5/12/2025
Last update
5/12/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 23 Reviews
8
Supplement Facts
Serving Size: 1 Capsule
Serving Per Container: 60
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
200 mg
†
Top Medical Research Studies
9
We investigated how coenzyme Q10 might help with heart function after a heart attack, particularly focusing on its role in heart remodeling. In a well-structured study involving 55 patients with left ventricular dysfunction following an acute myocardial infarction, we compared the effects of coenzyme Q10 to a placebo over a 24-week period.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
Read More
9
We explored how coenzyme Q10 (CoQ10) impacts heart damage caused by a lack of blood flow, known as ischemia, followed by the restoration of blood flow, which can lead to further injury. In our study, we utilized a rat model divided into three groups: a control group that did not undergo any induced heart injury, a group that experienced ischemia and reperfusion, and a group pre-treated with CoQ10 before the injury.
The results indicated that CoQ10 treatment significantly reduced signs of myocardial cell death, often associated with heart attacks. Specifically, we observed a decrease in apoptotic DNA, which is a marker of cell death, and an increase in the production of nitric oxide, a vital molecule for heart health. This suggests that CoQ10 not only helps combat oxidative stress but also enhances the heart's resilience against damage caused during ischemia and subsequent reperfusion.
Overall, our findings align with previous research highlighting CoQ10's potential to protect heart tissue during critical injury phases. By regulating gene expression linked to cell survival, CoQ10 appears to offer a protective effect that could be valuable in heart attack treatments.
The results indicated that CoQ10 treatment significantly reduced signs of myocardial cell death, often associated with heart attacks. Specifically, we observed a decrease in apoptotic DNA, which is a marker of cell death, and an increase in the production of nitric oxide, a vital molecule for heart health. This suggests that CoQ10 not only helps combat oxidative stress but also enhances the heart's resilience against damage caused during ischemia and subsequent reperfusion.
Overall, our findings align with previous research highlighting CoQ10's potential to protect heart tissue during critical injury phases. By regulating gene expression linked to cell survival, CoQ10 appears to offer a protective effect that could be valuable in heart attack treatments.
Read More
8
We embarked on a study to explore how Coenzyme Q10 (CoQ10) might aid in recovering cardiac function following a heart attack, or myocardial infarction (MI). By measuring the effects of CoQ10 on both patients and mice, we aimed to understand its role in promoting heart health post-MI.
Our research included a comparison between MI patients receiving CoQ10 and those who did not. We conducted evaluations at one and three months after treatments to assess heart function. In the animal model, we observed that mice receiving CoQ10 showed improved heart performance compared to those that did not, suggesting significant benefits for heart recovery.
An interesting finding was that CoQ10 appears to inhibit certain inflammatory responses in the heart, specifically by affecting a pathway associated with macrophages, which are immune cells that can contribute to inflammation. By preventing these macrophages from accumulating in the heart and activating pro-inflammatory signals, CoQ10 may help to reduce the harmful effects of inflammation following a heart attack.
Overall, our results indicate that CoQ10 can be a valuable addition to treatment plans for individuals recovering from heart attacks, potentially speeding up recovery and improving heart function.
Our research included a comparison between MI patients receiving CoQ10 and those who did not. We conducted evaluations at one and three months after treatments to assess heart function. In the animal model, we observed that mice receiving CoQ10 showed improved heart performance compared to those that did not, suggesting significant benefits for heart recovery.
An interesting finding was that CoQ10 appears to inhibit certain inflammatory responses in the heart, specifically by affecting a pathway associated with macrophages, which are immune cells that can contribute to inflammation. By preventing these macrophages from accumulating in the heart and activating pro-inflammatory signals, CoQ10 may help to reduce the harmful effects of inflammation following a heart attack.
Overall, our results indicate that CoQ10 can be a valuable addition to treatment plans for individuals recovering from heart attacks, potentially speeding up recovery and improving heart function.
