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SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B12(as Methylcobalamin)
5,000 mcg
208,330%
Top Medical Research Studies
4
Vitamin B12's limited effect on Alzheimer's
Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials.
Moderate relevance to Alzheimer's treatment
We explored the potential role of vitamin B12, alongside folic acid, in slowing the progression of Alzheimer's disease (AD) through a meta-analysis of randomized control trials. Our aim was to determine whether these supplements might improve cognitive function, daily life activities, and influence blood homocysteine levels in individuals diagnosed with AD.
After carefully sifting through studies, we found five that met our criteria. These studies assessed the cognitive changes in participants through the Mini-Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog). Additionally, they examined the impact on daily functioning as well as blood homocysteine levels.
The results showed that after six months of treatment, participants taking vitamin B12 and folic acid did experience a slight improvement in MMSE scores compared to those on a placebo. However, there was no significant change in the ADAS-Cog scores, which means some cognitive aspects didn’t show marked improvement. Likewise, daily life functioning did not see any benefits from the supplements.
Importantly, we also noted a significant reduction in blood homocysteine levels following the supplementation, suggesting a biochemical effect of the treatment. Overall, while vitamin B12 shows promise in enhancing some cognitive measures, it does not translate directly into broader cognitive or daily functioning improvements in Alzheimer's patients.
After carefully sifting through studies, we found five that met our criteria. These studies assessed the cognitive changes in participants through the Mini-Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog). Additionally, they examined the impact on daily functioning as well as blood homocysteine levels.
The results showed that after six months of treatment, participants taking vitamin B12 and folic acid did experience a slight improvement in MMSE scores compared to those on a placebo. However, there was no significant change in the ADAS-Cog scores, which means some cognitive aspects didn’t show marked improvement. Likewise, daily life functioning did not see any benefits from the supplements.
Importantly, we also noted a significant reduction in blood homocysteine levels following the supplementation, suggesting a biochemical effect of the treatment. Overall, while vitamin B12 shows promise in enhancing some cognitive measures, it does not translate directly into broader cognitive or daily functioning improvements in Alzheimer's patients.
Read More
8
Vitamin B12 linked to reduced Alzheimer's risk
Associations among dietary 1-carbon metabolism nutrients, genetic risk, and Alzheimer disease: a prospective cohort study.
Insightful, though complex, findings
We conducted a thorough analysis to explore the relationship between vitamin B12 and the risk of developing Alzheimer’s disease (AD). Our research involved a large cohort of 192,214 participants who provided dietary information through 24-hour dietary questionnaires. This extensive study allowed us to investigate not just vitamin B12 alone, but in conjunction with other one-carbon metabolism (OCM) nutrients.
Through our analysis, we observed notable findings. Those who consumed higher amounts of OCM nutrients, including vitamin B12, showed a reduced risk of developing Alzheimer's. Specifically, for individuals with early-onset Alzheimer’s, increased dietary intake of vitamin B12 correlated with a significant decrease in risk—by about 71%. This suggests that maintaining a diet rich in vitamin B12, alongside other beneficial nutrients, could be particularly advantageous to those at greater genetic risk for Alzheimer’s.
Overall, our results emphasize that while vitamin B12 is an important part of the diet, it works best in conjunction with other OCM nutrients. This reinforces the idea that a balanced diet may offer protective benefits against Alzheimer’s. As we move forward, these insights could help guide dietary recommendations for individuals with high genetic risks of AD.
Through our analysis, we observed notable findings. Those who consumed higher amounts of OCM nutrients, including vitamin B12, showed a reduced risk of developing Alzheimer's. Specifically, for individuals with early-onset Alzheimer’s, increased dietary intake of vitamin B12 correlated with a significant decrease in risk—by about 71%. This suggests that maintaining a diet rich in vitamin B12, alongside other beneficial nutrients, could be particularly advantageous to those at greater genetic risk for Alzheimer’s.
Overall, our results emphasize that while vitamin B12 is an important part of the diet, it works best in conjunction with other OCM nutrients. This reinforces the idea that a balanced diet may offer protective benefits against Alzheimer’s. As we move forward, these insights could help guide dietary recommendations for individuals with high genetic risks of AD.
Read More
7
Vitamin B12 and Alzheimer’s connection
Markers of Vitamin B12 Status in Relation to Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Cognitive Performance.
Study does not isolate treatment effects
We explored how different markers of vitamin B12 status influence biomarkers of Alzheimer's disease (AD) and cognitive performance. The study focused on 462 patients, ranging from 40 to 94 years old, who were assessed at the Memory Clinic of Ulm University Hospital in Germany.
