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SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.7
USERS' SCORE
Excellent
Based on 23 Reviews
9.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Quercetin
500 mg
†
Top Medical Research Studies
9
Quercetin alleviates asthma symptoms
Quercetin inhibits ferroptosis through the SIRT1/Nrf2/HO-1 signaling pathway and alleviates asthma disease.
Potential but needs cautious application
We explored how quercetin, a natural compound found in fruits and vegetables, can impact asthma symptoms. Using an ovalbumin-induced mouse model of asthma, we aimed to uncover whether quercetin can help inhibit a process known as ferroptosis, potentially offering a new therapeutic approach for asthma sufferers.
Our findings showed that quercetin effectively reduced inflammation in the asthmatic mice. Specifically, it lowered levels of inflammatory factors such as IL-4, IL-5, and IL-13—substances typically elevated during an asthma attack. Notably, we also observed that quercetin increased the levels of superoxide dismutase, an important antioxidant, while decreasing malondialdehyde and ferric ions that are associated with oxidative stress.
Additionally, quercetin appeared to boost the expression of key proteins involved in defending against oxidative stress, specifically SIRT1, Nrf2, and HO-1. This suggests that quercetin not only helps combat inflammation but may also protect against cellular damage within the lungs. Overall, our study indicates that quercetin holds promise as a beneficial treatment for asthma by addressing both inflammatory and oxidative stress pathways.
Our findings showed that quercetin effectively reduced inflammation in the asthmatic mice. Specifically, it lowered levels of inflammatory factors such as IL-4, IL-5, and IL-13—substances typically elevated during an asthma attack. Notably, we also observed that quercetin increased the levels of superoxide dismutase, an important antioxidant, while decreasing malondialdehyde and ferric ions that are associated with oxidative stress.
Additionally, quercetin appeared to boost the expression of key proteins involved in defending against oxidative stress, specifically SIRT1, Nrf2, and HO-1. This suggests that quercetin not only helps combat inflammation but may also protect against cellular damage within the lungs. Overall, our study indicates that quercetin holds promise as a beneficial treatment for asthma by addressing both inflammatory and oxidative stress pathways.
Read More
9
Quercetin shows promise for asthma
The Alleviating Impacts of Quercetin on Inflammation and Oxidant-antioxidant Imbalance in Rats with Allergic Asthma.
Directly addresses quercetin's effects
We explored the impact of quercetin, a natural plant compound, on asthma by testing its anti-inflammatory and antioxidant properties in a controlled study with rats. Asthma was induced in the rats using a substance called ovalbumin, and they were divided into four groups: a control group, an asthma group treated with a saline solution, another asthma group treated with dexamethasone (a common asthma medication), and a group treated with quercetin.
After one week of daily injections of quercetin and dexamethasone, we noted significant changes in various biological markers. Quercetin appeared to lower the expression of several inflammatory factors linked to asthma, such as Gata-3 and TNF-α. It also positively influenced oxidative stress by reducing levels of malondialdehyde, a marker of cell damage, while boosting antioxidants in both the serum and lung tissue.
Our findings suggest that quercetin does more than just alleviate inflammatory responses; it also enhances the body's defenses against oxidative stress, particularly in the lungs. Overall, quercetin shows great potential as an effective treatment for asthma, helping to manage both inflammation and oxidative stress at the tissue level.
After one week of daily injections of quercetin and dexamethasone, we noted significant changes in various biological markers. Quercetin appeared to lower the expression of several inflammatory factors linked to asthma, such as Gata-3 and TNF-α. It also positively influenced oxidative stress by reducing levels of malondialdehyde, a marker of cell damage, while boosting antioxidants in both the serum and lung tissue.
Our findings suggest that quercetin does more than just alleviate inflammatory responses; it also enhances the body's defenses against oxidative stress, particularly in the lungs. Overall, quercetin shows great potential as an effective treatment for asthma, helping to manage both inflammation and oxidative stress at the tissue level.
Read More
9
Quercetin improves asthma symptoms
Quercetin Alleviates Asthma-Induced Airway Inflammation and Remodeling through Downregulating Periostin via Blocking TGF-β1/Smad Pathway.
Direct investigation of quercetin's effects
We explored how quercetin, a natural compound, may help alleviate asthma symptoms. The focus was on its potential role regarding periostin, a protein linked to inflammatory responses in the lungs, and its interaction with the TGF-β1/Smad pathway, a key signaling system in asthma.
