' 
![]()
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.2
USERS' SCORE
Good
Based on 1 Reviews
8.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9
Folate's impact on gout therapy
A multicentre, efficacy and safety study of methotrexate to increase response rates in patients with uncontrolled gout receiving pegloticase (MIRROR): 12-month efficacy, safety, immunogenicity, and pharmacokinetic findings during long-term extension of an open-label study.
Folate's role not clarified
We explored the efficacy of methotrexate in conjunction with folate as a treatment approach for patients suffering from uncontrolled gout, specifically those using the medication pegloticase. The study aimed to understand how this combination therapy could enhance response rates and overall treatment success compared to pegloticase alone.
Patients involved in the study had high serum urate levels and struggled with urate-lowering therapy. Over a 12-month period, we observed that combining pegloticase with methotrexate and administering folate produced a significant responder rate of 79%. This was a noteworthy improvement over the 42% responder rate linked to pegloticase by itself.
While the study did highlight the benefits of using methotrexate, it also indicated that the specific contribution of folate was difficult to isolate. The results showed that the co-therapy was generally well tolerated, with patients experiencing sustained reductions in urate levels and fewer gout flares. Overall, the findings suggest that methotrexate may play a key role in increasing treatment response by reducing the formation of antibodies against pegloticase, yet we must remain cautious regarding the isolated benefits of folate alone in this context.
Patients involved in the study had high serum urate levels and struggled with urate-lowering therapy. Over a 12-month period, we observed that combining pegloticase with methotrexate and administering folate produced a significant responder rate of 79%. This was a noteworthy improvement over the 42% responder rate linked to pegloticase by itself.
While the study did highlight the benefits of using methotrexate, it also indicated that the specific contribution of folate was difficult to isolate. The results showed that the co-therapy was generally well tolerated, with patients experiencing sustained reductions in urate levels and fewer gout flares. Overall, the findings suggest that methotrexate may play a key role in increasing treatment response by reducing the formation of antibodies against pegloticase, yet we must remain cautious regarding the isolated benefits of folate alone in this context.
Read More
8
Vitamin B shows promise for gout
Synergic effect in the reduction of serum uric acid level between ethanol extract of and vitamin B.
Study scores synergistic effects
We investigated how vitamin B, when paired with the ethanol extract of AG, impacts uric acid levels, particularly in relation to gout. The study compared different parts of the AG plant, noting how its effectiveness in inhibiting xanthine oxidase varied across seasons. Among all the parts, the autumn leaf extract, designated as AG-D006, emerged as the most potent.
Our findings revealed that when we combined AG-D006 with vitamin B, there was a significant boost in inhibiting xanthine oxidase, a key enzyme involved in uric acid production. Additionally, this combination led to a notable decrease in uric acid levels in hyperuricemic rats during in vivo tests.
Despite the encouraging results, it's essential to acknowledge that our study blended AG extract with vitamin B, making it challenging to isolate the specific effects of vitamin B on gout by itself. However, AG-D006 paired with vitamin B shows promising potential as a functional food for managing gout.
Our findings revealed that when we combined AG-D006 with vitamin B, there was a significant boost in inhibiting xanthine oxidase, a key enzyme involved in uric acid production. Additionally, this combination led to a notable decrease in uric acid levels in hyperuricemic rats during in vivo tests.
Despite the encouraging results, it's essential to acknowledge that our study blended AG extract with vitamin B, making it challenging to isolate the specific effects of vitamin B on gout by itself. However, AG-D006 paired with vitamin B shows promising potential as a functional food for managing gout.
Read More
8
Folic acid aids gout management
Folic acid and zinc improve hyperuricemia by altering the gut microbiota of rats with high-purine diet-induced hyperuricemia.
Combined effects complicate evaluation
We explored the impact of folic acid on gout, particularly focusing on its ability to reduce uric acid levels in rats with hyperuricemia. This condition, characterized by elevated uric acid, can arise from a high-purine diet. By establishing a model using this diet, we could examine how folic acid—and zinc—affects the overall state of hyperuricemia and gut microbiota.
Our findings showed that both folic acid and zinc not only lowered uric acid levels but also regulated important enzymatic activities associated with uric acid production. Furthermore, we discovered that these treatments changed the gut microbiota composition, promoting beneficial probiotic bacteria while reducing potentially harmful ones. This balance may lead to improved gut health and, by extension, support in managing gout symptoms.
While the study highlights promising results concerning the combined use of folic acid and zinc, we must acknowledge that it's difficult to isolate the specific effects of folic acid alone on gout. Overall, this research points towards folic acid, along with zinc, as a potential new therapy for improving hyperuricemia, but further studies are needed to clarify the individual contributions of each treatment.
Our findings showed that both folic acid and zinc not only lowered uric acid levels but also regulated important enzymatic activities associated with uric acid production. Furthermore, we discovered that these treatments changed the gut microbiota composition, promoting beneficial probiotic bacteria while reducing potentially harmful ones. This balance may lead to improved gut health and, by extension, support in managing gout symptoms.