By measuring levels of vitamin B12, holotranscobalamin, homocysteine, and methylmalonic acid, we aimed to see how these factors related to cerebrospinal fluid (CSF) indicators like amyloid beta and total-tau, which are linked to Alzheimer's. Results showed that higher levels of methylmalonic acid (MMA) were strongly associated with increased total-tau values, suggesting a link between B12 status and AD pathology. Furthermore, moderate levels of MMA were correlated with lower amyloid levels.
Interestingly, while vitamin B12 itself did not show notable links, other markers like MMA were connected to cognitive performance, particularly in areas such as episodic memory and executive function. This suggests that vitamin B12-related markers may serve as independent predictors of cognitive decline and Alzheimer's pathology.
Though the findings present a compelling case for the role of vitamin B12 in Alzheimer's, it’s clear that further research, including randomized controlled trials, is needed to determine the actual benefits of B12 supplementation in slowing cognitive decline and brain changes.
By measuring levels of vitamin B12, holotranscobalamin, homocysteine, and methylmalonic acid, we aimed to see how these factors related to cerebrospinal fluid (CSF) indicators like amyloid beta and total-tau, which are linked to Alzheimer's. Results showed that higher levels of methylmalonic acid (MMA) were strongly associated with increased total-tau values, suggesting a link between B12 status and AD pathology. Furthermore, moderate levels of MMA were correlated with lower amyloid levels.
Interestingly, while vitamin B12 itself did not show notable links, other markers like MMA were connected to cognitive performance, particularly in areas such as episodic memory and executive function. This suggests that vitamin B12-related markers may serve as independent predictors of cognitive decline and Alzheimer's pathology.
Though the findings present a compelling case for the role of vitamin B12 in Alzheimer's, it’s clear that further research, including randomized controlled trials, is needed to determine the actual benefits of B12 supplementation in slowing cognitive decline and brain changes.
Read More
Most Useful Reviews
7.8
Quality recommendation
This is a very high-quality product. I recommend it for my patients who exhibit mild Alzheimer’s and neurological issues.
Read More
8.8
Improved memory recall
Energy and progress!!! I'm pleased I ordered Methyl B12!!! I take it in the morning and can feel an increase in energy compared to what I’ve experienced for a long time!!! My mother had alzheimer's and at 67, I hope this Methyl B12 will help maintain my brain health like it has my energy. After taking an anxiety medication for eight months, I began experiencing memory issues, often forgetting words mid-conversation. I discovered memory problems were a side effect of that medication. Some users reported improvements after stopping the medication. Since taking Methyl B12, I’ve noticed progress in recalling words during conversations. Thank you, Jarrow Formulas, for my increased energy. I look forward to further memory improvement and will update if I see changes.
Read More
7.5
Cognitive support
I find the lovely cherry-flavoured sublingual B12 active form beneficial. I gave it to an elderly relative, given that a B12 deficiency can provoke Alzheimer’s and other cognitive disorders.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6
8
Vitamin B12 linked to reduced Alzheimer's risk
Associations among dietary 1-carbon metabolism nutrients, genetic risk, and Alzheimer disease: a prospective cohort study.
Insightful, though complex, findings
We conducted a thorough analysis to explore the relationship between vitamin B12 and the risk of developing Alzheimer’s disease (AD). Our research involved a large cohort of 192,214 participants who provided dietary information through 24-hour dietary questionnaires. This extensive study allowed us to investigate not just vitamin B12 alone, but in conjunction with other one-carbon metabolism (OCM) nutrients.
Through our analysis, we observed notable findings. Those who consumed higher amounts of OCM nutrients, including vitamin B12, showed a reduced risk of developing Alzheimer's. Specifically, for individuals with early-onset Alzheimer’s, increased dietary intake of vitamin B12 correlated with a significant decrease in risk—by about 71%. This suggests that maintaining a diet rich in vitamin B12, alongside other beneficial nutrients, could be particularly advantageous to those at greater genetic risk for Alzheimer’s.
Overall, our results emphasize that while vitamin B12 is an important part of the diet, it works best in conjunction with other OCM nutrients. This reinforces the idea that a balanced diet may offer protective benefits against Alzheimer’s. As we move forward, these insights could help guide dietary recommendations for individuals with high genetic risks of AD.
Through our analysis, we observed notable findings. Those who consumed higher amounts of OCM nutrients, including vitamin B12, showed a reduced risk of developing Alzheimer's. Specifically, for individuals with early-onset Alzheimer’s, increased dietary intake of vitamin B12 correlated with a significant decrease in risk—by about 71%. This suggests that maintaining a diet rich in vitamin B12, alongside other beneficial nutrients, could be particularly advantageous to those at greater genetic risk for Alzheimer’s.
Overall, our results emphasize that while vitamin B12 is an important part of the diet, it works best in conjunction with other OCM nutrients. This reinforces the idea that a balanced diet may offer protective benefits against Alzheimer’s. As we move forward, these insights could help guide dietary recommendations for individuals with high genetic risks of AD.