Read More
Most Useful Reviews
9
Palpitations ceased
15 people found this helpful
Great product! I purchased this for heart concerns as I was experiencing frequent heart palpitations. After I began taking this product, they disappeared.
Read More
9
Heart health enhancer
6 people found this helpful
Coenzyme Q10 is referred to as a “youth and health supplement.” It's a potent antioxidant that stimulates cell regeneration and participates in energy production, thus contributing to skin hydration and collagen production. After 40, natural synthesis decreases, so it’s wise to adapt your diet accordingly. CoQ10 is critical for energy provision to cells and prolongs their lifespan, particularly enhancing heart function. Regular intake may slow skin aging and promote overall vitality. It contains a well-studied form of Q10, highly recommended!
Read More
9
Energy boost
2 people found this helpful
This is my favourite health supplement! I've taken it for several years, and my heart problems have vanished. I've noticed significant increases in energy. I drink 100 mg daily, and if I'm feeling unwell or under pressure, I take two at once. I always say: whoever takes this will never die! 😉
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
- All Researches
9
We explored the connection between acute heart attacks and potential liver and kidney complications, specifically focusing on the role of coenzyme Q10 (Q10). In our study, we examined male rats divided into groups—some receiving normal saline and others pretreated with Q10 for 28 days, followed by an induced heart attack using isoprenaline (ISO).
Our findings revealed that ISO administration increased oxidative stress and negatively affected liver and kidney health. However, those pretreated with Q10 showed notable protection against both biochemical and tissue changes linked to these complications. We observed significantly improved antioxidant levels and a reduction in harmful liver and kidney enzymes. Furthermore, the histopathological examination indicated less severe damage in the tissues of the rats given Q10 compared to those that received ISO alone.
Overall, this study suggests that coenzyme Q10 may help shield the liver and kidneys during recovery from a heart attack by counteracting oxidative stress and reducing fibrotic changes. This finding highlights the potential of Q10 as a supportive treatment during critical cardiac events.
Our findings revealed that ISO administration increased oxidative stress and negatively affected liver and kidney health. However, those pretreated with Q10 showed notable protection against both biochemical and tissue changes linked to these complications. We observed significantly improved antioxidant levels and a reduction in harmful liver and kidney enzymes. Furthermore, the histopathological examination indicated less severe damage in the tissues of the rats given Q10 compared to those that received ISO alone.
Overall, this study suggests that coenzyme Q10 may help shield the liver and kidneys during recovery from a heart attack by counteracting oxidative stress and reducing fibrotic changes. This finding highlights the potential of Q10 as a supportive treatment during critical cardiac events.
Read More
9
We explored the effectiveness of coenzyme Q10 (CoQ10) when used alongside epigallocatechin gallate (EGCG) in protecting heart cells after a myocardial infarction (MI). The study focused on liposome nanoparticles made with distearyl phosphatidylcholine (DSPC) to deliver these compounds effectively. By doing this, we aimed to see whether this combination could reduce oxidative stress and cell death in heart tissue.
Our results showed that these liposome nanoparticles, referred to as CE-LNPs, were well-tolerated by cells and were taken up efficiently by macrophages. These nanoparticles successfully lowered harmful reactive oxygen species (ROS) in heart cells under stress, lessened cell death, and helped maintain the health and growth of those cells. We validated these positive outcomes through various tests that confirm their anti-apoptotic properties, or their ability to prevent cell death.
In a mouse model of MI, the CE-LNPs significantly reduced scar tissue formation, aiding in cardiac recovery and enhancing heart function. These findings suggest that using CoQ10 in conjunction with EGCG within DSPC liposomes can provide protective effects against heart damage following a heart attack. However, since these two were tested together, we note that isolating the specific impact of CoQ10 alone remains challenging. Overall, we have evidence of a promising approach for heart protection using these formulations.
