Last update
4/4/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.2
USERS' SCORE
Good
Based on 11 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
8
We investigated the effects of folinic acid on patients with chronic fatigue syndrome (CFS), where many also showed signs of B-cell immunodeficiency and reactivated Epstein-Barr virus (EBV) infection. Among 58 evaluated patients, a significant 81% reported symptom improvement after folinic acid treatment. This suggests that many CFS cases may respond positively to folinic acid, shedding light on a possible therapeutic avenue.
Read More
8
Folic acid boosts cognitive function
We examined the effects of folic acid treatment on patients experiencing chronic fatigue related to neurological and psychiatric disorders.
In a group of 16 patients—some with known folate deficiency and others with idiopathic cases—we found common complaints of exhaustion and cognitive issues.
After 6 to 12 months of folic acid therapy, we noted significant improvements in intellectual functioning through various tests. This suggests that addressing folate deficiencies may help alleviate some symptoms of chronic fatigue.
In a group of 16 patients—some with known folate deficiency and others with idiopathic cases—we found common complaints of exhaustion and cognitive issues.
After 6 to 12 months of folic acid therapy, we noted significant improvements in intellectual functioning through various tests. This suggests that addressing folate deficiencies may help alleviate some symptoms of chronic fatigue.
Read More
5
We investigated the connection between serum folate levels and chronic fatigue syndrome (CFS) in a group of 60 patients. Our findings revealed that a striking 50% of these individuals had folate levels below 3.0 micrograms per liter, indicating a potential deficiency in this essential nutrient.
While it’s clear that some patients with CFS are not getting enough folic acid, our study stops short of establishing a direct cause-and-effect relationship. The information lacks treatment outcome data, which means we cannot definitively say that folate supplementation will improve symptoms of CFS or enhance overall well-being.
This research sheds light on a potential factor affecting those with chronic fatigue syndrome and underlines the importance of monitoring vitamin levels in patients. However, further studies are essential to determine the role folate supplementation might play in managing this complex condition.
While it’s clear that some patients with CFS are not getting enough folic acid, our study stops short of establishing a direct cause-and-effect relationship. The information lacks treatment outcome data, which means we cannot definitively say that folate supplementation will improve symptoms of CFS or enhance overall well-being.
This research sheds light on a potential factor affecting those with chronic fatigue syndrome and underlines the importance of monitoring vitamin levels in patients. However, further studies are essential to determine the role folate supplementation might play in managing this complex condition.
Read More
Most Useful Reviews
9
Increased energy levels
2 people found this helpful
I initially purchased iron and B12 separately to raise my ferritin levels. Within a month, I felt noticeably different, with enhanced strength and energy after years of chronic fatigue syndrome. This supplement greatly improved my iron absorption, a process that had proven ineffective before.
Read More
9
Boosts energy levels
I really like this form of folate! I truly notice the difference; I have more energy. As someone with chronic fatigue syndrome, I find that this does help make a positive difference in my daily life.
Read More
7.5
Reduced fatigue
1 people found this helpful
Since taking folic acid and vitamin D, my daily fatigue has improved. This product is easy to swallow and has no unpleasant smell, making it a beneficial addition to my routine.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.2
- All Researches
8
We assessed how folic acid, combined with vitamin B12, affects patients with chronic fatigue syndrome, or myalgic encephalomyelitis (ME). In this study, 38 patients were surveyed after receiving weekly B12 injections for six months to several years.
Those classified as "Good responders" showed significant improvements compared to "Mild responders." They had higher doses of B12, more oral folic acid intake, and less reliance on strong painkillers.
Overall, while some experienced meaningful benefits, the variability among responses suggests further research is needed to tailor treatments effectively.
Those classified as "Good responders" showed significant improvements compared to "Mild responders." They had higher doses of B12, more oral folic acid intake, and less reliance on strong painkillers.
Overall, while some experienced meaningful benefits, the variability among responses suggests further research is needed to tailor treatments effectively.
Read More
8
We investigated the effects of folinic acid on patients with chronic fatigue syndrome (CFS), where many also showed signs of B-cell immunodeficiency and reactivated Epstein-Barr virus (EBV) infection. Among 58 evaluated patients, a significant 81% reported symptom improvement after folinic acid treatment. This suggests that many CFS cases may respond positively to folinic acid, shedding light on a possible therapeutic avenue.
