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SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.6
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B12(as Methylcobalamin)
5,000 mcg
208,330%
Top Medical Research Studies
9
Vitamin B12 may improve arthritis
Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice.
High relevance to arthritis treatment
We investigated the effects of vitamin B12 on rheumatoid arthritis, particularly focusing on its impact on peptidylarginine deiminase isoform 4 (PADI-4), an enzyme linked to the disease's progression. Our study revealed that vitamin B12 effectively inhibited this enzyme more than another related enzyme, PADI-2, highlighting its potential as a therapeutic agent.
We observed that vitamin B12 treatment led to lower overall levels of citrullination, which is important since unregulated citrullination is a common issue in rheumatoid arthritis. Additionally, when hydroxocobalamin, a form of vitamin B12, was administered to mice, it significantly reduced the severity of arthritis symptoms in those with collagen type II antibody induced arthritis (CAIA).
Importantly, we found that vitamin B12 also decreased the expression of various pro-inflammatory factors and cytokines often elevated in rheumatoid arthritis, including IL17A, TNFα, and IL-6. These findings suggest that vitamin B12 may have a beneficial role in managing rheumatoid arthritis, warranting further exploration of its therapeutic potential.
We observed that vitamin B12 treatment led to lower overall levels of citrullination, which is important since unregulated citrullination is a common issue in rheumatoid arthritis. Additionally, when hydroxocobalamin, a form of vitamin B12, was administered to mice, it significantly reduced the severity of arthritis symptoms in those with collagen type II antibody induced arthritis (CAIA).
Importantly, we found that vitamin B12 also decreased the expression of various pro-inflammatory factors and cytokines often elevated in rheumatoid arthritis, including IL17A, TNFα, and IL-6. These findings suggest that vitamin B12 may have a beneficial role in managing rheumatoid arthritis, warranting further exploration of its therapeutic potential.
Read More
9.5
Zeolite/B12 for arthritis relief
Therapeutic Potential of Zeolites/Vitamin B12 Nanocomposite on Complete Freund's Adjuvant-Induced Arthritis as a Bone Disorder: In Vivo Study and Bio-Molecular Investigations.
Direct link to vitamin B12 impact
We delved into the potential benefits of a unique combination of zeolites and vitamin B12 for treating arthritis, which is a challenging autoimmune disease. This study specifically looked at a model of arthritis induced by complete Freund's adjuvant, examining how this novel nanocomposite might alleviate some of the severe symptoms associated with the condition.
During our investigation, we took a close look at the effects of this zeolite/vitamin B12 formulation on arthritic rats. The results were encouraging; we observed significant improvements in the joint health of the animals. The amount of inflammation decreased, and there was a notable reduction in joint damage, which is often characterized by tissue swelling and deterioration.
Important biomarkers indicating inflammation and immune response were positively influenced as well. For instance, levels of pro-inflammatory cytokines like IL-1β and TNF-α decreased, while beneficial markers like IL-4 increased. Additionally, the antioxidant activities in the arthritis-affected rats improved, showcasing the potential for this treatment to not only combat arthritis symptoms but also to support overall joint health.
Overall, our findings suggest that the zeolite/vitamin B12 nanocomposite may be a promising new therapeutic option for those grappling with rheumatoid arthritis, showcasing both anti-inflammatory and antioxidant properties. We're excited about its potential to enhance treatments for arthritis in the future.
During our investigation, we took a close look at the effects of this zeolite/vitamin B12 formulation on arthritic rats. The results were encouraging; we observed significant improvements in the joint health of the animals. The amount of inflammation decreased, and there was a notable reduction in joint damage, which is often characterized by tissue swelling and deterioration.
Important biomarkers indicating inflammation and immune response were positively influenced as well. For instance, levels of pro-inflammatory cytokines like IL-1β and TNF-α decreased, while beneficial markers like IL-4 increased. Additionally, the antioxidant activities in the arthritis-affected rats improved, showcasing the potential for this treatment to not only combat arthritis symptoms but also to support overall joint health.
Overall, our findings suggest that the zeolite/vitamin B12 nanocomposite may be a promising new therapeutic option for those grappling with rheumatoid arthritis, showcasing both anti-inflammatory and antioxidant properties. We're excited about its potential to enhance treatments for arthritis in the future.
Read More
9
Hydroxyapatite with Vitamin B12 benefits
A Novel Hydroxyapatite/Vitamin B Nanoformula for Treatment of Bone Damage: Preparation, Characterization, and Anti-Arthritic, Anti-Inflammatory, and Antioxidant Activities in Chemically Induced Arthritic Rats.
Significant vitamin B12 impact
We investigated how a newly developed combination of hydroxyapatite and vitamin B12 can help treat arthritis, using a model of arthritis created with Complete Freund's adjuvant in rats. Through careful analysis, including various scientific techniques, we found that this unique nanoformula effectively delivered vitamin B12 to the targeted areas of inflammation in the body.
Our results showed that treating rats with this combination led to a significant decrease in critical markers related to arthritis, such as rheumatoid factor and inflammation-related proteins like IL-1β and TNF-α. At the same time, we noted an increase in beneficial substances like IL-4, which is known to help reduce inflammation, as well as improvements in antioxidants that fight oxidative stress.
