Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.8
USERS' SCORE
Good
Based on 11 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
8
We examined the effects of folic acid supplementation on blood clot events in patients with end-stage kidney disease (ESKD). Analyzing data from over 2,000 patients, we divided them into daily and weekly supplementation groups for a mean follow-up of 5.8 years.
Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.
More research is needed to fully understand the potential of folate in preventing thrombosis in this population.
Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.
More research is needed to fully understand the potential of folate in preventing thrombosis in this population.
Read More
8
We investigated how folic acid (FA) affects blood clotting in response to carbon black exposure. Adult mice were exposed to filtered air or carbon black for 28 days. We found that carbon black increased blood clotting and spurred the development of a certain type of blood cells in the spleen. Interestingly, while carbon black lowered folic acid levels, administering FA helped restore normal coagulation by inhibiting certain enzymes in spleen macrophages. This suggests that folic acid could be beneficial in protecting against increased clotting risks related to carbon black exposure.
Read More
8
In this case, we observed a 19-year-old man who developed severe peripheral neuropathy and central pulmonary embolism after using nitrous oxide recreationally. Elevated levels of homocysteine and methylmalonic acid indicated vitamin B₁₂ inactivation due to the substance. After discontinuing nitrous oxide and undergoing treatment with B vitamins for six months, the patient showed remarkable recovery, with symptoms significantly reduced. This highlights that even low levels of nitrous oxide use can lead to serious health issues, including increased blood clot risks. Awareness is crucial for young individuals who may use this substance.
Read More
Most Useful Reviews
9
Reduced blood clot
59 people found this helpful
I switched to this more affordable complex to lower my homocysteine, which is harmful to blood vessels and can cause blood clots. After taking it, my levels went down from 9.3 to 5.5. I'll continue using it, particularly since it’s essential for girls planning pregnancy.
Read More
9
Normalised blood clot
26 people found this helpful
My husband, who has type 2 diabetes, experienced a drop in vitamins while on medication. He takes this supplement and his blood counts have normalised, along with lower homocysteine levels. It’s effective and necessary for diabetes and blood clots. I highly recommend it!
Read More
9
Blood clot decreased
2 people found this helpful
I began taking this supplement to lower my homocysteine, which was previously high. After two months, my levels dropped significantly, indicating its effectiveness. I’m continuing with a lower dosage and am pleased with the results concerning blood clots.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.8
- All Researches
9.5
We explored the effects of high serum homocysteine levels on blood clot risks within a group of 1,014 patients who experienced thrombotic events. This group underwent a thorough evaluation for various thrombophilic conditions. Notably, we found that 12% of these patients had treatable high homocysteine levels.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
Read More
9
We explored the intriguing case of a 30-year-old woman who experienced severe headaches and neurological symptoms, later linked to blood clotting issues. Initially diagnosed with suspected viral encephalopathy, she faced multiple health challenges including a pulmonary embolism and persistent migraines.
After undergoing various investigations, her doctors discovered she had a dangerously high homocysteine level of over 350 μmol/L, indicating a metabolic disorder known as homocystinuria due to cystathionine β-synthase deficiency. This condition is typically identified in childhood, making her case particularly unusual.
To tackle her elevated homocysteine, a treatment plan involving vitamin B6 (pyridoxine) and betaine was implemented. Remarkably, this approach successfully normalized her homocysteine levels, and she has since avoided any further thrombotic events. Though vitamin B6 is a key player in her treatment, it was administered alongside betaine, which complicates isolating the effects of B6 on blood clot prevention alone.
After undergoing various investigations, her doctors discovered she had a dangerously high homocysteine level of over 350 μmol/L, indicating a metabolic disorder known as homocystinuria due to cystathionine β-synthase deficiency. This condition is typically identified in childhood, making her case particularly unusual.