To gain insights, we constructed a model using mice sensitized to ovalbumin—an allergen that triggers asthma—and administered quercetin among other treatments. We carefully observed changes in inflammatory responses, airway remodeling, and hyperresponsiveness, using various tests and analyses to measure inflammation markers and proteins involved in airway fibrosis.
Our findings revealed that quercetin significantly reduced the levels of periostin and inhibited airway inflammation and fibrosis. It also showed a tendency to reduce airway hyperreactivity, suggesting that quercetin works through suppressing the TGF-β1/Smad signaling pathway.
Overall, our study supports quercetin as a promising candidate for asthma treatment, highlighting how it effectively targets specific pathways involved in the disease, offering a protective effect against its symptoms.
To gain insights, we constructed a model using mice sensitized to ovalbumin—an allergen that triggers asthma—and administered quercetin among other treatments. We carefully observed changes in inflammatory responses, airway remodeling, and hyperresponsiveness, using various tests and analyses to measure inflammation markers and proteins involved in airway fibrosis.
Our findings revealed that quercetin significantly reduced the levels of periostin and inhibited airway inflammation and fibrosis. It also showed a tendency to reduce airway hyperreactivity, suggesting that quercetin works through suppressing the TGF-β1/Smad signaling pathway.
Overall, our study supports quercetin as a promising candidate for asthma treatment, highlighting how it effectively targets specific pathways involved in the disease, offering a protective effect against its symptoms.
Read More
Most Useful Reviews
10
Expedites relief
Today is my first day in ages without using my inhaler, thanks to quercetin. It opens up my lungs, even during an asthma attack, in just a few minutes. I love it!
Read More
10
Symptom relief
Close to magic! After years struggling with severe adrenal fatigue and asthma, Quercetin has worked wonders. I no longer have allergic reactions to foods or wine. I take 500 mg, splitting the dose, especially after meals, and have found it effective. The product quality is excellent, and I’m grateful to the producers. Quercetin should be highly recommended for anyone suffering from allergies and asthma.
Read More
8.8
Feeling better
Although I have only taken this supplement twice, I already notice improvement in my asthma and sinus issues. I'm breathing easier and feel more relaxed. I'm excited to see how it will help in the long term!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.7
9
Quercetin alleviates asthma symptoms
Quercetin inhibits ferroptosis through the SIRT1/Nrf2/HO-1 signaling pathway and alleviates asthma disease.
Potential but needs cautious application
We explored how quercetin, a natural compound found in fruits and vegetables, can impact asthma symptoms. Using an ovalbumin-induced mouse model of asthma, we aimed to uncover whether quercetin can help inhibit a process known as ferroptosis, potentially offering a new therapeutic approach for asthma sufferers.
Our findings showed that quercetin effectively reduced inflammation in the asthmatic mice. Specifically, it lowered levels of inflammatory factors such as IL-4, IL-5, and IL-13—substances typically elevated during an asthma attack. Notably, we also observed that quercetin increased the levels of superoxide dismutase, an important antioxidant, while decreasing malondialdehyde and ferric ions that are associated with oxidative stress.
Additionally, quercetin appeared to boost the expression of key proteins involved in defending against oxidative stress, specifically SIRT1, Nrf2, and HO-1. This suggests that quercetin not only helps combat inflammation but may also protect against cellular damage within the lungs. Overall, our study indicates that quercetin holds promise as a beneficial treatment for asthma by addressing both inflammatory and oxidative stress pathways.
Our findings showed that quercetin effectively reduced inflammation in the asthmatic mice. Specifically, it lowered levels of inflammatory factors such as IL-4, IL-5, and IL-13—substances typically elevated during an asthma attack. Notably, we also observed that quercetin increased the levels of superoxide dismutase, an important antioxidant, while decreasing malondialdehyde and ferric ions that are associated with oxidative stress.
Additionally, quercetin appeared to boost the expression of key proteins involved in defending against oxidative stress, specifically SIRT1, Nrf2, and HO-1. This suggests that quercetin not only helps combat inflammation but may also protect against cellular damage within the lungs. Overall, our study indicates that quercetin holds promise as a beneficial treatment for asthma by addressing both inflammatory and oxidative stress pathways.
