Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.4
USERS' SCORE
Good
Based on 109 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Quercetin
500 mg
†
Top Medical Research Studies
9
Quercetin may alleviate allergy symptoms
We conducted a study involving 66 Japanese adults suffering from allergy symptoms, focusing on the potential of a quercetin-containing supplement. Participants took either the supplement or a placebo daily for four weeks.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Read More
8
We explored how quercetin may help alleviate allergies by examining its impact on certain immune cells involved in allergic reactions. Using different types of mast cells, we observed that quercetin triggered the production of heme oxygenase-1 (HO-1), which plays a key role in this process.
Interestingly, when we inhibited HO-1, the protective effects of quercetin vanished, suggesting that the Nrf2-HO-1 pathway is crucial for its anti-allergic actions. Our findings strongly indicate that quercetin could be valuable in managing allergic responses.
Interestingly, when we inhibited HO-1, the protective effects of quercetin vanished, suggesting that the Nrf2-HO-1 pathway is crucial for its anti-allergic actions. Our findings strongly indicate that quercetin could be valuable in managing allergic responses.
Read More
9.5
We delved into the effects of quercetin on peanut-induced anaphylactic reactions using a rat model. The study involved sensitized Wistar rats divided into treatment and control groups. After four weeks of quercetin treatment, we observed a significant decrease in plasma histamine levels and anaphylactic responses.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Read More
Most Useful Reviews
10
Life-changing solution
140 people found this helpful
It saved me from my chronic allergies in spring and summer. I suffered from allergies until I was 30 years old when I discovered Quercetin. More people should know about this product, as even doctors often prescribe ineffective medications that only temporarily alleviate symptoms.
Read More
10
Magical relief
87 people found this helpful
Quercetin has been nothing short of magic for treating my allergies, particularly during mastocytosis attacks. After years of suffering, I found that it effectively blocked histamine action, allowing me to eat foods that typically triggered reactions. I recommend taking it carefully, splitting doses to avoid sensitivity, but the product quality is excellent. It's a must-try for anyone with allergies.
Read More
9
Reduced reliance on Zyrtec
83 people found this helpful
Quercetin has dramatically reduced my use of Zyrtec! I used to take Zyrtec daily for indoor and outdoor allergies. After developing rashes from allergy shots, I switched to taking 1 or 2 quercetin tablets daily. It seems to alleviate most of my allergies. While I still experience some symptoms, I use less than 50 Zyrtec a year now instead of 365.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.4
- All Researches
9.5
We delved into the effects of quercetin on peanut-induced anaphylactic reactions using a rat model. The study involved sensitized Wistar rats divided into treatment and control groups. After four weeks of quercetin treatment, we observed a significant decrease in plasma histamine levels and anaphylactic responses.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Read More
9
Quercetin shows promise in allergies
We delved into the potential of quercetin as a therapeutic option for treating allergic rhinitis, a common condition affecting roughly 40% of the global population. This study utilized various in-silico approaches, such as network pharmacology and molecular docking, to identify compounds from traditional medicinal plants and assess their effectiveness.
Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.
While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.
Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.
While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.
Read More
9
We investigated how a specific leaf extract affects allergic inflammation in immune cell lines.
Our study revealed that this extract notably reduced the release of allergy-related chemicals like histamine. It also decreased inflammatory responses by limiting the activity of certain enzymes involved in inflammation.
The findings suggest that the active compounds in the extract, specifically quercetin and kaempferol, could offer therapeutic benefits in managing allergies.
Our study revealed that this extract notably reduced the release of allergy-related chemicals like histamine. It also decreased inflammatory responses by limiting the activity of certain enzymes involved in inflammation.
The findings suggest that the active compounds in the extract, specifically quercetin and kaempferol, could offer therapeutic benefits in managing allergies.
Read More
9
Quercetin may alleviate allergy symptoms
We conducted a study involving 66 Japanese adults suffering from allergy symptoms, focusing on the potential of a quercetin-containing supplement. Participants took either the supplement or a placebo daily for four weeks.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Read More
9
Holo-BLG offers allergy protection
We investigated how the milk protein beta-lactoglobulin (BLG), particularly its holo form, could shield against pollen allergies. In our study, BALB/c mice received nasal pretreatments with holo-BLG containing quercetin-iron complexes before being exposed to birch pollen allergens.
We observed that this treatment led to lower levels of allergy-related antibodies and reduced inflammatory responses. Essentially, holo-BLG appeared to offer protection from allergic reactions not just specifically to itself but also to unrelated allergens, suggesting a potential role in enhancing immune response against various pollen allergens.
We observed that this treatment led to lower levels of allergy-related antibodies and reduced inflammatory responses. Essentially, holo-BLG appeared to offer protection from allergic reactions not just specifically to itself but also to unrelated allergens, suggesting a potential role in enhancing immune response against various pollen allergens.
Read More
User Reviews
USERS' SCORE
Good
Based on 109 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
10
Life-changing solution
140 people found this helpful
It saved me from my chronic allergies in spring and summer. I suffered from allergies until I was 30 years old when I discovered Quercetin. More people should know about this product, as even doctors often prescribe ineffective medications that only temporarily alleviate symptoms.