To tackle her elevated homocysteine, a treatment plan involving vitamin B6 (pyridoxine) and betaine was implemented. Remarkably, this approach successfully normalized her homocysteine levels, and she has since avoided any further thrombotic events. Though vitamin B6 is a key player in her treatment, it was administered alongside betaine, which complicates isolating the effects of B6 on blood clot prevention alone.
Read More
9
We observed a fascinating case involving a 14-year-old girl who experienced severe headaches and nausea, leading to the discovery of cerebral venous thrombosis (CVT) and significantly elevated plasma homocysteine levels. Through comprehensive genetic testing, we identified a rare genetic change called loss of heterozygosity (LOH) affecting the methylenetetrahydrofolate reductase (MTHFR) gene, which plays a crucial role in processing folate in the body.
In treating the patient, we included supplementary folate along with anticoagulants to manage the thrombosis. While we noted improvements in her symptoms and a decrease in thrombosis severity, it is essential to recognize that the isolated effect of folate on blood clotting cannot be fully established due to the concurrent use of anticoagulants and other vitamin supplements. Therefore, while folate forms part of the treatment, its direct impact on clot formation requires further investigation.
The combination of anticoagulants, nutritional supplements, and genetic insights showcases an integrated approach to managing complex medical issues, highlighting that while folate is beneficial, its role is part of a broader strategy.
In treating the patient, we included supplementary folate along with anticoagulants to manage the thrombosis. While we noted improvements in her symptoms and a decrease in thrombosis severity, it is essential to recognize that the isolated effect of folate on blood clotting cannot be fully established due to the concurrent use of anticoagulants and other vitamin supplements. Therefore, while folate forms part of the treatment, its direct impact on clot formation requires further investigation.
The combination of anticoagulants, nutritional supplements, and genetic insights showcases an integrated approach to managing complex medical issues, highlighting that while folate is beneficial, its role is part of a broader strategy.
Read More
9
We encountered a compelling case that sheds light on the relationship between vitamin B-12 deficiency and a condition known as pseudo-thrombotic microangiopathic anemia. This condition often mimics more severe blood disorders requiring aggressive treatments. However, during this case, we observed that addressing the deficiency with vitamin B-12 injections led to a significant improvement.
Our patient, a 51-year-old man, originally presented with symptoms like weakness and difficulty breathing, which raised alarms for potential blood issues. Upon extensive examination, he was found to have severe microangiopathic anemia with initial concerns pointing towards serious conditions like thrombotic thrombocytopenic purpura (TTP). Thankfully, after treatment with vitamin B-12 to combat the deficiency caused by pernicious anemia, the patient saw a marked recovery in both his symptoms and blood parameters.
This case highlights the importance of recognizing vitamin deficiencies as a potential cause of blood disorders. It demonstrates that what may appear to be serious hematological issues can sometimes be addressed with simple vitamin supplementation, likely saving patients from unnecessary invasive treatments.
Our patient, a 51-year-old man, originally presented with symptoms like weakness and difficulty breathing, which raised alarms for potential blood issues. Upon extensive examination, he was found to have severe microangiopathic anemia with initial concerns pointing towards serious conditions like thrombotic thrombocytopenic purpura (TTP). Thankfully, after treatment with vitamin B-12 to combat the deficiency caused by pernicious anemia, the patient saw a marked recovery in both his symptoms and blood parameters.
This case highlights the importance of recognizing vitamin deficiencies as a potential cause of blood disorders. It demonstrates that what may appear to be serious hematological issues can sometimes be addressed with simple vitamin supplementation, likely saving patients from unnecessary invasive treatments.
Read More
8
We examined the impact of vitamin B12 deficiency on cerebral venous sinus thrombosis (CVST) through a case series involving three patients. Each case presented symptoms like headaches and, in some instances, visual disturbances. All patients showed elevated homocysteine levels and had low vitamin B12. Treatment included anticoagulation therapy and vitamin supplementation, leading to positive responses and, in two cases, resolution of thrombosis. This suggests that monitoring vitamin B12 levels, particularly in vegetarian diets, is crucial and could help prevent CVST.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced blood clot
59 people found this helpful
I switched to this more affordable complex to lower my homocysteine, which is harmful to blood vessels and can cause blood clots. After taking it, my levels went down from 9.3 to 5.5. I'll continue using it, particularly since it’s essential for girls planning pregnancy.
