Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.8
USERS' SCORE
Good
Based on 5 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₁₂ (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9
We delved into the complexities surrounding a specific genetic mutation in the LMBRD1 gene, which is linked to a variant form of cobalamin (vitamin B12) deficiency. This study highlighted a 15-year-old male with symptoms typical of Dyskeratosis Congenita, including skin hyperpigmentation and ulcers. After identifying a novel splice site deletion in the gene, we learned that this alteration can heavily impact vitamin B12 metabolism and lead to various clinical manifestations, including ulcers.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Read More
9.5
We explored the connection between recurrent aphthous stomatitis (RAS), commonly known as oral ulcers, and various hematological parameters, particularly focusing on vitamin B12. Our systematic review and meta-analysis brought together multiple studies to identify how deficiencies in this vitamin and other blood-related factors might influence the formation and recurrence of these painful ulcers.
From our analysis, we discovered that individuals suffering from RAS had significantly lower levels of vitamin B12 and hemoglobin compared to healthy individuals. Specifically, our findings showed that participants with vitamin B12 deficiency were nearly three times more likely to develop RAS than those without the deficiency. This suggests that vitamin B12 may play a crucial role in maintaining oral health and preventing the occurrence of these ulcers.
The study highlights that addressing vitamin B12 levels could be a beneficial strategy in managing RAS. By ensuring adequate levels of this essential vitamin, we might reduce the frequency and severity of ulcers that many deal with regularly. Overall, our research emphasizes the importance of monitoring and potentially supplementing vitamin B12 for those experiencing recurrent oral ulcers.
From our analysis, we discovered that individuals suffering from RAS had significantly lower levels of vitamin B12 and hemoglobin compared to healthy individuals. Specifically, our findings showed that participants with vitamin B12 deficiency were nearly three times more likely to develop RAS than those without the deficiency. This suggests that vitamin B12 may play a crucial role in maintaining oral health and preventing the occurrence of these ulcers.
The study highlights that addressing vitamin B12 levels could be a beneficial strategy in managing RAS. By ensuring adequate levels of this essential vitamin, we might reduce the frequency and severity of ulcers that many deal with regularly. Overall, our research emphasizes the importance of monitoring and potentially supplementing vitamin B12 for those experiencing recurrent oral ulcers.
Read More
9
Golden kiwifruit aids gastric healing
We examined the effects of hydro-alcoholic extracts from golden kiwifruit flesh and peel on ulcers caused by indomethacin in rats. The study involved several groups, including a control that received just water and one that received indomethacin to induce gastric ulcers.
Results indicated that golden kiwifruit extracts reduced stomach damage and improved healing compared to controls. Notably, the extracts elevated vitamin B levels and showcased antioxidant properties. While Lansoprazole also helped, golden kiwifruit extracts showed even greater potential benefits for ulcer treatment.
Results indicated that golden kiwifruit extracts reduced stomach damage and improved healing compared to controls. Notably, the extracts elevated vitamin B levels and showcased antioxidant properties. While Lansoprazole also helped, golden kiwifruit extracts showed even greater potential benefits for ulcer treatment.
Read More
Most Useful Reviews
9
Effective treatment
B12 has been beneficial for my mouth ulcers.
Read More
9
Ulcers cured
I purchased this for my son, as vitamin B12 deficiency can lead to oral ulcers. After two weeks, all symptoms have disappeared. The medication is effective, and I recommend it.
Read More
7.5
Healed ulcers
Troche is easy to swallow as it's a lozenge. My mouth ulcers have healed!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.8
- All Researches
9.5
We explored the connection between recurrent aphthous stomatitis (RAS), commonly known as oral ulcers, and various hematological parameters, particularly focusing on vitamin B12. Our systematic review and meta-analysis brought together multiple studies to identify how deficiencies in this vitamin and other blood-related factors might influence the formation and recurrence of these painful ulcers.
From our analysis, we discovered that individuals suffering from RAS had significantly lower levels of vitamin B12 and hemoglobin compared to healthy individuals. Specifically, our findings showed that participants with vitamin B12 deficiency were nearly three times more likely to develop RAS than those without the deficiency. This suggests that vitamin B12 may play a crucial role in maintaining oral health and preventing the occurrence of these ulcers.
