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SCIENTIFIC SCORE
Likely Ineffective
Based on 1 Research
4
USERS' SCORE
Good
Based on 1 Review
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₁₂ (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
4
Vitamin B12's unclear impact on glioblastoma
Effect of pyridoxine or cobalamin supplementation on apoptosis and cell cycle progression in a human glioblastoma cell line.
Moderately limited relevance
We explored the effects of vitamin B12 (cobalamin) supplementation on a human glioblastoma cell line known as U-87 MG. Our main goal was to understand how cobalamin, particularly in combination with pyridoxine (vitamin B6), influences cell viability and the process of cell death, known as apoptosis.
Our approach involved treating the glioblastoma cells with varying concentrations of vitamin B12 over a period of 24 to 72 hours. We assessed the health of the cells and their progression through the cell cycle using methods like spectrophotometry and flow cytometry. We also measured specific proteins associated with cell survival and death through western blot analysis.
We found that while vitamin B6 supplementation led to decreased cell viability and increased signs of apoptosis, the role of vitamin B12 was less clear. It appeared that cobalamin did not significantly enhance or inhibit cell death on its own. However, when combined with pyridoxine, it seemed to reduce the cytotoxic effects of vitamin B6.
In summary, while vitamin B12 in isolation did not show a direct benefit for the glioblastoma cells in our study, its potential to influence the effects of other vitamins highlights a complex interaction deserving of further exploration.
Our approach involved treating the glioblastoma cells with varying concentrations of vitamin B12 over a period of 24 to 72 hours. We assessed the health of the cells and their progression through the cell cycle using methods like spectrophotometry and flow cytometry. We also measured specific proteins associated with cell survival and death through western blot analysis.
We found that while vitamin B6 supplementation led to decreased cell viability and increased signs of apoptosis, the role of vitamin B12 was less clear. It appeared that cobalamin did not significantly enhance or inhibit cell death on its own. However, when combined with pyridoxine, it seemed to reduce the cytotoxic effects of vitamin B6.
In summary, while vitamin B12 in isolation did not show a direct benefit for the glioblastoma cells in our study, its potential to influence the effects of other vitamins highlights a complex interaction deserving of further exploration.
Read More
Most Useful Reviews
7.5
Improved energy levels
After maintaining a strict raw and vegan diet for three years, my B12 levels were alarmingly low. However, after a month of taking bioavailable B12 supplements, my levels rose to nearly 600 units, normalising my condition. This not only enhanced my sleep but also reduced my anxiety. I noticed increased calmness and energy, particularly when I began exercising regularly, which is crucial in managing my brain tumour.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Ineffective
Based on 1 Research
4
4
Vitamin B12's unclear impact on glioblastoma
Effect of pyridoxine or cobalamin supplementation on apoptosis and cell cycle progression in a human glioblastoma cell line.
Moderately limited relevance
We explored the effects of vitamin B12 (cobalamin) supplementation on a human glioblastoma cell line known as U-87 MG. Our main goal was to understand how cobalamin, particularly in combination with pyridoxine (vitamin B6), influences cell viability and the process of cell death, known as apoptosis.
Our approach involved treating the glioblastoma cells with varying concentrations of vitamin B12 over a period of 24 to 72 hours. We assessed the health of the cells and their progression through the cell cycle using methods like spectrophotometry and flow cytometry. We also measured specific proteins associated with cell survival and death through western blot analysis.
We found that while vitamin B6 supplementation led to decreased cell viability and increased signs of apoptosis, the role of vitamin B12 was less clear. It appeared that cobalamin did not significantly enhance or inhibit cell death on its own. However, when combined with pyridoxine, it seemed to reduce the cytotoxic effects of vitamin B6.
In summary, while vitamin B12 in isolation did not show a direct benefit for the glioblastoma cells in our study, its potential to influence the effects of other vitamins highlights a complex interaction deserving of further exploration.
Our approach involved treating the glioblastoma cells with varying concentrations of vitamin B12 over a period of 24 to 72 hours. We assessed the health of the cells and their progression through the cell cycle using methods like spectrophotometry and flow cytometry. We also measured specific proteins associated with cell survival and death through western blot analysis.
We found that while vitamin B6 supplementation led to decreased cell viability and increased signs of apoptosis, the role of vitamin B12 was less clear. It appeared that cobalamin did not significantly enhance or inhibit cell death on its own. However, when combined with pyridoxine, it seemed to reduce the cytotoxic effects of vitamin B6.
In summary, while vitamin B12 in isolation did not show a direct benefit for the glioblastoma cells in our study, its potential to influence the effects of other vitamins highlights a complex interaction deserving of further exploration.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.4
7.5
Improved energy levels
After maintaining a strict raw and vegan diet for three years, my B12 levels were alarmingly low. However, after a month of taking bioavailable B12 supplements, my levels rose to nearly 600 units, normalising my condition. This not only enhanced my sleep but also reduced my anxiety. I noticed increased calmness and energy, particularly when I began exercising regularly, which is crucial in managing my brain tumour.
Read More