Our results showed that these liposome nanoparticles, referred to as CE-LNPs, were well-tolerated by cells and were taken up efficiently by macrophages. These nanoparticles successfully lowered harmful reactive oxygen species (ROS) in heart cells under stress, lessened cell death, and helped maintain the health and growth of those cells. We validated these positive outcomes through various tests that confirm their anti-apoptotic properties, or their ability to prevent cell death.
In a mouse model of MI, the CE-LNPs significantly reduced scar tissue formation, aiding in cardiac recovery and enhancing heart function. These findings suggest that using CoQ10 in conjunction with EGCG within DSPC liposomes can provide protective effects against heart damage following a heart attack. However, since these two were tested together, we note that isolating the specific impact of CoQ10 alone remains challenging. Overall, we have evidence of a promising approach for heart protection using these formulations.
Read More
9
We investigated how coenzyme Q10 might help with heart function after a heart attack, particularly focusing on its role in heart remodeling. In a well-structured study involving 55 patients with left ventricular dysfunction following an acute myocardial infarction, we compared the effects of coenzyme Q10 to a placebo over a 24-week period.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
Read More
9
We explored how coenzyme Q10 (CoQ10) impacts heart damage caused by a lack of blood flow, known as ischemia, followed by the restoration of blood flow, which can lead to further injury. In our study, we utilized a rat model divided into three groups: a control group that did not undergo any induced heart injury, a group that experienced ischemia and reperfusion, and a group pre-treated with CoQ10 before the injury.
The results indicated that CoQ10 treatment significantly reduced signs of myocardial cell death, often associated with heart attacks. Specifically, we observed a decrease in apoptotic DNA, which is a marker of cell death, and an increase in the production of nitric oxide, a vital molecule for heart health. This suggests that CoQ10 not only helps combat oxidative stress but also enhances the heart's resilience against damage caused during ischemia and subsequent reperfusion.
Overall, our findings align with previous research highlighting CoQ10's potential to protect heart tissue during critical injury phases. By regulating gene expression linked to cell survival, CoQ10 appears to offer a protective effect that could be valuable in heart attack treatments.
The results indicated that CoQ10 treatment significantly reduced signs of myocardial cell death, often associated with heart attacks. Specifically, we observed a decrease in apoptotic DNA, which is a marker of cell death, and an increase in the production of nitric oxide, a vital molecule for heart health. This suggests that CoQ10 not only helps combat oxidative stress but also enhances the heart's resilience against damage caused during ischemia and subsequent reperfusion.
Overall, our findings align with previous research highlighting CoQ10's potential to protect heart tissue during critical injury phases. By regulating gene expression linked to cell survival, CoQ10 appears to offer a protective effect that could be valuable in heart attack treatments.
Read More
8
Coenzyme Q10 may aid heart recovery
We explored the effects of coenzyme Q10 in conjunction with lisinopril as a treatment for patients suffering from ventricular septal rupture (VSR) following a heart attack. This rare complication can lead to severe issues and is typically treated with surgery. However, not all hospitals have the facilities for immediate surgical intervention, making alternative treatments essential.
In a recent case, a 74-year-old woman was admitted with late-onset myocardial infarction and subsequently diagnosed with VSR and pulmonary hypertension. As her condition worsened, traditional treatment with vasopressors was initiated. To enhance her recovery, doctors introduced lisinopril and coenzyme Q10, which reportedly supported her heart function and stability over three months.
While the findings suggest that the combination of these two treatments could improve energy production and tissue healing, it is crucial to note the difficulty in isolating the effects of coenzyme Q10 alone from lisinopril. This limitation makes it hard to draw definitive conclusions about how effective coenzyme Q10 is on its own for managing heart attack complications.
In a recent case, a 74-year-old woman was admitted with late-onset myocardial infarction and subsequently diagnosed with VSR and pulmonary hypertension. As her condition worsened, traditional treatment with vasopressors was initiated. To enhance her recovery, doctors introduced lisinopril and coenzyme Q10, which reportedly supported her heart function and stability over three months.
