Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
5.6
USERS' SCORE
Good
Based on 14 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
9
We explored how folic acid could influence recovery after a heart attack. Through a study on mice, we induced heart attacks and then treated them with folic acid for four weeks. The results were promising, showing that the treatment improved heart function and increased essential enzyme levels that help process homocysteine, a harmful byproduct in the body.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
Read More
8
We explored how dietary intake of folate, along with vitamins B6 and B12, impacts heart health in a large UK cohort of 115,664 participants aged 40-70.
After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.
However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.
However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
Read More
8
We examined the effects of folic acid fortification on preventing diseases, particularly heart attacks, and its related medical costs. The introduction of mandatory folate fortification in various countries has shown remarkable cost savings and improved health outcomes. Our study in Sakado City involved individuals with specific genetic markers and demonstrated a notable reduction in homocysteine levels, which is linked to heart health.
While there was an increase in folate levels, the decrease in heart attack rates wasn't specified as significant. Overall, mandatory folic acid fortification is cost-effective and may reduce heart attack incidents, supporting its broader implementation in Japan.
While there was an increase in folate levels, the decrease in heart attack rates wasn't specified as significant. Overall, mandatory folic acid fortification is cost-effective and may reduce heart attack incidents, supporting its broader implementation in Japan.
Read More
Most Useful Reviews
9
Reduced heart disease risk
221 people found this helpful
My blood test showed elevated homocysteine, which can lead to heart attacks. I was prescribed Methylfolate, and after two weeks of taking 4000 mcg, my levels dropped from 14 to 5.8. Remember, high homocysteine can damage blood vessels. Stay healthy!
Read More
9
Lowered anxiety levels
7 people found this helpful
My doctor recommended 5-MTHF due to our family's history of high homocysteine, which is linked to heart disease and can cause anxiety. After three days on this, I finally started sleeping through the night, so I can highly recommend it.
Read More
9
Stabilised heart rate
7 people found this helpful
I've been taking this supplement for six months after my homocysteine was 16. My pulse, which was previously high, now stays under 65. I haven’t retested my levels yet, but I definitely recommend it for anyone with similar issues.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
5.6
- All Researches
9
We explored how folic acid could influence recovery after a heart attack. Through a study on mice, we induced heart attacks and then treated them with folic acid for four weeks. The results were promising, showing that the treatment improved heart function and increased essential enzyme levels that help process homocysteine, a harmful byproduct in the body.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
Read More
9
We explored the potential of targeting folate receptors with specialized exosomes to treat myocardial infarction, commonly known as a heart attack. The study centered around an innovative injectable hydrogel made from silk fibroin and alginate, designed to temporarily hold and release these folate-targeted exosomes. This combination aimed to improve heart healing after a damaging episode of myocardial ischemia/reperfusion.
Our findings showed that administering this hydrogel loaded with folate receptor-targeted exosomes significantly improved heart function in affected rats. We observed enhanced metrics such as ejection fraction and fractional shortening, coupled with reduced fibrosis in the cardiac tissue. Furthermore, molecular analysis indicated an increase in heart health markers while simultaneously reducing markers associated with fibrosis.
This study highlights the promising role of exosomes in heart treatment. However, we should note that it's difficult to isolate the specific effects of folate from the overall mechanism of the composite treatment.Overall, the results support the idea that these targeted exosomes can contribute to better heart recovery post-infarction, marking an exciting step forward in cardiac therapy.
Our findings showed that administering this hydrogel loaded with folate receptor-targeted exosomes significantly improved heart function in affected rats. We observed enhanced metrics such as ejection fraction and fractional shortening, coupled with reduced fibrosis in the cardiac tissue. Furthermore, molecular analysis indicated an increase in heart health markers while simultaneously reducing markers associated with fibrosis.
This study highlights the promising role of exosomes in heart treatment. However, we should note that it's difficult to isolate the specific effects of folate from the overall mechanism of the composite treatment.Overall, the results support the idea that these targeted exosomes can contribute to better heart recovery post-infarction, marking an exciting step forward in cardiac therapy.
Read More
8
We explored how dietary intake of folate, along with vitamins B6 and B12, impacts heart health in a large UK cohort of 115,664 participants aged 40-70.
After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.
However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.
However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
Read More
8
We examined the effects of folic acid fortification on preventing diseases, particularly heart attacks, and its related medical costs. The introduction of mandatory folate fortification in various countries has shown remarkable cost savings and improved health outcomes. Our study in Sakado City involved individuals with specific genetic markers and demonstrated a notable reduction in homocysteine levels, which is linked to heart health.
While there was an increase in folate levels, the decrease in heart attack rates wasn't specified as significant. Overall, mandatory folic acid fortification is cost-effective and may reduce heart attack incidents, supporting its broader implementation in Japan.
