' 
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 15 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
8
Folate improves cold agglutinin anemia
Coexistence of Cold Agglutinin and Cryoglobulin in a Patient With Severe Anemia Following COVID-19 Infection.
Effects of folate treatment noted
We explored the intriguing case of a patient battling severe anemia after a COVID-19 infection. This patient exhibited both cold agglutinin and cryoglobulin, revealing some interesting findings when we examined their direct antiglobulin test results.
We noted that the test showed C3d positivity while being immunoglobulin G negative, indicating that the patient did not have evident hemolytic anemia or thrombosis. Interestingly, there was no clinically significant IgM monoclonal gammopathy reported, which suggests that the situation might not be as dire as it seems at first glance.
Treatment involved folic acid supplementation, which led to a noticeable improvement in the patient's anemia. Alongside this, we observed a decrease in the cold agglutination titer, and the direct antiglobulin test turned negative, hinting that folate may play a role in managing cold agglutinin-related issues, though it’s essential to view this within the broader context of other influences.
Despite the persistent cryoglobulinemia, the patient did not experience thrombosis or any significant complications. This case prompts us to carefully consider the use of immunosuppressive therapies for cold-related hematologic disorders following COVID-19, particularly as many factors may be at play in affecting patient outcomes.
We noted that the test showed C3d positivity while being immunoglobulin G negative, indicating that the patient did not have evident hemolytic anemia or thrombosis. Interestingly, there was no clinically significant IgM monoclonal gammopathy reported, which suggests that the situation might not be as dire as it seems at first glance.
Treatment involved folic acid supplementation, which led to a noticeable improvement in the patient's anemia. Alongside this, we observed a decrease in the cold agglutination titer, and the direct antiglobulin test turned negative, hinting that folate may play a role in managing cold agglutinin-related issues, though it’s essential to view this within the broader context of other influences.
Despite the persistent cryoglobulinemia, the patient did not experience thrombosis or any significant complications. This case prompts us to carefully consider the use of immunosuppressive therapies for cold-related hematologic disorders following COVID-19, particularly as many factors may be at play in affecting patient outcomes.
Read More
Most Useful Reviews
8.8
Improved cold tolerance
I have suffered from Chronic Fatigue Syndrome for many years. I tried a comparable product from Solgar, Metafolin, which worked but upset my stomach. This product does the same without causing any discomfort. It essentially alters my perception and tolerance to cold; I no longer feel it penetrating my bones as I did before. While it hasn't completely removed my brain fog, it has subtly improved my ability to focus, allowing me to concentrate better without the haze I previously experienced.
Read More
9.5
Prevented winter colds
These excellent vitamins come in a powerful dosage. Since I began taking them in January, I’ve noticed significant improvements. My energy levels have increased, leading to better sleep quality. Furthermore, I’ve not caught a cold during winter, a time when I typically get ill. Thanks to the dosage, I don’t have to take them daily, and it will last a long time.
Read More
8.8
Reduced cold extremities
During winter, my fingertips would hurt from cold extremities. Since I’ve started taking methylfolic acid, this has improved remarkably. The capsule size is quite small, which I appreciate.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
Folate improves cold agglutinin anemia
Coexistence of Cold Agglutinin and Cryoglobulin in a Patient With Severe Anemia Following COVID-19 Infection.
Effects of folate treatment noted
We explored the intriguing case of a patient battling severe anemia after a COVID-19 infection. This patient exhibited both cold agglutinin and cryoglobulin, revealing some interesting findings when we examined their direct antiglobulin test results.
We noted that the test showed C3d positivity while being immunoglobulin G negative, indicating that the patient did not have evident hemolytic anemia or thrombosis. Interestingly, there was no clinically significant IgM monoclonal gammopathy reported, which suggests that the situation might not be as dire as it seems at first glance.
Treatment involved folic acid supplementation, which led to a noticeable improvement in the patient's anemia. Alongside this, we observed a decrease in the cold agglutination titer, and the direct antiglobulin test turned negative, hinting that folate may play a role in managing cold agglutinin-related issues, though it’s essential to view this within the broader context of other influences.
Despite the persistent cryoglobulinemia, the patient did not experience thrombosis or any significant complications. This case prompts us to carefully consider the use of immunosuppressive therapies for cold-related hematologic disorders following COVID-19, particularly as many factors may be at play in affecting patient outcomes.
We noted that the test showed C3d positivity while being immunoglobulin G negative, indicating that the patient did not have evident hemolytic anemia or thrombosis. Interestingly, there was no clinically significant IgM monoclonal gammopathy reported, which suggests that the situation might not be as dire as it seems at first glance.
Treatment involved folic acid supplementation, which led to a noticeable improvement in the patient's anemia. Alongside this, we observed a decrease in the cold agglutination titer, and the direct antiglobulin test turned negative, hinting that folate may play a role in managing cold agglutinin-related issues, though it’s essential to view this within the broader context of other influences.
Despite the persistent cryoglobulinemia, the patient did not experience thrombosis or any significant complications. This case prompts us to carefully consider the use of immunosuppressive therapies for cold-related hematologic disorders following COVID-19, particularly as many factors may be at play in affecting patient outcomes.
Read More
User Reviews
USERS' SCORE
Good
Based on 15 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Improved cold tolerance
I have suffered from Chronic Fatigue Syndrome for many years. I tried a comparable product from Solgar, Metafolin, which worked but upset my stomach. This product does the same without causing any discomfort. It essentially alters my perception and tolerance to cold; I no longer feel it penetrating my bones as I did before. While it hasn't completely removed my brain fog, it has subtly improved my ability to focus, allowing me to concentrate better without the haze I previously experienced.
Read More
9.5
Prevented winter colds
These excellent vitamins come in a powerful dosage. Since I began taking them in January, I’ve noticed significant improvements. My energy levels have increased, leading to better sleep quality. Furthermore, I’ve not caught a cold during winter, a time when I typically get ill. Thanks to the dosage, I don’t have to take them daily, and it will last a long time.
Read More
8.8
Reduced cold extremities
During winter, my fingertips would hurt from cold extremities. Since I’ve started taking methylfolic acid, this has improved remarkably. The capsule size is quite small, which I appreciate.
9.5
Strengthened immunity
Though I've taken methyl folate for a short time, I’ve noticed improvements in my mood and immunity. I contracted a virus, but it barely affected me; I experienced just minor symptoms. Previously, my colds lasted longer. Doubling my daily dose has kept my strength intact, and I'm pleased with the supplement's quality and my improved sleep.
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9.5
Quick recovery
I’ve been taking this supplement for a short period, and I’ve already noticed enhanced immunity. When I caught a virus, my symptoms were minimal and cleared up within two days. Previously, I would suffer from colds lasting much longer. After increasing my dose, I felt no residual weakness and was delighted with the quality of this product.
Read More