Read More
8
Vitamin B12 supports cognitive function
Vitamin D, Folic Acid and Vitamin B Can Reverse Vitamin D Deficiency-Induced Learning and Memory Impairment by Altering 27-Hydroxycholesterol and S-Adenosylmethionine.
Mixed results from vitamin B12
We explored the effects of vitamin B12, along with vitamin D and folic acid, on improving learning and memory in mice with vitamin D deficiency. The study involved feeding C57BL/6J mice a vitamin D-deficient diet for 13 weeks before supplementing them with these vitamins for eight weeks.
After this supplementation, we observed significant improvements in the mice’s learning and memory abilities, as evidenced by tests such as the Morris Water Maze and the Novel Object Recognition test. Specifically, the mice that received vitamin B12 alongside vitamin D and folic acid showed better performance, indicating that these nutrients could work together to reverse cognitive impairments due to vitamin D deficiency.
Our results suggest that vitamin B12 plays a supportive role in enhancing cognitive function, particularly when paired with other vitamins that support overall health. Notably, while vitamin B12's isolated benefits can't be entirely determined in this setup, its inclusion in the co-supplementation regimen illustrates its potential importance in tackling vitamin D deficiency effects.
After this supplementation, we observed significant improvements in the mice’s learning and memory abilities, as evidenced by tests such as the Morris Water Maze and the Novel Object Recognition test. Specifically, the mice that received vitamin B12 alongside vitamin D and folic acid showed better performance, indicating that these nutrients could work together to reverse cognitive impairments due to vitamin D deficiency.
Our results suggest that vitamin B12 plays a supportive role in enhancing cognitive function, particularly when paired with other vitamins that support overall health. Notably, while vitamin B12's isolated benefits can't be entirely determined in this setup, its inclusion in the co-supplementation regimen illustrates its potential importance in tackling vitamin D deficiency effects.
Read More
7
Vitamin B12 aids Alzheimer therapy
Synergistic Effect of Donepezil and Neurotropic B Vitamins on Dysregulated Antioxidant, Inflammation and Neurotransmitter Status in Aluminium Chloride-Induced Neurotoxicity in Rats.
Limited isolated effect observed
We investigated the effects of vitamin B12 in combination with donepezil on rats suffering from aluminium chloride-induced neurotoxicity, a model mimicking aspects of Alzheimer’s disease. Our study involved several groups of rats, some receiving only aluminium chloride, while others were treated with donepezil and/or vitamin B12, along with vitamin B6 and vitamin B1. Over 40 days, we closely examined the biochemical changes in their brains and their behavior in cognitive tests.
Our observations revealed that vitamin B12, when combined with donepezil, contributed positively by reducing levels of harmful markers typically associated with neurotoxicity. The combination therapy showed enhanced protection compared to donepezil alone, boosting measures of neurotransmitter levels and antioxidant activity while lowering inflammation and oxidative stress indicators.
While vitamin B12 played a significant role in this combination therapy, we noted that the best results came from the combination of donepezil and vitamin B1. However, our findings illustrate that even though vitamin B12 showed effectiveness, it works best alongside donepezil and other B vitamins, rather than in isolation. This underscores the potential of combination therapies in tackling the complexities of neurodegenerative conditions like Alzheimer’s.
Our observations revealed that vitamin B12, when combined with donepezil, contributed positively by reducing levels of harmful markers typically associated with neurotoxicity. The combination therapy showed enhanced protection compared to donepezil alone, boosting measures of neurotransmitter levels and antioxidant activity while lowering inflammation and oxidative stress indicators.
While vitamin B12 played a significant role in this combination therapy, we noted that the best results came from the combination of donepezil and vitamin B1. However, our findings illustrate that even though vitamin B12 showed effectiveness, it works best alongside donepezil and other B vitamins, rather than in isolation. This underscores the potential of combination therapies in tackling the complexities of neurodegenerative conditions like Alzheimer’s.
Read More
7
Vitamin B12 and Alzheimer’s connection
Markers of Vitamin B12 Status in Relation to Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Cognitive Performance.
Study does not isolate treatment effects
We explored how different markers of vitamin B12 status influence biomarkers of Alzheimer's disease (AD) and cognitive performance. The study focused on 462 patients, ranging from 40 to 94 years old, who were assessed at the Memory Clinic of Ulm University Hospital in Germany.
By measuring levels of vitamin B12, holotranscobalamin, homocysteine, and methylmalonic acid, we aimed to see how these factors related to cerebrospinal fluid (CSF) indicators like amyloid beta and total-tau, which are linked to Alzheimer's. Results showed that higher levels of methylmalonic acid (MMA) were strongly associated with increased total-tau values, suggesting a link between B12 status and AD pathology. Furthermore, moderate levels of MMA were correlated with lower amyloid levels.
