic analysis in similar thrombotic cases.
After receiving a combination of anticoagulation therapy and supplementation with folate, B12, and B6, her condition improved remarkably over a month, reducing intracranial pressure and alleviating symptoms. This case emphasizes the importance of such genetic analysis in similar thrombotic cases.
2
We investigated how folate and other B-vitamins impact blood clot formation and breakdown in patients with coronary artery disease (CAD). Our large study included nearly 2,000 CAD participants who were given different combinations of folic acid and B-vitamins over 3.8 years as part of the Western Norway B-Vitamin Intervention Trial.
Despite our efforts, we found that folate treatment didn't lead to significant changes in important measures of blood clot functionality, specifically clot lysis time (CLT) and maximum absorbance (Absmax). These factors are critical for understanding how blood clots behave, especially in the context of cardiovascular events like heart attacks.
We observed that higher levels of certain metabolites like homocysteine thiolactone and cysteine were linked to worse outcomes, indicating that while folate did not improve CLT or Absmax, some sulfur-containing compounds might play a significant role in predicting heart risks. Overall, the lack of improvement from B-vitamin therapy sheds light on the complexity of nutrition’s role in heart health.
Despite our efforts, we found that folate treatment didn't lead to significant changes in important measures of blood clot functionality, specifically clot lysis time (CLT) and maximum absorbance (Absmax). These factors are critical for understanding how blood clots behave, especially in the context of cardiovascular events like heart attacks.
We observed that higher levels of certain metabolites like homocysteine thiolactone and cysteine were linked to worse outcomes, indicating that while folate did not improve CLT or Absmax, some sulfur-containing compounds might play a significant role in predicting heart risks. Overall, the lack of improvement from B-vitamin therapy sheds light on the complexity of nutrition’s role in heart health.
References
- Zhang Y, Ye H, Chen D, Yan G, Li Z, et al. Recurrent syncope after hysteroscopy finally diagnosed as cerebral venous sinus thrombosis: a case report. AJOG Glob Rep. 2025;5:100446. 10.1016/j.xagr.2025.100446
- Turcu-Stiolica A, Naidin MS, Halmagean S, Ionescu AM, Pirici I. The Impact of the Dietary Intake of Vitamin B12, Folic Acid, and Vitamin D3 on Homocysteine Levels and the Health-Related Quality of Life of Levodopa-Treated Patients with Parkinson's Disease-A Pilot Study in Romania. Diagnostics (Basel). 2024;14. 10.3390/diagnostics14151609
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. 10.1186/s12883-023-03200-y
- Lin SS, Fan IW, Chen CY, Su YJ. A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report. Med Int (Lond). 2022;2:20. 10.3892/mi.2022.45
- Tu YR, Tu KH, Lee CC, Fan PC, Yen CL, et al. Supplementation with Folic Acid and Cardiovascular Outcomes in End-Stage Kidney Disease: A Multi-Institution Cohort Study. Nutrients. 2022;14. 10.3390/nu14194162
- Chaloulis SK, Tsaousis KT. Cystoid Macular Edema Associated With Venous Stasis in a Patient With Previously Undiagnosed Hyperhomocysteinemia. Cureus. 2021;13:e20782. 10.7759/cureus.20782
- Lauretta MP, Melotti RM, Sangermano C, George AM, Badenes R, et al. Homocysteine Plasmatic Concentration in Brain-Injured Neurocritical Care Patients: Systematic Review of Clinical Evidence. J Clin Med. 2022;11. 10.3390/jcm11020394
- Meng Q, Li B, Huang N, Wei S, Ren Q, et al. Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential. J Hazard Mater. 2022;424:127354. 10.1016/j.jhazmat.2021.127354
- Cao Y, Yao T, Chen H, Liu H, Li C, et al. The association of serum folate and homocysteine on venous thromboembolism in patients with colorectal cancer: a cross-sectional study. Transl Cancer Res. 2023;12:125. 10.21037/tcr-22-2839
- Sikora M, Skrzydlewski P, Perła-Kaján J, Jakubowski H. Homocysteine thiolactone contributes to the prognostic value of fibrin clot structure/function in coronary artery disease. PLoS One. 2022;17:e0275956. 10.1371/journal.pone.0275956
- Hudson JL, Laura DM, Berrocal AM. CENTRAL RETINAL VEIN OCCLUSION IN 12-YEAR-OLD GIRL WITH METHYLENETETRAHYDROFOLATE REDUCTASE MUTATION: A CASE REPORT AND REVIEW OF THE LITERATURE. Retin Cases Brief Rep. 2023;17:734. 10.1097/ICB.0000000000001283
