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SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.4
USERS' SCORE
Good
Based on 19 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
9
Folinic acid improves CFS symptoms
Clinical activity of folinic acid in patients with chronic fatigue syndrome.
High relevance to folate treatment
We aimed to explore the effects of folinic acid, also known as leucovorin, on patients suffering from chronic fatigue syndrome (CFS). Our investigation revealed some fascinating findings about this often misunderstood condition, particularly the links to immune response and Epstein-Barr virus (EBV) infection.
In our evaluation of 58 CFS patients, we discovered that nearly all had previously been exposed to EBV, with a striking 72% showing signs of active reactivation. Additionally, an overwhelming 94% were found to have a severe B-cell immunodeficiency, evidenced by a marked reduction in their CD19+IgM+ mature B-lymphocyte population.
What stood out was that after treatment with folinic acid, an impressive 81% of the participants reported experiencing a noticeable improvement in their symptoms. This suggests that folinic acid might play a significant role in the management of CFS, particularly for those struggling with related immune deficiencies and EBV responses.
Our findings bring new insights into CFS, indicating that it may be a condition responding well to folinic acid treatment. This opens up exciting avenues for further research into effective therapies for those affected by this challenging syndrome.
In our evaluation of 58 CFS patients, we discovered that nearly all had previously been exposed to EBV, with a striking 72% showing signs of active reactivation. Additionally, an overwhelming 94% were found to have a severe B-cell immunodeficiency, evidenced by a marked reduction in their CD19+IgM+ mature B-lymphocyte population.
What stood out was that after treatment with folinic acid, an impressive 81% of the participants reported experiencing a noticeable improvement in their symptoms. This suggests that folinic acid might play a significant role in the management of CFS, particularly for those struggling with related immune deficiencies and EBV responses.
Our findings bring new insights into CFS, indicating that it may be a condition responding well to folinic acid treatment. This opens up exciting avenues for further research into effective therapies for those affected by this challenging syndrome.
Read More
8
Folate improves fatigue-related disorders
Folate-responsive neurological and mental disorders: report of 16 cases. Neuropsychological correlates of computerized transaxial tomography and radionuclide cisternography in folic acid deficiencies.
Strong relevance to fatigue treatment
We examined two groups of patients who exhibited neurological and psychiatric disorders responsive to folic acid treatment. The first group of seven individuals suffered from an acquired folate deficiency due to either poor absorption of nutrients or an inadequate diet. Their symptoms included significant fatigue, weight loss, and various neurological impairments. The second group, consisting of nine patients, presented idiopathic folate deficiency with chronic fatigue and family histories of restless legs syndrome.
Through neuropsychological testing, we observed abnormal intellectual functioning in all patients, along with issues highlighted on imaging studies like computerized transaxial tomography. Remarkably, after 6 to 12 months of folic acid therapy, a substantial improvement in their cognitive abilities and overall functioning was recorded.
This suggests that addressing folate deficiency might alleviate some aspects of fatigue and cognitive decline commonly associated with chronic fatigue syndrome. Our findings imply that long-term folate supplementation may lead to positive changes in those struggling with fatigue-related conditions, although the label of chronic fatigue syndrome was not explicitly used.
Through neuropsychological testing, we observed abnormal intellectual functioning in all patients, along with issues highlighted on imaging studies like computerized transaxial tomography. Remarkably, after 6 to 12 months of folic acid therapy, a substantial improvement in their cognitive abilities and overall functioning was recorded.
This suggests that addressing folate deficiency might alleviate some aspects of fatigue and cognitive decline commonly associated with chronic fatigue syndrome. Our findings imply that long-term folate supplementation may lead to positive changes in those struggling with fatigue-related conditions, although the label of chronic fatigue syndrome was not explicitly used.
Read More
5
CFS and folate deficiency link
Serum folate and chronic fatigue syndrome.
Moderate relevance; no treatment data
We investigated the connection between serum folate levels and chronic fatigue syndrome (CFS) in a group of 60 patients. Our findings revealed that a striking 50% of these individuals had folate levels below 3.0 micrograms per liter, indicating a potential deficiency in this essential nutrient.
While it’s clear that some patients with CFS are not getting enough folic acid, our study stops short of establishing a direct cause-and-effect relationship. The information lacks treatment outcome data, which means we cannot definitively say that folate supplementation will improve symptoms of CFS or enhance overall well-being.
This research sheds light on a potential factor affecting those with chronic fatigue syndrome and underlines the importance of monitoring vitamin levels in patients. However, further studies are essential to determine the role folate supplementation might play in managing this complex condition.
While it’s clear that some patients with CFS are not getting enough folic acid, our study stops short of establishing a direct cause-and-effect relationship. The information lacks treatment outcome data, which means we cannot definitively say that folate supplementation will improve symptoms of CFS or enhance overall well-being.
This research sheds light on a potential factor affecting those with chronic fatigue syndrome and underlines the importance of monitoring vitamin levels in patients. However, further studies are essential to determine the role folate supplementation might play in managing this complex condition.