While the findings suggest that the combination of these two treatments could improve energy production and tissue healing, it is crucial to note the difficulty in isolating the effects of coenzyme Q10 alone from lisinopril. This limitation makes it hard to draw definitive conclusions about how effective coenzyme Q10 is on its own for managing heart attack complications.
Read More
User Reviews
USERS' SCORE
Good
Based on 23 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Palpitations ceased
15 people found this helpful
Great product! I purchased this for heart concerns as I was experiencing frequent heart palpitations. After I began taking this product, they disappeared.
Read More
9
Heart health enhancer
6 people found this helpful
Coenzyme Q10 is referred to as a “youth and health supplement.” It's a potent antioxidant that stimulates cell regeneration and participates in energy production, thus contributing to skin hydration and collagen production. After 40, natural synthesis decreases, so it’s wise to adapt your diet accordingly. CoQ10 is critical for energy provision to cells and prolongs their lifespan, particularly enhancing heart function. Regular intake may slow skin aging and promote overall vitality. It contains a well-studied form of Q10, highly recommended!
Read More
9
Energy boost
2 people found this helpful
This is my favourite health supplement! I've taken it for several years, and my heart problems have vanished. I've noticed significant increases in energy. I drink 100 mg daily, and if I'm feeling unwell or under pressure, I take two at once. I always say: whoever takes this will never die! 😉
Read More
10
Palpitations reduced
1 people found this helpful
I experienced heart palpitations due to a faulty heart nerve (thought to be a birth defect). Two of these daily have completely eliminated my palpitations.
Read More
10
Heart relief
1 people found this helpful
I highly recommend this for anyone over 40. I take it regularly, and since then, my heart issues have alleviated, which is the key benefit.
Read More
Frequently Asked Questions
6
Immediate effect
1 people found this helpful
I felt the heart benefits right away, but unfortunately, it upset my stomach too much for me to continue using it!
10
Palpitations reduced
1 people found this helpful
I experienced heart palpitations due to a faulty heart nerve (thought to be a birth defect). Two of these daily have completely eliminated my palpitations.
10
Heart relief
1 people found this helpful
I highly recommend this for anyone over 40. I take it regularly, and since then, my heart issues have alleviated, which is the key benefit.
9
Palpitations ceased
15 people found this helpful
Great product! I purchased this for heart concerns as I was experiencing frequent heart palpitations. After I began taking this product, they disappeared.
9
Energy boost
2 people found this helpful
This is my favourite health supplement! I've taken it for several years, and my heart problems have vanished. I've noticed significant increases in energy. I drink 100 mg daily, and if I'm feeling unwell or under pressure, I take two at once. I always say: whoever takes this will never die! 😉
9
Heart health enhancer
6 people found this helpful
Coenzyme Q10 is referred to as a “youth and health supplement.” It's a potent antioxidant that stimulates cell regeneration and participates in energy production, thus contributing to skin hydration and collagen production. After 40, natural synthesis decreases, so it’s wise to adapt your diet accordingly. CoQ10 is critical for energy provision to cells and prolongs their lifespan, particularly enhancing heart function. Regular intake may slow skin aging and promote overall vitality. It contains a well-studied form of Q10, highly recommended!
7.5
Stabilises heart health
1 people found this helpful
I love Jarrow products; great quality and ingredients. As a heart patient, I notice a difference when I take it. My health status remains stable, indicating its effectiveness. I've used it for over 10 years and believe strongly in its benefits for my heart and skin, and my overall energy.
7.5
Increases good cholesterol
I used Coenzyme Q10 in an anti-cholesterol protocol with garlic and red fermented rice. It helped raise the level of "good" cholesterol, positively impacting my heart condition and reducing risks. We plan to continue this regimen.
2
No discernible results
2 people found this helpful
Following my cardiologist's advice, I took 200mg of coenzyme and selenium for heart health, but I haven't observed any improvement. I'm quite disappointed!
