5/22/2025
Last update
5/22/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B12(as Methylcobalamin)
5,000 mcg
208,330%
Top Medical Research Studies
8
We explored the potential effects of vitamin B12 on cold sensitivity in a study using rats with induced neuropathic pain. The focus was to see whether vitamin B12, both alone and in combination with the pain reliever diclofenac, could alleviate cold and mechanical allodynia—a condition where non-painful stimuli are perceived as painful.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
Read More
7
Mg-Teadiola reduces stress responses
We explored how a combination of magnesium, B vitamins, Rhodiola, and green tea—collectively referred to as Mg-Teadiola—affects stress levels and pain response in chronically stressed individuals. In a 28-day trial, 40 participants received either the supplement or a placebo.
The findings revealed that those taking Mg-Teadiola experienced a reduction in stress scores and improved sensitivity to cold. Brain scans showed changes in areas linked to stress and pain perception, suggesting the treatment helps manage stress responses effectively.
The findings revealed that those taking Mg-Teadiola experienced a reduction in stress scores and improved sensitivity to cold. Brain scans showed changes in areas linked to stress and pain perception, suggesting the treatment helps manage stress responses effectively.
Read More
7
In our exploration of neuropathic pain relief, we found that Vitamin B12 has a notable impact on cold sensitivity in rats with nerve injuries. The study involved male Wistar rats that underwent infraorbital nerve constriction, simulating a model of trigeminal neuropathic pain.
We treated these rats with B vitamins, particularly focusing on Vitamin B12, to assess its effectiveness in alleviating cold hyperalgesia, which is an increased sensitivity to cold. The results showed that Vitamin B12, when given at a lower dose alongside carbamazepine, helped reduce cold pain sensitivity at certain time points.
However, the combination treatment limited our ability to fully understand the isolated effect of Vitamin B12. Still, it suggests that including B12 in pain management may offer additional benefits for those suffering from this type of nerve pain.
We treated these rats with B vitamins, particularly focusing on Vitamin B12, to assess its effectiveness in alleviating cold hyperalgesia, which is an increased sensitivity to cold. The results showed that Vitamin B12, when given at a lower dose alongside carbamazepine, helped reduce cold pain sensitivity at certain time points.
However, the combination treatment limited our ability to fully understand the isolated effect of Vitamin B12. Still, it suggests that including B12 in pain management may offer additional benefits for those suffering from this type of nerve pain.
Read More
Most Useful Reviews
9
Vanquished depression
64 people found this helpful
This has significantly improved my mood. I had symptoms indicating low histamine, including fatigue and a lack of energy. After taking Vitamin B12, I now feel happy and energetic, as if a switch flipped. If you are low histamine like me, this could positively change your life.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
- All Researches
8
We explored the potential effects of vitamin B12 on cold sensitivity in a study using rats with induced neuropathic pain. The focus was to see whether vitamin B12, both alone and in combination with the pain reliever diclofenac, could alleviate cold and mechanical allodynia—a condition where non-painful stimuli are perceived as painful.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
Read More
7
Mg-Teadiola reduces stress responses
We explored how a combination of magnesium, B vitamins, Rhodiola, and green tea—collectively referred to as Mg-Teadiola—affects stress levels and pain response in chronically stressed individuals. In a 28-day trial, 40 participants received either the supplement or a placebo.
The findings revealed that those taking Mg-Teadiola experienced a reduction in stress scores and improved sensitivity to cold. Brain scans showed changes in areas linked to stress and pain perception, suggesting the treatment helps manage stress responses effectively.
The findings revealed that those taking Mg-Teadiola experienced a reduction in stress scores and improved sensitivity to cold. Brain scans showed changes in areas linked to stress and pain perception, suggesting the treatment helps manage stress responses effectively.
Read More
7
In our exploration of neuropathic pain relief, we found that Vitamin B12 has a notable impact on cold sensitivity in rats with nerve injuries. The study involved male Wistar rats that underwent infraorbital nerve constriction, simulating a model of trigeminal neuropathic pain.
We treated these rats with B vitamins, particularly focusing on Vitamin B12, to assess its effectiveness in alleviating cold hyperalgesia, which is an increased sensitivity to cold. The results showed that Vitamin B12, when given at a lower dose alongside carbamazepine, helped reduce cold pain sensitivity at certain time points.
However, the combination treatment limited our ability to fully understand the isolated effect of Vitamin B12. Still, it suggests that including B12 in pain management may offer additional benefits for those suffering from this type of nerve pain.
We treated these rats with B vitamins, particularly focusing on Vitamin B12, to assess its effectiveness in alleviating cold hyperalgesia, which is an increased sensitivity to cold. The results showed that Vitamin B12, when given at a lower dose alongside carbamazepine, helped reduce cold pain sensitivity at certain time points.
However, the combination treatment limited our ability to fully understand the isolated effect of Vitamin B12. Still, it suggests that including B12 in pain management may offer additional benefits for those suffering from this type of nerve pain.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Vanquished depression
64 people found this helpful
This has significantly improved my mood. I had symptoms indicating low histamine, including fatigue and a lack of energy. After taking Vitamin B12, I now feel happy and energetic, as if a switch flipped. If you are low histamine like me, this could positively change your life.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Pickering G, Noah L, Pereira B, Goubayon J, Leray V, et al. Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study. Front Nutr. 2023;10:1211321. 10.3389/fnut.2023.1211321
- Tamaddonfard E, Samadi F, Egdami K. The effects of vitamin B12 and diclofenac and their combination on cold and mechanical allodynia in a neuropathic pain model in rats. Vet Res Forum. 2013;4:19.
- Kopruszinski CM, Reis RC, Chichorro JG. B vitamins relieve neuropathic pain behaviors induced by infraorbital nerve constriction in rats. Life Sci. 2012;91:1187. 10.1016/j.lfs.2012.08.025
