' 
SCIENTIFIC SCORE
Questionable
Based on 23 Researches
5.8
USERS' SCORE
Good
Based on 14 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
9
Folic acid improves heart function
Folic acid mitigated cardiac dysfunction by normalizing the levels of tissue inhibitor of metalloproteinase and homocysteine-metabolizing enzymes postmyocardial infarction in mice.
Heart health treatment relevance
We explored how folic acid could influence recovery after a heart attack. Through a study on mice, we induced heart attacks and then treated them with folic acid for four weeks. The results were promising, showing that the treatment improved heart function and increased essential enzyme levels that help process homocysteine, a harmful byproduct in the body.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
Read More
8
Folate intake reduces heart disease risk
Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
Highly relevant study findings
We explored how dietary intake of folate, along with vitamins B6 and B12, impacts heart health in a large UK cohort of 115,664 participants aged 40-70.
After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.
However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.
However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
Read More
8
Folic acid fortification reduces costs
Medical cost savings in Sakado City and worldwide achieved by preventing disease by folic acid fortification.
High relevance for health savings
We examined the effects of folic acid fortification on preventing diseases, particularly heart attacks, and its related medical costs. The introduction of mandatory folate fortification in various countries has shown remarkable cost savings and improved health outcomes. Our study in Sakado City involved individuals with specific genetic markers and demonstrated a notable reduction in homocysteine levels, which is linked to heart health.
While there was an increase in folate levels, the decrease in heart attack rates wasn't specified as significant. Overall, mandatory folic acid fortification is cost-effective and may reduce heart attack incidents, supporting its broader implementation in Japan.
While there was an increase in folate levels, the decrease in heart attack rates wasn't specified as significant. Overall, mandatory folic acid fortification is cost-effective and may reduce heart attack incidents, supporting its broader implementation in Japan.
Read More
Most Useful Reviews
9.5
Reduced heart disease risk
My blood test showed elevated homocysteine, which can lead to heart attacks. I was prescribed Methylfolate, and after two weeks of taking 4000 mcg, my levels dropped from 14 to 5.8. Remember, high homocysteine can damage blood vessels. Stay healthy!
Read More
9.5
Lowered anxiety levels
My doctor recommended 5-MTHF due to our family's history of high homocysteine, which is linked to heart disease and can cause anxiety. After three days on this, I finally started sleeping through the night, so I can highly recommend it.
Read More
9.5
Stabilised heart rate
I've been taking this supplement for six months after my homocysteine was 16. My pulse, which was previously high, now stays under 65. I haven’t retested my levels yet, but I definitely recommend it for anyone with similar issues.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 23 Researches
5.8
- All Researches
9
Folic acid improves heart function
Folic acid mitigated cardiac dysfunction by normalizing the levels of tissue inhibitor of metalloproteinase and homocysteine-metabolizing enzymes postmyocardial infarction in mice.
Heart health treatment relevance
We explored how folic acid could influence recovery after a heart attack. Through a study on mice, we induced heart attacks and then treated them with folic acid for four weeks. The results were promising, showing that the treatment improved heart function and increased essential enzyme levels that help process homocysteine, a harmful byproduct in the body.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
Read More
9
Exosomes enhance heart recovery post-MI
Release of exosomes from injectable silk fibroin and alginate composite hydrogel for treatment of myocardial infarction.
Composite treatment complicates isolated benefits
We explored the potential of targeting folate receptors with specialized exosomes to treat myocardial infarction, commonly known as a heart attack. The study centered around an innovative injectable hydrogel made from silk fibroin and alginate, designed to temporarily hold and release these folate-targeted exosomes. This combination aimed to improve heart healing after a damaging episode of myocardial ischemia/reperfusion.
Our findings showed that administering this hydrogel loaded with folate receptor-targeted exosomes significantly improved heart function in affected rats. We observed enhanced metrics such as ejection fraction and fractional shortening, coupled with reduced fibrosis in the cardiac tissue. Furthermore, molecular analysis indicated an increase in heart health markers while simultaneously reducing markers associated with fibrosis.