Read More
Most Useful Reviews
9.5
Significant improvement
I have been using this supplement for a couple of years after discovering I have the MTHFR gene mutation, which necessitates its use. Upon starting, I felt revitalised with more energy and mental clarity. I had to gradually increase the dosage due to chronic fatigue syndrome, but I’ve seen significant improvement and will continue using it.
Read More
9.5
Increased energy levels
I initially purchased iron and B12 separately to raise my ferritin levels. Within a month, I felt noticeably different, with enhanced strength and energy after years of chronic fatigue syndrome. This supplement greatly improved my iron absorption, a process that had proven ineffective before.
Read More
8.3
Life-changing effects
Methylfolate transformed my life. I struggled with depression and fatigue, but after taking it, I experienced a marked improvement in my mood and energy levels, which helped with my chronic fatigue syndrome.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.4
9
Folinic acid improves CFS symptoms
Clinical activity of folinic acid in patients with chronic fatigue syndrome.
High relevance to folate treatment
We aimed to explore the effects of folinic acid, also known as leucovorin, on patients suffering from chronic fatigue syndrome (CFS). Our investigation revealed some fascinating findings about this often misunderstood condition, particularly the links to immune response and Epstein-Barr virus (EBV) infection.
In our evaluation of 58 CFS patients, we discovered that nearly all had previously been exposed to EBV, with a striking 72% showing signs of active reactivation. Additionally, an overwhelming 94% were found to have a severe B-cell immunodeficiency, evidenced by a marked reduction in their CD19+IgM+ mature B-lymphocyte population.
What stood out was that after treatment with folinic acid, an impressive 81% of the participants reported experiencing a noticeable improvement in their symptoms. This suggests that folinic acid might play a significant role in the management of CFS, particularly for those struggling with related immune deficiencies and EBV responses.
Our findings bring new insights into CFS, indicating that it may be a condition responding well to folinic acid treatment. This opens up exciting avenues for further research into effective therapies for those affected by this challenging syndrome.
In our evaluation of 58 CFS patients, we discovered that nearly all had previously been exposed to EBV, with a striking 72% showing signs of active reactivation. Additionally, an overwhelming 94% were found to have a severe B-cell immunodeficiency, evidenced by a marked reduction in their CD19+IgM+ mature B-lymphocyte population.
What stood out was that after treatment with folinic acid, an impressive 81% of the participants reported experiencing a noticeable improvement in their symptoms. This suggests that folinic acid might play a significant role in the management of CFS, particularly for those struggling with related immune deficiencies and EBV responses.
Our findings bring new insights into CFS, indicating that it may be a condition responding well to folinic acid treatment. This opens up exciting avenues for further research into effective therapies for those affected by this challenging syndrome.
Read More
8
B12 and folic acid show promise
Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.
Study highlights folate's complexity
We aimed to evaluate how folic acid, in combination with vitamin B12, impacts individuals with chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME). Our study focused on a group of 38 patients who had received weekly B12 injections for six months to several years.
During our research, we categorized the patients into two groups: Good responders and Mild responders, based on their improvement in symptoms. We found that those who responded positively had received B12 injections more frequently and at higher doses compared to those with lesser improvement. They also tended to use more folic acid daily and were less likely to use strong analgesics.
Our findings suggested a clear relationship between the dosage of B12 and folic acid and the degree of improvement reported by the participants. However, we noted a higher occurrence of fibromyalgia among those with milder responses, indicating that the presence of additional conditions might affect outcomes.
Overall, we observed a dose-response effect suggesting that B12 and folic acid together could bring about meaningful improvements in CFS symptoms. Also, we identified the importance of being aware of possible thyroid issues and highlighted the need for more precise research regarding their interaction with other medications.
During our research, we categorized the patients into two groups: Good responders and Mild responders, based on their improvement in symptoms. We found that those who responded positively had received B12 injections more frequently and at higher doses compared to those with lesser improvement. They also tended to use more folic acid daily and were less likely to use strong analgesics.
Our findings suggested a clear relationship between the dosage of B12 and folic acid and the degree of improvement reported by the participants. However, we noted a higher occurrence of fibromyalgia among those with milder responses, indicating that the presence of additional conditions might affect outcomes.
Overall, we observed a dose-response effect suggesting that B12 and folic acid together could bring about meaningful improvements in CFS symptoms. Also, we identified the importance of being aware of possible thyroid issues and highlighted the need for more precise research regarding their interaction with other medications.
Read More
8
Folate improves fatigue-related disorders
Folate-responsive neurological and mental disorders: report of 16 cases. Neuropsychological correlates of computerized transaxial tomography and radionuclide cisternography in folic acid deficiencies.
Strong relevance to fatigue treatment
We examined two groups of patients who exhibited neurological and psychiatric disorders responsive to folic acid treatment. The first group of seven individuals suffered from an acquired folate deficiency due to either poor absorption of nutrients or an inadequate diet. Their symptoms included significant fatigue, weight loss, and various neurological impairments. The second group, consisting of nine patients, presented idiopathic folate deficiency with chronic fatigue and family histories of restless legs syndrome.
Through neuropsychological testing, we observed abnormal intellectual functioning in all patients, along with issues highlighted on imaging studies like computerized transaxial tomography. Remarkably, after 6 to 12 months of folic acid therapy, a substantial improvement in their cognitive abilities and overall functioning was recorded.
