Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 4 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Serving Per Container: 60
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
200 mg
†
Top Medical Research Studies
8
Coenzyme Q10 shows effectiveness against migraines
We investigated the effectiveness of coenzyme Q10 in treating migraines in children, comparing it with the commonly prescribed medication, amitriptyline. Our study involved 72 children, aged 5 to 15, who met the criteria for migraine diagnosis set by the International Headache Society.
Over a three-month period, we observed that coenzyme Q10 had positive therapeutic effects, particularly for those requiring long-term treatment. While amitriptyline provided quicker results, the differences between the two treatments in effectiveness were not significantly noticeable after three months. Both treatments led to improvements in the quality of life for the children involved.
Importantly, we noted that children taking amitriptyline experienced more side effects compared to those receiving coenzyme Q10. This finding positions coenzyme Q10 as a promising option due to its comparable effectiveness and better tolerated adverse effect profile.
Over a three-month period, we observed that coenzyme Q10 had positive therapeutic effects, particularly for those requiring long-term treatment. While amitriptyline provided quicker results, the differences between the two treatments in effectiveness were not significantly noticeable after three months. Both treatments led to improvements in the quality of life for the children involved.
Importantly, we noted that children taking amitriptyline experienced more side effects compared to those receiving coenzyme Q10. This finding positions coenzyme Q10 as a promising option due to its comparable effectiveness and better tolerated adverse effect profile.
Read More
7
Co-Q10 reduces oxidative stress in migraines
We aimed to understand how Coenzyme Q10 (Co-Q10) could help reduce oxidative stress and improve cholesterol levels in individuals suffering from migraines. This involved a well-structured clinical trial with 84 female participants, all diagnosed with episodic migraines. For a period of 12 weeks, half of the participants took a daily dose of Co-Q10, while the other half received a placebo.
After the trial, we discovered some interesting findings. The group that received Co-Q10 showed a significant reduction in levels of malondialdehyde (MDA), a marker related to oxidative stress, compared to the placebo group. However, Co-Q10 did not significantly impact overall antioxidant capacity.
In terms of cholesterol, those taking Co-Q10 experienced an increase in high-density lipoprotein cholesterol (HDL-C), known as the "good" cholesterol. They also had a notable reduction in body fat percentage. Nevertheless, other cholesterol levels and triglycerides did not show significant changes.
Overall, our results suggest that Co-Q10 supplementation can improve certain features associated with migraines, particularly oxidative stress and some lipid profiles. However, it appears that the effects are specific, and not all lipid parameters were influenced.
After the trial, we discovered some interesting findings. The group that received Co-Q10 showed a significant reduction in levels of malondialdehyde (MDA), a marker related to oxidative stress, compared to the placebo group. However, Co-Q10 did not significantly impact overall antioxidant capacity.
In terms of cholesterol, those taking Co-Q10 experienced an increase in high-density lipoprotein cholesterol (HDL-C), known as the "good" cholesterol. They also had a notable reduction in body fat percentage. Nevertheless, other cholesterol levels and triglycerides did not show significant changes.
Overall, our results suggest that Co-Q10 supplementation can improve certain features associated with migraines, particularly oxidative stress and some lipid profiles. However, it appears that the effects are specific, and not all lipid parameters were influenced.
Read More
8
We explored how coenzyme Q10 could potentially help alleviate headaches, particularly for those suffering from migraines. This study painted a detailed picture of migraine's link to nutritional deficiencies, particularly the role of vital nutrients in reducing the frequency and intensity of migraine attacks.
Coenzyme Q10 emerged as a noteworthy option due to its involvement in mitochondrial function and energy metabolism within the brain. By addressing oxidative stress and inflammation—two key contributors to migraines—this supplement shows promise for bringing relief to those who struggle with frequent headaches.
Alongside coenzyme Q10, other supplements like riboflavin, omega-3 fatty acids, and magnesium were also noted for their positive effects. However, the research highlights the need for more in-depth studies to fully understand how these nutrients impact headache sufferers.
Overall, coenzyme Q10 is one among several promising supplements that could form part of a well-rounded approach to migraine management.
Coenzyme Q10 emerged as a noteworthy option due to its involvement in mitochondrial function and energy metabolism within the brain. By addressing oxidative stress and inflammation—two key contributors to migraines—this supplement shows promise for bringing relief to those who struggle with frequent headaches.