Read More
9
Quercetin aids asthma treatment
Mechanisms of Bushenyiqi decoction in the treatment of asthma: an investigation based on network pharmacology with experimental validation.
Key components but no isolation
We explored the potential of quercetin, a key component of Bushenyiqi decoction (BYD), in treating asthma. Through a combination of network pharmacology and experimental validation, we examined its effects on asthma symptoms and the underlying mechanisms behind them.
Our research highlighted that BYD significantly improves airway responsiveness and decreases inflammation in allergic asthma mice. We identified quercetin, along with other active ingredients in BYD, as critical players in targeting specific genes related to asthma, particularly interleukin 6 (IL-6), epidermal growth factor receptor (EGFR), and hypoxia-inducible factor 1 alpha (HIF1A).
The phosphatidylinositol-3-kinase/AKT signaling pathway also emerged as crucial in this process. Our findings suggest that quercetin contributes to reducing inflammation and respiratory symptoms in asthma by regulating these targets.
Overall, this investigation underscores the importance of quercetin as a valuable element of BYD in mitigating asthma-related inflammation, providing new insights into traditional Chinese medicine's effective strategies.
Our research highlighted that BYD significantly improves airway responsiveness and decreases inflammation in allergic asthma mice. We identified quercetin, along with other active ingredients in BYD, as critical players in targeting specific genes related to asthma, particularly interleukin 6 (IL-6), epidermal growth factor receptor (EGFR), and hypoxia-inducible factor 1 alpha (HIF1A).
The phosphatidylinositol-3-kinase/AKT signaling pathway also emerged as crucial in this process. Our findings suggest that quercetin contributes to reducing inflammation and respiratory symptoms in asthma by regulating these targets.
Overall, this investigation underscores the importance of quercetin as a valuable element of BYD in mitigating asthma-related inflammation, providing new insights into traditional Chinese medicine's effective strategies.
Read More
9
Quercetin reduces airway inflammation
Quercetin supplementation attenuates airway hyperreactivity and restores airway relaxation in rat pups exposed to hyperoxia.
Moderate relevance to asthma treatment
We aimed to investigate the potential benefits of quercetin, a natural compound, in addressing airway hyperreactivity and inflammation in newborn rats exposed to high levels of oxygen. High oxygen environments often lead to lung injuries and increased airway sensitivity, mimicking some aspects of asthma.
To conduct this study, we divided young rats into groups exposed to either high oxygen or regular air for a week. Some of these groups received quercetin injections, while others did not. By measuring the contraction of tracheal smooth muscles in response to a specific chemical, we noted significant improvements in those treated with quercetin.
Specifically, quercetin reduced the excessive contraction observed in the high-oxygen groups and restored relaxation in the muscles, suggesting a protective effect. We also found that quercetin treatment lowered inflammation markers in the lungs, which is significant, given that inflammation often exacerbates asthma symptoms.
Overall, our findings indicate that quercetin could play a valuable role in managing airway hyperreactivity and associated inflammation, presenting a promising avenue for future therapies aimed at young patients with similar breathing issues.
To conduct this study, we divided young rats into groups exposed to either high oxygen or regular air for a week. Some of these groups received quercetin injections, while others did not. By measuring the contraction of tracheal smooth muscles in response to a specific chemical, we noted significant improvements in those treated with quercetin.
Specifically, quercetin reduced the excessive contraction observed in the high-oxygen groups and restored relaxation in the muscles, suggesting a protective effect. We also found that quercetin treatment lowered inflammation markers in the lungs, which is significant, given that inflammation often exacerbates asthma symptoms.
Overall, our findings indicate that quercetin could play a valuable role in managing airway hyperreactivity and associated inflammation, presenting a promising avenue for future therapies aimed at young patients with similar breathing issues.
Read More
9
Quercetin shows promise for asthma
The Alleviating Impacts of Quercetin on Inflammation and Oxidant-antioxidant Imbalance in Rats with Allergic Asthma.
Directly addresses quercetin's effects
We explored the impact of quercetin, a natural plant compound, on asthma by testing its anti-inflammatory and antioxidant properties in a controlled study with rats. Asthma was induced in the rats using a substance called ovalbumin, and they were divided into four groups: a control group, an asthma group treated with a saline solution, another asthma group treated with dexamethasone (a common asthma medication), and a group treated with quercetin.
