5/21/2025
Last update
5/21/2025
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.2
USERS' SCORE
Good
Based on 12 Reviews
8.6
Supplement Facts
Serving Size: 2 Capsule
Amount Per Serving
%DV
Sulforaphane Glucosinolate(from Broccoli Seed Extract [Brassica oleracea L. Italica] in a Proprietary Blend Containing Myrosinase Enzyme)
35 mg
†
Top Medical Research Studies
9
Broccoli sprouts lower prostate cancer risk
We tested how a diet rich in broccoli sprouts affects prostate cancer using TRAMP mice as our model. Throughout the study, we observed that broccoli sprout intake significantly reduced both the occurrence and severity of prostate cancer, showing a 11- and 2.4-fold decrease in cancer development at different ages.
Additionally, a notable drop in HDAC3 protein expression was recorded, suggesting a potential link between broccoli consumption and lower prostate cancer risk. However, while we found changes in histone modifications, the influence on mRNA levels didn't translate into significant protein-level changes.
Additionally, a notable drop in HDAC3 protein expression was recorded, suggesting a potential link between broccoli consumption and lower prostate cancer risk. However, while we found changes in histone modifications, the influence on mRNA levels didn't translate into significant protein-level changes.
Read More
9
This study focused on how sulforaphane, a compound found in broccoli, and TRAIL, a cancer-fighting agent, work together to combat advanced prostate cancer resistant to treatments.
We discovered that sulforaphane had a stronger impact on the cancer stem-like cells compared to TRAIL, although their combined effect was even more powerful.
Importantly, the treatment significantly reduced tumor growth in tests without causing harmful side effects. Overall, these findings suggest that increasing sulforaphane intake through diet could enhance cancer-fighting strategies involving TRAIL.
We discovered that sulforaphane had a stronger impact on the cancer stem-like cells compared to TRAIL, although their combined effect was even more powerful.
Importantly, the treatment significantly reduced tumor growth in tests without causing harmful side effects. Overall, these findings suggest that increasing sulforaphane intake through diet could enhance cancer-fighting strategies involving TRAIL.
Read More
8
We explored how sulforaphane (SFN), found in broccoli, affects prostate cancer by analyzing the expression of long noncoding RNAs (lncRNAs) in normal and cancerous prostate cells. Our findings showed that SFN significantly changed the expression of around 100 lncRNAs, normalizing some in cancer cells.
Notably, a specific lncRNA, LINC01116, was linked to increased cancer cell growth. When we reduced its expression, prostate cancer cell proliferation decreased and colony formation dropped sharply. Overall, our research highlights how dietary compounds like SFN may play a role in prostate cancer prevention.
Notably, a specific lncRNA, LINC01116, was linked to increased cancer cell growth. When we reduced its expression, prostate cancer cell proliferation decreased and colony formation dropped sharply. Overall, our research highlights how dietary compounds like SFN may play a role in prostate cancer prevention.
Read More
Most Useful Reviews
9
Promising effects
61 people found this helpful
This is a great product for prostate cancer sufferers. It shows promise in eliminating prostate cancer cells and lowering PSA levels. PCSPES.net can answer questions about alternative therapies for prostate cancer, which I trust. PCSPES and POMI10x are the best proven supplements so far.
Read More
7.5
Slowed cancer growth
10 people found this helpful
While I cannot be certain, since using this product, the growth rate of my prostate cancer seems to have significantly slowed.
Read More
9
Cancer remission aid
8 people found this helpful
This supplement has been excellent for my prostate cancer, which is now in remission!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.2
- All Researches
9
We investigated whether broccoli and garlic supplements could enhance beneficial compounds in prostate tissue. In a study with 42 men facing a prostate biopsy, participants were randomly assigned to receive either broccoli-derived glucoraphanin or garlic-derived alliin for four weeks.
After the trial, we found that sulforaphane from broccoli was significantly higher in the prostate tissue of those taking the supplement. However, the alliin from garlic showed no significant increase in prostate tissue compared to non-supplemented men. Overall, while broccoli appears to contribute positively, garlic did not show a notable benefit.
After the trial, we found that sulforaphane from broccoli was significantly higher in the prostate tissue of those taking the supplement. However, the alliin from garlic showed no significant increase in prostate tissue compared to non-supplemented men. Overall, while broccoli appears to contribute positively, garlic did not show a notable benefit.