Moreover, the nanoformula demonstrated the ability to repair joint tissue better, resulting in less inflammation and damage to the cartilage and bones over time. These findings highlight the potential of vitamin B12 not only in managing arthritis symptoms but in actively contributing to joint healing and reducing inflammation.
Overall, the introduction of vitamin B12 into arthritis treatment through this innovative nanoformula is promising, showing that it can be an effective addition to therapeutic strategies for better management of arthritis symptoms and joint health.
Our results showed that treating rats with this combination led to a significant decrease in critical markers related to arthritis, such as rheumatoid factor and inflammation-related proteins like IL-1β and TNF-α. At the same time, we noted an increase in beneficial substances like IL-4, which is known to help reduce inflammation, as well as improvements in antioxidants that fight oxidative stress.
Moreover, the nanoformula demonstrated the ability to repair joint tissue better, resulting in less inflammation and damage to the cartilage and bones over time. These findings highlight the potential of vitamin B12 not only in managing arthritis symptoms but in actively contributing to joint healing and reducing inflammation.
Overall, the introduction of vitamin B12 into arthritis treatment through this innovative nanoformula is promising, showing that it can be an effective addition to therapeutic strategies for better management of arthritis symptoms and joint health.
Read More
Most Useful Reviews
9.5
Pain relief
I have suffered from rheumatoid arthritis for over ten years. After discovering that avoiding gluten significantly reduces my pain, I researched further and found a link between peripheral neuropathy, B12 deficiency, and arthritis. I started taking Jarrow methyl B12 from iHerb, and within days, my excruciating pain subsided, allowing me to walk almost pain-free. I've also identified intolerances to other foods, such as tomatoes and strawberries.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.6
9.5
Zeolite/B12 for arthritis relief
Therapeutic Potential of Zeolites/Vitamin B12 Nanocomposite on Complete Freund's Adjuvant-Induced Arthritis as a Bone Disorder: In Vivo Study and Bio-Molecular Investigations.
Direct link to vitamin B12 impact
We delved into the potential benefits of a unique combination of zeolites and vitamin B12 for treating arthritis, which is a challenging autoimmune disease. This study specifically looked at a model of arthritis induced by complete Freund's adjuvant, examining how this novel nanocomposite might alleviate some of the severe symptoms associated with the condition.
During our investigation, we took a close look at the effects of this zeolite/vitamin B12 formulation on arthritic rats. The results were encouraging; we observed significant improvements in the joint health of the animals. The amount of inflammation decreased, and there was a notable reduction in joint damage, which is often characterized by tissue swelling and deterioration.
Important biomarkers indicating inflammation and immune response were positively influenced as well. For instance, levels of pro-inflammatory cytokines like IL-1β and TNF-α decreased, while beneficial markers like IL-4 increased. Additionally, the antioxidant activities in the arthritis-affected rats improved, showcasing the potential for this treatment to not only combat arthritis symptoms but also to support overall joint health.
Overall, our findings suggest that the zeolite/vitamin B12 nanocomposite may be a promising new therapeutic option for those grappling with rheumatoid arthritis, showcasing both anti-inflammatory and antioxidant properties. We're excited about its potential to enhance treatments for arthritis in the future.
During our investigation, we took a close look at the effects of this zeolite/vitamin B12 formulation on arthritic rats. The results were encouraging; we observed significant improvements in the joint health of the animals. The amount of inflammation decreased, and there was a notable reduction in joint damage, which is often characterized by tissue swelling and deterioration.
Important biomarkers indicating inflammation and immune response were positively influenced as well. For instance, levels of pro-inflammatory cytokines like IL-1β and TNF-α decreased, while beneficial markers like IL-4 increased. Additionally, the antioxidant activities in the arthritis-affected rats improved, showcasing the potential for this treatment to not only combat arthritis symptoms but also to support overall joint health.
Overall, our findings suggest that the zeolite/vitamin B12 nanocomposite may be a promising new therapeutic option for those grappling with rheumatoid arthritis, showcasing both anti-inflammatory and antioxidant properties. We're excited about its potential to enhance treatments for arthritis in the future.
Read More
9
Vitamin B12 may improve arthritis
Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice.
High relevance to arthritis treatment
We investigated the effects of vitamin B12 on rheumatoid arthritis, particularly focusing on its impact on peptidylarginine deiminase isoform 4 (PADI-4), an enzyme linked to the disease's progression. Our study revealed that vitamin B12 effectively inhibited this enzyme more than another related enzyme, PADI-2, highlighting its potential as a therapeutic agent.
We observed that vitamin B12 treatment led to lower overall levels of citrullination, which is important since unregulated citrullination is a common issue in rheumatoid arthritis. Additionally, when hydroxocobalamin, a form of vitamin B12, was administered to mice, it significantly reduced the severity of arthritis symptoms in those with collagen type II antibody induced arthritis (CAIA).