8
We embarked on a study to explore how Coenzyme Q10 (CoQ10) might aid in recovering cardiac function following a heart attack, or myocardial infarction (MI). By measuring the effects of CoQ10 on both patients and mice, we aimed to understand its role in promoting heart health post-MI.
Our research included a comparison between MI patients receiving CoQ10 and those who did not. We conducted evaluations at one and three months after treatments to assess heart function. In the animal model, we observed that mice receiving CoQ10 showed improved heart performance compared to those that did not, suggesting significant benefits for heart recovery.
An interesting finding was that CoQ10 appears to inhibit certain inflammatory responses in the heart, specifically by affecting a pathway associated with macrophages, which are immune cells that can contribute to inflammation. By preventing these macrophages from accumulating in the heart and activating pro-inflammatory signals, CoQ10 may help to reduce the harmful effects of inflammation following a heart attack.
Overall, our results indicate that CoQ10 can be a valuable addition to treatment plans for individuals recovering from heart attacks, potentially speeding up recovery and improving heart function.
Our research included a comparison between MI patients receiving CoQ10 and those who did not. We conducted evaluations at one and three months after treatments to assess heart function. In the animal model, we observed that mice receiving CoQ10 showed improved heart performance compared to those that did not, suggesting significant benefits for heart recovery.
An interesting finding was that CoQ10 appears to inhibit certain inflammatory responses in the heart, specifically by affecting a pathway associated with macrophages, which are immune cells that can contribute to inflammation. By preventing these macrophages from accumulating in the heart and activating pro-inflammatory signals, CoQ10 may help to reduce the harmful effects of inflammation following a heart attack.
Overall, our results indicate that CoQ10 can be a valuable addition to treatment plans for individuals recovering from heart attacks, potentially speeding up recovery and improving heart function.
9
We explored how coenzyme Q10 (CoQ10) impacts heart damage caused by a lack of blood flow, known as ischemia, followed by the restoration of blood flow, which can lead to further injury. In our study, we utilized a rat model divided into three groups: a control group that did not undergo any induced heart injury, a group that experienced ischemia and reperfusion, and a group pre-treated with CoQ10 before the injury.
The results indicated that CoQ10 treatment significantly reduced signs of myocardial cell death, often associated with heart attacks. Specifically, we observed a decrease in apoptotic DNA, which is a marker of cell death, and an increase in the production of nitric oxide, a vital molecule for heart health. This suggests that CoQ10 not only helps combat oxidative stress but also enhances the heart's resilience against damage caused during ischemia and subsequent reperfusion.
Overall, our findings align with previous research highlighting CoQ10's potential to protect heart tissue during critical injury phases. By regulating gene expression linked to cell survival, CoQ10 appears to offer a protective effect that could be valuable in heart attack treatments.
The results indicated that CoQ10 treatment significantly reduced signs of myocardial cell death, often associated with heart attacks. Specifically, we observed a decrease in apoptotic DNA, which is a marker of cell death, and an increase in the production of nitric oxide, a vital molecule for heart health. This suggests that CoQ10 not only helps combat oxidative stress but also enhances the heart's resilience against damage caused during ischemia and subsequent reperfusion.
Overall, our findings align with previous research highlighting CoQ10's potential to protect heart tissue during critical injury phases. By regulating gene expression linked to cell survival, CoQ10 appears to offer a protective effect that could be valuable in heart attack treatments.
8
Coenzyme Q10 may aid heart recovery
We explored the effects of coenzyme Q10 in conjunction with lisinopril as a treatment for patients suffering from ventricular septal rupture (VSR) following a heart attack. This rare complication can lead to severe issues and is typically treated with surgery. However, not all hospitals have the facilities for immediate surgical intervention, making alternative treatments essential.
