' 
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
USERS' SCORE
Good
Based on 16 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
9
Folic acid impacts blood clotting
Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential.
Significant relevance to folate's effects
We investigated how folic acid affects blood clotting, particularly when exposed to carbon black (CB), a common industrial substance. In our study with adult C57BL/6 mice, we found that prolonged exposure to CB led to increased blood clotting potential due to changes in the spleen, where extra blood cell production occurs.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Read More
8
Cerebral venous sinus thrombosis case
Recurrent syncope after hysteroscopy finally diagnosed as cerebral venous sinus thrombosis: a case report.
Important for post-surgery diagnosis
We explored a unique case of recurrent fainting after hysteroscopy, ultimately revealed as cerebral venous sinus thrombosis (CVST). This rare condition can mimic symptoms of more common complications like TURP syndrome, making diagnosis tricky.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
Read More
8
Pediatric blood clot management insights
CENTRAL RETINAL VEIN OCCLUSION IN 12-YEAR-OLD GIRL WITH METHYLENETETRAHYDROFOLATE REDUCTASE MUTATION: A CASE REPORT AND REVIEW OF THE LITERATURE.
Research indicates folate's role
We examined the case of a healthy 12-year-old girl who experienced a central retinal vein occlusion. This incident was particularly notable because she later developed retinal neovascularization at the age of 24. This timing marks the longest gap reported between such a pediatric event and subsequent complications.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Read More
Most Useful Reviews
9.5
Lowered homocysteine level
Understanding my homocysteine level is crucial as I plan my pregnancy. After discovering it was high, I switched to methyl folate due to allergies with regular folic acid. Within a month, my levels decreased significantly, and I felt more energetic with clearer thoughts—definitely effective.
Read More
9.5
Monitored effectiveness
The correct form of methyl folate raised my B9 levels and reduced homocysteine alongside B12. I plan to continue taking it while monitoring my blood tests.
Read More
9.5
Thins blood well
The best form of folic acid is as folates. It is especially beneficial for those with a blood clot condition. I am planning a pregnancy and have thrombophilia; my doctor recommended this particular form as it aids in thinning the blood effectively.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
- All Researches
9
Supplementation improves health outcomes
The Impact of the Dietary Intake of Vitamin B12, Folic Acid, and Vitamin D3 on Homocysteine Levels and the Health-Related Quality of Life of Levodopa-Treated Patients with Parkinson's Disease-A Pilot Study in Romania.
High relevance in Parkinson's management
We conducted a multi-center trial in Romania to explore how vitamin B12, folic acid, and vitamin D3 supplements could help lower homocysteine levels in Parkinson's disease patients on levodopa treatment.
Over six months, we observed that participants who took these supplements experienced a significant reduction in homocysteine levels and an improvement in their overall quality of life.
The findings suggest that nutritional support can play a vital role in managing Parkinson's disease, potentially reducing risks associated with elevated homocysteine, such as blood clots and other complications.
Over six months, we observed that participants who took these supplements experienced a significant reduction in homocysteine levels and an improvement in their overall quality of life.
The findings suggest that nutritional support can play a vital role in managing Parkinson's disease, potentially reducing risks associated with elevated homocysteine, such as blood clots and other complications.
Read More
9
Folate's role in thrombosis treatment
Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report.
Moderately relevant case findings
We observed a fascinating case involving a 14-year-old girl who experienced severe headaches and nausea, leading to the discovery of cerebral venous thrombosis (CVT) and significantly elevated plasma homocysteine levels. Through comprehensive genetic testing, we identified a rare genetic change called loss of heterozygosity (LOH) affecting the methylenetetrahydrofolate reductase (MTHFR) gene, which plays a crucial role in processing folate in the body.
In treating the patient, we included supplementary folate along with anticoagulants to manage the thrombosis. While we noted improvements in her symptoms and a decrease in thrombosis severity, it is essential to recognize that the isolated effect of folate on blood clotting cannot be fully established due to the concurrent use of anticoagulants and other vitamin supplements. Therefore, while folate forms part of the treatment, its direct impact on clot formation requires further investigation.
The combination of anticoagulants, nutritional supplements, and genetic insights showcases an integrated approach to managing complex medical issues, highlighting that while folate is beneficial, its role is part of a broader strategy.
In treating the patient, we included supplementary folate along with anticoagulants to manage the thrombosis. While we noted improvements in her symptoms and a decrease in thrombosis severity, it is essential to recognize that the isolated effect of folate on blood clotting cannot be fully established due to the concurrent use of anticoagulants and other vitamin supplements. Therefore, while folate forms part of the treatment, its direct impact on clot formation requires further investigation.
The combination of anticoagulants, nutritional supplements, and genetic insights showcases an integrated approach to managing complex medical issues, highlighting that while folate is beneficial, its role is part of a broader strategy.
Read More
9
Folic acid impacts blood clotting
Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential.
Significant relevance to folate's effects
We investigated how folic acid affects blood clotting, particularly when exposed to carbon black (CB), a common industrial substance. In our study with adult C57BL/6 mice, we found that prolonged exposure to CB led to increased blood clotting potential due to changes in the spleen, where extra blood cell production occurs.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Read More
8
Cerebral venous sinus thrombosis case
Recurrent syncope after hysteroscopy finally diagnosed as cerebral venous sinus thrombosis: a case report.
Important for post-surgery diagnosis
We explored a unique case of recurrent fainting after hysteroscopy, ultimately revealed as cerebral venous sinus thrombosis (CVST). This rare condition can mimic symptoms of more common complications like TURP syndrome, making diagnosis tricky.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
Read More
8
MTHFR mutation linked to thrombosis
Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report.
Significant case for research
We examined a unique case of cerebral venous thrombosis in a 14-year-old girl, associated with hyperhomocysteinemia and a rare mutation at the MTHFR locus. The patient displayed symptoms like headaches and nausea, with significantly elevated homocysteine levels.
After receiving a combination of anticoagulation therapy and supplementation with folate, B12, and B6, her condition improved remarkably over a month, reducing intracranial pressure and alleviating symptoms. This case emphasizes the importance of such genetic analysis in similar thrombotic cases.
After receiving a combination of anticoagulation therapy and supplementation with folate, B12, and B6, her condition improved remarkably over a month, reducing intracranial pressure and alleviating symptoms. This case emphasizes the importance of such genetic analysis in similar thrombotic cases.
Read More
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Lowered homocysteine level
Understanding my homocysteine level is crucial as I plan my pregnancy. After discovering it was high, I switched to methyl folate due to allergies with regular folic acid. Within a month, my levels decreased significantly, and I felt more energetic with clearer thoughts—definitely effective.
Read More
9.5
Monitored effectiveness
The correct form of methyl folate raised my B9 levels and reduced homocysteine alongside B12. I plan to continue taking it while monitoring my blood tests.
9.5
Thins blood well
The best form of folic acid is as folates. It is especially beneficial for those with a blood clot condition. I am planning a pregnancy and have thrombophilia; my doctor recommended this particular form as it aids in thinning the blood effectively.
8.8
Decreased homocysteine
Folic acid in the form of methyl folate is better absorbed, leading to decreased homocysteine in my blood. I take it in preparation for pregnancy, as it supports my nervous system and provides energy. The taste is neutral, and the capsule size is convenient.
8.5
Improved blood levels
This product effectively raised my vitamin B9 levels as part of my anaemia treatment.
