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Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 25 Researches
8.2
USERS' SCORE
Good
Based on 6 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9
We sought to understand how intramuscular vitamin B12 could help alleviate low back pain in patients with mechanical lumbago. In a rigorous study involving 60 participants, we compared the effects of vitamin B12 to a placebo.
Our findings indicated that those receiving the vitamin reported significantly less pain and disability, as measured by a visual scale and disability questionnaire. Notably, those on vitamin B12 also used less paracetamol than the placebo group.
Overall, our study confirmed that vitamin B12 can be effective for treating low back pain without nutritional deficiency.
Our findings indicated that those receiving the vitamin reported significantly less pain and disability, as measured by a visual scale and disability questionnaire. Notably, those on vitamin B12 also used less paracetamol than the placebo group.
Overall, our study confirmed that vitamin B12 can be effective for treating low back pain without nutritional deficiency.
Read More
8
This study evaluated the effects of intramuscular methylcobalamin injections on chronic low back pain.
In a rigorously designed double-blinded, randomized controlled trial, 60 patients were divided into treatment and placebo groups.
We observed significant improvements in pain and disability scores among those receiving methylcobalamin compared to the placebo.
Additionally, the treatment was found to be safe, with only minor side effects reported.
In a rigorously designed double-blinded, randomized controlled trial, 60 patients were divided into treatment and placebo groups.
We observed significant improvements in pain and disability scores among those receiving methylcobalamin compared to the placebo.
Additionally, the treatment was found to be safe, with only minor side effects reported.
Read More
9
We explored the effects of vitamin B12 treatment on a patient experiencing severe back pain, along with other symptoms associated with subacute combined degeneration (SCD) from prolonged vitamin B12 deficiency. This case involved a 49-year-old man who faced a year of worsening weakness, pain, and gait abnormalities.
Upon diagnosis, he began receiving intramuscular vitamin B12 injections. Remarkably, within weeks, we observed significant improvements in his pain levels and mobility. This underscores the importance of recognizing vitamin B12 deficiency early since it can lead to debilitating conditions but is often reversible through timely treatment.
Our findings highlight how addressing nutrient deficiencies can enhance overall health and well-being. In this specific case, vitamin B12 not only alleviated back pain but also restored functioning, improving quality of life for the patient.
Upon diagnosis, he began receiving intramuscular vitamin B12 injections. Remarkably, within weeks, we observed significant improvements in his pain levels and mobility. This underscores the importance of recognizing vitamin B12 deficiency early since it can lead to debilitating conditions but is often reversible through timely treatment.
Our findings highlight how addressing nutrient deficiencies can enhance overall health and well-being. In this specific case, vitamin B12 not only alleviated back pain but also restored functioning, improving quality of life for the patient.
Read More
Most Useful Reviews
9
Improved iron levels
22 people found this helpful
After struggling with anaemia in 2018 and spending about 8000r on injections and tests, my iron level increased by just 3 units, which was disappointing. I discovered the Aicher website and ordered vitamin B12 along with iron, as B12 aids absorption. After three weeks, my results improved significantly. Additionally, the B vitamins help to decrease homocysteine levels, which is crucial for vascular health.
Read More
9
Numbness resolved
7 people found this helpful
I developed back pain and numbness from poor posture while using my computer, which led to thoughts of surgery for my carpal tunnel syndrome. After researching, I tried vitamin B12, which gradually eased my symptoms over a month. I can hardly believe the numbness has vanished. I highly recommend this supplement to anyone with similar issues.
Read More
9
Bone pain disappeared
This supplement tastes like chewable tablets, and my family enjoyed it. My mother experienced a significant positive effect, as her long-standing bone pains vanished.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 25 Researches
8.2
- All Researches
9.5
We investigated the impact of a treatment combining mannitol and vitamin B on piriformis syndrome (PS), which is characterized by sciatic nerve entrapment. In a study involving 22 patients, participants received a five-day intravenous infusion of mannitol alongside a six-week regimen of vitamin B, including B1, B2, and B12.
