I was having severe pain in both of my hands, especially my thumb. I was told by an orthaepedic surgeon and a nuerosurgeon that I had Carpal tunnel syndrome and needed surgery to alleviate the pain. I also had tingling in my lips and face, the nuerosurgeon told me that the tingling was probably allergies. My MRI showed degenerative disks, I am only 52 years old. I was not satisfied with either of the doctors diagnosis, so I did some research and found that I had multiple symptoms of B12 deficiency. I also read in a blog that someone had used JARROW brand Methyl B-12 for many years. I have been taking JARROW Methyl B-12 for five weeks now, the tingling in my face and lips had stopped within 10 days, the severe stabbing, burning pain in my thumb had become tolerable in two weeks. Each day there seems to be a little less pain, and I am looking forward to being pain free as the damage that has been done by the B-12 Deficiency is repaired. I am ordering my 4th bottle today, because everyone I tell about my ordeal wants to start taking it; so I give them mine (after I keep a few from the bottle) and order another bottle for myself. I can always count on AMAZON to get it to me fast