Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8
Supplement Facts
Serving Size:  1 Tablet
Amount Per Serving
%DV
Vitamin B12(as Methylcobalamin)
5,000 mcg
208,330%

Top Medical Research Studies

We investigated the potential of cyanocobalamin, or Vitamin B12, as a treatment for skin inflammation using a cutting-edge transdermal delivery system. The research focused on microneedle patches that effectively deliver this antioxidant form of Vitamin B12 into the skin.

Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.

However, it's important to note that while the results are promising, further studies are needed for broader applications.
Read More
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.

Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.

Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.

Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Read More
9
Probiotic treatment shows effectiveness
We examined how a combined probiotic treatment affects children with food allergies. The study included 92 kids with both skin and gastrointestinal symptoms. Those who took the probiotic showed a significant drop in their allergy symptoms over 21 days, including a decrease in inflammation markers.

Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
Read More

Most Useful Reviews

9
Effective ingredient choices
This is an excellent quality product. The carefully selected ingredients did not cause any allergies or negative reactions. The large package size lasts long, with average-sized capsules that have a neutral taste. I noticed improvements within a week; my intestinal function and metabolism have enhanced while my nervous system feels more stable. I have no doubts about its effectiveness in treating allergies.
Read More
8
Positive allergen response
The best tasting B-12 I've tried; previous options were only average. I enjoy taking these lozenges as they have a great flavour and no bitter aftertaste. The ingredients are suitable for my allergies to dairy and soy. Even though I used to favour injections, I will supplement with these. I appreciate the variety, pricing, and service from iHerb.
Read More
1
Allergy symptoms experienced
I believe this product caused nose itching and a runny nose, so I stopped using it.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
  • All Researches
9
Probiotic treatment shows effectiveness
We examined how a combined probiotic treatment affects children with food allergies. The study included 92 kids with both skin and gastrointestinal symptoms. Those who took the probiotic showed a significant drop in their allergy symptoms over 21 days, including a decrease in inflammation markers.

Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
Read More
We investigated the potential of cyanocobalamin, or Vitamin B12, as a treatment for skin inflammation using a cutting-edge transdermal delivery system. The research focused on microneedle patches that effectively deliver this antioxidant form of Vitamin B12 into the skin.

Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.

However, it's important to note that while the results are promising, further studies are needed for broader applications.
Read More
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.

Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.

Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.

Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Read More

User Reviews

USERS' SCORE
Good
Based on 4 Reviews
8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Effective ingredient choices
This is an excellent quality product. The carefully selected ingredients did not cause any allergies or negative reactions. The large package size lasts long, with average-sized capsules that have a neutral taste. I noticed improvements within a week; my intestinal function and metabolism have enhanced while my nervous system feels more stable. I have no doubts about its effectiveness in treating allergies.
Read More
8
Positive allergen response
The best tasting B-12 I've tried; previous options were only average. I enjoy taking these lozenges as they have a great flavour and no bitter aftertaste. The ingredients are suitable for my allergies to dairy and soy. Even though I used to favour injections, I will supplement with these. I appreciate the variety, pricing, and service from iHerb.
Read More
1
Allergy symptoms experienced
I believe this product caused nose itching and a runny nose, so I stopped using it.
Read More
7.5
Pain relief
9 people found this helpful
Fast help for B12 deficiency. I was experiencing severe pain in my hands due to carpal tunnel syndrome, and the tingling in my lips and face was attributed to allergies. After researching, I discovered I had symptoms of B12 deficiency. Taking JARROW Methyl B-12 for five weeks has alleviated the tingling and reduced the pain significantly, aiding in my recovery. I plan to continue using it as it’s made a remarkable difference.
Read More

Frequently Asked Questions

9
Effective ingredient choices
This is an excellent quality product. The carefully selected ingredients did not cause any allergies or negative reactions. The large package size lasts long, with average-sized capsules that have a neutral taste. I noticed improvements within a week; my intestinal function and metabolism have enhanced while my nervous system feels more stable. I have no doubts about its effectiveness in treating allergies.
1
Allergy symptoms experienced
I believe this product caused nose itching and a runny nose, so I stopped using it.
9
Probiotic treatment shows effectiveness
We examined how a combined probiotic treatment affects children with food allergies. The study included 92 kids with both skin and gastrointestinal symptoms. Those who took the probiotic showed a significant drop in their allergy symptoms over 21 days, including a decrease in inflammation markers.

Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.

Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.

Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.

Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.

References

  1. Guillot AJ, Martínez-Navarrete M, Giner RM, Recio MC, Santos HA, et al. Cyanocobalamin-loaded dissolving microneedles diminish skin inflammation in vivo. J Control Release. 2024;375:537. doi:10.1016/j.jconrel.2024.09.032
  2. Vorobieva OA, Shih EV, Drozdov VN, Shikh NV. [The results of the use of a combined probiotic ( and spp. ВB-12) in children with gastrointestinal and skin manifestations of food allergy]. Vopr Pitan. 2023;92:79. doi:10.33029/0042-8833-2023-92-3-79-86
  3. El Rhermoul FZ, Mustafa A, Wagner A, Nakonechna A, Kayode OS, et al. Vitamin B Hypersensitivity: A Retrospective Multicenter Study. J Allergy Clin Immunol Pract. 2024;12:699. doi:10.1016/j.jaip.2023.10.037
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