Our observations highlighted significant improvements in clinical assessments, particularly in tenderness and pain levels assessed by various tests and scales. Notably, the Numeric Rating Scale demonstrated a marked reduction in pain at rest, at night, and during activities, which were all statistically significant. Additionally, the swelling around the sciatic nerve also showed a noteworthy decrease.
While vitamin B12 was part of this combination treatment, we must acknowledge that the study's focus on mannitol alongside the vitamins makes it challenging to isolate vitamin B12's specific effects on back pain alone.
Nevertheless, the results suggest that the combined approach might be a promising alternative for managing PS effectively.
Our observations highlighted significant improvements in clinical assessments, particularly in tenderness and pain levels assessed by various tests and scales. Notably, the Numeric Rating Scale demonstrated a marked reduction in pain at rest, at night, and during activities, which were all statistically significant. Additionally, the swelling around the sciatic nerve also showed a noteworthy decrease.
While vitamin B12 was part of this combination treatment, we must acknowledge that the study's focus on mannitol alongside the vitamins makes it challenging to isolate vitamin B12's specific effects on back pain alone.
Nevertheless, the results suggest that the combined approach might be a promising alternative for managing PS effectively.
Read More
9
Combination therapy shows effectiveness
We set out to explore whether a rehabilitation program combined with specific supplements could effectively treat sciatica in young patients. Our study involved 128 individuals who were divided into three groups: one receiving both rehabilitation and supplements, one only with rehabilitation, and one with only supplements.
After treatment, the group with both rehabilitation and supplements showed significant improvement in pain relief and overall quality of life compared to the others. While the supplement-only group didn’t perform as well, this combination approach proved beneficial, particularly in reducing pain and enhancing stability.
After treatment, the group with both rehabilitation and supplements showed significant improvement in pain relief and overall quality of life compared to the others. While the supplement-only group didn’t perform as well, this combination approach proved beneficial, particularly in reducing pain and enhancing stability.
Read More
We explored how effective vitamin B complex, alongside nonsteroidal anti-inflammatory drugs, is in treating back pain. Our study involved 70 patients divided into two groups, one receiving a vitamin B complex blend and the other a different pain relief combination.
Both groups showed improvement, but the first group experienced a clearer reduction in pain levels over time. By the third visit, they reported significantly less discomfort compared to the second group. Though both treatments were effective, the vitamin B complex showed a more pronounced impact on pain relief and patient satisfaction.
Both groups showed improvement, but the first group experienced a clearer reduction in pain levels over time. By the third visit, they reported significantly less discomfort compared to the second group. Though both treatments were effective, the vitamin B complex showed a more pronounced impact on pain relief and patient satisfaction.
Read More
9
We sought to understand how intramuscular vitamin B12 could help alleviate low back pain in patients with mechanical lumbago. In a rigorous study involving 60 participants, we compared the effects of vitamin B12 to a placebo.
Our findings indicated that those receiving the vitamin reported significantly less pain and disability, as measured by a visual scale and disability questionnaire. Notably, those on vitamin B12 also used less paracetamol than the placebo group.
Overall, our study confirmed that vitamin B12 can be effective for treating low back pain without nutritional deficiency.
Our findings indicated that those receiving the vitamin reported significantly less pain and disability, as measured by a visual scale and disability questionnaire. Notably, those on vitamin B12 also used less paracetamol than the placebo group.
Overall, our study confirmed that vitamin B12 can be effective for treating low back pain without nutritional deficiency.
Read More
9
Vitamin B complex effective for pain
We examined how Dolo-Neurobion, a blend of essential B vitamins and an analgesic, affects acute lumbosacral pain. In a study of 53 patients, we found that this treatment yielded good to excellent results in 77.4% of cases, while 15.1% experienced moderate effects. The approach combined initial parenteral dosing with continuation through oral intake, and any necessary antibiotics were also used. Most notably, we observed no significant side effects, making Dolo-Neurobion a promising option for back pain relief linked to pelvic organ issues.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved iron levels
22 people found this helpful
After struggling with anaemia in 2018 and spending about 8000r on injections and tests, my iron level increased by just 3 units, which was disappointing. I discovered the Aicher website and ordered vitamin B12 along with iron, as B12 aids absorption. After three weeks, my results improved significantly. Additionally, the B vitamins help to decrease homocysteine levels, which is crucial for vascular health.