After one week of daily injections of quercetin and dexamethasone, we noted significant changes in various biological markers. Quercetin appeared to lower the expression of several inflammatory factors linked to asthma, such as Gata-3 and TNF-α. It also positively influenced oxidative stress by reducing levels of malondialdehyde, a marker of cell damage, while boosting antioxidants in both the serum and lung tissue.
Our findings suggest that quercetin does more than just alleviate inflammatory responses; it also enhances the body's defenses against oxidative stress, particularly in the lungs. Overall, quercetin shows great potential as an effective treatment for asthma, helping to manage both inflammation and oxidative stress at the tissue level.
After one week of daily injections of quercetin and dexamethasone, we noted significant changes in various biological markers. Quercetin appeared to lower the expression of several inflammatory factors linked to asthma, such as Gata-3 and TNF-α. It also positively influenced oxidative stress by reducing levels of malondialdehyde, a marker of cell damage, while boosting antioxidants in both the serum and lung tissue.
Our findings suggest that quercetin does more than just alleviate inflammatory responses; it also enhances the body's defenses against oxidative stress, particularly in the lungs. Overall, quercetin shows great potential as an effective treatment for asthma, helping to manage both inflammation and oxidative stress at the tissue level.
Read More
9
Quercetin improves asthma symptoms
Quercetin Alleviates Asthma-Induced Airway Inflammation and Remodeling through Downregulating Periostin via Blocking TGF-β1/Smad Pathway.
Direct investigation of quercetin's effects
We explored how quercetin, a natural compound, may help alleviate asthma symptoms. The focus was on its potential role regarding periostin, a protein linked to inflammatory responses in the lungs, and its interaction with the TGF-β1/Smad pathway, a key signaling system in asthma.
To gain insights, we constructed a model using mice sensitized to ovalbumin—an allergen that triggers asthma—and administered quercetin among other treatments. We carefully observed changes in inflammatory responses, airway remodeling, and hyperresponsiveness, using various tests and analyses to measure inflammation markers and proteins involved in airway fibrosis.
Our findings revealed that quercetin significantly reduced the levels of periostin and inhibited airway inflammation and fibrosis. It also showed a tendency to reduce airway hyperreactivity, suggesting that quercetin works through suppressing the TGF-β1/Smad signaling pathway.
Overall, our study supports quercetin as a promising candidate for asthma treatment, highlighting how it effectively targets specific pathways involved in the disease, offering a protective effect against its symptoms.
To gain insights, we constructed a model using mice sensitized to ovalbumin—an allergen that triggers asthma—and administered quercetin among other treatments. We carefully observed changes in inflammatory responses, airway remodeling, and hyperresponsiveness, using various tests and analyses to measure inflammation markers and proteins involved in airway fibrosis.
Our findings revealed that quercetin significantly reduced the levels of periostin and inhibited airway inflammation and fibrosis. It also showed a tendency to reduce airway hyperreactivity, suggesting that quercetin works through suppressing the TGF-β1/Smad signaling pathway.
Overall, our study supports quercetin as a promising candidate for asthma treatment, highlighting how it effectively targets specific pathways involved in the disease, offering a protective effect against its symptoms.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 23 Reviews
9.1
10
Symptom relief
Close to magic! After years struggling with severe adrenal fatigue and asthma, Quercetin has worked wonders. I no longer have allergic reactions to foods or wine. I take 500 mg, splitting the dose, especially after meals, and have found it effective. The product quality is excellent, and I’m grateful to the producers. Quercetin should be highly recommended for anyone suffering from allergies and asthma.
Read More
10
Breathable relief
This supplement has been a game-changer for managing my asthma, allowing me to breathe easier. Since taking it, I've experienced fewer itchiness and skin rashes too.
10
Inhaler free
After two weeks on Quercetin, I no longer need my inhaler for bronchial asthma; breathing has become much easier.
10
No inhaler needed
The quality and value of Quercetin are excellent. I've been taking one capsule daily, and I haven’t needed an asthma inhaler for over a year now. I prefer it without bromelain due to my sensitivity.
10
Expedites relief
Today is my first day in ages without using my inhaler, thanks to quercetin. It opens up my lungs, even during an asthma attack, in just a few minutes. I love it!