In a recent case, a 74-year-old woman was admitted with late-onset myocardial infarction and subsequently diagnosed with VSR and pulmonary hypertension. As her condition worsened, traditional treatment with vasopressors was initiated. To enhance her recovery, doctors introduced lisinopril and coenzyme Q10, which reportedly supported her heart function and stability over three months.
While the findings suggest that the combination of these two treatments could improve energy production and tissue healing, it is crucial to note the difficulty in isolating the effects of coenzyme Q10 alone from lisinopril. This limitation makes it hard to draw definitive conclusions about how effective coenzyme Q10 is on its own for managing heart attack complications.
In a recent case, a 74-year-old woman was admitted with late-onset myocardial infarction and subsequently diagnosed with VSR and pulmonary hypertension. As her condition worsened, traditional treatment with vasopressors was initiated. To enhance her recovery, doctors introduced lisinopril and coenzyme Q10, which reportedly supported her heart function and stability over three months.
While the findings suggest that the combination of these two treatments could improve energy production and tissue healing, it is crucial to note the difficulty in isolating the effects of coenzyme Q10 alone from lisinopril. This limitation makes it hard to draw definitive conclusions about how effective coenzyme Q10 is on its own for managing heart attack complications.
8
We conducted a thorough investigation into how coenzyme Q10 affects heart attack risks, using a systematic review and meta-analysis of various clinical trials. Our research included data from a significant number of participants, which allowed us to draw more definitive conclusions about this supplement's benefits.
The findings indicate that coenzyme Q10 supplementation can be beneficial in reducing the risk of heart-related issues. Specifically, we observed a decrease in all-cause mortality events associated with its use. This means that incorporating coenzyme Q10 into one’s health regimen could potentially lead to a healthier heart and a longer life.
However, it’s important to note that while coenzyme Q10 shows promise, the overall context matters. Not every micronutrient contributes positively in all areas, and the balance between different nutrients is crucial for promoting cardiovascular health. Thus, while coenzyme Q10 may help, it's essential to consider it as part of a broader approach to heart health.
The findings indicate that coenzyme Q10 supplementation can be beneficial in reducing the risk of heart-related issues. Specifically, we observed a decrease in all-cause mortality events associated with its use. This means that incorporating coenzyme Q10 into one’s health regimen could potentially lead to a healthier heart and a longer life.
However, it’s important to note that while coenzyme Q10 shows promise, the overall context matters. Not every micronutrient contributes positively in all areas, and the balance between different nutrients is crucial for promoting cardiovascular health. Thus, while coenzyme Q10 may help, it's essential to consider it as part of a broader approach to heart health.
2
No predictive value of coenzyme Q10
We set out to investigate whether the levels of coenzyme Q10 in the blood could serve as an early warning sign for left ventricular remodelling following a heart attack, specifically ST-elevation myocardial infarction (STEMI). Our study included 68 patients who had undergone successful revascularization via primary percutaneous coronary intervention.
Within four days of their procedure, we measured their plasma coenzyme Q10 levels using advanced scientific methods and then conducted follow-up echocardiography six months later. The goal was to see if those initial coenzyme Q10 levels could predict changes in the left ventricle, which is crucial for heart function.
However, we found no significant evidence to suggest that plasma coenzyme Q10 concentration could be used as a predictive marker for left ventricular remodelling after a heart attack. This means that, despite its importance in energy production and antioxidant defense in the heart, coenzyme Q10 levels alone aren't reliable in forecasting heart recovery in this context.
Within four days of their procedure, we measured their plasma coenzyme Q10 levels using advanced scientific methods and then conducted follow-up echocardiography six months later. The goal was to see if those initial coenzyme Q10 levels could predict changes in the left ventricle, which is crucial for heart function.
However, we found no significant evidence to suggest that plasma coenzyme Q10 concentration could be used as a predictive marker for left ventricular remodelling after a heart attack. This means that, despite its importance in energy production and antioxidant defense in the heart, coenzyme Q10 levels alone aren't reliable in forecasting heart recovery in this context.
