' 
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 8 Reviews
8.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₁₂ (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
8
Vitamin B12 shows cold pain relief
The effects of vitamin B12 and diclofenac and their combination on cold and mechanical allodynia in a neuropathic pain model in rats.
Combination treatment effects noted
We explored the potential effects of vitamin B12 on cold sensitivity in a study using rats with induced neuropathic pain. The focus was to see whether vitamin B12, both alone and in combination with the pain reliever diclofenac, could alleviate cold and mechanical allodynia—a condition where non-painful stimuli are perceived as painful.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
Read More
7
B12 may reduce cold sensitivity
B vitamins relieve neuropathic pain behaviors induced by infraorbital nerve constriction in rats.
Combination treatment limits conclusions
In our exploration of neuropathic pain relief, we found that Vitamin B12 has a notable impact on cold sensitivity in rats with nerve injuries. The study involved male Wistar rats that underwent infraorbital nerve constriction, simulating a model of trigeminal neuropathic pain.
We treated these rats with B vitamins, particularly focusing on Vitamin B12, to assess its effectiveness in alleviating cold hyperalgesia, which is an increased sensitivity to cold. The results showed that Vitamin B12, when given at a lower dose alongside carbamazepine, helped reduce cold pain sensitivity at certain time points.
However, the combination treatment limited our ability to fully understand the isolated effect of Vitamin B12. Still, it suggests that including B12 in pain management may offer additional benefits for those suffering from this type of nerve pain.
We treated these rats with B vitamins, particularly focusing on Vitamin B12, to assess its effectiveness in alleviating cold hyperalgesia, which is an increased sensitivity to cold. The results showed that Vitamin B12, when given at a lower dose alongside carbamazepine, helped reduce cold pain sensitivity at certain time points.
However, the combination treatment limited our ability to fully understand the isolated effect of Vitamin B12. Still, it suggests that including B12 in pain management may offer additional benefits for those suffering from this type of nerve pain.
Read More
Most Useful Reviews
9.5
Strengthened immunity
Great drug! My doctor, a neurologist, prescribed this to maintain my nervous system, which was vital as I found the noise in my ears very disturbing. I had to place the tablets in my mouth for quicker results. The small plates have a slightly sweet lemon flavour. I was pleased with its effectiveness; I didn't catch a cold this autumn, and my immunity was fortified. Joint mobility significantly increased, with no more crunching, and my sleep has improved. This vitamin helped stabilise my overall psychological state, and my nervous system is now fine. An excellent dietary supplement at a budget price!
Read More
8.3
Strengthened immunity
Great drug! My neurologist prescribed this supplement to support my nervous system, as the tinnitus was quite bothersome. I found it necessary to place the tablets in my mouth for quicker results. The small plates offer a slightly sweet lemon taste. I was pleased with how effective it was; I did not catch a cold this autumn, and my immune system strengthened. My joint mobility has significantly improved, with no crunching, and my sleep has enhanced. This vitamin really helped stabilise my overall psychological state, and my nervous system is in good shape. An excellent budget-friendly dietary supplement!
Read More
8.8
Reduced cold hands
Great choice! I advise everyone! The perfect combination of price and quality. I have hypothyroidism and Hashimoto's thyroiditis, and vitamin B12 is essential with my diagnosis. After taking it for a month, I noticed improvements from the first day. My cold hands have ceased, my mind is clearer, and I feel much less nervous. I take one tablet before bed, sometimes in the morning before a heavy working day.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
Vitamin B12 shows cold pain relief
The effects of vitamin B12 and diclofenac and their combination on cold and mechanical allodynia in a neuropathic pain model in rats.
Combination treatment effects noted
We explored the potential effects of vitamin B12 on cold sensitivity in a study using rats with induced neuropathic pain. The focus was to see whether vitamin B12, both alone and in combination with the pain reliever diclofenac, could alleviate cold and mechanical allodynia—a condition where non-painful stimuli are perceived as painful.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
Read More
7
B12 may reduce cold sensitivity
B vitamins relieve neuropathic pain behaviors induced by infraorbital nerve constriction in rats.
Combination treatment limits conclusions
In our exploration of neuropathic pain relief, we found that Vitamin B12 has a notable impact on cold sensitivity in rats with nerve injuries. The study involved male Wistar rats that underwent infraorbital nerve constriction, simulating a model of trigeminal neuropathic pain.
We treated these rats with B vitamins, particularly focusing on Vitamin B12, to assess its effectiveness in alleviating cold hyperalgesia, which is an increased sensitivity to cold. The results showed that Vitamin B12, when given at a lower dose alongside carbamazepine, helped reduce cold pain sensitivity at certain time points.
However, the combination treatment limited our ability to fully understand the isolated effect of Vitamin B12. Still, it suggests that including B12 in pain management may offer additional benefits for those suffering from this type of nerve pain.
We treated these rats with B vitamins, particularly focusing on Vitamin B12, to assess its effectiveness in alleviating cold hyperalgesia, which is an increased sensitivity to cold. The results showed that Vitamin B12, when given at a lower dose alongside carbamazepine, helped reduce cold pain sensitivity at certain time points.
However, the combination treatment limited our ability to fully understand the isolated effect of Vitamin B12. Still, it suggests that including B12 in pain management may offer additional benefits for those suffering from this type of nerve pain.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Strengthened immunity
Great drug! My doctor, a neurologist, prescribed this to maintain my nervous system, which was vital as I found the noise in my ears very disturbing. I had to place the tablets in my mouth for quicker results. The small plates have a slightly sweet lemon flavour. I was pleased with its effectiveness; I didn't catch a cold this autumn, and my immunity was fortified. Joint mobility significantly increased, with no more crunching, and my sleep has improved. This vitamin helped stabilise my overall psychological state, and my nervous system is now fine. An excellent dietary supplement at a budget price!
Read More
8.3
Strengthened immunity
Great drug! My neurologist prescribed this supplement to support my nervous system, as the tinnitus was quite bothersome. I found it necessary to place the tablets in my mouth for quicker results. The small plates offer a slightly sweet lemon taste. I was pleased with how effective it was; I did not catch a cold this autumn, and my immune system strengthened. My joint mobility has significantly improved, with no crunching, and my sleep has enhanced. This vitamin really helped stabilise my overall psychological state, and my nervous system is in good shape. An excellent budget-friendly dietary supplement!
Read More
8.8
Reduced cold hands
Great choice! I advise everyone! The perfect combination of price and quality. I have hypothyroidism and Hashimoto's thyroiditis, and vitamin B12 is essential with my diagnosis. After taking it for a month, I noticed improvements from the first day. My cold hands have ceased, my mind is clearer, and I feel much less nervous. I take one tablet before bed, sometimes in the morning before a heavy working day.
Read More
9.5
Cold prevention success.
Immune system boost. I take B12 as part of my immune system regimen, particularly to keep shingles at bay, since my mother suffered a severe case that led to nerve pain. In my research on preventing outbreaks, I found a combination of supplements to boost immunity, and this is a critical part of that plan. Since starting, I haven't fallen ill at all, including with colds and flus. I plan to continue my immune support routine to fend off illness and hopefully prevent shingles too!
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8.8
Faster recovery from cold
Good form B12! I have been taking this supplement for a short time, but I've already noticed my immune system strengthening. I caught a viral illness, perhaps the most common one in 2020, but I overcame it almost unnoticed. A slight stuffy nose and general weakness were the only noticeable symptoms, which passed in 2 days! Previously, I had colds that lasted longer. I doubled my daily dose of B12 during this period and was thrilled to find my strength intact, with no residual weakness.
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