Importantly, we found that vitamin B12 also decreased the expression of various pro-inflammatory factors and cytokines often elevated in rheumatoid arthritis, including IL17A, TNFα, and IL-6. These findings suggest that vitamin B12 may have a beneficial role in managing rheumatoid arthritis, warranting further exploration of its therapeutic potential.
We observed that vitamin B12 treatment led to lower overall levels of citrullination, which is important since unregulated citrullination is a common issue in rheumatoid arthritis. Additionally, when hydroxocobalamin, a form of vitamin B12, was administered to mice, it significantly reduced the severity of arthritis symptoms in those with collagen type II antibody induced arthritis (CAIA).
Importantly, we found that vitamin B12 also decreased the expression of various pro-inflammatory factors and cytokines often elevated in rheumatoid arthritis, including IL17A, TNFα, and IL-6. These findings suggest that vitamin B12 may have a beneficial role in managing rheumatoid arthritis, warranting further exploration of its therapeutic potential.
Read More
9
Hydroxyapatite with Vitamin B12 benefits
A Novel Hydroxyapatite/Vitamin B Nanoformula for Treatment of Bone Damage: Preparation, Characterization, and Anti-Arthritic, Anti-Inflammatory, and Antioxidant Activities in Chemically Induced Arthritic Rats.
Significant vitamin B12 impact
We investigated how a newly developed combination of hydroxyapatite and vitamin B12 can help treat arthritis, using a model of arthritis created with Complete Freund's adjuvant in rats. Through careful analysis, including various scientific techniques, we found that this unique nanoformula effectively delivered vitamin B12 to the targeted areas of inflammation in the body.
Our results showed that treating rats with this combination led to a significant decrease in critical markers related to arthritis, such as rheumatoid factor and inflammation-related proteins like IL-1β and TNF-α. At the same time, we noted an increase in beneficial substances like IL-4, which is known to help reduce inflammation, as well as improvements in antioxidants that fight oxidative stress.
Moreover, the nanoformula demonstrated the ability to repair joint tissue better, resulting in less inflammation and damage to the cartilage and bones over time. These findings highlight the potential of vitamin B12 not only in managing arthritis symptoms but in actively contributing to joint healing and reducing inflammation.
Overall, the introduction of vitamin B12 into arthritis treatment through this innovative nanoformula is promising, showing that it can be an effective addition to therapeutic strategies for better management of arthritis symptoms and joint health.
Our results showed that treating rats with this combination led to a significant decrease in critical markers related to arthritis, such as rheumatoid factor and inflammation-related proteins like IL-1β and TNF-α. At the same time, we noted an increase in beneficial substances like IL-4, which is known to help reduce inflammation, as well as improvements in antioxidants that fight oxidative stress.
Moreover, the nanoformula demonstrated the ability to repair joint tissue better, resulting in less inflammation and damage to the cartilage and bones over time. These findings highlight the potential of vitamin B12 not only in managing arthritis symptoms but in actively contributing to joint healing and reducing inflammation.
Overall, the introduction of vitamin B12 into arthritis treatment through this innovative nanoformula is promising, showing that it can be an effective addition to therapeutic strategies for better management of arthritis symptoms and joint health.
Read More
7
Vitamin B12 shows limited effect
Associations of Homocysteine, Folate, and Vitamin B12 with Osteoarthritis: A Mendelian Randomization Study.
Moderate relevance in study findings
We explored the relationship between homocysteine levels and vitamins B12 and folate concerning osteoarthritis (OA) through a two-sample Mendelian randomization approach. This method allowed us to look at genetically predicted levels of these substances to see how they correlate with OA.
The study revealed that higher homocysteine levels might negatively affect OA outcomes, especially in weight-bearing joints like the knees and hips, and it appeared that this impact was more pronounced in females. Interestingly, genetically predicted folate seemed to offer some protective benefits against overall OA and specifically for spine OA.
While vitamin B12 showed some encouraging trends, particularly alongside folate regarding knee OA, the results didn’t establish a strong standalone effect for B12 in preventing or treating arthritis. Overall, we noted that lowering homocysteine could be a potential avenue for OA treatment and prevention, highlighting the importance of these vitamins in managing joint health.
The study revealed that higher homocysteine levels might negatively affect OA outcomes, especially in weight-bearing joints like the knees and hips, and it appeared that this impact was more pronounced in females. Interestingly, genetically predicted folate seemed to offer some protective benefits against overall OA and specifically for spine OA.
While vitamin B12 showed some encouraging trends, particularly alongside folate regarding knee OA, the results didn’t establish a strong standalone effect for B12 in preventing or treating arthritis. Overall, we noted that lowering homocysteine could be a potential avenue for OA treatment and prevention, highlighting the importance of these vitamins in managing joint health.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Pain relief
I have suffered from rheumatoid arthritis for over ten years. After discovering that avoiding gluten significantly reduces my pain, I researched further and found a link between peripheral neuropathy, B12 deficiency, and arthritis. I started taking Jarrow methyl B12 from iHerb, and within days, my excruciating pain subsided, allowing me to walk almost pain-free. I've also identified intolerances to other foods, such as tomatoes and strawberries.
Read More