We investigated whether coenzyme Q10 (CoQ10) could help prevent kidney injury caused by contrast dye during heart procedures in patients experiencing a type of heart attack known as STEMI. In our study, 150 patients undergoing primary percutaneous coronary intervention (PCI) were divided into two groups. One group received CoQ10 alongside standard intravenous hydration, while the other received a placebo.
CoQ10 was given orally, starting with a 400 mg dose before the procedure, followed by 200 mg twice a day for three days post-procedure. We closely monitored serum creatinine levels and assessed kidney function at various points after the procedure. Additionally, we measured levels of certain antioxidants and markers of oxidative stress before and after the PCI.
Our findings suggested that supplementing with CoQ10 may be beneficial for preventing contrast-induced acute kidney injury. Thus, it appears that CoQ10 can serve as a useful addition to hydration strategies in protecting the kidneys during critical cardiac interventions.
CoQ10 was given orally, starting with a 400 mg dose before the procedure, followed by 200 mg twice a day for three days post-procedure. We closely monitored serum creatinine levels and assessed kidney function at various points after the procedure. Additionally, we measured levels of certain antioxidants and markers of oxidative stress before and after the PCI.
Our findings suggested that supplementing with CoQ10 may be beneficial for preventing contrast-induced acute kidney injury. Thus, it appears that CoQ10 can serve as a useful addition to hydration strategies in protecting the kidneys during critical cardiac interventions.
9
We investigated how coenzyme Q10 might help with heart function after a heart attack, particularly focusing on its role in heart remodeling. In a well-structured study involving 55 patients with left ventricular dysfunction following an acute myocardial infarction, we compared the effects of coenzyme Q10 to a placebo over a 24-week period.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
7
We explored the potential effects of coenzyme Q10 (CoQ10) supplementation on heart attacks and related cardiovascular issues. This supplement, known for its role in energy production and its antioxidant properties, has generated interest as a possible support in managing heart health.
Several randomized clinical trials have looked into the impact of CoQ10 on heart attack patients and those dealing with conditions like heart failure and hypertension. These studies have noted promising decreases in inflammatory markers and oxidative stress, which are crucial factors in heart disease.
However, while the results are encouraging, many studies included diverse cardiovascular issues rather than focusing solely on heart attacks. More extensive research with larger groups of patients will be necessary to claim CoQ10's effectiveness specifically for heart attack treatment. It's vital to continue evaluating this supplement's role while we await further scientific findings.
Several randomized clinical trials have looked into the impact of CoQ10 on heart attack patients and those dealing with conditions like heart failure and hypertension. These studies have noted promising decreases in inflammatory markers and oxidative stress, which are crucial factors in heart disease.
However, while the results are encouraging, many studies included diverse cardiovascular issues rather than focusing solely on heart attacks. More extensive research with larger groups of patients will be necessary to claim CoQ10's effectiveness specifically for heart attack treatment. It's vital to continue evaluating this supplement's role while we await further scientific findings.