Read More
9
Numbness resolved
7 people found this helpful
I developed back pain and numbness from poor posture while using my computer, which led to thoughts of surgery for my carpal tunnel syndrome. After researching, I tried vitamin B12, which gradually eased my symptoms over a month. I can hardly believe the numbness has vanished. I highly recommend this supplement to anyone with similar issues.
Read More
9
Bone pain disappeared
This supplement tastes like chewable tablets, and my family enjoyed it. My mother experienced a significant positive effect, as her long-standing bone pains vanished.
Read More
7.5
Reduced joint pain
15 people found this helpful
My endocrinologist recommended this supplement because of elevated homocysteine levels. The vitamins were tasty and taken sublingually. To my surprise, my joint pain, especially in my back due to a herniated lumbar spine, lessened significantly. I started getting sick less often, and I’ve repurchased the vitamins for my grandson, as they truly work.
Read More
9
Muscle pain relief
After using this product, I noticed a significant decrease in my muscle pain.
Read More
Frequently Asked Questions
9
Numbness resolved
7 people found this helpful
I developed back pain and numbness from poor posture while using my computer, which led to thoughts of surgery for my carpal tunnel syndrome. After researching, I tried vitamin B12, which gradually eased my symptoms over a month. I can hardly believe the numbness has vanished. I highly recommend this supplement to anyone with similar issues.
7.5
Reduced joint pain
15 people found this helpful
My endocrinologist recommended this supplement because of elevated homocysteine levels. The vitamins were tasty and taken sublingually. To my surprise, my joint pain, especially in my back due to a herniated lumbar spine, lessened significantly. I started getting sick less often, and I’ve repurchased the vitamins for my grandson, as they truly work.
9
Improved iron levels
22 people found this helpful
After struggling with anaemia in 2018 and spending about 8000r on injections and tests, my iron level increased by just 3 units, which was disappointing. I discovered the Aicher website and ordered vitamin B12 along with iron, as B12 aids absorption. After three weeks, my results improved significantly. Additionally, the B vitamins help to decrease homocysteine levels, which is crucial for vascular health.
9
Bone pain disappeared
This supplement tastes like chewable tablets, and my family enjoyed it. My mother experienced a significant positive effect, as her long-standing bone pains vanished.
9
Muscle pain relief
After using this product, I noticed a significant decrease in my muscle pain.
7.5
Neurological relief
I suffer from a neurological condition causing severe body pain, so I purchased this vitamin for nerve protection. I find more relief when I take it during episodes of pain. Its pleasant taste allows me to consume it quickly, and I believe it also helps with headaches and nausea due to motion sickness.
8
This study evaluated the effects of intramuscular methylcobalamin injections on chronic low back pain.
In a rigorously designed double-blinded, randomized controlled trial, 60 patients were divided into treatment and placebo groups.
We observed significant improvements in pain and disability scores among those receiving methylcobalamin compared to the placebo.
Additionally, the treatment was found to be safe, with only minor side effects reported.
In a rigorously designed double-blinded, randomized controlled trial, 60 patients were divided into treatment and placebo groups.
We observed significant improvements in pain and disability scores among those receiving methylcobalamin compared to the placebo.
Additionally, the treatment was found to be safe, with only minor side effects reported.
8
We conducted a thorough multicenter study involving 418 patients to assess the combined effect of diclofenac and vitamin B1, B6, and B12 on back pain. Over two weeks, we found that more patients achieved complete pain relief with the vitamin combination compared to diclofenac alone.
Specifically, 53 patients on the combination ended treatment early due to sufficient relief, compared to 48 in the diclofenac-only group. The results also showed significant improvements in pain scores, especially for those with severe pain. While some side effects were noted, they were similar between both treatment groups.