Alongside coenzyme Q10, other supplements like riboflavin, omega-3 fatty acids, and magnesium were also noted for their positive effects. However, the research highlights the need for more in-depth studies to fully understand how these nutrients impact headache sufferers.
Overall, coenzyme Q10 is one among several promising supplements that could form part of a well-rounded approach to migraine management.
Read More
Most Useful Reviews
9
Effective relief
This product is invaluable for my wife's tension headaches. It effectively alleviates her pain if taken immediately at the onset or as a preventative measure when she anticipates a rough day.
Read More
7.5
Reduced headaches
102 people found this helpful
A remarkable effect is just the beginning! The effective dosage of coenzyme Q10 is 2 mg per kg of body weight daily. I ordered this supplement and found useful feedback. The effect was promised after 4-6 weeks, but I noticed changes after 10 days. First, my nails strengthened significantly; they were previously brittle and broke easily. Secondly, I've become calmer and more confident, making it easier to communicate with others. Now, after approximately 4 weeks of taking coenzyme Q10, I noticed less daytime sleepiness after lunch and, most importantly, my debilitating headaches have ceased, which used to occur weekly, especially with weather changes. I'm immensely pleased and will continue taking it. I've also started Omega-3 for vascular support. If this review helps you, please click YES. Thank you!
Read More
7.5
Headaches alleviated
4 people found this helpful
Before taking this drug, I experienced libido issues, fatigue, and persistent headaches which worsened my quality of life. A doctor prescribed pills for high cholesterol, but they weakened my arms and legs. I stopped taking them, and Coenzyme Q10 improved everything except my cholesterol levels, which did drop. My quality of life improved, and negative symptoms disappeared. I also quit smoking and drinking while using this supplement.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
- All Researches
9.5
Coenzyme Q10 reduces migraine symptoms
We engaged in a study that aimed to explore the impact of Coenzyme Q10 when combined with L-carnitine on migraine symptoms. Our research involved 56 participants aged between 20 and 40 years, all experiencing migraine headaches. They were randomly divided into two groups: one received daily doses of 30 mg of Coenzyme Q10 and 500 mg of L-carnitine, while the other group got placebo tablets.
Over an 8-week period, we gathered data on the severity, duration, frequency of headache attacks, and even checked levels of lactate—a marker of mitochondrial metabolism. By the end of the study, we observed significant improvements across the board. Participants reported reductions in headache severity, duration, frequency, and lactate levels, highlighting the potential of these supplements in alleviating migraine symptoms.
The findings suggest that this combination therapy could be beneficial for those struggling with migraine headaches. This study not only provides evidence of the positive effects of Coenzyme Q10 and L-carnitine but also opens the door for further exploration into their use in headache management strategies.
Over an 8-week period, we gathered data on the severity, duration, frequency of headache attacks, and even checked levels of lactate—a marker of mitochondrial metabolism. By the end of the study, we observed significant improvements across the board. Participants reported reductions in headache severity, duration, frequency, and lactate levels, highlighting the potential of these supplements in alleviating migraine symptoms.
The findings suggest that this combination therapy could be beneficial for those struggling with migraine headaches. This study not only provides evidence of the positive effects of Coenzyme Q10 and L-carnitine but also opens the door for further exploration into their use in headache management strategies.
Read More
9
We assessed how nonprescription therapies, including coenzyme Q10, affect headaches related to vestibular migraine (VM). In a detailed study conducted over two years with participants diagnosed with VM, we encouraged patients to optimize their lifestyle through proper sleep, hydration, exercise, and nutrition.
Among the treatments, a combination product featuring riboflavin, magnesium, coenzyme Q10, and feverfew was used. After three months of treatment, our findings showed a notable reduction in symptoms. Specifically, measures of dizziness and severity of vertigo were significantly improved for many participants.
About half of the patients reported a positive change in their symptoms, suggesting that the combination's components—including coenzyme Q10—may help alleviate headache severity associated with VM. However, it's essential to remember that we cannot determine the specific impact of coenzyme Q10 alone due to its inclusion with other therapies.