Read More
10
Magical relief
87 people found this helpful
Quercetin has been nothing short of magic for treating my allergies, particularly during mastocytosis attacks. After years of suffering, I found that it effectively blocked histamine action, allowing me to eat foods that typically triggered reactions. I recommend taking it carefully, splitting doses to avoid sensitivity, but the product quality is excellent. It's a must-try for anyone with allergies.
Read More
9
Reduced reliance on Zyrtec
83 people found this helpful
Quercetin has dramatically reduced my use of Zyrtec! I used to take Zyrtec daily for indoor and outdoor allergies. After developing rashes from allergy shots, I switched to taking 1 or 2 quercetin tablets daily. It seems to alleviate most of my allergies. While I still experience some symptoms, I use less than 50 Zyrtec a year now instead of 365.
Read More
9
Seasonal relief
68 people found this helpful
Quercetin, especially with nettle extract, can significantly ease seasonal allergies if taken beforehand. Many users report complete symptom elimination or minimal reactions. As an antioxidant, it also benefits overall health and supports blood vessels. In combination with Gotu Kola extract, it helps with venous issues like spider veins.
Read More
10
Cured husband's allergies
40 people found this helpful
Praise the Lord, it cured my husband's allergies! After trying numerous OTC allergy medications, he was still miserable. Following research, I suggested quercetin combined with Nature's Way Nettle leaf to help. It was miraculous; he went from looking dreadful to perfectly normal! No more drugs and chemicals, and he now happily takes them.
Read More
Frequently Asked Questions
9
Highly recommended
5 people found this helpful
For allergies, it works beautifully! I’ve taken Quercetin on and off, and Jarrow is a superb brand. Along with Vitamin C, my allergies clear up in a few days. I highly recommend the combination!
9
Effective against colds
5 people found this helpful
Good for allergies. I take it with vitamin C for optimal effectiveness. If I take 1500mg at the onset of a cold, it clears my symptoms overnight.
9
Minimises reactions
14 people found this helpful
My alternative medicine doctor recommended Quercetin alongside my allergy medication. It helps keep my reactions low, especially when I anticipate problematic foods. I take several capsules daily, and it has proven effective in managing my allergies.
9
Seasonal relief
68 people found this helpful
Quercetin, especially with nettle extract, can significantly ease seasonal allergies if taken beforehand. Many users report complete symptom elimination or minimal reactions. As an antioxidant, it also benefits overall health and supports blood vessels. In combination with Gotu Kola extract, it helps with venous issues like spider veins.
7.5
Eased eczema symptoms
8 people found this helpful
Quercetin significantly helped my husband manage his severe eczema caused by allergies, allowing him to sleep better. It's effective, particularly taken before bed for calming hypersensitivity reactions.
9
Reduces allergy symptoms
2 people found this helpful
Quercetin effectively reduces allergy symptoms. I take 500 mg three times a day, which helps reduce inflammation and supports my immune system. It also strengthens my respiratory system for seasonal allergies and supports neurogenic processes.
9
Goodbye antihistamines
2 people found this helpful
Quercetin is a fantastic supplement for those suffering from allergies, helping me to avoid over-the-counter antihistamines.
7.5
Reduces congestion
6 people found this helpful
Works well for reducing allergic rhinitis. It significantly decreases congestion due to allergies. I typically take one twice a day or two when symptoms are strong, and I appreciate that it doesn’t contain bromelain, which I’m sensitive to.
10
Magical relief
87 people found this helpful
Quercetin has been nothing short of magic for treating my allergies, particularly during mastocytosis attacks. After years of suffering, I found that it effectively blocked histamine action, allowing me to eat foods that typically triggered reactions. I recommend taking it carefully, splitting doses to avoid sensitivity, but the product quality is excellent. It's a must-try for anyone with allergies.
9
We investigated how a specific leaf extract affects allergic inflammation in immune cell lines.
Our study revealed that this extract notably reduced the release of allergy-related chemicals like histamine. It also decreased inflammatory responses by limiting the activity of certain enzymes involved in inflammation.
The findings suggest that the active compounds in the extract, specifically quercetin and kaempferol, could offer therapeutic benefits in managing allergies.
Our study revealed that this extract notably reduced the release of allergy-related chemicals like histamine. It also decreased inflammatory responses by limiting the activity of certain enzymes involved in inflammation.
The findings suggest that the active compounds in the extract, specifically quercetin and kaempferol, could offer therapeutic benefits in managing allergies.
9
Quercetin may alleviate allergy symptoms
We conducted a study involving 66 Japanese adults suffering from allergy symptoms, focusing on the potential of a quercetin-containing supplement. Participants took either the supplement or a placebo daily for four weeks.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
7
Quercetin shows potential for allergies
We explored the potential benefits of quercetin and other dietary components in managing allergic reactions. Research indicates that quercetin may play a role in reducing symptoms of allergic rhinitis by suppressing inflammatory mediators from mast cells, essential players in allergic responses.
Our analysis highlighted that while quercetin shows promise, it’s one of several dietary factors needing further investigation, especially due to concerns about how well our bodies can use these nutrients. Continued research on improving their bioavailability is crucial for maximizing their effects on allergies.