Read More
9
Normalised blood clot
26 people found this helpful
My husband, who has type 2 diabetes, experienced a drop in vitamins while on medication. He takes this supplement and his blood counts have normalised, along with lower homocysteine levels. It’s effective and necessary for diabetes and blood clots. I highly recommend it!
Read More
9
Blood clot decreased
2 people found this helpful
I began taking this supplement to lower my homocysteine, which was previously high. After two months, my levels dropped significantly, indicating its effectiveness. I’m continuing with a lower dosage and am pleased with the results concerning blood clots.
Read More
7.5
Improved blood clot
241 people found this helpful
Super! I take this supplement periodically to correct my anemia and low cholesterol. It's very effective; my tests showed a deficiency in B12 and B9, leading to lower haemoglobin. After taking this, my performance improved along with my lipid profile. I am confident this supplement significantly contributed to my results, which physical activity and diet couldn't achieve alone.
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9
Blood clot improvement
84 people found this helpful
I take this for my son with ADHD. Recommended by our neurologist, it has improved his blood counts and lowered homocysteine. My son dissolves the tablets easily due to their pleasant taste. We are satisfied with this supplement.
Read More
Frequently Asked Questions
9
Blood clot decreased
2 people found this helpful
I began taking this supplement to lower my homocysteine, which was previously high. After two months, my levels dropped significantly, indicating its effectiveness. I’m continuing with a lower dosage and am pleased with the results concerning blood clots.
9
Lowered homocysteine
1 people found this helpful
I found this vitamin B complex excellent for lowering homocysteine, which I took alongside TMG. B vitamins are crucial for cellular metabolism, supporting the immune system, and regulating blood sugar, thus preventing diabetes. They are also helpful for neurological and mental health issues like depression and apathy, and are recommended for anaemia. After two months of use, my homocysteine levels significantly improved.
7.5
Blood clot relief
20 people found this helpful
After struggling with anaemia for an extended time, I incorporated sublingual tablets into my routine. Over a month and a half, my blood values improved substantially, and I feel much better physically. This supplement has enhanced my sleep quality and mental clarity, crucial for avoiding blood clots.
9
Reduced blood clot
59 people found this helpful
I switched to this more affordable complex to lower my homocysteine, which is harmful to blood vessels and can cause blood clots. After taking it, my levels went down from 9.3 to 5.5. I'll continue using it, particularly since it’s essential for girls planning pregnancy.
9
Normalised blood clot
26 people found this helpful
My husband, who has type 2 diabetes, experienced a drop in vitamins while on medication. He takes this supplement and his blood counts have normalised, along with lower homocysteine levels. It’s effective and necessary for diabetes and blood clots. I highly recommend it!
7.5
Effective for blood clot
22 people found this helpful
After suffering from anaemia, I sought alternatives beyond expensive injections, finding this vitamin B complex. It effectively raised my iron levels and notably lowered my homocysteine, vital for preventing blood clots. This combined with my iron supplement gave me much better results.
8
We examined the impact of vitamin B12 deficiency on cerebral venous sinus thrombosis (CVST) through a case series involving three patients. Each case presented symptoms like headaches and, in some instances, visual disturbances. All patients showed elevated homocysteine levels and had low vitamin B12. Treatment included anticoagulation therapy and vitamin supplementation, leading to positive responses and, in two cases, resolution of thrombosis. This suggests that monitoring vitamin B12 levels, particularly in vegetarian diets, is crucial and could help prevent CVST.