Overall, this study offers encouraging preliminary evidence that nonprescription options can provide relief for VM sufferers, making it a vital area for further investigation.
Among the treatments, a combination product featuring riboflavin, magnesium, coenzyme Q10, and feverfew was used. After three months of treatment, our findings showed a notable reduction in symptoms. Specifically, measures of dizziness and severity of vertigo were significantly improved for many participants.
About half of the patients reported a positive change in their symptoms, suggesting that the combination's components—including coenzyme Q10—may help alleviate headache severity associated with VM. However, it's essential to remember that we cannot determine the specific impact of coenzyme Q10 alone due to its inclusion with other therapies.
Overall, this study offers encouraging preliminary evidence that nonprescription options can provide relief for VM sufferers, making it a vital area for further investigation.
Read More
9
We delved into the role of Coenzyme Q10 (CoQ10) in managing headache symptoms, particularly migraines. This exploration stemmed from the understanding that migraines are complex and may be influenced by various factors, including energy deficits in the brain.
CoQ10 is recognized for its function in boosting mitochondrial energy metabolism, which is seen as a potential avenue for alleviating headaches. We learned that certain nutrients, including CoQ10, have shown promise in reducing the frequency and severity of migraine attacks. In fact, studies reported significant reductions in headache occurrences when individuals incorporated CoQ10 into their regimen.
While we found evidence supporting CoQ10's effectiveness, it's important to note that it’s often studied alongside other supplements. This means that while CoQ10 may play a beneficial role, it's challenging to pinpoint its isolated effects definitively. Nevertheless, the insights from the research suggest that adding CoQ10 to our preventive strategies for migraines could be a worthy consideration.
CoQ10 is recognized for its function in boosting mitochondrial energy metabolism, which is seen as a potential avenue for alleviating headaches. We learned that certain nutrients, including CoQ10, have shown promise in reducing the frequency and severity of migraine attacks. In fact, studies reported significant reductions in headache occurrences when individuals incorporated CoQ10 into their regimen.
While we found evidence supporting CoQ10's effectiveness, it's important to note that it’s often studied alongside other supplements. This means that while CoQ10 may play a beneficial role, it's challenging to pinpoint its isolated effects definitively. Nevertheless, the insights from the research suggest that adding CoQ10 to our preventive strategies for migraines could be a worthy consideration.
Read More
9
Combined supplement shows promise
We explored the use of a dietary supplement combining magnesium, vitamin B2, feverfew, andrographis paniculata, and coenzyme Q10 to prevent episodic migraines. This pilot study involved 113 patients in Greece who followed the treatment for three months after a one-month baseline period.
Our main focus was on how this supplementation affected the number of migraine days each month. We also tracked changes in pain intensity, the use of acute medications for migraines, and the overall quality of life through various assessment tools.
The results indicated that the combination supplement, including coenzyme Q10, seemed effective in reducing monthly migraine days. However, since this was a single-arm study without a control group, we can't pinpoint the specific contribution of coenzyme Q10 alone. A randomized, placebo-controlled trial would be essential to confirm these promising findings and clarify the role of each component in the mix.
Our main focus was on how this supplementation affected the number of migraine days each month. We also tracked changes in pain intensity, the use of acute medications for migraines, and the overall quality of life through various assessment tools.
The results indicated that the combination supplement, including coenzyme Q10, seemed effective in reducing monthly migraine days. However, since this was a single-arm study without a control group, we can't pinpoint the specific contribution of coenzyme Q10 alone. A randomized, placebo-controlled trial would be essential to confirm these promising findings and clarify the role of each component in the mix.
Read More
9
We evaluated how effectively Coenzyme Q10, along with several other nutraceuticals, can help in preventing headaches in children and adolescents. The study involved 99 children aged 6 to 17 who were experiencing primary headaches. Over a period of 12 months, we monitored their headache frequency and the need for pain relief medications both before and after treatment.
Among the different treatments we used, Coenzyme Q10 was included in a combination called compound n°3, alongside magnesium oxide, Partenium, and Vitamin B2. Our findings showed that all three treatment compounds significantly reduced headache frequency and the reliance on pain relief medications. However, Coenzyme Q10’s effectiveness varied; it was found to be less effective than other combinations for certain types of headaches.