Specifically, 53 patients on the combination ended treatment early due to sufficient relief, compared to 48 in the diclofenac-only group. The results also showed significant improvements in pain scores, especially for those with severe pain. While some side effects were noted, they were similar between both treatment groups.
9
Combination therapy shows effectiveness
We set out to explore whether a rehabilitation program combined with specific supplements could effectively treat sciatica in young patients. Our study involved 128 individuals who were divided into three groups: one receiving both rehabilitation and supplements, one only with rehabilitation, and one with only supplements.
After treatment, the group with both rehabilitation and supplements showed significant improvement in pain relief and overall quality of life compared to the others. While the supplement-only group didn’t perform as well, this combination approach proved beneficial, particularly in reducing pain and enhancing stability.
After treatment, the group with both rehabilitation and supplements showed significant improvement in pain relief and overall quality of life compared to the others. While the supplement-only group didn’t perform as well, this combination approach proved beneficial, particularly in reducing pain and enhancing stability.
8
Vitamin B complex aids back pain relief
We examined how well celecoxib and a combined vitamin B complex worked for people experiencing lower back pain, comparing them with meloxicam.
Our findings indicated that celecoxib, especially when paired with Neuromultivit (a vitamin B complex), showed improved effectiveness in relieving both acute and chronic back pain.
Interestingly, while meloxicam offered similar initial pain relief, celecoxib was found to be superior for long-term recovery and quality of life improvements.
This suggests that adding vitamin B to treatment could enhance outcomes for those suffering from chronic lower back pain.
Our findings indicated that celecoxib, especially when paired with Neuromultivit (a vitamin B complex), showed improved effectiveness in relieving both acute and chronic back pain.
Interestingly, while meloxicam offered similar initial pain relief, celecoxib was found to be superior for long-term recovery and quality of life improvements.
This suggests that adding vitamin B to treatment could enhance outcomes for those suffering from chronic lower back pain.
References
- He C, Li J, Hu W, Xiao B, Fan T, et al. Effects of dexamethasone combined with vitamin B12 on percutaneous endoscopic interlaminar discectomy early outcomes: a randomized controlled trial. J Orthop Surg Res. 2024;19:733. 10.1186/s13018-024-05210-z
- Scaturro D, Vitagliani F, Tomasello S, Sconza C, Respizzi S, et al. Combined Rehabilitation with Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferolin Discogenic Sciatica in Young People: A Randomized Clinical Trial. Medicina (Kaunas). 2023;59. 10.3390/medicina59122197
- Antonen EG, Kruchek MM, Nikitina MV. [Evaluation of the effectiveness of treatment of patients with nonspecific pain syndrome in the lower back with celecoxib and a combined preparation of B vitamins]. Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122:65. 10.17116/jnevro202212208165
- Barantsevich ER, Yakovlev AA, Gavrilova EA, Gavrichenko AV, Pushkarev MS, et al. [Study of the clinical efficacy and safety of the scheme of step therapy of nonsteroidal anti-inflammatory drugs and a complex of B vitamins in patients with low back pain]. Zh Nevrol Psikhiatr Im S S Korsakova. 2021;121:67. 10.17116/jnevro202112110167
- Nava-Mesa MO, Aispuru Lanche GR. [Role of B vitamins, thiamine, pyridoxine, and cyanocobalamin in back pain and other musculoskeletal conditions: a narrative review]. Semergen. 2021;47:551. 10.1016/j.semerg.2021.01.010
- Calderon-Ospina CA, Nava-Mesa MO, Arbeláez Ariza CE. Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis. Pain Med. 2020;21:766. 10.1093/pm/pnz216
- Khabirov FA, Khaibullin TI, Granatov EV. [Evaluation of efficiency and safety of adding neuromultivit to basic therapy of vertebrogenic radiculopathy]. Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117:38. 10.17116/jnevro201711710138-43
- Chiu CK, Low TH, Tey YS, Singh VA, Shong HK. The efficacy and safety of intramuscular injections of methylcobalamin in patients with chronic nonspecific low back pain: a randomised controlled trial. Singapore Med J. 2011;52:868.