8
Vitamin B12 aids in thromboembolism recovery
We observed a rare case of cerebral venous thrombosis (CVT) associated with hyperhomocysteinemia and iron-deficiency anemia due to autoimmune gastritis.
The patient, a 47-year-old woman, experienced serious symptoms like impaired consciousness and motor difficulties. After thorough examinations like CT and MRI, she was treated with anticoagulants and given iron and vitamin B12 supplements.
Remarkably, the patient showed significant improvement and was discharged without neurological deficits, highlighting the potential role of vitamin B12 and iron in managing conditions linked to blood clots.
The patient, a 47-year-old woman, experienced serious symptoms like impaired consciousness and motor difficulties. After thorough examinations like CT and MRI, she was treated with anticoagulants and given iron and vitamin B12 supplements.
Remarkably, the patient showed significant improvement and was discharged without neurological deficits, highlighting the potential role of vitamin B12 and iron in managing conditions linked to blood clots.
8
We examined the effects of folic acid supplementation on blood clot events in patients with end-stage kidney disease (ESKD). Analyzing data from over 2,000 patients, we divided them into daily and weekly supplementation groups for a mean follow-up of 5.8 years.
Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.
More research is needed to fully understand the potential of folate in preventing thrombosis in this population.
Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.
More research is needed to fully understand the potential of folate in preventing thrombosis in this population.
References
- Baby N, George M, Rajasekharan A, Ajith S, Zabeer M, et al. Cerebral Venous Sinus Thrombosis Secondary to Vitamin B12 Deficiency - A Case Series with Emphasis on Food Fortification. Ann Afr Med. 2024;23:496. 10.4103/aam.aam_138_23
- Mochizuki T, Ryu B, Kushi K, Shima S, Sato S, et al. Cerebral venous thrombosis associated with hyperhomocysteinemia and iron-deficiency anemia induced by autoimmune gastritis: A case report and literature review. Neuroradiol J. 2023;36:491. 10.1177/19714009221147224
- Tu YR, Tu KH, Lee CC, Fan PC, Yen CL, et al. Supplementation with Folic Acid and Cardiovascular Outcomes in End-Stage Kidney Disease: A Multi-Institution Cohort Study. Nutrients. 2022;14. 10.3390/nu14194162
- Meng Q, Li B, Huang N, Wei S, Ren Q, et al. Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential. J Hazard Mater. 2022;424:127354. 10.1016/j.jhazmat.2021.127354
- Pedersen OB, Hvas AM, Grove EL. A 19-Year-Old Man with a History of Recreational Inhalation of Nitrous Oxide with Severe Peripheral Neuropathy and Central Pulmonary Embolism. Am J Case Rep. 2021;22:e931936. 10.12659/AJCR.931936
- Al Sulaiman K, Aljuhani O, Al Dossari M, Alshahrani A, Alharbi A, et al. Evaluation of thiamine as adjunctive therapy in COVID-19 critically ill patients: a two-center propensity score matched study. Crit Care. 2021;25:223. 10.1186/s13054-021-03648-9
- Woods E, Dawson C, Senthil L, Geberhiwot T. Cerebral venous thrombosis as the first presentation of classical homocystinuria in an adult patient. BMJ Case Rep. 2017;2017. 10.1136/bcr-2016-217477
- Kotwal J, Kotwal A, Bhalla S, Singh PK, Nair V. Effectiveness of homocysteine lowering vitamins in prevention of thrombotic tendency at high altitude area: A randomized field trial. Thromb Res. 2015;136:758. 10.1016/j.thromres.2015.08.001
- Glueck CJ, Smith D, Gandhi N, Hemachandra K, Shah P, et al. Treatable high homocysteine alone or in concert with five other thrombophilias in 1014 patients with thrombotic events. Blood Coagul Fibrinolysis. 2015;26:736. 10.1097/MBC.0000000000000276
- Awan Z, Aljenedil S, Rosenblatt DS, Cusson J, Gilfix BM, et al. Severe hyperhomocysteinemia due to cystathionine β-synthase deficiency, and Factor V Leiden mutation in a patient with recurrent venous thrombosis. Thromb J. 2014;12:30. 10.1186/s12959-014-0030-0
- Liu F, Zhu L, Chen P, Shi Z, Liu S. [Two cases of pulmonary thromboembolism associated with protein C and protein S deficiency and literature review]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013;38:971. 10.3969/j.issn.1672-7347.2013.09.018
- Mendiratta V, Prakash A, Jain A, Jain M. Isolated distal cutaneous thrombosis: an unusual presentation and an interesting etiology. Indian J Dermatol Venereol Leprol. 2011;77:494. 10.4103/0378-6323.82412
- Dworakowska D, Kazimierska E, Weyer-Hepka J, Dworakowski R, Jakóbiewicz-Banecka J, et al. [Hyperhomocysteinemia complicated by myocardial infarction and portal vein thrombosis--case report]. Pol Arch Med Wewn. 2006;115:234.