Overall, we found that nutraceuticals like Coenzyme Q10 are generally well-received by both parents and children and they seem to provide a promising alternative in headache management. While not every combination showed uniform effectiveness, our research supports the potential of these supplements in making headaches more manageable for children.
Among the different treatments we used, Coenzyme Q10 was included in a combination called compound n°3, alongside magnesium oxide, Partenium, and Vitamin B2. Our findings showed that all three treatment compounds significantly reduced headache frequency and the reliance on pain relief medications. However, Coenzyme Q10’s effectiveness varied; it was found to be less effective than other combinations for certain types of headaches.
Overall, we found that nutraceuticals like Coenzyme Q10 are generally well-received by both parents and children and they seem to provide a promising alternative in headache management. While not every combination showed uniform effectiveness, our research supports the potential of these supplements in making headaches more manageable for children.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective relief
This product is invaluable for my wife's tension headaches. It effectively alleviates her pain if taken immediately at the onset or as a preventative measure when she anticipates a rough day.
Read More
7.5
Reduced headaches
102 people found this helpful
A remarkable effect is just the beginning! The effective dosage of coenzyme Q10 is 2 mg per kg of body weight daily. I ordered this supplement and found useful feedback. The effect was promised after 4-6 weeks, but I noticed changes after 10 days. First, my nails strengthened significantly; they were previously brittle and broke easily. Secondly, I've become calmer and more confident, making it easier to communicate with others. Now, after approximately 4 weeks of taking coenzyme Q10, I noticed less daytime sleepiness after lunch and, most importantly, my debilitating headaches have ceased, which used to occur weekly, especially with weather changes. I'm immensely pleased and will continue taking it. I've also started Omega-3 for vascular support. If this review helps you, please click YES. Thank you!
Read More
7.5
Headaches alleviated
4 people found this helpful
Before taking this drug, I experienced libido issues, fatigue, and persistent headaches which worsened my quality of life. A doctor prescribed pills for high cholesterol, but they weakened my arms and legs. I stopped taking them, and Coenzyme Q10 improved everything except my cholesterol levels, which did drop. My quality of life improved, and negative symptoms disappeared. I also quit smoking and drinking while using this supplement.
Read More
6
Improved well-being
1 people found this helpful
Quality & price balance is excellent with this COQ10. Since I started taking it, I’ve experienced fewer headaches and better immune health. I definitely recommend this product and brand, but always consult a doctor before trying any supplements.
Read More
Frequently Asked Questions
7.5
Reduced headaches
102 people found this helpful
A remarkable effect is just the beginning! The effective dosage of coenzyme Q10 is 2 mg per kg of body weight daily. I ordered this supplement and found useful feedback. The effect was promised after 4-6 weeks, but I noticed changes after 10 days. First, my nails strengthened significantly; they were previously brittle and broke easily. Secondly, I've become calmer and more confident, making it easier to communicate with others. Now, after approximately 4 weeks of taking coenzyme Q10, I noticed less daytime sleepiness after lunch and, most importantly, my debilitating headaches have ceased, which used to occur weekly, especially with weather changes. I'm immensely pleased and will continue taking it. I've also started Omega-3 for vascular support. If this review helps you, please click YES. Thank you!
6
Improved well-being
1 people found this helpful
Quality & price balance is excellent with this COQ10. Since I started taking it, I’ve experienced fewer headaches and better immune health. I definitely recommend this product and brand, but always consult a doctor before trying any supplements.
9
Effective relief
This product is invaluable for my wife's tension headaches. It effectively alleviates her pain if taken immediately at the onset or as a preventative measure when she anticipates a rough day.
7.5
Headaches alleviated
4 people found this helpful
Before taking this drug, I experienced libido issues, fatigue, and persistent headaches which worsened my quality of life. A doctor prescribed pills for high cholesterol, but they weakened my arms and legs. I stopped taking them, and Coenzyme Q10 improved everything except my cholesterol levels, which did drop. My quality of life improved, and negative symptoms disappeared. I also quit smoking and drinking while using this supplement.
7
Co-Q10 reduces oxidative stress in migraines
We aimed to understand how Coenzyme Q10 (Co-Q10) could help reduce oxidative stress and improve cholesterol levels in individuals suffering from migraines. This involved a well-structured clinical trial with 84 female participants, all diagnosed with episodic migraines. For a period of 12 weeks, half of the participants took a daily dose of Co-Q10, while the other half received a placebo.
