Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.9
USERS' SCORE
Good
Based on 71 Reviews
8.9
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Saccharomyces boulardii(an S. cerevisiae Strain)
250 mg(5 Billion CFU)
†
MOS Yeast Fraction(Min. 35% Manno-oligosaccharides [MOS]) (S. cerevisiae)
200 mg
†
Top Medical Research Studies
9
We focused on the effects of the probiotic Saccharomyces boulardii on Multiple Sclerosis (MS) patients, comparing its benefits to a placebo over four months.
Notably, we found that Saccharomyces boulardii significantly lowered inflammatory markers and improved overall antioxidant capacity. Participants also reported less pain and fatigue, alongside enhancements in their quality of life compared to those receiving the placebo.
This suggests that incorporating Saccharomyces boulardii might help alleviate some symptoms related to MS, offering a beneficial avenue for symptom management.
Notably, we found that Saccharomyces boulardii significantly lowered inflammatory markers and improved overall antioxidant capacity. Participants also reported less pain and fatigue, alongside enhancements in their quality of life compared to those receiving the placebo.
This suggests that incorporating Saccharomyces boulardii might help alleviate some symptoms related to MS, offering a beneficial avenue for symptom management.
Read More
9
We evaluated how Saccharomyces boulardii affects IgA nephropathy in mice, particularly after an oral poliovirus vaccine (OPV).
The mice were divided into four groups—some receiving the OPV alone, others along with S. boulardii, and a few with just S. boulardii or no treatment.
After six weeks, we found that only the mice receiving the OPV alone showed signs of IgA nephropathy, with increased levels of serum IgA and kidney abnormalities.
In contrast, those treated with S. boulardii or receiving no treatment had normal results.
These findings suggest that S. boulardii can effectively prevent vaccine-induced IgA nephropathy in experimental models.
The mice were divided into four groups—some receiving the OPV alone, others along with S. boulardii, and a few with just S. boulardii or no treatment.
After six weeks, we found that only the mice receiving the OPV alone showed signs of IgA nephropathy, with increased levels of serum IgA and kidney abnormalities.
In contrast, those treated with S. boulardii or receiving no treatment had normal results.
These findings suggest that S. boulardii can effectively prevent vaccine-induced IgA nephropathy in experimental models.
Read More
8
Saccharomyces boulardii shows potential
We investigated how Saccharomyces boulardii might help with inflammation in arthritis by focusing on its effects on gut health. Using a rat model of collagen-induced arthritis, we administered S. boulardii alongside Methotrexate for eight weeks.
Our findings highlighted S. boulardii's potential to positively influence gut bacteria, which could be crucial for inflammation management. While the results seem promising, further studies are needed to clearly establish its effectiveness in autoimmune conditions like arthritis.
Our findings highlighted S. boulardii's potential to positively influence gut bacteria, which could be crucial for inflammation management. While the results seem promising, further studies are needed to clearly establish its effectiveness in autoimmune conditions like arthritis.
Read More
Most Useful Reviews
9.5
Reduced inflammation
These capsules significantly reduce inflammation in my gastrointestinal tract, supporting my autoimmunity. They aid nutrient absorption, improve skin health, and overall wellness.
Read More
9.5
Improved digestion
The Tombs of Bulardi Panacea effectively counteracts many "intestinal reptiles" including Candida and assists in normalising stool and digestion. It particularly aids in managing the bacterium Helicobacter, which can trigger gastritis, and boosts immune system function, crucial since 80% of immunity is linked to our intestines. I intend to order this supplement regularly, as it has significantly improved my digestive tract, and I believe I may eventually forget about my autoimmune disorder.
Read More
9.5
C Diff protection
This probiotic is superb for preventing C Diff. My son suffered two episodes after antibiotics, and adding one capsule to his morning smoothie has kept it away ever since. I couldn't be more satisfied.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.9
- All Researches
9
We focused on the effects of the probiotic Saccharomyces boulardii on Multiple Sclerosis (MS) patients, comparing its benefits to a placebo over four months.
