Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
USERS' SCORE
Moderately Good
Based on 22 Reviews
7.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
8
This cross-sectional study analyzed data from nearly 10,000 adults to investigate the link between dietary folate intake and severe headaches. We found that individuals with higher folate intake were less likely to report severe headaches. For example, those in the highest intake category showed a notable decrease in headache prevalence. Interestingly, this connection seemed especially relevant for women aged 20-50, suggesting they could benefit from increasing their folate consumption. Overall, while the findings indicate a potential protective effect of folic acid, they highlight the importance of a balanced diet for headache management.
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8
We explored how dietary folate intake might be linked to severe headaches or migraines through a comprehensive analysis of data from the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2004. By examining over 4,100 adults, we observed that around 17% reported experiencing severe headaches or migraines. Importantly, our study used advanced statistical methods to ensure accurate and meaningful results.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
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8
We explored the relationship between dietary vitamin B and folate intake and the risk of migraines in US adults. Analyzing data from over 7,000 participants aged 20 and older from the National Health and Nutrition Examination Survey, we found that higher intake of these nutrients was linked to a lower risk of severe headaches or migraines.
Interestingly, those who consumed significant amounts of both vitamin B and folate experienced even greater benefits in preventing migraines. While further research is needed, these findings suggest that increasing our intake of vitamin B and folate might help in managing migraines.
Interestingly, those who consumed significant amounts of both vitamin B and folate experienced even greater benefits in preventing migraines. While further research is needed, these findings suggest that increasing our intake of vitamin B and folate might help in managing migraines.
Read More
Most Useful Reviews
10
Headache relief
Good quality. After a month, I started feeling better as my headaches stopped. I definitely recommend this manufacturer.
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10
No more headaches
So good! This is not my first time buying this product. I was suffering from a horrible headache with no known cause, but after starting this folic acid, my bad headaches are completely gone. I'm really pleased with the results.
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9
Significant improvement
Great! My anxiety has significantly decreased, and I feel calmer and more confident. I've started sleeping well through the night. My headaches have also occurred much less frequently, which is a significant bonus from taking magnesium. It effectively combats headaches related to vascular spasms. I recommend it for its optimal size, pleasant taste, and natural ingredients that promote health.
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
- All Researches
9
We investigated a unique case involving a 14-year-old girl suffering from headaches and diagnosed with cerebral venous thrombosis linked to a rare mutation at the MTHFR locus.
After identifying elevated homocysteine levels and significant intracranial pressure, her treatment combined anticoagulation and vitamin supplements. Remarkably, one month later, her headaches resolved, and imaging showed notable improvement in her condition.
This case suggests that rare genetic mutations and corresponding treatments could play a key role in managing headache and thrombotic conditions.
After identifying elevated homocysteine levels and significant intracranial pressure, her treatment combined anticoagulation and vitamin supplements. Remarkably, one month later, her headaches resolved, and imaging showed notable improvement in her condition.
This case suggests that rare genetic mutations and corresponding treatments could play a key role in managing headache and thrombotic conditions.
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9
We explored how B vitamins, including folic acid, might alleviate migraine headaches in women with episodic migraine. Conducting a well-structured double-blind, placebo-controlled trial, we assessed 120 participants over 12 weeks.
Results showed significant improvements in headache frequency and migraine-related disability among those taking the B vitamins, compared to the placebo group. Folic acid, along with other B vitamins, appeared beneficial in reducing the need for abortive medication. However, more extensive studies are necessary to solidify these findings.
Results showed significant improvements in headache frequency and migraine-related disability among those taking the B vitamins, compared to the placebo group. Folic acid, along with other B vitamins, appeared beneficial in reducing the need for abortive medication. However, more extensive studies are necessary to solidify these findings.
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9
We examined the connection between genetic differences in folate metabolism and migraine experiences in children aged 7 to 18. The study involved 54 children with migraine symptoms and a control group of 115 others without neurological issues.
Focusing on four specific genetic variants linked to folate metabolism, we found that children with migraines were more likely to have a certain rare genetic variant that may increase plasma homocysteine levels, potentially indicating a hidden folate deficiency. In addition to genetic testing, we looked at vitamin B levels and the effectiveness of Cortexin, a treatment administered to the children.