After the trial, we discovered some interesting findings. The group that received Co-Q10 showed a significant reduction in levels of malondialdehyde (MDA), a marker related to oxidative stress, compared to the placebo group. However, Co-Q10 did not significantly impact overall antioxidant capacity.
In terms of cholesterol, those taking Co-Q10 experienced an increase in high-density lipoprotein cholesterol (HDL-C), known as the "good" cholesterol. They also had a notable reduction in body fat percentage. Nevertheless, other cholesterol levels and triglycerides did not show significant changes.
Overall, our results suggest that Co-Q10 supplementation can improve certain features associated with migraines, particularly oxidative stress and some lipid profiles. However, it appears that the effects are specific, and not all lipid parameters were influenced.
After the trial, we discovered some interesting findings. The group that received Co-Q10 showed a significant reduction in levels of malondialdehyde (MDA), a marker related to oxidative stress, compared to the placebo group. However, Co-Q10 did not significantly impact overall antioxidant capacity.
In terms of cholesterol, those taking Co-Q10 experienced an increase in high-density lipoprotein cholesterol (HDL-C), known as the "good" cholesterol. They also had a notable reduction in body fat percentage. Nevertheless, other cholesterol levels and triglycerides did not show significant changes.
Overall, our results suggest that Co-Q10 supplementation can improve certain features associated with migraines, particularly oxidative stress and some lipid profiles. However, it appears that the effects are specific, and not all lipid parameters were influenced.
8
We delved into the effects of coenzyme Q10 (CoQ10) on migraine headaches, specifically looking at how it might reduce the severity, frequency, and duration of these painful episodes. The study was a systematic review and meta-analysis that included randomized control trials comparing CoQ10 with a placebo, ensuring that we had a robust method for analysis.
Our findings indicated that CoQ10 can indeed be beneficial for adults suffering from migraines. It showed promise in reducing both the duration and the frequency of migraine attacks. However, while the results are encouraging, we noted that CoQ10's efficacy could be influenced when combined with other treatments, which slightly complicates the understanding of its isolated effects.
Overall, our exploration suggests that CoQ10 is a valuable option for those looking for ways to manage migraine headaches. As we look toward the future, more research might further clarify its role in migraine treatment and enhance our understanding of how best to utilize this compound.
Our findings indicated that CoQ10 can indeed be beneficial for adults suffering from migraines. It showed promise in reducing both the duration and the frequency of migraine attacks. However, while the results are encouraging, we noted that CoQ10's efficacy could be influenced when combined with other treatments, which slightly complicates the understanding of its isolated effects.
Overall, our exploration suggests that CoQ10 is a valuable option for those looking for ways to manage migraine headaches. As we look toward the future, more research might further clarify its role in migraine treatment and enhance our understanding of how best to utilize this compound.
9
We assessed how nonprescription therapies, including coenzyme Q10, affect headaches related to vestibular migraine (VM). In a detailed study conducted over two years with participants diagnosed with VM, we encouraged patients to optimize their lifestyle through proper sleep, hydration, exercise, and nutrition.
Among the treatments, a combination product featuring riboflavin, magnesium, coenzyme Q10, and feverfew was used. After three months of treatment, our findings showed a notable reduction in symptoms. Specifically, measures of dizziness and severity of vertigo were significantly improved for many participants.
About half of the patients reported a positive change in their symptoms, suggesting that the combination's components—including coenzyme Q10—may help alleviate headache severity associated with VM. However, it's essential to remember that we cannot determine the specific impact of coenzyme Q10 alone due to its inclusion with other therapies.
Overall, this study offers encouraging preliminary evidence that nonprescription options can provide relief for VM sufferers, making it a vital area for further investigation.
Among the treatments, a combination product featuring riboflavin, magnesium, coenzyme Q10, and feverfew was used. After three months of treatment, our findings showed a notable reduction in symptoms. Specifically, measures of dizziness and severity of vertigo were significantly improved for many participants.