Notably, we found that Saccharomyces boulardii significantly lowered inflammatory markers and improved overall antioxidant capacity. Participants also reported less pain and fatigue, alongside enhancements in their quality of life compared to those receiving the placebo.
This suggests that incorporating Saccharomyces boulardii might help alleviate some symptoms related to MS, offering a beneficial avenue for symptom management.
Notably, we found that Saccharomyces boulardii significantly lowered inflammatory markers and improved overall antioxidant capacity. Participants also reported less pain and fatigue, alongside enhancements in their quality of life compared to those receiving the placebo.
This suggests that incorporating Saccharomyces boulardii might help alleviate some symptoms related to MS, offering a beneficial avenue for symptom management.
Read More
9
We evaluated how Saccharomyces boulardii affects IgA nephropathy in mice, particularly after an oral poliovirus vaccine (OPV).
The mice were divided into four groups—some receiving the OPV alone, others along with S. boulardii, and a few with just S. boulardii or no treatment.
After six weeks, we found that only the mice receiving the OPV alone showed signs of IgA nephropathy, with increased levels of serum IgA and kidney abnormalities.
In contrast, those treated with S. boulardii or receiving no treatment had normal results.
These findings suggest that S. boulardii can effectively prevent vaccine-induced IgA nephropathy in experimental models.
The mice were divided into four groups—some receiving the OPV alone, others along with S. boulardii, and a few with just S. boulardii or no treatment.
After six weeks, we found that only the mice receiving the OPV alone showed signs of IgA nephropathy, with increased levels of serum IgA and kidney abnormalities.
In contrast, those treated with S. boulardii or receiving no treatment had normal results.
These findings suggest that S. boulardii can effectively prevent vaccine-induced IgA nephropathy in experimental models.
Read More
9
We explored a novel oral drug delivery system designed specifically for treating IgA nephropathy, an autoimmune disorder. Using hydroxychloroquine and dexamethasone paired with yeast cell walls, we aimed for targeted delivery to the ileal region.
Our findings revealed that this system effectively reduced harmful IgA levels and improved kidney tissue health in test subjects. We also noted significant reductions in inflammatory markers, suggesting potential benefits in managing IgA nephropathy through this innovative approach.
Our findings revealed that this system effectively reduced harmful IgA levels and improved kidney tissue health in test subjects. We also noted significant reductions in inflammatory markers, suggesting potential benefits in managing IgA nephropathy through this innovative approach.
Read More
9
We investigated the role of certain yeast polysaccharides in modulating immune responses related to autoimmune disorders. Our focus was on mannan/β-1,6-glucan-containing polysaccharides (MGCP), which showed strong anti-inflammatory properties.
MGCP prompted the development of regulatory T cells and reduced harmful immune responses in models of inflammatory diseases. While we saw promising results in laboratory settings, these findings emphasize the potential of using yeast-derived compounds for therapeutic approaches in treating autoimmune conditions.
MGCP prompted the development of regulatory T cells and reduced harmful immune responses in models of inflammatory diseases. While we saw promising results in laboratory settings, these findings emphasize the potential of using yeast-derived compounds for therapeutic approaches in treating autoimmune conditions.
Read More
9
We investigated the effects of a novel treatment targeting BAMBI, a protein involved in immune cell regulation, on autoimmune disorders like psoriasis and arthritis in mice. Through careful experimentation with control groups, we found that the anti-BAMBI antibody significantly increased protective Treg cells and reduced disease progression in various models. This treatment effectively prevented skin psoriasis and type II collagen-induced arthritis, hinting at new therapeutic possibilities for chronic inflammatory conditions driven by immune system dysfunction.
Read More
User Reviews
USERS' SCORE
Good
Based on 71 Reviews
8.9
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Reduced inflammation
These capsules significantly reduce inflammation in my gastrointestinal tract, supporting my autoimmunity. They aid nutrient absorption, improve skin health, and overall wellness.