After a 10-day course of Cortexin, many children reported significant improvements in their migraine symptoms, such as less headache pain, reduced fatigue, and better emotional stability. This suggests that while there’s a genetic connection to migraine, the treatment with Cortexin also plays a critical role in alleviating symptoms.
Focusing on four specific genetic variants linked to folate metabolism, we found that children with migraines were more likely to have a certain rare genetic variant that may increase plasma homocysteine levels, potentially indicating a hidden folate deficiency. In addition to genetic testing, we looked at vitamin B levels and the effectiveness of Cortexin, a treatment administered to the children.
After a 10-day course of Cortexin, many children reported significant improvements in their migraine symptoms, such as less headache pain, reduced fatigue, and better emotional stability. This suggests that while there’s a genetic connection to migraine, the treatment with Cortexin also plays a critical role in alleviating symptoms.
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8
We explored the relationship between dietary vitamin B and folate intake and the risk of migraines in US adults. Analyzing data from over 7,000 participants aged 20 and older from the National Health and Nutrition Examination Survey, we found that higher intake of these nutrients was linked to a lower risk of severe headaches or migraines.
Interestingly, those who consumed significant amounts of both vitamin B and folate experienced even greater benefits in preventing migraines. While further research is needed, these findings suggest that increasing our intake of vitamin B and folate might help in managing migraines.
Interestingly, those who consumed significant amounts of both vitamin B and folate experienced even greater benefits in preventing migraines. While further research is needed, these findings suggest that increasing our intake of vitamin B and folate might help in managing migraines.
Read More
8
This cross-sectional study analyzed data from nearly 10,000 adults to investigate the link between dietary folate intake and severe headaches. We found that individuals with higher folate intake were less likely to report severe headaches. For example, those in the highest intake category showed a notable decrease in headache prevalence. Interestingly, this connection seemed especially relevant for women aged 20-50, suggesting they could benefit from increasing their folate consumption. Overall, while the findings indicate a potential protective effect of folic acid, they highlight the importance of a balanced diet for headache management.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 22 Reviews
7.1
- All Reviews
- Positive Reviews
- Negative Reviews
10
Headache relief
Good quality. After a month, I started feeling better as my headaches stopped. I definitely recommend this manufacturer.
Read More
10
No more headaches
So good! This is not my first time buying this product. I was suffering from a horrible headache with no known cause, but after starting this folic acid, my bad headaches are completely gone. I'm really pleased with the results.
Read More
9
Significant improvement
Great! My anxiety has significantly decreased, and I feel calmer and more confident. I've started sleeping well through the night. My headaches have also occurred much less frequently, which is a significant bonus from taking magnesium. It effectively combats headaches related to vascular spasms. I recommend it for its optimal size, pleasant taste, and natural ingredients that promote health.
Read More
9
Pain relief
I took it for a headache, and it worked effectively. The product quality is very good, as are the ingredients.
Read More
9
Anemia treatment
Wonderful! I had methylfolate and iron deficiency anaemia. After a month of taking methyl folate, all my indicators returned to normal, and I am thrilled! My headaches and tiredness have gone.
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Frequently Asked Questions
10
Headache relief
Good quality. After a month, I started feeling better as my headaches stopped. I definitely recommend this manufacturer.
10
No more headaches
So good! This is not my first time buying this product. I was suffering from a horrible headache with no known cause, but after starting this folic acid, my bad headaches are completely gone. I'm really pleased with the results.
9
No side effects
The capsules are small but effective. Unlike the synthetic folic acid in the Russian medication, which caused me headaches, this methylfolate does not have such effects. After more than a week of use, I feel stronger without any side effects.
9
Headache aid
Real nice! Jarrow has always provided quality supplements. This methyl folate has significantly helped with my headaches after drinking coffee, along with mood and energy improvement.
0
Negative experience
Good, but I experience a lot of headache when taking it.
7.5
Fewer headaches
I take methyl folate due to high homocysteine levels along with B12. I've noticed that my headaches have decreased, which indicates the usefulness of these supplements. I hope my review is beneficial to you!
7.5
Fewer headaches
I take it for prevention. I take B9, B6, and B12 together once a week in easily absorbed forms with a high dosage. My headaches became less bothersome, and my memory has improved.
1
Unsuitable for me
This type of methylfolate did not suit me. After taking it, I experienced headaches. I tried several times with breaks, but unfortunately, the result was the same.