Read More
8
Folic acid boosts cognitive function
We examined the effects of folic acid treatment on patients experiencing chronic fatigue related to neurological and psychiatric disorders.
In a group of 16 patients—some with known folate deficiency and others with idiopathic cases—we found common complaints of exhaustion and cognitive issues.
After 6 to 12 months of folic acid therapy, we noted significant improvements in intellectual functioning through various tests. This suggests that addressing folate deficiencies may help alleviate some symptoms of chronic fatigue.
In a group of 16 patients—some with known folate deficiency and others with idiopathic cases—we found common complaints of exhaustion and cognitive issues.
After 6 to 12 months of folic acid therapy, we noted significant improvements in intellectual functioning through various tests. This suggests that addressing folate deficiencies may help alleviate some symptoms of chronic fatigue.
Read More
5
We investigated the connection between serum folate levels and chronic fatigue syndrome (CFS) in a group of 60 patients. Our findings revealed that a striking 50% of these individuals had folate levels below 3.0 micrograms per liter, indicating a potential deficiency in this essential nutrient.
While it’s clear that some patients with CFS are not getting enough folic acid, our study stops short of establishing a direct cause-and-effect relationship. The information lacks treatment outcome data, which means we cannot definitively say that folate supplementation will improve symptoms of CFS or enhance overall well-being.
This research sheds light on a potential factor affecting those with chronic fatigue syndrome and underlines the importance of monitoring vitamin levels in patients. However, further studies are essential to determine the role folate supplementation might play in managing this complex condition.
While it’s clear that some patients with CFS are not getting enough folic acid, our study stops short of establishing a direct cause-and-effect relationship. The information lacks treatment outcome data, which means we cannot definitively say that folate supplementation will improve symptoms of CFS or enhance overall well-being.
This research sheds light on a potential factor affecting those with chronic fatigue syndrome and underlines the importance of monitoring vitamin levels in patients. However, further studies are essential to determine the role folate supplementation might play in managing this complex condition.
Read More
2
We conducted a carefully designed study to investigate the effects of an injectable treatment combining bovine liver extract, folic acid, and cyanocobalamin on chronic fatigue syndrome (CFS). This involved a double-blind, placebo-controlled crossover trial with 15 patients who met definitive criteria for CFS.
Throughout the study, patients received both the treatment and a placebo in alternating phases. While we observed that both the treatment and placebo seemed to provide some improvement in functional status for the patients, our analysis showed no significant advantage of the liver extract and folic acid combination over the placebo.
This indicates that the response to folate, particularly, is unclear as the placebo effect appeared to be notably strong among participants. Overall, the findings suggest that further research may be needed to ascertain the definitive role of folate in managing chronic fatigue syndrome.
Throughout the study, patients received both the treatment and a placebo in alternating phases. While we observed that both the treatment and placebo seemed to provide some improvement in functional status for the patients, our analysis showed no significant advantage of the liver extract and folic acid combination over the placebo.
This indicates that the response to folate, particularly, is unclear as the placebo effect appeared to be notably strong among participants. Overall, the findings suggest that further research may be needed to ascertain the definitive role of folate in managing chronic fatigue syndrome.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Increased energy levels
2 people found this helpful
I initially purchased iron and B12 separately to raise my ferritin levels. Within a month, I felt noticeably different, with enhanced strength and energy after years of chronic fatigue syndrome. This supplement greatly improved my iron absorption, a process that had proven ineffective before.
Read More
9
Boosts energy levels
I really like this form of folate! I truly notice the difference; I have more energy. As someone with chronic fatigue syndrome, I find that this does help make a positive difference in my daily life.
Read More
7.5
Reduced fatigue
1 people found this helpful
Since taking folic acid and vitamin D, my daily fatigue has improved. This product is easy to swallow and has no unpleasant smell, making it a beneficial addition to my routine.
Read More
7.5
Reduces fatigue
Very useful for alleviating fatigue, this formula for folic acid is vital for pregnant women and effectively reduces the symptoms of chronic fatigue syndrome.