The study highlights that addressing vitamin B12 levels could be a beneficial strategy in managing RAS. By ensuring adequate levels of this essential vitamin, we might reduce the frequency and severity of ulcers that many deal with regularly. Overall, our research emphasizes the importance of monitoring and potentially supplementing vitamin B12 for those experiencing recurrent oral ulcers.
From our analysis, we discovered that individuals suffering from RAS had significantly lower levels of vitamin B12 and hemoglobin compared to healthy individuals. Specifically, our findings showed that participants with vitamin B12 deficiency were nearly three times more likely to develop RAS than those without the deficiency. This suggests that vitamin B12 may play a crucial role in maintaining oral health and preventing the occurrence of these ulcers.
The study highlights that addressing vitamin B12 levels could be a beneficial strategy in managing RAS. By ensuring adequate levels of this essential vitamin, we might reduce the frequency and severity of ulcers that many deal with regularly. Overall, our research emphasizes the importance of monitoring and potentially supplementing vitamin B12 for those experiencing recurrent oral ulcers.
Read More
9
Golden kiwifruit aids gastric healing
We examined the effects of hydro-alcoholic extracts from golden kiwifruit flesh and peel on ulcers caused by indomethacin in rats. The study involved several groups, including a control that received just water and one that received indomethacin to induce gastric ulcers.
Results indicated that golden kiwifruit extracts reduced stomach damage and improved healing compared to controls. Notably, the extracts elevated vitamin B levels and showcased antioxidant properties. While Lansoprazole also helped, golden kiwifruit extracts showed even greater potential benefits for ulcer treatment.
Results indicated that golden kiwifruit extracts reduced stomach damage and improved healing compared to controls. Notably, the extracts elevated vitamin B levels and showcased antioxidant properties. While Lansoprazole also helped, golden kiwifruit extracts showed even greater potential benefits for ulcer treatment.
Read More
9
We delved into the complexities surrounding a specific genetic mutation in the LMBRD1 gene, which is linked to a variant form of cobalamin (vitamin B12) deficiency. This study highlighted a 15-year-old male with symptoms typical of Dyskeratosis Congenita, including skin hyperpigmentation and ulcers. After identifying a novel splice site deletion in the gene, we learned that this alteration can heavily impact vitamin B12 metabolism and lead to various clinical manifestations, including ulcers.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Read More
9
We examined how vitamin B, particularly in the context of induced cellular plasticity, can impact ulcer healing. The research reveals that when the reprogramming factors OCT4, SOX2, KLF4, and MYC (known as OSKM) were expressed in mice, there was a notable depletion of vitamin B. This depletion was coupled with signs of methionine starvation, which can hinder proper metabolic functioning.
Our findings indicate that adding vitamin B can boost the efficiency of cellular reprogramming and enhance tissue repair processes. Specifically, vitamin B supplementation showed a considerable effect in accelerating recovery in models of ulcerative colitis. We also uncovered that vitamin B affects key epigenetic markers, which are essential for maintaining accurate gene expression during reprogramming and repair.
While the study highlights vitamin B's significant role in tissue healing, it doesn't specifically isolate vitamin B12 from other elements, making it difficult to pinpoint its individual contribution. Nonetheless, we can confidently say that boosting vitamin B levels could enhance the body's natural healing processes, particularly regarding ulcers.
Our findings indicate that adding vitamin B can boost the efficiency of cellular reprogramming and enhance tissue repair processes. Specifically, vitamin B supplementation showed a considerable effect in accelerating recovery in models of ulcerative colitis. We also uncovered that vitamin B affects key epigenetic markers, which are essential for maintaining accurate gene expression during reprogramming and repair.
While the study highlights vitamin B's significant role in tissue healing, it doesn't specifically isolate vitamin B12 from other elements, making it difficult to pinpoint its individual contribution. Nonetheless, we can confidently say that boosting vitamin B levels could enhance the body's natural healing processes, particularly regarding ulcers.
Read More
8
We explored the effects of vitamin B12 in treating recurrent ulcers caused by pyoderma gangrenosum (PG) based on a notable case report. PG, an inflammatory skin condition, is relatively rare and often presents as painful, ulcerative wounds. This case highlighted a 62-year-old man who was treated with vitamin B12 injections alongside other therapies, including steroid injections and topical antibiotics.