9
Deficiency correction
I experienced severe headaches due to a folic acid deficiency. My doctor recommended this form, and it had a noticeable effect on my condition.
9
Reduction in headaches
She took active forms of B12, B6, and folic acid as prescribed to support her cardiovascular and nervous systems. As a result, headaches and tension in her head and eyes decreased. Additionally, her haemoglobin improved significantly, and some blood counts showed enhancement. I'll be ordering more!
7
We delved into the link between serum folate levels and the occurrence of severe headaches or migraines in a large population. Using data from the National Health and Nutrition Examination Survey, we found that higher serum folate levels were associated with a lower likelihood of experiencing migraines.
The results suggested that this relationship was particularly strong among women, those aged 20 to 50, and non-Hispanic White individuals. However, while promising, further research is essential to confirm and broaden these findings.
The results suggested that this relationship was particularly strong among women, those aged 20 to 50, and non-Hispanic White individuals. However, while promising, further research is essential to confirm and broaden these findings.
8
We explored the relationship between dietary vitamin B and folate intake and the risk of migraines in US adults. Analyzing data from over 7,000 participants aged 20 and older from the National Health and Nutrition Examination Survey, we found that higher intake of these nutrients was linked to a lower risk of severe headaches or migraines.
Interestingly, those who consumed significant amounts of both vitamin B and folate experienced even greater benefits in preventing migraines. While further research is needed, these findings suggest that increasing our intake of vitamin B and folate might help in managing migraines.
Interestingly, those who consumed significant amounts of both vitamin B and folate experienced even greater benefits in preventing migraines. While further research is needed, these findings suggest that increasing our intake of vitamin B and folate might help in managing migraines.
4
We explored the role of B6, folate, and B12 in managing migraines, particularly for those with aura. Our systematic search uncovered twelve articles on the subject.
While the use of these vitamins didn't show promise in treating acute attacks, they did demonstrate significant benefits for adults with migraine with aura when used as preventive measures. Folate alone, however, did not outperform placebo.
Despite the mixed findings, these vitamins were generally well-tolerated, with mild gastrointestinal issues being the most common side effects. Further research is needed to confirm these results.
While the use of these vitamins didn't show promise in treating acute attacks, they did demonstrate significant benefits for adults with migraine with aura when used as preventive measures. Folate alone, however, did not outperform placebo.
Despite the mixed findings, these vitamins were generally well-tolerated, with mild gastrointestinal issues being the most common side effects. Further research is needed to confirm these results.
References
- Luwen H, Ping C, Qing-Rong O, Lei X, Linlin L, et al. Association between serum folate levels and migraine or severe headaches: A nationwide cross-sectional study. Medicine (Baltimore). 2024;103:e40458. doi:10.1097/MD.0000000000040458
- Tian S, Yu X, Wu L, Zheng H, Zhong X, et al. Vitamin B and folate intake are associated with lower risk of severe headache or migraine in adults: An analysis based on NHANES 1999-2004. Nutr Res. 2024;121:51. doi:10.1016/j.nutres.2023.11.008
- Tian S, Wu L, Zheng H, Zhong X, Liu M, et al. Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey. Br J Nutr. 2024;131:438. doi:10.1017/S000711452300137X
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. doi:10.1186/s12883-023-03200-y
- Nematgorgani S, Razeghi-Jahromi S, Jafari E, Togha M, Rafiee P, et al. B vitamins and their combination could reduce migraine headaches: A randomized double-blind controlled trial. Curr J Neurol. 2022;21:105. doi:10.18502/cjn.v21i2.10494
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. doi:10.1111/ane.13251
- Strozenko LA, Ponomaryov VS, Sanina OO, Lobanov YF. [The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children]. Zh Nevrol Psikhiatr Im S S Korsakova. 2025;125:47. doi:10.17116/jnevro202512501147
- Zhao D, Long X, Wang J. Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey. Front Nutr. 2024;11:1456502. doi:10.3389/fnut.2024.1456502
- Lin SS, Fan IW, Chen CY, Su YJ. A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report. Med Int (Lond). 2022;2:20. doi:10.3892/mi.2022.45
- Aydin H, Bucak IH, Geyik M. Vitamin B12 and folic acid levels in pediatric migraine patients. Acta Neurol Belg. 2021;121:1741. doi:10.1007/s13760-020-01491-3