This study highlights the promising role of exosomes in heart treatment. However, we should note that it's difficult to isolate the specific effects of folate from the overall mechanism of the composite treatment.Overall, the results support the idea that these targeted exosomes can contribute to better heart recovery post-infarction, marking an exciting step forward in cardiac therapy.
Our findings showed that administering this hydrogel loaded with folate receptor-targeted exosomes significantly improved heart function in affected rats. We observed enhanced metrics such as ejection fraction and fractional shortening, coupled with reduced fibrosis in the cardiac tissue. Furthermore, molecular analysis indicated an increase in heart health markers while simultaneously reducing markers associated with fibrosis.
This study highlights the promising role of exosomes in heart treatment. However, we should note that it's difficult to isolate the specific effects of folate from the overall mechanism of the composite treatment.Overall, the results support the idea that these targeted exosomes can contribute to better heart recovery post-infarction, marking an exciting step forward in cardiac therapy.
Read More
8
Folate intake reduces heart disease risk
Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
Highly relevant study findings
We explored how dietary intake of folate, along with vitamins B6 and B12, impacts heart health in a large UK cohort of 115,664 participants aged 40-70.
After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.
However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.
However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
Read More
8
Folic acid fortification reduces costs
Medical cost savings in Sakado City and worldwide achieved by preventing disease by folic acid fortification.
High relevance for health savings
We examined the effects of folic acid fortification on preventing diseases, particularly heart attacks, and its related medical costs. The introduction of mandatory folate fortification in various countries has shown remarkable cost savings and improved health outcomes. Our study in Sakado City involved individuals with specific genetic markers and demonstrated a notable reduction in homocysteine levels, which is linked to heart health.
While there was an increase in folate levels, the decrease in heart attack rates wasn't specified as significant. Overall, mandatory folic acid fortification is cost-effective and may reduce heart attack incidents, supporting its broader implementation in Japan.
While there was an increase in folate levels, the decrease in heart attack rates wasn't specified as significant. Overall, mandatory folic acid fortification is cost-effective and may reduce heart attack incidents, supporting its broader implementation in Japan.
Read More
8
Multivitamins may reduce heart attack risk
Multivitamin use and the risk of myocardial infarction: a population-based cohort of Swedish women.
High relevance to cardiovascular health.
We examined the link between multivitamin use, including folic acid, and the risk of heart attacks in women. Our study followed 31,671 women without heart disease and evaluated their supplement usage over ten years.
We discovered that those taking multivitamins had a lower chance of experiencing a heart attack, especially if they used them for over five years. However, in women with a prior history of heart disease, multivitamins didn’t show the same benefit.
More research is needed to fully understand these results and confirm our findings.
We discovered that those taking multivitamins had a lower chance of experiencing a heart attack, especially if they used them for over five years. However, in women with a prior history of heart disease, multivitamins didn’t show the same benefit.
More research is needed to fully understand these results and confirm our findings.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Reduced heart disease risk
My blood test showed elevated homocysteine, which can lead to heart attacks. I was prescribed Methylfolate, and after two weeks of taking 4000 mcg, my levels dropped from 14 to 5.8. Remember, high homocysteine can damage blood vessels. Stay healthy!
9.5
Lowered anxiety levels
My doctor recommended 5-MTHF due to our family's history of high homocysteine, which is linked to heart disease and can cause anxiety. After three days on this, I finally started sleeping through the night, so I can highly recommend it.
9.5
Stabilised heart rate
I've been taking this supplement for six months after my homocysteine was 16. My pulse, which was previously high, now stays under 65. I haven’t retested my levels yet, but I definitely recommend it for anyone with similar issues.
7
Enhances blood health
This supplement maintains optimal blood thickness, prevents thrombophlebitis and heart attack, and stimulates the immune system, promoting red blood cell and haemoglobin formation.
8.8
Lowers homocysteine levels
I took folate to lower my homocysteine, which was high at 10; it's now down to 7. For women planning a pregnancy, it ideally should be below 7, as elevated levels pose a risk for heart attacks. I got my mother to test her levels, and hers was 15, now she drinks folate too. It's essential to look after our parents!
Read More