References
- Chidebe EO, Moke EG, Asiwe JN, Ben-Azu B, Demaki WE, et al. Therapeutic effect of coenzyme-Q10 pretreatment on isoprenaline-induced cardiogenic hepatorenal complications in rats. Int J Physiol Pathophysiol Pharmacol. 2024;16:126. 10.62347/PFXZ9903
- Intan RE, Balti DR, Nugraha RA, Alkaff FF, Salamah S, et al. Angiotensin converting enzyme inhibitor and coenzyme Q10 as adjunctive treatment for patients with ventricular septal rupture following late onset myocardial infarction: a case report. J Pak Med Assoc. 2024;74:S81. 10.47391/JPMA.S6-ACSA-16
- Pan W, Zhou G, Hu M, Li G, Zhang M, et al. Coenzyme Q10 mitigates macrophage mediated inflammation in heart following myocardial infarction via the NLRP3/IL1β pathway. BMC Cardiovasc Disord. 2024;24:76. 10.1186/s12872-024-03729-x
- Lei W, Yang J, Wang J, Xiao Z, Zhou P, et al. Synergetic EGCG and coenzyme Q10 DSPC liposome nanoparticles protect against myocardial infarction. Biomater Sci. 2023;11:6862. 10.1039/d3bm00857f
- Ahmadimoghaddam D, Talebi SS, Rahmani A, Zamanirafe M, Parvaneh E, et al. Prevention of contrast induced-acute kidney injury using coenzyme Q10 in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Eur J Clin Pharmacol. 2023;79:1341. 10.1007/s00228-023-03546-9
- Mokhtari B, Badalzadeh R. Mitochondria-targeted combination treatment strategy counteracts myocardial reperfusion injury of aged rats by modulating autophagy and inflammatory response. Mol Biol Rep. 2023;50:3973. 10.1007/s11033-023-08318-3
- Li D, Zhang G, Wang Z, Guo J, Liu Y, et al. Idebenone attenuates ferroptosis by inhibiting excessive autophagy via the ROS-AMPK-mTOR pathway to preserve cardiac function after myocardial infarction. Eur J Pharmacol. 2023;943:175569. 10.1016/j.ejphar.2023.175569
- Yazdi A, Shirmohammadi K, Parvaneh E, Entezari-Maleki T, Hosseini SK, et al. Effects of coenzyme Q10 supplementation on oxidative stress biomarkers following reperfusion in STEMI patients undergoing primary percutaneous coronary intervention. J Cardiovasc Thorac Res. 2023;15:250. 10.34172/jcvtr.2023.31817
- An P, Wan S, Luo Y, Luo J, Zhang X, et al. Micronutrient Supplementation to Reduce Cardiovascular Risk. J Am Coll Cardiol. 2022;80:2269. 10.1016/j.jacc.2022.09.048
- Shah IA, Memon M, Ansari S, Kumar R, Chandio SA, et al. Role of Coenzyme Q10 in Prophylaxis of Myocardial Infarction. Cureus. 2021;13:e13137. 10.7759/cureus.13137
- Fontaine F, Legallois D, Créveuil C, Chtourou M, Coulbault L, et al. Is plasma concentration of coenzyme Q10 a predictive marker for left ventricular remodelling after revascularization for ST-segment elevation myocardial infarction?. Ann Clin Biochem. 2021;58:327. 10.1177/00045632211001100
- Martelli A, Testai L, Colletti A, Cicero AFG. Coenzyme Q: Clinical Applications in Cardiovascular Diseases. Antioxidants (Basel). 2020;9. 10.3390/antiox9040341
- Singh RB, Fedacko J, Mojto V, Pella D. Coenzyme Q10 Modulates Remodeling Possibly by Decreasing Angiotensin-Converting Enzyme in Patients with Acute Coronary Syndrome. Antioxidants (Basel). 2018;7. 10.3390/antiox7080099
- Khan NA, Abid M, Ahmad A, Abuzinadah MF, Basheikh M, et al. Cardioprotective Effect of Coenzyme Q on Apoptotic Myocardial Cell Death by Regulation of Bcl-2 Gene Expression. J Pharmacol Pharmacother. 2017;8:122. 10.4103/jpp.JPP_47_17
- Sharifi MH, Eftekhari MH, Ostovan MA, Rezaianazadeh A. Effects of a therapeutic lifestyle change diet and supplementation with Q10 plus L-carnitine on quality of life in patients with myocardial infarction: A randomized clinical trial. J Cardiovasc Thorac Res. 2017;9:21. 10.15171/jcvtr.2017.03
- Mirhashemi SM, Najafi V, Raygan F, Asemi Z. The effects of coenzyme Q10 supplementation on cardiometabolic markers in overweight type 2 diabetic patients with stable myocardial infarction: A randomized, double-blind, placebo-controlled trial. ARYA Atheroscler. 2016;12:158.