Interestingly, while vitamin B12 itself did not show notable links, other markers like MMA were connected to cognitive performance, particularly in areas such as episodic memory and executive function. This suggests that vitamin B12-related markers may serve as independent predictors of cognitive decline and Alzheimer's pathology.
Though the findings present a compelling case for the role of vitamin B12 in Alzheimer's, it’s clear that further research, including randomized controlled trials, is needed to determine the actual benefits of B12 supplementation in slowing cognitive decline and brain changes.
By measuring levels of vitamin B12, holotranscobalamin, homocysteine, and methylmalonic acid, we aimed to see how these factors related to cerebrospinal fluid (CSF) indicators like amyloid beta and total-tau, which are linked to Alzheimer's. Results showed that higher levels of methylmalonic acid (MMA) were strongly associated with increased total-tau values, suggesting a link between B12 status and AD pathology. Furthermore, moderate levels of MMA were correlated with lower amyloid levels.
Interestingly, while vitamin B12 itself did not show notable links, other markers like MMA were connected to cognitive performance, particularly in areas such as episodic memory and executive function. This suggests that vitamin B12-related markers may serve as independent predictors of cognitive decline and Alzheimer's pathology.
Though the findings present a compelling case for the role of vitamin B12 in Alzheimer's, it’s clear that further research, including randomized controlled trials, is needed to determine the actual benefits of B12 supplementation in slowing cognitive decline and brain changes.
Read More
4
Vitamin B12's limited effect on Alzheimer's
Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials.
Moderate relevance to Alzheimer's treatment
We explored the potential role of vitamin B12, alongside folic acid, in slowing the progression of Alzheimer's disease (AD) through a meta-analysis of randomized control trials. Our aim was to determine whether these supplements might improve cognitive function, daily life activities, and influence blood homocysteine levels in individuals diagnosed with AD.
After carefully sifting through studies, we found five that met our criteria. These studies assessed the cognitive changes in participants through the Mini-Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog). Additionally, they examined the impact on daily functioning as well as blood homocysteine levels.
The results showed that after six months of treatment, participants taking vitamin B12 and folic acid did experience a slight improvement in MMSE scores compared to those on a placebo. However, there was no significant change in the ADAS-Cog scores, which means some cognitive aspects didn’t show marked improvement. Likewise, daily life functioning did not see any benefits from the supplements.
Importantly, we also noted a significant reduction in blood homocysteine levels following the supplementation, suggesting a biochemical effect of the treatment. Overall, while vitamin B12 shows promise in enhancing some cognitive measures, it does not translate directly into broader cognitive or daily functioning improvements in Alzheimer's patients.
After carefully sifting through studies, we found five that met our criteria. These studies assessed the cognitive changes in participants through the Mini-Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog). Additionally, they examined the impact on daily functioning as well as blood homocysteine levels.
The results showed that after six months of treatment, participants taking vitamin B12 and folic acid did experience a slight improvement in MMSE scores compared to those on a placebo. However, there was no significant change in the ADAS-Cog scores, which means some cognitive aspects didn’t show marked improvement. Likewise, daily life functioning did not see any benefits from the supplements.
Importantly, we also noted a significant reduction in blood homocysteine levels following the supplementation, suggesting a biochemical effect of the treatment. Overall, while vitamin B12 shows promise in enhancing some cognitive measures, it does not translate directly into broader cognitive or daily functioning improvements in Alzheimer's patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
8.8
Memory improvement
This is a good brand of B-12. I give this vitamin along with Folic Acid to my husband for Alzheimer’s. It helps with his memory problems.
8.8
Improved memory recall
Energy and progress!!! I'm pleased I ordered Methyl B12!!! I take it in the morning and can feel an increase in energy compared to what I’ve experienced for a long time!!! My mother had alzheimer's and at 67, I hope this Methyl B12 will help maintain my brain health like it has my energy. After taking an anxiety medication for eight months, I began experiencing memory issues, often forgetting words mid-conversation. I discovered memory problems were a side effect of that medication. Some users reported improvements after stopping the medication. Since taking Methyl B12, I’ve noticed progress in recalling words during conversations. Thank you, Jarrow Formulas, for my increased energy. I look forward to further memory improvement and will update if I see changes.
Read More
7.8
Quality recommendation
This is a very high-quality product. I recommend it for my patients who exhibit mild Alzheimer’s and neurological issues.
7.5
Cognitive support
I find the lovely cherry-flavoured sublingual B12 active form beneficial. I gave it to an elderly relative, given that a B12 deficiency can provoke Alzheimer’s and other cognitive disorders.