Read More
9.5
Improved digestion
The Tombs of Bulardi Panacea effectively counteracts many "intestinal reptiles" including Candida and assists in normalising stool and digestion. It particularly aids in managing the bacterium Helicobacter, which can trigger gastritis, and boosts immune system function, crucial since 80% of immunity is linked to our intestines. I intend to order this supplement regularly, as it has significantly improved my digestive tract, and I believe I may eventually forget about my autoimmune disorder.
Read More
9.5
C Diff protection
This probiotic is superb for preventing C Diff. My son suffered two episodes after antibiotics, and adding one capsule to his morning smoothie has kept it away ever since. I couldn't be more satisfied.
Read More
8.3
Cured vaginal issues
I initially took half a capsule for feminine issues to improve microflora. After three days, my symptoms worsened, but after a week at two capsules daily, I felt much better. I now drink it with food twice daily. While I take many supplements, I believe this one helped with my autoimmune disorder.
Read More
9.5
Life-changing
After over a decade of stomach issues, doctors failed to determine the cause until I discovered these natural pills from a friend. They changed my life, allowing me to enjoy eating out without the anxiety of sudden bathroom needs. I am grateful for this treatment after living in discomfort for so long due to my autoimmune disorder.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Zhang C, Wang Y, Ullah H, Rahman AU, Wei J, et al. Saccharomyces boulardii (CNCM I-745) alleviates collagen-induced arthritis by partially maintaining intestinal mucosal integrity through TLR2/MYD88/NF-κB pathway inhibition. Int Immunopharmacol. 2024;139:112738. doi:10.1016/j.intimp.2024.112738
- Asghari KM, Dolatkhah N, Ayromlou H, Mirnasiri F, Dadfar T, et al. The effect of probiotic supplementation on the clinical and para-clinical findings of multiple sclerosis: a randomized clinical trial. Sci Rep. 2023;13:18577. doi:10.1038/s41598-023-46047-6
- Aghamohammadi D, Ayromlou H, Dolatkhah N, Jahanjoo F, Shakouri SK. The effects of probiotic Saccharomyces boulardii on the mental health, quality of life, fatigue, pain, and indices of inflammation and oxidative stress in patients with multiple sclerosis: study protocol for a double-blind randomized controlled clinical trial. Trials. 2019;20:379. doi:10.1186/s13063-019-3454-9
- Soylu A, Berktaş S, Sarioğlu S, Erbil G, Yilmaz O, et al. Saccharomyces boulardii prevents oral-poliovirus vaccine-induced IgA nephropathy in mice. Pediatr Nephrol. 2008;23:1287. doi:10.1007/s00467-008-0813-2
- Tian C, Yan M, Guo J, Zhou Y, Du B, et al. Yeast Cell Wall-Mediated Ileal Targeted Delivery System for IgA Nepharopathy Therapy. ACS Biomater Sci Eng. 2025;11:1498. doi:10.1021/acsbiomaterials.4c01941
- Vuscan P, Röring RJ, Kischkel B, Tintoré M, Cuñé J, et al. Effect of Saccharomyces cerevisiae β-glucan on the T helper cytokine profile. Cytokine. 2025;187:156871. doi:10.1016/j.cyto.2025.156871
- Lee C, Verma R, Byun S, Jeun EJ, Kim GC, et al. Structural specificities of cell surface β-glucan polysaccharides determine commensal yeast mediated immuno-modulatory activities. Nat Commun. 2021;12:3611. doi:10.1038/s41467-021-23929-9
- de Campos Fraga-Silva TF, Mimura LAN, de Oliveira LRC, Dos Santos Toledo JH, Borim PA, et al. Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop. Sci Rep. 2020;10:22190. doi:10.1038/s41598-020-79102-7
- Alvarez P, Augustín JJ, Tamayo E, Iglesias M, Acinas O, et al. Therapeutic Effects of Anti-Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor Treatment in Psoriasis and Arthritis. Arthritis Rheumatol. 2020;72:1547. doi:10.1002/art.41272
- Aboud C, Zamaria N, Cannistrà C. Treatment of hidradenitis suppurativa: Surgery and yeast (Saccharomyces cerevisiae)-exclusion diet. Results after 6 years. Surgery. 2020;167:1012. doi:10.1016/j.surg.2019.12.015
