Last update
4/4/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.9
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
8
We examined a patient who experienced severe anemia following COVID-19, presenting with both cold agglutinin and cryoglobulin. Testing showed positivity for C3d but no significant signs of hemolytic anemia or thrombosis.
Remarkably, the anemia improved with just folic acid supplementation, which also reduced the cold agglutination levels and normalized the direct antiglobulin test. Although cryoglobulinemia persisted, the patient remained symptom-free.
This suggests that thorough assessment is crucial before considering treatments for cold-related blood disorders following COVID-19.
Remarkably, the anemia improved with just folic acid supplementation, which also reduced the cold agglutination levels and normalized the direct antiglobulin test. Although cryoglobulinemia persisted, the patient remained symptom-free.
This suggests that thorough assessment is crucial before considering treatments for cold-related blood disorders following COVID-19.
Read More
Most Useful Reviews
9
Prevented winter colds
These excellent vitamins come in a powerful dosage. Since I began taking them in January, I’ve noticed significant improvements. My energy levels have increased, leading to better sleep quality. Furthermore, I’ve not caught a cold during winter, a time when I typically get ill. Thanks to the dosage, I don’t have to take them daily, and it will last a long time.
Read More
7.5
Reduced cold extremities
1 people found this helpful
During winter, my fingertips would hurt from cold extremities. Since I’ve started taking methylfolic acid, this has improved remarkably. The capsule size is quite small, which I appreciate.
Read More
9
Strengthened immunity
Though I've taken methyl folate for a short time, I’ve noticed improvements in my mood and immunity. I contracted a virus, but it barely affected me; I experienced just minor symptoms. Previously, my colds lasted longer. Doubling my daily dose has kept my strength intact, and I'm pleased with the supplement's quality and my improved sleep.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
We examined a patient who experienced severe anemia following COVID-19, presenting with both cold agglutinin and cryoglobulin. Testing showed positivity for C3d but no significant signs of hemolytic anemia or thrombosis.
Remarkably, the anemia improved with just folic acid supplementation, which also reduced the cold agglutination levels and normalized the direct antiglobulin test. Although cryoglobulinemia persisted, the patient remained symptom-free.
This suggests that thorough assessment is crucial before considering treatments for cold-related blood disorders following COVID-19.
Remarkably, the anemia improved with just folic acid supplementation, which also reduced the cold agglutination levels and normalized the direct antiglobulin test. Although cryoglobulinemia persisted, the patient remained symptom-free.
This suggests that thorough assessment is crucial before considering treatments for cold-related blood disorders following COVID-19.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Prevented winter colds
These excellent vitamins come in a powerful dosage. Since I began taking them in January, I’ve noticed significant improvements. My energy levels have increased, leading to better sleep quality. Furthermore, I’ve not caught a cold during winter, a time when I typically get ill. Thanks to the dosage, I don’t have to take them daily, and it will last a long time.
Read More
7.5
Reduced cold extremities
1 people found this helpful
During winter, my fingertips would hurt from cold extremities. Since I’ve started taking methylfolic acid, this has improved remarkably. The capsule size is quite small, which I appreciate.
Read More
9
Strengthened immunity
Though I've taken methyl folate for a short time, I’ve noticed improvements in my mood and immunity. I contracted a virus, but it barely affected me; I experienced just minor symptoms. Previously, my colds lasted longer. Doubling my daily dose has kept my strength intact, and I'm pleased with the supplement's quality and my improved sleep.
Read More
7.5
Family cold remedy
This remedy is indispensable in our cold region. My entire family takes it from September to May, and it significantly reduces the frequency of our illnesses.
Read More
7.5
Helpful for colds
This vitamin is effective for treating colds and provides great support.
Read More
Frequently Asked Questions
9
Prevented winter colds
These excellent vitamins come in a powerful dosage. Since I began taking them in January, I’ve noticed significant improvements. My energy levels have increased, leading to better sleep quality. Furthermore, I’ve not caught a cold during winter, a time when I typically get ill. Thanks to the dosage, I don’t have to take them daily, and it will last a long time.
7.5
Reduced cold extremities
1 people found this helpful
During winter, my fingertips would hurt from cold extremities. Since I’ve started taking methylfolic acid, this has improved remarkably. The capsule size is quite small, which I appreciate.
7.5
Family cold remedy
This remedy is indispensable in our cold region. My entire family takes it from September to May, and it significantly reduces the frequency of our illnesses.
References
- Kaneko M, Masuda Y, Ishikawa K, Shikata H. Coexistence of Cold Agglutinin and Cryoglobulin in a Patient With Severe Anemia Following COVID-19 Infection. Cureus. 2024;16:e75257. 10.7759/cureus.75257
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