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SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.7
USERS' SCORE
Good
Based on 5 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₁₂ (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9
Genetic insights into ulcer healing
Phenotype puzzle: the role of novel LMBRD1 gene variant in Cbl deficiency causing Dyskeratosis Congenita-like clinical manifestations.
Vitamin B12 aids in ulcer healing
We delved into the complexities surrounding a specific genetic mutation in the LMBRD1 gene, which is linked to a variant form of cobalamin (vitamin B12) deficiency. This study highlighted a 15-year-old male with symptoms typical of Dyskeratosis Congenita, including skin hyperpigmentation and ulcers. After identifying a novel splice site deletion in the gene, we learned that this alteration can heavily impact vitamin B12 metabolism and lead to various clinical manifestations, including ulcers.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Read More
9.5
Vitamin B12's Role in Oral Health
Hematological parameters in patients with recurrent Aphthous Stomatitis: a systematic review and meta-analysis.
Moderate relevance to hematological factors
We explored the connection between recurrent aphthous stomatitis (RAS), commonly known as oral ulcers, and various hematological parameters, particularly focusing on vitamin B12. Our systematic review and meta-analysis brought together multiple studies to identify how deficiencies in this vitamin and other blood-related factors might influence the formation and recurrence of these painful ulcers.
From our analysis, we discovered that individuals suffering from RAS had significantly lower levels of vitamin B12 and hemoglobin compared to healthy individuals. Specifically, our findings showed that participants with vitamin B12 deficiency were nearly three times more likely to develop RAS than those without the deficiency. This suggests that vitamin B12 may play a crucial role in maintaining oral health and preventing the occurrence of these ulcers.
The study highlights that addressing vitamin B12 levels could be a beneficial strategy in managing RAS. By ensuring adequate levels of this essential vitamin, we might reduce the frequency and severity of ulcers that many deal with regularly. Overall, our research emphasizes the importance of monitoring and potentially supplementing vitamin B12 for those experiencing recurrent oral ulcers.
From our analysis, we discovered that individuals suffering from RAS had significantly lower levels of vitamin B12 and hemoglobin compared to healthy individuals. Specifically, our findings showed that participants with vitamin B12 deficiency were nearly three times more likely to develop RAS than those without the deficiency. This suggests that vitamin B12 may play a crucial role in maintaining oral health and preventing the occurrence of these ulcers.
The study highlights that addressing vitamin B12 levels could be a beneficial strategy in managing RAS. By ensuring adequate levels of this essential vitamin, we might reduce the frequency and severity of ulcers that many deal with regularly. Overall, our research emphasizes the importance of monitoring and potentially supplementing vitamin B12 for those experiencing recurrent oral ulcers.
Read More
9
Vitamin B enhances ulcer recovery
Vitamin B is a limiting factor for induced cellular plasticity and tissue repair.
Vitamin B12 effects not isolated
We examined how vitamin B, particularly in the context of induced cellular plasticity, can impact ulcer healing. The research reveals that when the reprogramming factors OCT4, SOX2, KLF4, and MYC (known as OSKM) were expressed in mice, there was a notable depletion of vitamin B. This depletion was coupled with signs of methionine starvation, which can hinder proper metabolic functioning.
Our findings indicate that adding vitamin B can boost the efficiency of cellular reprogramming and enhance tissue repair processes. Specifically, vitamin B supplementation showed a considerable effect in accelerating recovery in models of ulcerative colitis. We also uncovered that vitamin B affects key epigenetic markers, which are essential for maintaining accurate gene expression during reprogramming and repair.
While the study highlights vitamin B's significant role in tissue healing, it doesn't specifically isolate vitamin B12 from other elements, making it difficult to pinpoint its individual contribution. Nonetheless, we can confidently say that boosting vitamin B levels could enhance the body's natural healing processes, particularly regarding ulcers.
Our findings indicate that adding vitamin B can boost the efficiency of cellular reprogramming and enhance tissue repair processes. Specifically, vitamin B supplementation showed a considerable effect in accelerating recovery in models of ulcerative colitis. We also uncovered that vitamin B affects key epigenetic markers, which are essential for maintaining accurate gene expression during reprogramming and repair.
While the study highlights vitamin B's significant role in tissue healing, it doesn't specifically isolate vitamin B12 from other elements, making it difficult to pinpoint its individual contribution. Nonetheless, we can confidently say that boosting vitamin B levels could enhance the body's natural healing processes, particularly regarding ulcers.
Read More
Most Useful Reviews
9.5
Effective treatment
B12 has been beneficial for my mouth ulcers.
