Quercetin effectively reduces nauseaBrain mitochondrial damage attenuation by quercetin and N-acetyl cysteine: peripheral and central antiemetic effects.
Comprehensive effect evaluation of quercetin.
We explored how quercetin, a natural antioxidant, affects nausea induced by substances like ipecac and copper sulfate in a controlled study involving chickens. Both quercetin and another antioxidant called N-acetylcysteine (NAC) were tested to see whether they could alleviate emesis (vomiting) and also protect the brain from oxidative damage.
Our findings revealed that quercetin and NAC did, in fact, significantly reduce vomiting compared to the control group. We observed notable improvements in markers of oxidative damage in the brain, such as reduced lipid peroxidation and lower levels of reactive oxygen species and protein carbonyls after administering quercetin and NAC. This suggests that these substances enhance mitochondrial function and boost antioxidant levels within the body.
Interestingly, when we combined quercetin with NAC, the effects were even more pronounced, implying that utilizing both together may offer greater protection against nausea and brain oxidative stress. Overall, this study indicates that quercetin could play a valuable role in managing nausea through both peripheral effects (like reducing vomiting) and central effects (like protecting the brain).
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