Read More
9
Broccoli sprouts lower prostate cancer risk
We tested how a diet rich in broccoli sprouts affects prostate cancer using TRAMP mice as our model. Throughout the study, we observed that broccoli sprout intake significantly reduced both the occurrence and severity of prostate cancer, showing a 11- and 2.4-fold decrease in cancer development at different ages.
Additionally, a notable drop in HDAC3 protein expression was recorded, suggesting a potential link between broccoli consumption and lower prostate cancer risk. However, while we found changes in histone modifications, the influence on mRNA levels didn't translate into significant protein-level changes.
Additionally, a notable drop in HDAC3 protein expression was recorded, suggesting a potential link between broccoli consumption and lower prostate cancer risk. However, while we found changes in histone modifications, the influence on mRNA levels didn't translate into significant protein-level changes.
Read More
9
This study focused on how sulforaphane, a compound found in broccoli, and TRAIL, a cancer-fighting agent, work together to combat advanced prostate cancer resistant to treatments.
We discovered that sulforaphane had a stronger impact on the cancer stem-like cells compared to TRAIL, although their combined effect was even more powerful.
Importantly, the treatment significantly reduced tumor growth in tests without causing harmful side effects. Overall, these findings suggest that increasing sulforaphane intake through diet could enhance cancer-fighting strategies involving TRAIL.
We discovered that sulforaphane had a stronger impact on the cancer stem-like cells compared to TRAIL, although their combined effect was even more powerful.
Importantly, the treatment significantly reduced tumor growth in tests without causing harmful side effects. Overall, these findings suggest that increasing sulforaphane intake through diet could enhance cancer-fighting strategies involving TRAIL.
Read More
8
Sulforaphane's potential in prostate cancer
We explored the role of sulforaphane, a compound from broccoli, in combating prostate cancer. This review spans various studies that assess how sulforaphane can potentially hinder the development and progression of prostatic tumors, utilizing methods ranging from in vitro, in vivo, to clinical settings.
While many findings suggest its promising protective effects, our analysis highlighted some limitations and the need for further research to fully understand its therapeutic potential. Overall, more work is needed before sulforaphane can be firmly established as an effective treatment option.
While many findings suggest its promising protective effects, our analysis highlighted some limitations and the need for further research to fully understand its therapeutic potential. Overall, more work is needed before sulforaphane can be firmly established as an effective treatment option.
Read More
8
We explored how sulforaphane (SFN), found in broccoli, affects prostate cancer by analyzing the expression of long noncoding RNAs (lncRNAs) in normal and cancerous prostate cells. Our findings showed that SFN significantly changed the expression of around 100 lncRNAs, normalizing some in cancer cells.
Notably, a specific lncRNA, LINC01116, was linked to increased cancer cell growth. When we reduced its expression, prostate cancer cell proliferation decreased and colony formation dropped sharply. Overall, our research highlights how dietary compounds like SFN may play a role in prostate cancer prevention.
Notably, a specific lncRNA, LINC01116, was linked to increased cancer cell growth. When we reduced its expression, prostate cancer cell proliferation decreased and colony formation dropped sharply. Overall, our research highlights how dietary compounds like SFN may play a role in prostate cancer prevention.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Promising effects
61 people found this helpful
This is a great product for prostate cancer sufferers. It shows promise in eliminating prostate cancer cells and lowering PSA levels. PCSPES.net can answer questions about alternative therapies for prostate cancer, which I trust. PCSPES and POMI10x are the best proven supplements so far.
Read More
7.5
Slowed cancer growth
10 people found this helpful
While I cannot be certain, since using this product, the growth rate of my prostate cancer seems to have significantly slowed.
Read More
9
Cancer remission aid
8 people found this helpful
This supplement has been excellent for my prostate cancer, which is now in remission!
Read More
7.5
Preventive measure
5 people found this helpful
A man in his 60s had difficulty urinating, leading to a prostate cancer diagnosis. After learning about the benefits of sulforaphane in broccoli for preventing tumour formation, I decided to take this product as a preventive measure against cancer.
Read More
9
Prostate health
1 people found this helpful
Excellent! Of all the brands I have tried, this broccoli extract is the best. It has noticeably improved my prostate health after just a week.
Read More
Frequently Asked Questions
9
Prostate health
1 people found this helpful
Excellent! Of all the brands I have tried, this broccoli extract is the best. It has noticeably improved my prostate health after just a week.
7.5
Slowed cancer growth
10 people found this helpful
While I cannot be certain, since using this product, the growth rate of my prostate cancer seems to have significantly slowed.