While there was an increase in folate levels, the decrease in heart attack rates wasn't specified as significant. Overall, mandatory folic acid fortification is cost-effective and may reduce heart attack incidents, supporting its broader implementation in Japan.
Read More
8
We examined the link between multivitamin use, including folic acid, and the risk of heart attacks in women. Our study followed 31,671 women without heart disease and evaluated their supplement usage over ten years.
We discovered that those taking multivitamins had a lower chance of experiencing a heart attack, especially if they used them for over five years. However, in women with a prior history of heart disease, multivitamins didn’t show the same benefit.
More research is needed to fully understand these results and confirm our findings.
We discovered that those taking multivitamins had a lower chance of experiencing a heart attack, especially if they used them for over five years. However, in women with a prior history of heart disease, multivitamins didn’t show the same benefit.
More research is needed to fully understand these results and confirm our findings.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced heart disease risk
221 people found this helpful
My blood test showed elevated homocysteine, which can lead to heart attacks. I was prescribed Methylfolate, and after two weeks of taking 4000 mcg, my levels dropped from 14 to 5.8. Remember, high homocysteine can damage blood vessels. Stay healthy!
Read More
9
Lowered anxiety levels
7 people found this helpful
My doctor recommended 5-MTHF due to our family's history of high homocysteine, which is linked to heart disease and can cause anxiety. After three days on this, I finally started sleeping through the night, so I can highly recommend it.
Read More
9
Stabilised heart rate
7 people found this helpful
I've been taking this supplement for six months after my homocysteine was 16. My pulse, which was previously high, now stays under 65. I haven’t retested my levels yet, but I definitely recommend it for anyone with similar issues.
Read More
9
Enhances blood health
This supplement maintains optimal blood thickness, prevents thrombophlebitis and heart attack, and stimulates the immune system, promoting red blood cell and haemoglobin formation.
Read More
7.5
Lowers homocysteine levels
301 people found this helpful
I took folate to lower my homocysteine, which was high at 10; it's now down to 7. For women planning a pregnancy, it ideally should be below 7, as elevated levels pose a risk for heart attacks. I got my mother to test her levels, and hers was 15, now she drinks folate too. It's essential to look after our parents!
Read More
Frequently Asked Questions
9
Lowered anxiety levels
7 people found this helpful
My doctor recommended 5-MTHF due to our family's history of high homocysteine, which is linked to heart disease and can cause anxiety. After three days on this, I finally started sleeping through the night, so I can highly recommend it.
9
Reduced heart disease risk
221 people found this helpful
My blood test showed elevated homocysteine, which can lead to heart attacks. I was prescribed Methylfolate, and after two weeks of taking 4000 mcg, my levels dropped from 14 to 5.8. Remember, high homocysteine can damage blood vessels. Stay healthy!
9
Stabilised heart rate
7 people found this helpful
I've been taking this supplement for six months after my homocysteine was 16. My pulse, which was previously high, now stays under 65. I haven’t retested my levels yet, but I definitely recommend it for anyone with similar issues.
7.5
Heart attack prevention
210 people found this helpful
My homocysteine was 10; now it's 7 after taking folate, essential for women planning pregnancy. It's crucial for heart health as levels above 7 increase the risk for heart attacks. My mother had 15 and now takes folate with me. Take care of your health and consult your doctor!
0
Induced panic attacks
As someone with a MTHFR mutation, I was recommended this supplement. Unfortunately, I had a poor reaction after two months, experiencing heightened anxiety, panic attacks, and migraines. It took about two weeks after stopping for my symptoms to improve.
7.5
Cholesterol improvement
10 people found this helpful
I started this pill at 680 mcg, along with omega 3 and vitamin D3. My cholesterol was borderline high at 5.8 mmol/L but dropped to 5.03 mmol/L after two months. I'm pleased with the results. However, it's a synthetic product, not plant-based.
9
Anemia treatment
5 people found this helpful
This supplement, combined with B12 and iron, helped save my father from the dangers of elderly anaemia, which can affect heart health. We initially took two a day for two weeks and then switched to one daily. Don’t overlook the importance of B12 to avoid serious complications.
7.5
Lowers homocysteine levels
301 people found this helpful
I took folate to lower my homocysteine, which was high at 10; it's now down to 7. For women planning a pregnancy, it ideally should be below 7, as elevated levels pose a risk for heart attacks. I got my mother to test her levels, and hers was 15, now she drinks folate too. It's essential to look after our parents!
8
We explored how dietary intake of folate, along with vitamins B6 and B12, impacts heart health in a large UK cohort of 115,664 participants aged 40-70.
After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.
However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.
However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
7
We explored a new way to improve stem cell therapy for heart attack recovery using a folic acid hydrogels. This innovative hydrogel helps retain induced pluripotent stem (iPS) cells better in the heart post-injection.