Read More
9.5
Ulcers cured
I purchased this for my son, as vitamin B12 deficiency can lead to oral ulcers. After two weeks, all symptoms have disappeared. The medication is effective, and I recommend it.
Read More
8.8
Healed ulcers
Troche is easy to swallow as it's a lozenge. My mouth ulcers have healed!
Read More
Most Recommended Products for Ulcer
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.7
9.5
Vitamin B12's Role in Oral Health
Hematological parameters in patients with recurrent Aphthous Stomatitis: a systematic review and meta-analysis.
Moderate relevance to hematological factors
We explored the connection between recurrent aphthous stomatitis (RAS), commonly known as oral ulcers, and various hematological parameters, particularly focusing on vitamin B12. Our systematic review and meta-analysis brought together multiple studies to identify how deficiencies in this vitamin and other blood-related factors might influence the formation and recurrence of these painful ulcers.
From our analysis, we discovered that individuals suffering from RAS had significantly lower levels of vitamin B12 and hemoglobin compared to healthy individuals. Specifically, our findings showed that participants with vitamin B12 deficiency were nearly three times more likely to develop RAS than those without the deficiency. This suggests that vitamin B12 may play a crucial role in maintaining oral health and preventing the occurrence of these ulcers.
The study highlights that addressing vitamin B12 levels could be a beneficial strategy in managing RAS. By ensuring adequate levels of this essential vitamin, we might reduce the frequency and severity of ulcers that many deal with regularly. Overall, our research emphasizes the importance of monitoring and potentially supplementing vitamin B12 for those experiencing recurrent oral ulcers.
From our analysis, we discovered that individuals suffering from RAS had significantly lower levels of vitamin B12 and hemoglobin compared to healthy individuals. Specifically, our findings showed that participants with vitamin B12 deficiency were nearly three times more likely to develop RAS than those without the deficiency. This suggests that vitamin B12 may play a crucial role in maintaining oral health and preventing the occurrence of these ulcers.
The study highlights that addressing vitamin B12 levels could be a beneficial strategy in managing RAS. By ensuring adequate levels of this essential vitamin, we might reduce the frequency and severity of ulcers that many deal with regularly. Overall, our research emphasizes the importance of monitoring and potentially supplementing vitamin B12 for those experiencing recurrent oral ulcers.
Read More
9
Genetic insights into ulcer healing
Phenotype puzzle: the role of novel LMBRD1 gene variant in Cbl deficiency causing Dyskeratosis Congenita-like clinical manifestations.
Vitamin B12 aids in ulcer healing
We delved into the complexities surrounding a specific genetic mutation in the LMBRD1 gene, which is linked to a variant form of cobalamin (vitamin B12) deficiency. This study highlighted a 15-year-old male with symptoms typical of Dyskeratosis Congenita, including skin hyperpigmentation and ulcers. After identifying a novel splice site deletion in the gene, we learned that this alteration can heavily impact vitamin B12 metabolism and lead to various clinical manifestations, including ulcers.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Read More
9
Vitamin B enhances ulcer recovery
Vitamin B is a limiting factor for induced cellular plasticity and tissue repair.
Vitamin B12 effects not isolated
We examined how vitamin B, particularly in the context of induced cellular plasticity, can impact ulcer healing. The research reveals that when the reprogramming factors OCT4, SOX2, KLF4, and MYC (known as OSKM) were expressed in mice, there was a notable depletion of vitamin B. This depletion was coupled with signs of methionine starvation, which can hinder proper metabolic functioning.
Our findings indicate that adding vitamin B can boost the efficiency of cellular reprogramming and enhance tissue repair processes. Specifically, vitamin B supplementation showed a considerable effect in accelerating recovery in models of ulcerative colitis. We also uncovered that vitamin B affects key epigenetic markers, which are essential for maintaining accurate gene expression during reprogramming and repair.
While the study highlights vitamin B's significant role in tissue healing, it doesn't specifically isolate vitamin B12 from other elements, making it difficult to pinpoint its individual contribution. Nonetheless, we can confidently say that boosting vitamin B levels could enhance the body's natural healing processes, particularly regarding ulcers.
Our findings indicate that adding vitamin B can boost the efficiency of cellular reprogramming and enhance tissue repair processes. Specifically, vitamin B supplementation showed a considerable effect in accelerating recovery in models of ulcerative colitis. We also uncovered that vitamin B affects key epigenetic markers, which are essential for maintaining accurate gene expression during reprogramming and repair.