About half of the patients reported a positive change in their symptoms, suggesting that the combination's components—including coenzyme Q10—may help alleviate headache severity associated with VM. However, it's essential to remember that we cannot determine the specific impact of coenzyme Q10 alone due to its inclusion with other therapies.
Overall, this study offers encouraging preliminary evidence that nonprescription options can provide relief for VM sufferers, making it a vital area for further investigation.
7
We examined how coenzyme Q10 might impact headaches, particularly for those experiencing migraines. This popular supplement is known for its potential health benefits, and it has found its place among various non-drug treatments. Current evidence suggests it can be especially valuable for specific groups of people, like adolescents or pregnant women, who may not respond well to traditional medication.
While coenzyme Q10 doesn't claim a cure for headaches, our findings indicate a modest level of effectiveness. Importantly, it maintains a strong safety profile, making it an appealing option for those seeking alternatives to conventional drug therapy. Although the benefits may not be extraordinary, the tolerability of coenzyme Q10 offers hope for individuals who previously struggled to find suitable treatment without side effects.
While coenzyme Q10 doesn't claim a cure for headaches, our findings indicate a modest level of effectiveness. Importantly, it maintains a strong safety profile, making it an appealing option for those seeking alternatives to conventional drug therapy. Although the benefits may not be extraordinary, the tolerability of coenzyme Q10 offers hope for individuals who previously struggled to find suitable treatment without side effects.
9
We conducted an observational multicenter study involving 91 children suffering from various types of headaches, including migraines with and without aura, as well as tension-type headaches. Over 16 weeks, participants received a fixed-dose regimen that included CoQ10 along with other natural supplements, aiming to assess the impact on headache frequency and intensity.
Our observations revealed that the herbal supplement, which included CoQ10, significantly reduced the frequency of headaches among participants with tension-type headaches. For these patients, the average number of headaches dropped remarkably from nearly 12 to about 5 by the end of the treatment, even maintaining improvements several weeks after stopping the supplement.
However, while CoQ10 showed promise, it's important to note that children with migraines did experience reduced headache frequency during the treatment. Some benefits persisted even after treatment stopped, but for those with migraines without aura, the reduction wasn't as dramatic. We didn’t find substantial improvements in pain intensity for tension-type headache patients, indicating that while there are positive outcomes, the results are mixed.
Overall, this study supports the use of nutraceuticals like CoQ10 in managing pediatric headaches, particularly for tension-type headaches, but emphasizes the need for further research to isolate individual supplement effects.
Our observations revealed that the herbal supplement, which included CoQ10, significantly reduced the frequency of headaches among participants with tension-type headaches. For these patients, the average number of headaches dropped remarkably from nearly 12 to about 5 by the end of the treatment, even maintaining improvements several weeks after stopping the supplement.
However, while CoQ10 showed promise, it's important to note that children with migraines did experience reduced headache frequency during the treatment. Some benefits persisted even after treatment stopped, but for those with migraines without aura, the reduction wasn't as dramatic. We didn’t find substantial improvements in pain intensity for tension-type headache patients, indicating that while there are positive outcomes, the results are mixed.
Overall, this study supports the use of nutraceuticals like CoQ10 in managing pediatric headaches, particularly for tension-type headaches, but emphasizes the need for further research to isolate individual supplement effects.
8
We explored how coenzyme Q10 could potentially help alleviate headaches, particularly for those suffering from migraines. This study painted a detailed picture of migraine's link to nutritional deficiencies, particularly the role of vital nutrients in reducing the frequency and intensity of migraine attacks.
Coenzyme Q10 emerged as a noteworthy option due to its involvement in mitochondrial function and energy metabolism within the brain. By addressing oxidative stress and inflammation—two key contributors to migraines—this supplement shows promise for bringing relief to those who struggle with frequent headaches.
Alongside coenzyme Q10, other supplements like riboflavin, omega-3 fatty acids, and magnesium were also noted for their positive effects. However, the research highlights the need for more in-depth studies to fully understand how these nutrients impact headache sufferers.
Overall, coenzyme Q10 is one among several promising supplements that could form part of a well-rounded approach to migraine management.
Coenzyme Q10 emerged as a noteworthy option due to its involvement in mitochondrial function and energy metabolism within the brain. By addressing oxidative stress and inflammation—two key contributors to migraines—this supplement shows promise for bringing relief to those who struggle with frequent headaches.