- Levin OS, Moseĭkin IA. [Vitamin B complex (milgamma) in the treatment of vertebrogenic lumbosacral radiculopathy]. Zh Nevrol Psikhiatr Im S S Korsakova. 2009;109:30.
- Mibielli MA, Geller M, Cohen JC, Goldberg SG, Cohen MT, et al. Diclofenac plus B vitamins versus diclofenac monotherapy in lumbago: the DOLOR study. Curr Med Res Opin. 2009;25:2589. 10.3111/13696990903246911
- Mauro GL, Martorana U, Cataldo P, Brancato G, Letizia G. Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci. 2000;4:53.
- Brüggemann G, Koehler CO, Koch EM. [Results of a double-blind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebrae. A multicenter study]. Klin Wochenschr. 1990;68:116.
- Kuhlwein A, Meyer HJ, Koehler CO. [Reduced diclofenac administration by B vitamins: results of a randomized double-blind study with reduced daily doses of diclofenac (75 mg diclofenac versus 75 mg diclofenac plus B vitamins) in acute lumbar vertebral syndromes]. Klin Wochenschr. 1990;68:107.
- Kunt T. [Complaints in the lumbosacral region and their management with Dolo-Neurobion]. Fortschr Med. 1978;96:299.
- Jurna I. [Analgesic and analgesia-potentiating action of B vitamins]. Schmerz. 1998;12:136.
- Vetter G, Brüggemann G, Lettko M, Schwieger G, Asbach H, et al. [Shortening diclofenac therapy by B vitamins. Results of a randomized double-blind study, diclofenac 50 mg versus diclofenac 50 mg plus B vitamins, in painful spinal diseases with degenerative changes]. Z Rheumatol. 1988;47:351.
- Chen H, Yan L, Wang J, Sun Y, Li X, et al. Methotrexate prevents epidural fibrosis through endoplasmic reticulum stress signalling pathway. Eur J Pharmacol. 2017;796:131. 10.1016/j.ejphar.2016.12.032
- Demko AW, Rustom DH. Progressive Decrease in Function and Ambulation Potential: A Case of Subacute Combined Degeneration. Cureus. 2024;16:e64027. 10.7759/cureus.64027
- Li QD, Yang JS, Gong HL, Wei JM, Wang XF, et al. Can Additional Facet Joint Block Improve the Clinical Outcome of Kyphoplasty for Acute Osteoporotic Vertebral Compression Fractures?. Pain Physician. 2021;24:283.
- Mibielli MAN, Nunes CP, Goldberg H, Buchman L, Oliveira L, et al. Nucleotides Cytidine and Uridine Associated with Vitamin B12 vs B-Complex Vitamins in the Treatment of Low Back Pain: The NUBES Study. J Pain Res. 2020;13:2531. 10.2147/JPR.S277024
- Yang JS, Liu KX, Chu L, Chan YK, Fan H, et al. Cocktail Treatment with a Gelatin Sponge Impregnated with Ropivacaine, Dexamethasone, and Vitamin B12 Promotes Early Postoperative Recovery after Percutaneous Endoscopic Lumbar Discectomy: A Retrospective, Case-Controlled Study. Pain Physician. 2020;23:E211.
- Buesing S, Costa M, Schilling JM, Moeller-Bertram T. Vitamin B12 as a Treatment for Pain. Pain Physician. 2019;22:E45.
- Huang ZF, Lin BQ, Torsha TT, Dilshad S, Yang DS, et al. Effect of Mannitol plus Vitamins B in the management of patients with piriformis syndrome. J Back Musculoskelet Rehabil. 2019;32:329. 10.3233/BMR-170983
- Zhang M, Han W, Hu S, Xu H. Methylcobalamin: a potential vitamin of pain killer. Neural Plast. 2013;2013:424651. 10.1155/2013/424651
- Mibielli MA, Nunes CP, Cohen JC, Scussel AB, Higashi R, et al. Treatment of acute, non-traumatic pain using a combination of diclofenac-cholestyramine, uridine triphosphate, cytidine monophosphate, and hydroxycobalamin. Proc West Pharmacol Soc. 2010;53:5.