While the inclusion of vitamin B12 in the treatment regimen is interesting, we must recognize that its specific impact on healing ulcers cannot be easily determined. The treatment involved multiple approaches, making it challenging to isolate the benefits of vitamin B12 alone.
Ultimately, this case reinforces the importance of looking for underlying causes like nutritional deficiencies in conditions such as PG. Though vitamin B12 supplementation is crucial for overall health and might contribute to the healing process, we can't draw definitive conclusions about its effectiveness based solely on this case.
While the inclusion of vitamin B12 in the treatment regimen is interesting, we must recognize that its specific impact on healing ulcers cannot be easily determined. The treatment involved multiple approaches, making it challenging to isolate the benefits of vitamin B12 alone.
Ultimately, this case reinforces the importance of looking for underlying causes like nutritional deficiencies in conditions such as PG. Though vitamin B12 supplementation is crucial for overall health and might contribute to the healing process, we can't draw definitive conclusions about its effectiveness based solely on this case.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective treatment
B12 has been beneficial for my mouth ulcers.
Read More
9
Ulcers cured
I purchased this for my son, as vitamin B12 deficiency can lead to oral ulcers. After two weeks, all symptoms have disappeared. The medication is effective, and I recommend it.
Read More
7.5
Healed ulcers
Troche is easy to swallow as it's a lozenge. My mouth ulcers have healed!
Read More
7.5
Relieved ulcers
The taste is pleasant. I take one tablet each morning, as I’ve heard that B12 can alleviate oral ulcers, and it seems to be effective for me. I will continue taking it.
Read More
7.5
Canker sores improved
I struggled with canker sores under my tongue, but this improved my condition. It's a pleasant-tasting pink pill, easy to take; however, consistent use is necessary for complete relief. Unfortunately, it disrupted my sleep.
Read More
Frequently Asked Questions
9
Ulcers cured
I purchased this for my son, as vitamin B12 deficiency can lead to oral ulcers. After two weeks, all symptoms have disappeared. The medication is effective, and I recommend it.
7.5
Canker sores improved
I struggled with canker sores under my tongue, but this improved my condition. It's a pleasant-tasting pink pill, easy to take; however, consistent use is necessary for complete relief. Unfortunately, it disrupted my sleep.
7.5
Healed ulcers
Troche is easy to swallow as it's a lozenge. My mouth ulcers have healed!
9
Effective treatment
B12 has been beneficial for my mouth ulcers.
7.5
Relieved ulcers
The taste is pleasant. I take one tablet each morning, as I’ve heard that B12 can alleviate oral ulcers, and it seems to be effective for me. I will continue taking it.
9
Golden kiwifruit aids gastric healing
We examined the effects of hydro-alcoholic extracts from golden kiwifruit flesh and peel on ulcers caused by indomethacin in rats. The study involved several groups, including a control that received just water and one that received indomethacin to induce gastric ulcers.
Results indicated that golden kiwifruit extracts reduced stomach damage and improved healing compared to controls. Notably, the extracts elevated vitamin B levels and showcased antioxidant properties. While Lansoprazole also helped, golden kiwifruit extracts showed even greater potential benefits for ulcer treatment.
Results indicated that golden kiwifruit extracts reduced stomach damage and improved healing compared to controls. Notably, the extracts elevated vitamin B levels and showcased antioxidant properties. While Lansoprazole also helped, golden kiwifruit extracts showed even greater potential benefits for ulcer treatment.
9.5
We explored the connection between recurrent aphthous stomatitis (RAS), commonly known as oral ulcers, and various hematological parameters, particularly focusing on vitamin B12. Our systematic review and meta-analysis brought together multiple studies to identify how deficiencies in this vitamin and other blood-related factors might influence the formation and recurrence of these painful ulcers.
From our analysis, we discovered that individuals suffering from RAS had significantly lower levels of vitamin B12 and hemoglobin compared to healthy individuals. Specifically, our findings showed that participants with vitamin B12 deficiency were nearly three times more likely to develop RAS than those without the deficiency. This suggests that vitamin B12 may play a crucial role in maintaining oral health and preventing the occurrence of these ulcers.