9
Cancer remission aid
8 people found this helpful
This supplement has been excellent for my prostate cancer, which is now in remission!
7.5
Increased energy
After my husband underwent treatment for prostate cancer, I gave him this product. He reported feeling more energised.
7.5
Effective treatment
3 people found this helpful
This is very good! Many medical studies indicate that it can kill cancer cells. It is expensive but effective, offering numerous benefits when used alongside fasting.
8
Prevention benefits
1 people found this helpful
Sulforaphane halts the development of cancer cells and possesses anti-inflammatory properties, similar to curcumin. Broccoli also contains other beneficial substances that support the immune system and prevent cancer cell multiplication.
7
We explored whether diets rich in broccoli can help slow down prostate cancer progression, largely thanks to a compound called sulforaphane. While previous research in cells and animals has suggested various protective mechanisms, current human studies point out that sulforaphane may create an environment that hinders cancer development. However, it is important to note that specific evidence linking broccoli consumption directly to reduced risk in humans is still developing. Overall, while there's promising potential, definitive conclusions remain elusive.
8
We explored how sulforaphane (SFN), found in broccoli, affects prostate cancer by analyzing the expression of long noncoding RNAs (lncRNAs) in normal and cancerous prostate cells. Our findings showed that SFN significantly changed the expression of around 100 lncRNAs, normalizing some in cancer cells.
Notably, a specific lncRNA, LINC01116, was linked to increased cancer cell growth. When we reduced its expression, prostate cancer cell proliferation decreased and colony formation dropped sharply. Overall, our research highlights how dietary compounds like SFN may play a role in prostate cancer prevention.
Notably, a specific lncRNA, LINC01116, was linked to increased cancer cell growth. When we reduced its expression, prostate cancer cell proliferation decreased and colony formation dropped sharply. Overall, our research highlights how dietary compounds like SFN may play a role in prostate cancer prevention.
4
We explored the effects of sulforaphane-rich broccoli extracts on men with recurrent prostate cancer in a clinical trial involving 20 patients.
Our goal was to see if the treatment could lead to significant declines in PSA levels. While only one patient showed the desired level of PSA decline, we did observe that treatment extended the time before PSA levels doubled, indicating some positive change.
We found the treatment to be safe, which suggests that with higher doses, sulforaphane could have potential in prostate cancer management.
Our goal was to see if the treatment could lead to significant declines in PSA levels. While only one patient showed the desired level of PSA decline, we did observe that treatment extended the time before PSA levels doubled, indicating some positive change.
We found the treatment to be safe, which suggests that with higher doses, sulforaphane could have potential in prostate cancer management.
7
Sulforaphane alters cancer cell genes
We explored how sulforaphane, a compound in broccoli, impacts normal and cancerous prostate cells. Through RNA sequencing, we found that sulforaphane significantly altered gene expression, with different effects depending on the cell type. Notably, it decreased the levels of a key protein called Sp1 in cancer cells. While our findings suggest that sulforaphane can target cancer-specific processes, the exact mechanisms are still being clarified. Overall, this research highlights sulforaphane's potential as a dietary agent against prostate cancer.
8
We examined a trial involving 199 men with localized prostate cancer, where participants received either a food supplement containing broccoli, pomegranate, green tea, and turmeric, or a placebo for six months.
The results were promising. Men consuming the supplement showed a significantly lower rise in PSA levels compared to those on placebo. Specifically, the rise was 14.7% in the supplement group versus 78.5% in the placebo group.
While the short-term benefits are notable, we recognize the need for further research to fully understand the long-term effects of such dietary interventions on prostate cancer.
The results were promising. Men consuming the supplement showed a significantly lower rise in PSA levels compared to those on placebo. Specifically, the rise was 14.7% in the supplement group versus 78.5% in the placebo group.
While the short-term benefits are notable, we recognize the need for further research to fully understand the long-term effects of such dietary interventions on prostate cancer.
8
Sulforaphane's potential in prostate cancer
We explored the role of sulforaphane, a compound from broccoli, in combating prostate cancer. This review spans various studies that assess how sulforaphane can potentially hinder the development and progression of prostatic tumors, utilizing methods ranging from in vitro, in vivo, to clinical settings.
While many findings suggest its promising protective effects, our analysis highlighted some limitations and the need for further research to fully understand its therapeutic potential. Overall, more work is needed before sulforaphane can be firmly established as an effective treatment option.