While the study highlights vitamin B's significant role in tissue healing, it doesn't specifically isolate vitamin B12 from other elements, making it difficult to pinpoint its individual contribution. Nonetheless, we can confidently say that boosting vitamin B levels could enhance the body's natural healing processes, particularly regarding ulcers.
Read More
8
Vitamin B12's role in ulcer treatment
Idiopathic recurrent pyoderma gangrenosum with cobalamin deficiency in a 62-year-old male: a case report.
Moderate relevance to treatment efficacy
We explored the effects of vitamin B12 in treating recurrent ulcers caused by pyoderma gangrenosum (PG) based on a notable case report. PG, an inflammatory skin condition, is relatively rare and often presents as painful, ulcerative wounds. This case highlighted a 62-year-old man who was treated with vitamin B12 injections alongside other therapies, including steroid injections and topical antibiotics.
While the inclusion of vitamin B12 in the treatment regimen is interesting, we must recognize that its specific impact on healing ulcers cannot be easily determined. The treatment involved multiple approaches, making it challenging to isolate the benefits of vitamin B12 alone.
Ultimately, this case reinforces the importance of looking for underlying causes like nutritional deficiencies in conditions such as PG. Though vitamin B12 supplementation is crucial for overall health and might contribute to the healing process, we can't draw definitive conclusions about its effectiveness based solely on this case.
While the inclusion of vitamin B12 in the treatment regimen is interesting, we must recognize that its specific impact on healing ulcers cannot be easily determined. The treatment involved multiple approaches, making it challenging to isolate the benefits of vitamin B12 alone.
Ultimately, this case reinforces the importance of looking for underlying causes like nutritional deficiencies in conditions such as PG. Though vitamin B12 supplementation is crucial for overall health and might contribute to the healing process, we can't draw definitive conclusions about its effectiveness based solely on this case.
Read More
8
Vitamin B12's unclear ulcer impact
Successful Management of a Young Patient Suffering From Pyoderma Gangrenosum Following Gastric Bypass Surgery: A Case Report.
Complex treatment with combined factors
We observed a case involving a 27-year-old male who developed a non-healing ulcer on his left leg after undergoing gastric bypass surgery three years earlier. The ulcer was diagnosed as pyoderma gangrenosum (PG), a condition characterized by painful skin lesions with no identifiable causes.
To tackle this challenging condition, the patient received a combination of treatments, including systemic immunomodulators, surgical debridement, and vacuum application to promote healing. An interesting aspect of his treatment was the administration of vitamin B12, alongside other supplements and medications like Infliximab.
Despite the presence of vitamin B12 in the regimen, it's essential to note that the study does not isolate its effect, making it difficult to determine how much vitamin B12 specifically contributed to the healing of the ulcer. Multiple doses of Infliximab and supportive vitamins all played roles together in achieving satisfactory healing for the patient, underscoring the importance of a comprehensive approach in treating ulcers associated with PG.
Overall, while vitamin B12 was included in the treatment, we can't definitively claim it was a key factor in improving the ulcer condition without clearer evidence isolating its effect.
To tackle this challenging condition, the patient received a combination of treatments, including systemic immunomodulators, surgical debridement, and vacuum application to promote healing. An interesting aspect of his treatment was the administration of vitamin B12, alongside other supplements and medications like Infliximab.
Despite the presence of vitamin B12 in the regimen, it's essential to note that the study does not isolate its effect, making it difficult to determine how much vitamin B12 specifically contributed to the healing of the ulcer. Multiple doses of Infliximab and supportive vitamins all played roles together in achieving satisfactory healing for the patient, underscoring the importance of a comprehensive approach in treating ulcers associated with PG.
Overall, while vitamin B12 was included in the treatment, we can't definitively claim it was a key factor in improving the ulcer condition without clearer evidence isolating its effect.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.5
9.5
Effective treatment
B12 has been beneficial for my mouth ulcers.
9.5
Ulcers cured
I purchased this for my son, as vitamin B12 deficiency can lead to oral ulcers. After two weeks, all symptoms have disappeared. The medication is effective, and I recommend it.
8.8
Healed ulcers
Troche is easy to swallow as it's a lozenge. My mouth ulcers have healed!
8.8
Relieved ulcers
The taste is pleasant. I take one tablet each morning, as I’ve heard that B12 can alleviate oral ulcers, and it seems to be effective for me. I will continue taking it.
6.3
Canker sores improved
I struggled with canker sores under my tongue, but this improved my condition. It's a pleasant-tasting pink pill, easy to take; however, consistent use is necessary for complete relief. Unfortunately, it disrupted my sleep.