The study highlights that addressing vitamin B12 levels could be a beneficial strategy in managing RAS. By ensuring adequate levels of this essential vitamin, we might reduce the frequency and severity of ulcers that many deal with regularly. Overall, our research emphasizes the importance of monitoring and potentially supplementing vitamin B12 for those experiencing recurrent oral ulcers.
From our analysis, we discovered that individuals suffering from RAS had significantly lower levels of vitamin B12 and hemoglobin compared to healthy individuals. Specifically, our findings showed that participants with vitamin B12 deficiency were nearly three times more likely to develop RAS than those without the deficiency. This suggests that vitamin B12 may play a crucial role in maintaining oral health and preventing the occurrence of these ulcers.
The study highlights that addressing vitamin B12 levels could be a beneficial strategy in managing RAS. By ensuring adequate levels of this essential vitamin, we might reduce the frequency and severity of ulcers that many deal with regularly. Overall, our research emphasizes the importance of monitoring and potentially supplementing vitamin B12 for those experiencing recurrent oral ulcers.
8
We explored the effects of vitamin B12 in treating recurrent ulcers caused by pyoderma gangrenosum (PG) based on a notable case report. PG, an inflammatory skin condition, is relatively rare and often presents as painful, ulcerative wounds. This case highlighted a 62-year-old man who was treated with vitamin B12 injections alongside other therapies, including steroid injections and topical antibiotics.
While the inclusion of vitamin B12 in the treatment regimen is interesting, we must recognize that its specific impact on healing ulcers cannot be easily determined. The treatment involved multiple approaches, making it challenging to isolate the benefits of vitamin B12 alone.
Ultimately, this case reinforces the importance of looking for underlying causes like nutritional deficiencies in conditions such as PG. Though vitamin B12 supplementation is crucial for overall health and might contribute to the healing process, we can't draw definitive conclusions about its effectiveness based solely on this case.
While the inclusion of vitamin B12 in the treatment regimen is interesting, we must recognize that its specific impact on healing ulcers cannot be easily determined. The treatment involved multiple approaches, making it challenging to isolate the benefits of vitamin B12 alone.
Ultimately, this case reinforces the importance of looking for underlying causes like nutritional deficiencies in conditions such as PG. Though vitamin B12 supplementation is crucial for overall health and might contribute to the healing process, we can't draw definitive conclusions about its effectiveness based solely on this case.
References
- Aleid IS, Alfheeaid HA, Aljutaily T, Alhomaid RM, Alharbi HF, et al. Gastroprotective Effects of , Golden Kiwifruit Flesh, and Golden Kiwifruit Peel Extracts Individually or in Combination against Indomethacin-Induced Gastric Ulcer in Rats. Nutrients. 2021;13. doi:10.3390/nu13103499
- Shah A, Khuba S, Kumar C S, Shanmukhaiah C, George M, et al. Phenotype puzzle: the role of novel LMBRD1 gene variant in Cbl deficiency causing Dyskeratosis Congenita-like clinical manifestations. J Hum Genet. 2025;70:207. doi:10.1038/s10038-025-01320-6
- Mousavi T, Jalali H, Moosazadeh M. Hematological parameters in patients with recurrent Aphthous Stomatitis: a systematic review and meta-analysis. BMC Oral Health. 2024;24:339. doi:10.1186/s12903-024-04072-5
- Kovatcheva M, Melendez E, Chondronasiou D, Pietrocola F, Bernad R, et al. Vitamin B is a limiting factor for induced cellular plasticity and tissue repair. Nat Metab. 2023;5:1911. doi:10.1038/s42255-023-00916-6
- Sitaula S, Kharel S, Sherpali A, Shrees V, Mainali A. Idiopathic recurrent pyoderma gangrenosum with cobalamin deficiency in a 62-year-old male: a case report. Ann Med Surg (Lond). 2023;85:528. doi:10.1097/MS9.0000000000000253
- Albeladi AM, Busbaih Z, Almohammed Saleh AA, AlAlwan AQ, Aljughayman MA, et al. Successful Management of a Young Patient Suffering From Pyoderma Gangrenosum Following Gastric Bypass Surgery: A Case Report. Cureus. 2023;15:e34305. doi:10.7759/cureus.34305