While many findings suggest its promising protective effects, our analysis highlighted some limitations and the need for further research to fully understand its therapeutic potential. Overall, more work is needed before sulforaphane can be firmly established as an effective treatment option.
References
- Mordecai J, Ullah S, Ahmad I. Sulforaphane and Its Protective Role in Prostate Cancer: A Mechanistic Approach. Int J Mol Sci. 2023;24. 10.3390/ijms24086979
- Livingstone TL, Saha S, Bernuzzi F, Savva GM, Troncoso-Rey P, et al. Accumulation of Sulforaphane and Alliin in Human Prostate Tissue. Nutrients. 2022;14. 10.3390/nu14163263
- Lan T, Park Y, Colditz GA, Liu J, Wang M, et al. Adolescent Plant Product Intake in Relation to Later Prostate Cancer Risk and Mortality in the NIH-AARP Diet and Health Study. J Nutr. 2021;151:3223. 10.1093/jn/nxab241
- Hahm ER, Singh KB, Kim SH, Powolny AA, Singh SV. The Role of Lysosome-associated Membrane Protein 2 in Prostate Cancer Chemopreventive Mechanisms of Sulforaphane. Cancer Prev Res (Phila). 2020;13:661. 10.1158/1940-6207.CAPR-20-0054
- Zhang Z, Garzotto M, Davis EW, Mori M, Stoller WA, et al. Sulforaphane Bioavailability and Chemopreventive Activity in Men Presenting for Biopsy of the Prostate Gland: A Randomized Controlled Trial. Nutr Cancer. 2020;72:74. 10.1080/01635581.2019.1619783
- Traka MH, Melchini A, Coode-Bate J, Al Kadhi O, Saha S, et al. Transcriptional changes in prostate of men on active surveillance after a 12-mo glucoraphanin-rich broccoli intervention-results from the Effect of Sulforaphane on prostate CAncer PrEvention (ESCAPE) randomized controlled trial. Am J Clin Nutr. 2019;109:1133. 10.1093/ajcn/nqz012
- Ferreira PMP, Rodrigues LARL, de Alencar Carnib LP, de Lima Sousa PV, Nolasco Lugo LM, et al. Cruciferous Vegetables as Antioxidative, Chemopreventive and Antineoplasic Functional Foods: Preclinical and Clinical Evidences of Sulforaphane Against Prostate Cancers. Curr Pharm Des. 2018;24:4779. 10.2174/1381612825666190116124233
- Beaver LM, Lӧhr CV, Clarke JD, Glasser ST, Watson GW, et al. Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in HDAC3 Protein Expression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice. Curr Dev Nutr. 2018;2:nzy002. 10.1093/cdn/nzy002
- Dinkova-Kostova AT, Fahey JW, Kostov RV, Kensler TW. KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane. Trends Food Sci Technol. 2017;69:257. 10.1016/j.tifs.2017.02.002
- Beaver LM, Kuintzle R, Buchanan A, Wiley MW, Glasser ST, et al. Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer. J Nutr Biochem. 2017;42:72. 10.1016/j.jnutbio.2017.01.001
- Sakao K, Vyas AR, Chinni SR, Amjad AI, Parikh R, et al. CXCR4 is a novel target of cancer chemopreventative isothiocyanates in prostate cancer cells. Cancer Prev Res (Phila). 2015;8:365. 10.1158/1940-6207.CAPR-14-0386
- Alumkal JJ, Slottke R, Schwartzman J, Cherala G, Munar M, et al. A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer. Invest New Drugs. 2015;33:480. 10.1007/s10637-014-0189-z
- Traka MH, Melchini A, Mithen RF. Sulforaphane and prostate cancer interception. Drug Discov Today. 2014;19:1488. 10.1016/j.drudis.2014.07.007
- Beaver LM, Buchanan A, Sokolowski EI, Riscoe AN, Wong CP, et al. Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention. Mol Nutr Food Res. 2014;58:2001. 10.1002/mnfr.201400269
- Labsch S, Liu L, Bauer N, Zhang Y, Aleksandrowicz E, et al. Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells. Int J Oncol. 2014;44:1470. 10.3892/ijo.2014.2335
- Thomas R, Williams M, Sharma H, Chaudry A, Bellamy P. A double-blind, placebo-controlled randomised trial evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer--the U.K. NCRN Pomi-T study. Prostate Cancer Prostatic Dis. 2014;17:180. 10.1038/pcan.2014.6