This suggests that addressing folate deficiency might alleviate some aspects of fatigue and cognitive decline commonly associated with chronic fatigue syndrome. Our findings imply that long-term folate supplementation may lead to positive changes in those struggling with fatigue-related conditions, although the label of chronic fatigue syndrome was not explicitly used.
Through neuropsychological testing, we observed abnormal intellectual functioning in all patients, along with issues highlighted on imaging studies like computerized transaxial tomography. Remarkably, after 6 to 12 months of folic acid therapy, a substantial improvement in their cognitive abilities and overall functioning was recorded.
This suggests that addressing folate deficiency might alleviate some aspects of fatigue and cognitive decline commonly associated with chronic fatigue syndrome. Our findings imply that long-term folate supplementation may lead to positive changes in those struggling with fatigue-related conditions, although the label of chronic fatigue syndrome was not explicitly used.
Read More
5
CFS and folate deficiency link
Serum folate and chronic fatigue syndrome.
Moderate relevance; no treatment data
We investigated the connection between serum folate levels and chronic fatigue syndrome (CFS) in a group of 60 patients. Our findings revealed that a striking 50% of these individuals had folate levels below 3.0 micrograms per liter, indicating a potential deficiency in this essential nutrient.
While it’s clear that some patients with CFS are not getting enough folic acid, our study stops short of establishing a direct cause-and-effect relationship. The information lacks treatment outcome data, which means we cannot definitively say that folate supplementation will improve symptoms of CFS or enhance overall well-being.
This research sheds light on a potential factor affecting those with chronic fatigue syndrome and underlines the importance of monitoring vitamin levels in patients. However, further studies are essential to determine the role folate supplementation might play in managing this complex condition.
While it’s clear that some patients with CFS are not getting enough folic acid, our study stops short of establishing a direct cause-and-effect relationship. The information lacks treatment outcome data, which means we cannot definitively say that folate supplementation will improve symptoms of CFS or enhance overall well-being.
This research sheds light on a potential factor affecting those with chronic fatigue syndrome and underlines the importance of monitoring vitamin levels in patients. However, further studies are essential to determine the role folate supplementation might play in managing this complex condition.
Read More
2
No significant benefit from folate
Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome.
Difficulty isolating folate effects
We conducted a carefully designed study to investigate the effects of an injectable treatment combining bovine liver extract, folic acid, and cyanocobalamin on chronic fatigue syndrome (CFS). This involved a double-blind, placebo-controlled crossover trial with 15 patients who met definitive criteria for CFS.
Throughout the study, patients received both the treatment and a placebo in alternating phases. While we observed that both the treatment and placebo seemed to provide some improvement in functional status for the patients, our analysis showed no significant advantage of the liver extract and folic acid combination over the placebo.
This indicates that the response to folate, particularly, is unclear as the placebo effect appeared to be notably strong among participants. Overall, the findings suggest that further research may be needed to ascertain the definitive role of folate in managing chronic fatigue syndrome.
Throughout the study, patients received both the treatment and a placebo in alternating phases. While we observed that both the treatment and placebo seemed to provide some improvement in functional status for the patients, our analysis showed no significant advantage of the liver extract and folic acid combination over the placebo.
This indicates that the response to folate, particularly, is unclear as the placebo effect appeared to be notably strong among participants. Overall, the findings suggest that further research may be needed to ascertain the definitive role of folate in managing chronic fatigue syndrome.
Read More
User Reviews
USERS' SCORE
Good
Based on 19 Reviews
8.6
9.5
Improved sleep quality
After giving birth, I experienced persistent fatigue and pain in my legs, particularly at night, making sleep difficult. I decided to take iron tests, which showed I had low levels. Since starting this medication, my leg pain has lessened and my sleep has improved significantly. I still feel a slight deficiency, so I will continue seeking a solution.
Read More
9.5
Significant improvement
I have been using this supplement for a couple of years after discovering I have the MTHFR gene mutation, which necessitates its use. Upon starting, I felt revitalised with more energy and mental clarity. I had to gradually increase the dosage due to chronic fatigue syndrome, but I’ve seen significant improvement and will continue using it.
Read More
9.5
Increased energy levels
I initially purchased iron and B12 separately to raise my ferritin levels. Within a month, I felt noticeably different, with enhanced strength and energy after years of chronic fatigue syndrome. This supplement greatly improved my iron absorption, a process that had proven ineffective before.
Read More
9.5
Improved leg condition
I take folate rather than folic acid, even outside of pregnancy, and have found it beneficial for my health. Despite not having taken it prior to my first pregnancy, I believe it could help avoid passing hereditary health issues onto my child. It has alleviated my restless leg syndrome symptoms, which caused significant discomfort at night.
Read More
8.8
Boosted energy levels
Initially, I took one tiny capsule daily, but after discovering my MTHFR issue, I tried taking ten over two days. The effect was astonishing; I felt energetic for five days and woke easily each morning, even after heavy drinking. My usual need for 12 hours of sleep decreased to just 9. I plan to increase my dosage.
Read More