Alongside coenzyme Q10, other supplements like riboflavin, omega-3 fatty acids, and magnesium were also noted for their positive effects. However, the research highlights the need for more in-depth studies to fully understand how these nutrients impact headache sufferers.
Overall, coenzyme Q10 is one among several promising supplements that could form part of a well-rounded approach to migraine management.
References
- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. doi:10.1007/s11916-025-01358-3
- Tavasoli A, Rezazadeh M, Kachuei M. Eyebrow bleeding as a rare migraine symptom: a case report. Ann Med Surg (Lond). 2024;86:7377. doi:10.1097/MS9.0000000000002655
- Hajhashemy Z, Golpour-Hamedani S, Eshaghian N, Sadeghi O, Khorvash F, et al. Practical supplements for prevention and management of migraine attacks: a narrative review. Front Nutr. 2024;11:1433390. doi:10.3389/fnut.2024.1433390
- Hannigan IP, Rosengren SM, Di Tanna GL, Watson SRD, Welgampola MS. Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study. Intern Med J. 2024;54:916. doi:10.1111/imj.16314
- Dahri M, Sarafan Sadeghi A, Pahlavani N, Nattagh-Eshtivani E, Hashemilar M, et al. The Effects of Coenzyme Q10 Supplementation on Oxidative Status and Lipid Profile in Migraine Patients: A Randomized Double-Blinded Controlled Clinical Trial. Clin Nutr Res. 2023;12:257. doi:10.7762/cnr.2023.12.4.257
- Gaul C, Zaranek L, Goßrau G. [Complementary and supplementary procedures in the treatment of headache]. Schmerz. 2023;37:448. doi:10.1007/s00482-023-00738-1
- Yaghini O, Hoseini N, Ghazavi MR, Mansouri V, Nasiri J, et al. A Comparative Study on the Efficacy of Coenzyme Q10 and Amitriptyline in the Prophylactic Treatment of Migraine Headaches in Children: A Randomized Controlled Trial. Adv Biomed Res. 2022;11:43. doi:10.4103/abr.abr_235_20
- Quintana S, Russo M, Torelli P. Nutraceuticals and migraine: further strategy for the treatment of specific conditions. Neurol Sci. 2022;43:6565. doi:10.1007/s10072-022-06250-1
- Ariyanfar S, Razeghi Jahromi S, Togha M, Ghorbani Z. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep. 2022;26:193. doi:10.1007/s11916-022-01019-9
- Kaur K, Hernandez V, Al Hajaj SW, Ebrahim AM, Razack M, et al. The Efficacy of Herbal Supplements and Nutraceuticals for Prevention of Migraine: Can They Help?. Cureus. 2021;13:e14868. doi:10.7759/cureus.14868
- Sazali S, Badrin S, Norhayati MN, Idris NS. Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis. BMJ Open. 2021;11:e039358. doi:10.1136/bmjopen-2020-039358
- Vikelis M, Dermitzakis EV, Vlachos GS, Soldatos P, Spingos KC, et al. Open Label Prospective Experience of Supplementation with a Fixed Combination of Magnesium, Vitamin B2, Feverfew, Andrographis Paniculata and Coenzyme Q10 for Episodic Migraine Prophylaxis. J Clin Med. 2020;10. doi:10.3390/jcm10010067
- Onofri A, Necozione S, Tozzi E. Complementary and alternative medicine (CAM) in headache of children and adolescents: open-label Italian study. Clin Ter. 2020;171:e393. doi:10.7417/CT.2020.2246
- Lisicki M, Schoenen J. Metabolic treatments of migraine. Expert Rev Neurother. 2020;20:295. doi:10.1080/14737175.2020.1729130
- Moscano F, Guiducci M, Maltoni L, Striano P, Ledda MG, et al. An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache. Ital J Pediatr. 2019;45:36. doi:10.1186/s13052-019-0624-z
- Hajihashemi P, Askari G, Khorvash F, Reza Maracy M, Nourian M. The effects of concurrent Coenzyme Q10, L-carnitine supplementation in migraine prophylaxis: A randomized, placebo-controlled, double-blind trial. Cephalalgia. 2019;39:648. doi:10.1177/0333102418821661