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. 10.1186/s12883-023-03200-y
- Cao Y, Yao T, Chen H, Liu H, Li C, et al. The association of serum folate and homocysteine on venous thromboembolism in patients with colorectal cancer: a cross-sectional study. Transl Cancer Res. 2023;12:125. 10.21037/tcr-22-2839
- Lin SS, Fan IW, Chen CY, Su YJ. A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report. Med Int (Lond). 2022;2:20. 10.3892/mi.2022.45
- Sikora M, Skrzydlewski P, Perła-Kaján J, Jakubowski H. Homocysteine thiolactone contributes to the prognostic value of fibrin clot structure/function in coronary artery disease. PLoS One. 2022;17:e0275956. 10.1371/journal.pone.0275956
- Hudson JL, Laura DM, Berrocal AM. CENTRAL RETINAL VEIN OCCLUSION IN 12-YEAR-OLD GIRL WITH METHYLENETETRAHYDROFOLATE REDUCTASE MUTATION: A CASE REPORT AND REVIEW OF THE LITERATURE. Retin Cases Brief Rep. 2023;17:734. 10.1097/ICB.0000000000001283
- Chaloulis SK, Tsaousis KT. Cystoid Macular Edema Associated With Venous Stasis in a Patient With Previously Undiagnosed Hyperhomocysteinemia. Cureus. 2021;13:e20782. 10.7759/cureus.20782
- Mohamed Yile MEH, Berteau E, Ramdani N, Mouyen T, Ferrier N. Uncommon Thromboembolic Events in Young Adults: A Rare Cause Uncovered. Cureus. 2025;17:e76962. 10.7759/cureus.76962
- Haddad F, Boukhal Z, El Rhaoussi FZ, Tahiri M, Hliwa W, et al. Neurological and Cardiovascular Complications Revealing Biermer's Disease: A Case Report. Cureus. 2024;16:e58601. 10.7759/cureus.58601
- Khaliq L, Kabir KF, Pyai K, Hadid T, Collins-Hamel B. A Simple Vitamin Deficiency With Life-Threatening Complications: A Case of B12 Deficiency and Hyperhomocysteinemia-Induced Thrombosis. Cureus. 2023;15:e42908. 10.7759/cureus.42908
- Banjongjit A, Sutamnartpong P, Mahanupap P, Phanachet P, Thanakitcharu S. Nitrous Oxide-Induced Cerebral Venous Thrombosis: A Case Report, Potential Mechanisms, and Literature Review. Cureus. 2023;15:e41428. 10.7759/cureus.41428
- Landry I, Chowdhury T, Hussein S, Thomas L. Life-Threatening Microangiopathy or Vitamin Deficiency: A Case Report of the Clinical Manifestations of Pseudo-Thrombotic Microangiopathic Anemia. Cureus. 2021;13:e20228. 10.7759/cureus.20228