Read More
7.5
Supports pregnancy development
Help for the heart and blood vessels, and support for intrauterine development comes from methylfolate, which is more active than regular folic acid. Methylfolate prevents deficiencies, reduces the risk of neural tube defects, and ensures normal fetal growth. For adults, it reduces homocysteine levels, maintains cell renewal, and supports brain function, which can help alleviate chronic fatigue syndrome.
Read More
Frequently Asked Questions
9
Increased energy levels
2 people found this helpful
I initially purchased iron and B12 separately to raise my ferritin levels. Within a month, I felt noticeably different, with enhanced strength and energy after years of chronic fatigue syndrome. This supplement greatly improved my iron absorption, a process that had proven ineffective before.
7.5
Helps maintain normalcy
I can't identify any specific difference with this supplement, which is fine as it helps me maintain my normal state and manage chronic fatigue syndrome more effectively, especially when taken with B12.
7
High absorption rate
I combine this active vitamin B supplement for vitamins 6, 9, and 12 due to its impressive absorption, which helps combat fatigue and chronic fatigue syndrome effectively.
8
We investigated the effects of folinic acid on patients with chronic fatigue syndrome (CFS), where many also showed signs of B-cell immunodeficiency and reactivated Epstein-Barr virus (EBV) infection. Among 58 evaluated patients, a significant 81% reported symptom improvement after folinic acid treatment. This suggests that many CFS cases may respond positively to folinic acid, shedding light on a possible therapeutic avenue.
8
We assessed how folic acid, combined with vitamin B12, affects patients with chronic fatigue syndrome, or myalgic encephalomyelitis (ME). In this study, 38 patients were surveyed after receiving weekly B12 injections for six months to several years.
Those classified as "Good responders" showed significant improvements compared to "Mild responders." They had higher doses of B12, more oral folic acid intake, and less reliance on strong painkillers.
Overall, while some experienced meaningful benefits, the variability among responses suggests further research is needed to tailor treatments effectively.
Those classified as "Good responders" showed significant improvements compared to "Mild responders." They had higher doses of B12, more oral folic acid intake, and less reliance on strong painkillers.
Overall, while some experienced meaningful benefits, the variability among responses suggests further research is needed to tailor treatments effectively.
5
We investigated the connection between serum folate levels and chronic fatigue syndrome (CFS) in a group of 60 patients. Our findings revealed that a striking 50% of these individuals had folate levels below 3.0 micrograms per liter, indicating a potential deficiency in this essential nutrient.
While it’s clear that some patients with CFS are not getting enough folic acid, our study stops short of establishing a direct cause-and-effect relationship. The information lacks treatment outcome data, which means we cannot definitively say that folate supplementation will improve symptoms of CFS or enhance overall well-being.
This research sheds light on a potential factor affecting those with chronic fatigue syndrome and underlines the importance of monitoring vitamin levels in patients. However, further studies are essential to determine the role folate supplementation might play in managing this complex condition.
While it’s clear that some patients with CFS are not getting enough folic acid, our study stops short of establishing a direct cause-and-effect relationship. The information lacks treatment outcome data, which means we cannot definitively say that folate supplementation will improve symptoms of CFS or enhance overall well-being.
This research sheds light on a potential factor affecting those with chronic fatigue syndrome and underlines the importance of monitoring vitamin levels in patients. However, further studies are essential to determine the role folate supplementation might play in managing this complex condition.
References
- Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. 10.1371/journal.pone.0124648
- Lundell K, Qazi S, Eddy L, Uckun FM. Clinical activity of folinic acid in patients with chronic fatigue syndrome. Arzneimittelforschung. 2006;56:399. PubMed
- Botez MI, Fontaine F, Botez T, Bachevalier J. Folate-responsive neurological and mental disorders: report of 16 cases. Neuropsychological correlates of computerized transaxial tomography and radionuclide cisternography in folic acid deficiencies. Eur Neurol. 1977;16:230. PubMed
- Jacobson W, Saich T, Borysiewicz LK, Behan WM, Behan PO, et al. Serum folate and chronic fatigue syndrome. Neurology. 1993;43:2645. PubMed
- Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med. 1989;149:2501. PubMed
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