For two years I suffered horrible esophageal spasms and indigestion, daily, that would go on for hours. I tried everything I could think of and nothing worked. (antacids, etc.) Then one of my friends sent me an article that said one of the symptoms of a B-12 deficiency is digestive problems. A B-12 deficiency seemed a likely possibility since I have had my gallbladder removed and am taking omeprazole. After I had my gallbladder out the indigestion began and eventually got so bad the esophageal spasms started up. Horrible. It would radiate from my stomach up my chest and into my lower jaw, over and over for hours on end. I spent many nights fighting nausea and standing over a sink drooling heavily. I had no idea such misery was possible until it happened to me. I didn't hold much hope that this would work, because nothing else did, but I figured I'd try it and if it didn't work I'd only be out a few dollars. Within days I was about 80% better. It gets a little better every day. My doctor poo-poohs this but my take on it is: after two years of sheer torture/agony it worked. I don't understand how it worked or why it worked only that it did--and that is good enough for me