While the study highlights promising results concerning the combined use of folic acid and zinc, we must acknowledge that it's difficult to isolate the specific effects of folic acid alone on gout. Overall, this research points towards folic acid, along with zinc, as a potential new therapy for improving hyperuricemia, but further studies are needed to clarify the individual contributions of each treatment.
Read More
Most Useful Reviews
9.5
Gout relief confirmed
I researched multivitamins and noted that most are ineffective. However, folate and B vitamins stand out. I initially took a whole pill, but became irritable. Reducing it to half improved my energy and mood. Though I didn’t notice much difference for myself due to my diet, I sent some to my 80-year-old father, who has gout. Since he started taking it, he hasn’t had any gout issues at all. He now orders it regularly for ongoing relief.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.2
9
Folate's impact on gout therapy
A multicentre, efficacy and safety study of methotrexate to increase response rates in patients with uncontrolled gout receiving pegloticase (MIRROR): 12-month efficacy, safety, immunogenicity, and pharmacokinetic findings during long-term extension of an open-label study.
Folate's role not clarified
We explored the efficacy of methotrexate in conjunction with folate as a treatment approach for patients suffering from uncontrolled gout, specifically those using the medication pegloticase. The study aimed to understand how this combination therapy could enhance response rates and overall treatment success compared to pegloticase alone.
Patients involved in the study had high serum urate levels and struggled with urate-lowering therapy. Over a 12-month period, we observed that combining pegloticase with methotrexate and administering folate produced a significant responder rate of 79%. This was a noteworthy improvement over the 42% responder rate linked to pegloticase by itself.
While the study did highlight the benefits of using methotrexate, it also indicated that the specific contribution of folate was difficult to isolate. The results showed that the co-therapy was generally well tolerated, with patients experiencing sustained reductions in urate levels and fewer gout flares. Overall, the findings suggest that methotrexate may play a key role in increasing treatment response by reducing the formation of antibodies against pegloticase, yet we must remain cautious regarding the isolated benefits of folate alone in this context.
Patients involved in the study had high serum urate levels and struggled with urate-lowering therapy. Over a 12-month period, we observed that combining pegloticase with methotrexate and administering folate produced a significant responder rate of 79%. This was a noteworthy improvement over the 42% responder rate linked to pegloticase by itself.
While the study did highlight the benefits of using methotrexate, it also indicated that the specific contribution of folate was difficult to isolate. The results showed that the co-therapy was generally well tolerated, with patients experiencing sustained reductions in urate levels and fewer gout flares. Overall, the findings suggest that methotrexate may play a key role in increasing treatment response by reducing the formation of antibodies against pegloticase, yet we must remain cautious regarding the isolated benefits of folate alone in this context.
Read More
8
Vitamin B shows promise for gout
Synergic effect in the reduction of serum uric acid level between ethanol extract of and vitamin B.
Study scores synergistic effects
We investigated how vitamin B, when paired with the ethanol extract of AG, impacts uric acid levels, particularly in relation to gout. The study compared different parts of the AG plant, noting how its effectiveness in inhibiting xanthine oxidase varied across seasons. Among all the parts, the autumn leaf extract, designated as AG-D006, emerged as the most potent.
Our findings revealed that when we combined AG-D006 with vitamin B, there was a significant boost in inhibiting xanthine oxidase, a key enzyme involved in uric acid production. Additionally, this combination led to a notable decrease in uric acid levels in hyperuricemic rats during in vivo tests.
Despite the encouraging results, it's essential to acknowledge that our study blended AG extract with vitamin B, making it challenging to isolate the specific effects of vitamin B on gout by itself. However, AG-D006 paired with vitamin B shows promising potential as a functional food for managing gout.
Our findings revealed that when we combined AG-D006 with vitamin B, there was a significant boost in inhibiting xanthine oxidase, a key enzyme involved in uric acid production. Additionally, this combination led to a notable decrease in uric acid levels in hyperuricemic rats during in vivo tests.
Despite the encouraging results, it's essential to acknowledge that our study blended AG extract with vitamin B, making it challenging to isolate the specific effects of vitamin B on gout by itself. However, AG-D006 paired with vitamin B shows promising potential as a functional food for managing gout.
Read More
8
Folic acid aids gout management
Folic acid and zinc improve hyperuricemia by altering the gut microbiota of rats with high-purine diet-induced hyperuricemia.
Combined effects complicate evaluation
We explored the impact of folic acid on gout, particularly focusing on its ability to reduce uric acid levels in rats with hyperuricemia. This condition, characterized by elevated uric acid, can arise from a high-purine diet. By establishing a model using this diet, we could examine how folic acid—and zinc—affects the overall state of hyperuricemia and gut microbiota.