Our results showed that using the hydrogel not only increased the survival rate of these cells but also enhanced their ability to regenerate heart tissue. This led to better heart function and reduced adverse remodeling after damage. Overall, the study suggests that folic acid-based hydrogels could significantly boost the effectiveness of stem cell treatments for heart attacks.
Our results showed that using the hydrogel not only increased the survival rate of these cells but also enhanced their ability to regenerate heart tissue. This led to better heart function and reduced adverse remodeling after damage. Overall, the study suggests that folic acid-based hydrogels could significantly boost the effectiveness of stem cell treatments for heart attacks.
7
We investigated how folic acid (FA) might safeguard against heart damage induced by isoprenaline (ISO) in rats. Adult male Wistar albino rats received FA pretreatment for seven days before ISO was administered to mimic heart injury.
Our results showed that FA pretreatment helped reduce harmful markers indicating heart damage and oxidative stress. Specifically, FA lowered levels of homocysteine and improved antioxidant enzyme activities, suggesting a protective effect.
Ultimately, while FA demonstrated some benefits in this model, further research is needed to assess its real-world applications for heart health.
Our results showed that FA pretreatment helped reduce harmful markers indicating heart damage and oxidative stress. Specifically, FA lowered levels of homocysteine and improved antioxidant enzyme activities, suggesting a protective effect.
Ultimately, while FA demonstrated some benefits in this model, further research is needed to assess its real-world applications for heart health.
4
We aimed to determine the effectiveness of folic acid in preventing cardiovascular disease (CVD) through an updated meta-analysis of 26 randomized controlled trials involving nearly 59,000 participants. Our findings revealed that folic acid supplementation did not significantly impact the risk of CVD, coronary heart disease, or overall mortality.
Interestingly, there was a slight trend showing potential stroke risk reduction, although results were not conclusive. Overall, while supplementation may carry some modest benefits for stroke prevention, it does not appear to significantly reduce the risk of heart-related issues.
Interestingly, there was a slight trend showing potential stroke risk reduction, although results were not conclusive. Overall, while supplementation may carry some modest benefits for stroke prevention, it does not appear to significantly reduce the risk of heart-related issues.
4
We explored the relationship between folate levels and the risk of cardiovascular death, particularly focusing on heart attacks, in a group of hypertensive adults. This research followed nearly 3,000 adults over an 18-year period, utilizing data from the National Health and Nutrition Examination Survey conducted from 1991 to 1994, followed by a long-term follow-up until 2010.
What we found was intriguing. Participants with high levels of folate in their red blood cells exhibited a concerning trend—higher risks of cardiovascular deaths, especially from acute myocardial infarctions. For those in the low folate group, cardiovascular deaths occurred at a rate of about 13.04 per 1,000 person-years, while those with high folate had a rate of 26.61 per 1,000 person-years.
We observed that the median survival time for individuals in the high folate quartile was significantly shorter, suggesting a J-shaped association between folate levels and heart attack risk. These findings indicate that while moderate folate levels may be neutral, excessively high levels could heighten the risk of cardiovascular events, signaling that too much of a good thing can be detrimental.
In conclusion, while it’s clear that folate plays a role in heart health, especially for those with hypertension, those high levels might not be as beneficial as previously thought when it comes to reducing heart attack risks.
What we found was intriguing. Participants with high levels of folate in their red blood cells exhibited a concerning trend—higher risks of cardiovascular deaths, especially from acute myocardial infarctions. For those in the low folate group, cardiovascular deaths occurred at a rate of about 13.04 per 1,000 person-years, while those with high folate had a rate of 26.61 per 1,000 person-years.
We observed that the median survival time for individuals in the high folate quartile was significantly shorter, suggesting a J-shaped association between folate levels and heart attack risk. These findings indicate that while moderate folate levels may be neutral, excessively high levels could heighten the risk of cardiovascular events, signaling that too much of a good thing can be detrimental.
In conclusion, while it’s clear that folate plays a role in heart health, especially for those with hypertension, those high levels might not be as beneficial as previously thought when it comes to reducing heart attack risks.