Our analysis highlighted that while quercetin shows promise, it’s one of several dietary factors needing further investigation, especially due to concerns about how well our bodies can use these nutrients. Continued research on improving their bioavailability is crucial for maximizing their effects on allergies.
7
We investigated how quercetin works alongside fucoidan to help manage allergies, particularly type I hypersensitivity like hay fever. Our findings showed that when quercetin was taken together with fucoidan, even lower amounts could still provide significant anti-allergic effects.
Interestingly, taking just 50 μg of quercetin in combination with fucoidan produced similar benefits as higher doses alone. This suggests that the combination of these ingredients could lessen the need for larger fucoidan servings while still being effective.
It seems we’ve found a promising food combination that enhances allergy relief!
Interestingly, taking just 50 μg of quercetin in combination with fucoidan produced similar benefits as higher doses alone. This suggests that the combination of these ingredients could lessen the need for larger fucoidan servings while still being effective.
It seems we’ve found a promising food combination that enhances allergy relief!
References
- Islam KMT, Mahmud S. In-silico exploring pathway and mechanism-based therapeutics for allergic rhinitis: Network pharmacology, molecular docking, ADMET, quantum chemistry and machine learning based QSAR approaches. Comput Biol Med. 2025;187:109754. doi:10.1016/j.compbiomed.2025.109754
- Bunddulam P, Nakamura M, Zorig A, Hinata Y, Takasugi M, et al. Effects of Leaf Extract on Allergic Inflammation in Immune Cell Lines. Prev Nutr Food Sci. 2025;30:68. doi:10.3746/pnf.2025.30.1.68
- Kaag S, Lorentz A. Effects of Dietary Components on Mast Cells: Possible Use as Nutraceuticals for Allergies?. Cells. 2023;12. doi:10.3390/cells12222602
- Mizuno M, Fujioka A, Bitani S, Minato KI, Sakakibara H. Anti-Allergic Activity of Fucoidan Can Be Enhanced by Coexistence with Quercetin. Int J Mol Sci. 2022;23. doi:10.3390/ijms232012163
- Yamada S, Shirai M, Inaba Y, Takara T. Effects of repeated oral intake of a quercetin-containing supplement on allergic reaction: a randomized, placebo-controlled, double-blind parallel-group study. Eur Rev Med Pharmacol Sci. 2022;26:4331. doi:10.26355/eurrev_202206_29072
- Afify SM, Pali-Schöll I, Hufnagl K, Hofstetter G, El-Bassuoni MA, et al. Bovine Holo-Beta-Lactoglobulin Cross-Protects Against Pollen Allergies in an Innate Manner in BALB/c Mice: Potential Model for the Farm Effect. Front Immunol. 2021;12:611474. doi:10.3389/fimmu.2021.611474
- Ding Y, Che D, Li C, Cao J, Wang J, et al. Quercetin inhibits Mrgprx2-induced pseudo-allergic reaction via PLCγ-IP3R related Ca fluctuations. Int Immunopharmacol. 2019;66:185. doi:10.1016/j.intimp.2018.11.025
- Carbone ML, Lulli D, Passarelli F, Pastore S. Topical Plant Polyphenols Prevent Type I Interferon Signaling in the Skin and Suppress Contact Hypersensitivity. Int J Mol Sci. 2018;19. doi:10.3390/ijms19092652
- Takasugi M, Muta E, Yamada K, Arai H. A new method to evaluate anti-allergic effect of food component by measuring leukotriene B from a mouse mast cell line. Cytotechnology. 2018;70:177. doi:10.1007/s10616-017-0129-9
- Kim M, Lim SJ, Kang SW, Um BH, Nho CW. Aceriphyllum rossii extract and its active compounds, quercetin and kaempferol inhibit IgE-mediated mast cell activation and passive cutaneous anaphylaxis. J Agric Food Chem. 2014;62:3750. doi:10.1021/jf405486c
- Shishehbor F, Behroo L, Ghafouriyan Broujerdnia M, Namjoyan F, Latifi SM. Quercetin effectively quells peanut-induced anaphylactic reactions in the peanut sensitized rats. Iran J Allergy Asthma Immunol. 2010;9:27.
- Matsushima M, Takagi K, Ogawa M, Hirose E, Ota Y, et al. Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells. Inflamm Res. 2009;58:705. doi:10.1007/s00011-009-0039-1
- Cruz EA, Da-Silva SA, Muzitano MF, Silva PM, Costa SS, et al. Immunomodulatory pretreatment with Kalanchoe pinnata extract and its quercitrin flavonoid effectively protects mice against fatal anaphylactic shock. Int Immunopharmacol. 2008;8:1616. doi:10.1016/j.intimp.2008.07.006
- Shaik YB, Castellani ML, Perrella A, Conti F, Salini V, et al. Role of quercetin (a natural herbal compound) in allergy and inflammation. J Biol Regul Homeost Agents. 2006;20:47.
- Rogerio AP, Kanashiro A, Fontanari C, da Silva EV, Lucisano-Valim YM, et al. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res. 2007;56:402.