Our findings showed that both folic acid and zinc not only lowered uric acid levels but also regulated important enzymatic activities associated with uric acid production. Furthermore, we discovered that these treatments changed the gut microbiota composition, promoting beneficial probiotic bacteria while reducing potentially harmful ones. This balance may lead to improved gut health and, by extension, support in managing gout symptoms.
While the study highlights promising results concerning the combined use of folic acid and zinc, we must acknowledge that it's difficult to isolate the specific effects of folic acid alone on gout. Overall, this research points towards folic acid, along with zinc, as a potential new therapy for improving hyperuricemia, but further studies are needed to clarify the individual contributions of each treatment.
Our findings showed that both folic acid and zinc not only lowered uric acid levels but also regulated important enzymatic activities associated with uric acid production. Furthermore, we discovered that these treatments changed the gut microbiota composition, promoting beneficial probiotic bacteria while reducing potentially harmful ones. This balance may lead to improved gut health and, by extension, support in managing gout symptoms.
While the study highlights promising results concerning the combined use of folic acid and zinc, we must acknowledge that it's difficult to isolate the specific effects of folic acid alone on gout. Overall, this research points towards folic acid, along with zinc, as a potential new therapy for improving hyperuricemia, but further studies are needed to clarify the individual contributions of each treatment.
Read More
7
Folic acid may aid gout management
The Inhibitory Effect of Some Drugs on Lipase and Human Pancreatic Lipase: and Studies.
Uncertain specific effects revealed
This investigation focused on how certain medications, particularly folic acid, could influence lipase activity and possibly aid in managing gout. Gout is commonly associated with obesity and metabolic syndrome, making this research especially relevant for those at risk.
We looked at how folic acid, along with colchicine and febuxostat, inhibited lipases, which are important enzymes involved in fat digestion. Through laboratory studies, we discovered that folic acid showed a significant inhibition of lipase activity, with an IC50 value of 0.64 mg/ml, while febuxostat had a similar effect at 0.66 mg/ml.
Our in silico studies indicated that folic acid and febuxostat function as competitive inhibitors, meaning they compete with the enzyme for active sites. This suggests that increasing dietary folate could help in weight management and possibly reduce the risk of complications associated with conditions like neural tube defects (NTDs) during pregnancy.
Ultimately, our findings support the potential benefits of folic acid in managing weight and mitigating gout symptoms, although the specific impacts of folate alone on gout remain somewhat unclear when compared to other treatments.
We looked at how folic acid, along with colchicine and febuxostat, inhibited lipases, which are important enzymes involved in fat digestion. Through laboratory studies, we discovered that folic acid showed a significant inhibition of lipase activity, with an IC50 value of 0.64 mg/ml, while febuxostat had a similar effect at 0.66 mg/ml.
Our in silico studies indicated that folic acid and febuxostat function as competitive inhibitors, meaning they compete with the enzyme for active sites. This suggests that increasing dietary folate could help in weight management and possibly reduce the risk of complications associated with conditions like neural tube defects (NTDs) during pregnancy.
Ultimately, our findings support the potential benefits of folic acid in managing weight and mitigating gout symptoms, although the specific impacts of folate alone on gout remain somewhat unclear when compared to other treatments.
Read More
7
Folate shows no significant benefit
A case-control study of the association of diet and obesity with gout in Taiwan.
Limited impact on dietary analysis.
We observed the dietary and lifestyle risk factors associated with gout in Chinese men through a case-control study involving patients with gout and their healthy coworkers. This assessment included 92 individuals diagnosed with gout while compared against 92 healthy controls.
Interestingly, we found that while folate intake was examined as a potential factor, it did not show significant protective effects against gout when analyzed with other dietary components. Instead, our research highlighted that high alcohol consumption and low intakes of dietary fiber and vitamin C were linked to an increased risk of developing gout.
Additionally, we noted that measurements of central obesity, particularly waist-to-height ratio, had a notable impact on gout occurrence independent of body mass index. Thus, while folate was part of the diet we investigated, it was not identified as a major player in impacting gout outcomes.
Interestingly, we found that while folate intake was examined as a potential factor, it did not show significant protective effects against gout when analyzed with other dietary components. Instead, our research highlighted that high alcohol consumption and low intakes of dietary fiber and vitamin C were linked to an increased risk of developing gout.
Additionally, we noted that measurements of central obesity, particularly waist-to-height ratio, had a notable impact on gout occurrence independent of body mass index. Thus, while folate was part of the diet we investigated, it was not identified as a major player in impacting gout outcomes.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Reviews
8.6
9.5
Gout relief confirmed
I researched multivitamins and noted that most are ineffective. However, folate and B vitamins stand out. I initially took a whole pill, but became irritable. Reducing it to half improved my energy and mood. Though I didn’t notice much difference for myself due to my diet, I sent some to my 80-year-old father, who has gout. Since he started taking it, he hasn’t had any gout issues at all. He now orders it regularly for ongoing relief.
Read More