References
- Hua Y, He Z, Ni Y, Sun L, Wang R, et al. Silk fibroin and hydroxypropyl cellulose composite injectable hydrogel-containing extracellular vesicles for myocardial infarction repair. Biomed Phys Eng Express. 2024;10. 10.1088/2057-1976/ad40b2
- Sobot T, Bajic Z, Skrbic R, Uletilovic S, Mandic-Kovacevic N, et al. Effect of folic acid on isoprenaline-induced myocardial injury in rats. Physiol Int. 2024;111:80. 10.1556/2060.2023.00291
- Zhang B, Dong H, Xu Y, Xu D, Sun H, et al. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort. Eur J Clin Nutr. 2023;77:299. 10.1038/s41430-022-01206-2
- Khan SU, Khan MU, Riaz H, Valavoor S, Zhao D, et al. Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map. Ann Intern Med. 2019;171:190. 10.7326/M19-0341
- Borowczyk K, Piechocka J, Głowacki R, Dhar I, Midtun Ø, et al. Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial. J Intern Med. 2019;285:232. 10.1111/joim.12834
- Li H, Gao J, Shang Y, Hua Y, Ye M, et al. Folic Acid Derived Hydrogel Enhances the Survival and Promotes Therapeutic Efficacy of iPS Cells for Acute Myocardial Infarction. ACS Appl Mater Interfaces. 2018;10:24459. 10.1021/acsami.8b08659
- Martí-Carvajal AJ, Solà I, Lathyris D, Dayer M. Homocysteine-lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev. 2017;8:CD006612. 10.1002/14651858.CD006612.pub5
- Kagawa Y, Hiraoka M, Kageyama M, Kontai Y, Yurimoto M, et al. Medical cost savings in Sakado City and worldwide achieved by preventing disease by folic acid fortification. Congenit Anom (Kyoto). 2017;57:157. 10.1111/cga.12215
- Nigwekar SU, Kang A, Zoungas S, Cass A, Gallagher MP, et al. Interventions for lowering plasma homocysteine levels in dialysis patients. Cochrane Database Syst Rev. 2016;2016:CD004683. 10.1002/14651858.CD004683.pub4
- Söderström E, Eliasson M, Johnson O, Hallmans G, Weinehall L, et al. Plasma folate, but not homocysteine, is associated with Apolipoprotein A1 levels in a non-fortified population. Lipids Health Dis. 2013;12:74. 10.1186/1476-511X-12-74
- Yang HT, Lee M, Hong KS, Ovbiagele B, Saver JL. Efficacy of folic acid supplementation in cardiovascular disease prevention: an updated meta-analysis of randomized controlled trials. Eur J Intern Med. 2012;23:745. 10.1016/j.ejim.2012.07.004
- Mujibul Haq AM, M Giasuddin AS, Huque MM. Serum total homocysteine and lipoprotein (a) levels in acute myocardial infarction and their response to treatment with vitamins. J Coll Physicians Surg Pak. 2011;21:266.
- Rautiainen S, Akesson A, Levitan EB, Morgenstern R, Mittleman MA, et al. Multivitamin use and the risk of myocardial infarction: a population-based cohort of Swedish women. Am J Clin Nutr. 2010;92:1251. 10.3945/ajcn.2010.29371
- Qipshidze N, Tyagi N, Sen U, Givvimani S, Metreveli N, et al. Folic acid mitigated cardiac dysfunction by normalizing the levels of tissue inhibitor of metalloproteinase and homocysteine-metabolizing enzymes postmyocardial infarction in mice. Am J Physiol Heart Circ Physiol. 2010;299:H1484. 10.1152/ajpheart.00577.2010
- Ebbing M, Bønaa KH, Arnesen E, Ueland PM, Nordrehaug JE, et al. Combined analyses and extended follow-up of two randomized controlled homocysteine-lowering B-vitamin trials. J Intern Med. 2010;268:367. 10.1111/j.1365-2796.2010.02259.x
- Armitage JM, Bowman L, Clarke RJ, Wallendszus K, Bulbulia R, et al. Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial. JAMA. 2010;303:2486. 10.1001/jama.2010.840
- Ni Y, Hua Y, He Z, Hu W, Chen Z, et al. Release of exosomes from injectable silk fibroin and alginate composite hydrogel for treatment of myocardial infarction. J Biomater Appl. 2024;39:139. 10.1177/08853282241251610
- An P, Wan S, Luo Y, Luo J, Zhang X, et al. Micronutrient Supplementation to Reduce Cardiovascular Risk. J Am Coll Cardiol. 2022;80:2269. 10.1016/j.jacc.2022.09.048
- Sikora M, Skrzydlewski P, Perła-Kaján J, Jakubowski H. Homocysteine thiolactone contributes to the prognostic value of fibrin clot structure/function in coronary artery disease. PLoS One. 2022;17:e0275956. 10.1371/journal.pone.0275956
- Twum F, Morte N, Wei Y, Nkemjika S, Liu F, et al. Red blood cell folate and cardiovascular deaths among hypertensive adults, an 18-year follow-up of a national cohort. Hypertens Res. 2020;43:938. 10.1038/s41440-020-0482-5
- Saad Shaukat MH, Toledo-Garcia A, Torosoff M. Recurrent Myocardial Infarction Despite Normal C-reactive Protein in a Patient with Behcet's Disease and Compound Heterozygous Methylenetetrahydrofolate Reductase (MTHFR) Mutations (C677T and A1298C). Cureus. 2019;11:e5344. 10.7759/cureus.5344
